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Author : Anna L. Hill
Publisher :
ISBN 13 :
Total Pages : 454 pages
Book Rating : 4.:/5 (863 download)
Download or read book The Genetics and Genomics of Severe Asthma written by Anna L. Hill and published by . This book was released on 2006 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Xiangdong Wang
Publisher : Springer
ISBN 13 : 9811087644
Total Pages : 390 pages
Book Rating : 4.8/5 (11 download)
Download or read book Genomic Approach to Asthma written by Xiangdong Wang and published by Springer. This book was released on 2018-06-12 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume in the series, Translational Bioinformatics, provides an up-to-date overview of genomic approaches to asthma. By applying unbiased “-omics” combined with disease-focused and hypothesis-driven approaches, it enhances readers’ understanding of the asthma endotype. Furthermore, it elucidates how progress in -omics research, such as “genomic,” “transcriptomic,” “protomic,” and “metabolomic,” is applied in asthma, and reports on the related series of important breakthroughs in asthma development, classification, prevention and drug sensitivity. Also covering systems biology knowledge and methodologies, computational models and biostatistical methods to analyze big data, this book provides a valuable resource for scientists and researchers in the field of asthma and respiratory diseases.
Author : Dirkje S. Postma
Publisher : CRC Press
ISBN 13 :
Total Pages : 456 pages
Book Rating : 4.3/5 (91 download)
Download or read book Genetics of Asthma and Chronic Obstructive Pulmonary Disease written by Dirkje S. Postma and published by CRC Press. This book was released on 2007 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source spans the latest developments in the utilization of microarray techniques, linkage and association studies, mapping strategies, comparative genetics, microarray techniques, proteomics, and pharmacogenomics.
Author : Erick Forno
Publisher : Springer Nature
ISBN 13 : 3030274314
Total Pages : 365 pages
Book Rating : 4.0/5 (32 download)
Download or read book Severe Asthma in Children and Adolescents written by Erick Forno and published by Springer Nature. This book was released on 2019-11-13 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides readers with a comprehensive review of severe asthma in children and adolescents, covering epidemiology, genetics, risk factors, co-morbidities, clinical presentation, diagnosis and treatment. Written by leaders in the field, chapter discussions draw on the mechanisms driving the disease, genetics, multidisciplinary approaches, immunomodulators, and other important aspects in the management of the disease. Severe Asthma in Children and Adolescents: Mechanisms and Management is designed to be a practical guide, opening with an introduction on the epidemiology of severe childhood asthma, as well as a discussion of special considerations of the disease unique to the preschool-aged patient. The distinctions between the diagnosis and management of asthma in young children of various ages, and specific approaches for the adolescent with severe asthma, including the transition into adult care are then addressed. Finally, the book closes with a discussion on the current state and future avenues for severe asthma research. Severe Asthma in Children and Adolescents is an indispensable reference for the healthcare professional, for basic and translational researchers, as well as for students, residents and fellows.
