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The Fundamentals Of Modern Statistical Genetics
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Book Synopsis The Fundamentals of Modern Statistical Genetics by : Nan M. Laird
Download or read book The Fundamentals of Modern Statistical Genetics written by Nan M. Laird and published by Springer Science & Business Media. This book was released on 2010-12-13 with total page 226 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the statistical models and methods that are used to understand human genetics, following the historical and recent developments of human genetics. Starting with Mendel’s first experiments to genome-wide association studies, the book describes how genetic information can be incorporated into statistical models to discover disease genes. All commonly used approaches in statistical genetics (e.g. aggregation analysis, segregation, linkage analysis, etc), are used, but the focus of the book is modern approaches to association analysis. Numerous examples illustrate key points throughout the text, both of Mendelian and complex genetic disorders. The intended audience is statisticians, biostatisticians, epidemiologists and quantitatively- oriented geneticists and health scientists wanting to learn about statistical methods for genetic analysis, whether to better analyze genetic data, or to pursue research in methodology. A background in intermediate level statistical methods is required. The authors include few mathematical derivations, and the exercises provide problems for students with a broad range of skill levels. No background in genetics is assumed.
Book Synopsis The Fundamentals of Modern Statistical Genetics by : Nan M. Laird
Download or read book The Fundamentals of Modern Statistical Genetics written by Nan M. Laird and published by . This book was released on 2011-03-30 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Applied Statistical Genetics with R by : Andrea S. Foulkes
Download or read book Applied Statistical Genetics with R written by Andrea S. Foulkes and published by Springer Science & Business Media. This book was released on 2009-04-28 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistical genetics has become a core course in many graduate programs in public health and medicine. This book presents fundamental concepts and principles in this emerging field at a level that is accessible to students and researchers with a first course in biostatistics. Extensive examples are provided using publicly available data and the open source, statistical computing environment, R.
Book Synopsis Fundamentals of Modern Statistical Methods by : Rand R. Wilcox
Download or read book Fundamentals of Modern Statistical Methods written by Rand R. Wilcox and published by Springer Science & Business Media. This book was released on 2010-03-18 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conventional statistical methods have a very serious flaw. They routinely miss differences among groups or associations among variables that are detected by more modern techniques, even under very small departures from normality. Hundreds of journal articles have described the reasons standard techniques can be unsatisfactory, but simple, intuitive explanations are generally unavailable. Situations arise where even highly nonsignificant results become significant when analyzed with more modern methods. Without assuming the reader has any prior training in statistics, Part I of this book describes basic statistical principles from a point of view that makes their shortcomings intuitive and easy to understand. The emphasis is on verbal and graphical descriptions of concepts. Part II describes modern methods that address the problems covered in Part I. Using data from actual studies, many examples are included to illustrate the practical problems with conventional procedures and how more modern methods can make a substantial difference in the conclusions reached in many areas of statistical research. The second edition of this book includes a number of advances and insights that have occurred since the first edition appeared. Included are new results relevant to medians, regression, measures of association, strategies for comparing dependent groups, methods for dealing with heteroscedasticity, and measures of effect size.
Book Synopsis An Introduction to Statistical Genetic Data Analysis by : Melinda C. Mills
Download or read book An Introduction to Statistical Genetic Data Analysis written by Melinda C. Mills and published by MIT Press. This book was released on 2020-02-18 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.
Book Synopsis Introduction to Statistical Methods in Modern Genetics by : M.C. Yang
Download or read book Introduction to Statistical Methods in Modern Genetics written by M.C. Yang and published by CRC Press. This book was released on 2000-02-23 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the basic statistical theory behind modern genetics is not very difficult, most statistical genetics papers are not easy to read for beginners in the field, and formulae quickly become very tedious to fit a particular area of application. Introduction to Statistical Methods in Modern Genetics distinguishes between the necessary and unnecessary complexity in a presentation designed for graduate-level statistics students. The author keeps derivations simple, but does so without losing the mathematical details. He also provides the required background in modern genetics for those looking forward to entering this arena. Along with some of the statistical tools important in genetics applications, students will learn: How a gene is found How scientists have separated the genetic and environmental aspects of a person's intelligence How genetics are used in agriculture to improve crops and domestic animals What a DNA fingerprint is and why there are controversies about it Although the author assumes students have a foundation in basic statistics, an appendix provides the necessary background beyond the elementary, including multinomial distributions, inference on frequency tables, and discriminant analysis. With clear explanations, a multitude of figures, and exercise sets in each chapter, this text forms an outstanding entrée into the rapidly expanding world of genetic data analysis.
Book Synopsis Heterogeneity in Statistical Genetics by : Derek Gordon
Download or read book Heterogeneity in Statistical Genetics written by Derek Gordon and published by Springer Nature. This book was released on 2020-12-16 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heterogeneity, or mixtures, are ubiquitous in genetics. Even for data as simple as mono-genic diseases, populations are a mixture of affected and unaffected individuals. Still, most statistical genetic association analyses, designed to map genes for diseases and other genetic traits, ignore this phenomenon. In this book, we document methods that incorporate heterogeneity into the design and analysis of genetic and genomic association data. Among the key qualities of our developed statistics is that they include mixture parameters as part of the statistic, a unique component for tests of