Author : Garden Grove Garden Grove Press
Publisher :
ISBN 13 : 9781545180945
Total Pages : 188 pages
Book Rating : 4.1/5 (89 download)
Download or read book Medical Genetics of Asthma written by Garden Grove Garden Grove Press and published by . This book was released on 2017-04-05 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: This article collection reviews the medical genetics of asthma and includes 22 papers by various authors. Topics include: Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population; Association of ADAM33 gene polymorphisms with adult allergic asthma and rhinitis in a Chinese Han population; Respiratory symptoms among infants at risk for asthma: association with surfactant protein A haplotypes; A functional polymorphism in the SPINK5 gene is associated with asthma in a Chinese Han Population; Association of genetic variants in chromosome 17q21 and adult-onset asthma in a Chinese Han population; Analyses of associations between three positionally cloned asthma candidate genes and asthma or asthma-related phenotypes in a Chinese population; A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS); Mechanistic role of a disease-associated genetic variant within the ADAM33 asthma susceptibility gene; Association study between vitamin D receptor gene polymorphisms and asthma in the chinese han population: a case-control study; Evaluation of the toll-like receptor 6 Ser249Pro polymorphism in patients with asthma, atopic dermatitis and chronic obstructive pulmonary disease; Genome Wide Association Study to predict severe asthma exacerbations in children using random forests classifiers; Asthma: Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene as risk factors; Effects of endotoxin exposure on childhood asthma risk are modified by a genetic polymorphism in ACAA1; Comprehensive genetic assessment of a functional TLR9 promoter polymorphism: no replicable association with asthma or asthma-related phenotypes; Leukotriene B4 receptor locus gene characterisation and association studies in asthma; Vitamin D binding protein variants associate with asthma susceptibility in the Chinese han population; Investigating highly replicated asthma genes as candidate genes for allergic rhinitis; Association of CD14 -260 (-159) C>T and asthma: a systematic review and meta-analysis; The effect of CD14 and TLR4 gene polimorphisms on asthma phenotypes in adult Turkish asthma patients: a genetic study; Genome-wide association study identifies PERLD1 as asthma candidate gene; Large scale genotyping study for asthma in the Japanese population; ITGB5 and AGFG1 variants are associated with severity of airway responsiveness. Proceeds from the sale of this book go to the support of an elderly disabled person.
Author : A. Barry Kay
Publisher : Wiley-Blackwell
ISBN 13 : 9780865428676
Total Pages : 1872 pages
Book Rating : 4.4/5 (286 download)
Download or read book Allergy and Allergic Diseases written by A. Barry Kay and published by Wiley-Blackwell. This book was released on 1997-07-14 with total page 1872 pages. Available in PDF, EPUB and Kindle. Book excerpt: The most comprehensive and up-to-date allergy textbook in the world. Over 100 chapters written by world leading authorities covering virtually every aspect of basic and clinical allergy fully illustrated throughout with numerous overview diagrams and many colour illustrations. Authors contributing are from UK, Europe, North America and Australia.
Download or read book Investigation of Genetics and Genomics in Asthma written by and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Dhavendra Kumar
Publisher : Oxford Monographs on Medical G
ISBN 13 : 019989602X
Total Pages : 853 pages
Book Rating : 4.1/5 (998 download)
Download or read book Genomic Medicine written by Dhavendra Kumar and published by Oxford Monographs on Medical G. This book was released on 2014-10-15 with total page 853 pages. Available in PDF, EPUB and Kindle. Book excerpt: Preceded by Genomics and clinical medicine / edited by Dhavendra Kumar. [First edition]. 2008.
Author : Kian Fan Chung
Publisher : European Respiratory Society
ISBN 13 : 1849841047
Total Pages : 360 pages
Book Rating : 4.8/5 (498 download)
Download or read book Severe Asthma written by Kian Fan Chung and published by European Respiratory Society. This book was released on 2019-06-01 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Severe asthma is a form of asthma that responds poorly to currently available medication, and its patients represent those with greatest unmet needs. In the last 10 years, substantial progress has been made in terms of understanding some of the mechanisms that drive severe asthma; there have also been concomitant advances in the recognition of specific molecular phenotypes. This ERS Monograph covers all aspects of severe asthma – epidemiology, diagnosis, mechanisms, treatment and management – but has a particular focus on recent understanding of mechanistic heterogeneity based on an analytic approach using various ‘omics platforms applied to clinically well-defined asthma cohorts. How these advances have led to improved management targets is also emphasised. This book brings together the clinical and scientific expertise of those from around the world who are collaborating to solve the problem of severe asthma.
Author : Quentin Vanhaelen
Publisher : Humana
ISBN 13 : 9781493989546
Total Pages : 0 pages
Book Rating : 4.9/5 (895 download)
Download or read book Computational Methods for Drug Repurposing written by Quentin Vanhaelen and published by Humana. This book was released on 2018-12-14 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed book explores techniques commonly used for research into drug repurposing, a well-known strategy to find alternative indications for drugs which have already undergone toxicology and pharma-kinetic studies but have failed later stages during the development, via computational methods. Thereby, it addresses the intense challenges of identifying the appropriate type of algorithm and relevant technical information for computational repurposing. Written for the highly successful Methods in Molecular Biology series, the authors of each chapter use their experience in the field to describe the implementation and successful use of a specific repurposing method thus providing lab-ready instruction. Authoritative and practical, Computational Methods for Drug Repurposing serves as an ideal guide to researchers interested in this vital area of drug development.
Author : Geoffrey S. Ginsburg
Publisher : Academic Press
ISBN 13 : 0128006544
Total Pages : 372 pages
Book Rating : 4.1/5 (28 download)
Download or read book Genomic and Precision Medicine written by Geoffrey S. Ginsburg and published by Academic Press. This book was released on 2017-03-30 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genomic and Precision Medicine: Primary Care, Third Edition is an invaluable resource on the state-of-the-art tools, technologies and policy issues that are required to fully realize personalized health care in the area of primary care. One of the major areas where genomic and personalized medicine is most active is the realm of the primary care practitioner. Risk, family history, personal genomics and pharmacogenomics are becoming increasingly important to the PCP and their patients, and this book discusses the implications as they relate to primary care practitioners. Presents a comprehensive volume for primary care providers Provides succinct commentary and key learning points that will assist providers with their local needs for the implementation of genomic and personalized medicine Includes a current overview on major opportunities for genomic and personalized medicine in practice Highlights case studies that illustrate the practical use of genomics in the management in patients
Author : Mieczyslaw Pokorski
Publisher : Springer
ISBN 13 : 3319187937
Total Pages : 119 pages
Book Rating : 4.3/5 (191 download)
Download or read book Respiratory Health written by Mieczyslaw Pokorski and published by Springer. This book was released on 2015-07-29 with total page 119 pages. Available in PDF, EPUB and Kindle. Book excerpt: The tracheobronchial tree is open to the environment surrounding the body. Respiration has thus the essential bearing on general morbidity, vulnerability to disease and immunity. Further, respiratory function shapes the neuropsychological responses to succumbing to disease, controls the mind-to-body interaction and sets the perception of quality of life. The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services. Innovative strategies to promote prevention, care coordination and care integration as well as to align disease acceptance and quality of life measures also are tackled. Maintaining respiratory health is of rising research interest as a way of preventing a disease or a non pharmacological therapeutic succor. The book will be of interest to clinicians, family practitioners and medical researchers.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309222222
Total Pages : 142 pages
Book Rating : 4.3/5 (92 download)
Download or read book Toward Precision Medicine written by National Research Council and published by National Academies Press. This book was released on 2012-01-16 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt: Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward Precision Medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward Precision Medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy.
Author : Gary Peltz
Publisher : Springer Science & Business Media
ISBN 13 : 1592599303
Total Pages : 309 pages
Book Rating : 4.5/5 (925 download)
Download or read book Computational Genetics and Genomics written by Gary Peltz and published by Springer Science & Business Media. This book was released on 2007-11-05 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ultimately, the quality of the tools available for genetic analysis and experimental disease models will be assessed on the basis of whether they provide new information that generates novel treatments for human disease. In addition, the time frame in which genetic discoveries impact clinical practice is also an important dimension of how society assesses the results of the significant public financial investment in genetic research. Because of the investment and the increased expectation that new tre- ments will be found for common diseases, allowing decades to pass before basic discoveries are made and translated into new therapies is no longer acceptable. Computational Genetics and Genomics: Tools for Understanding Disease provides an overview and assessment of currently available and developing tools for genetic analysis. It is hoped that these new tools can be used to identify the genetic basis for susceptibility to disease. Although this very broad topic is addressed in many other books and journal articles, Computational Genetics and Genomics: Tools for Understanding Disease focuses on methods used for analyzing mouse genetic models of biomedically - portant traits. This volume aims to demonstrate that commonly used inbred mouse strains can be used to model virtually all human disea- related traits. Importantly, recently developed computational tools will enable the genetic basis for differences in disease-related traits to be rapidly identified using these inbred mouse strains. On average, a decade is required to carry out the development process required to demonstrate that a new disease treatment is beneficial.
Author : Dhavendra Kumar
Publisher : Academic Press
ISBN 13 : 0127999221
Total Pages : 360 pages
Book Rating : 4.1/5 (279 download)
Download or read book Medical and Health Genomics written by Dhavendra Kumar and published by Academic Press. This book was released on 2016-06-04 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medical and Health Genomics provides concise and evidence-based technical and practical information on the applied and translational aspects of genome sciences and the technologies related to non-clinical medicine and public health. Coverage is based on evolving paradigms of genomic medicine—in particular, the relation to public and population health genomics now being rapidly incorporated in health management and administration, with further implications for clinical population and disease management. Provides extensive coverage of the emergent field of health genomics and its huge relevance to healthcare management Presents user-friendly language accompanied by explanatory diagrams, figures, and many references for further study Covers the applied, but non-clinical, sciences across disease discovery, genetic analysis, genetic screening, and prevention and management Details the impact of clinical genomics across a diverse array of public and community health issues, and within a variety of global healthcare systems
Author : Sara L. Torres
Publisher :
ISBN 13 :
Total Pages : 322 pages
Book Rating : 4.:/5 (318 download)
Download or read book Genetic Predisposition to Disease written by Sara L. Torres and published by . This book was released on 2008 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: A genetic predisposition is a genetic effect which influences the phenotype of an organism but which can be modified by the environmental conditions. Genetic testing is able to identify individuals who are genetically predisposed to certain health problems such as cancer or other life altering diseases. This book discusses the determination of the genetic basis of health problems that will help the precise mechanisms of health problem such as a disease or physical disorder.
Author : Greg Gibson
Publisher : FT Press
ISBN 13 : 0132704218
Total Pages : 207 pages
Book Rating : 4.1/5 (327 download)
Download or read book It Takes a Genome written by Greg Gibson and published by FT Press. This book was released on 2008-12-24 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Human beings have astonishing genetic vulnerabilities. More than half of us will die from complex diseases that trace directly to those vulnerabilities, and the modern world we’ve created places us at unprecedented risk from them. In It Takes a Genome, Greg Gibson posits a revolutionary new hypothesis: Our genome is out of equilibrium, both with itself and its environment. Simply put, our genes aren’t coping well with modern culture. Our bodies were never designed to subsist on fat and sugary foods; our immune systems weren’t designed for today’s clean, bland environments; our minds weren’t designed to process hard-edged, artificial electronic inputs from dawn ‘til midnight. And that’s why so many of us suffer from chronic diseases that barely touched our ancestors. Gibson begins by revealing the stunningly complex ways in which multiple genes cooperate and interact to shape our bodies and influence our behaviors. Then, drawing on the very latest science, he explains the genetic “mismatches” that increasingly lead to cancer, diabetes, inflammatory and infectious diseases, AIDS, depression, and senility. He concludes with a look at the probable genetic variations in human psychology, sharing the evidence that traits like introversion and agreeableness are grounded in equally complex genetic interactions. It Takes A Genome demolishes yesterday’s stale debates over “nature vs. nurture,” introducing a new view that is far more intriguing, and far closer to the truth. See how broken genes cause cancer Meet the body’s “genetic repairmen”—and understand what happens when they fail The growing price of the modern lifestyle Why one-third of all Westerners have obesity, Type 2 diabetes, or other signs of “metabolic syndrome” The Alzheimer’s generation Why some of us are predisposed to dementia What’s really normal: the deepest lessons of the human genome The remarkable diversity of physical and emotional “normality”
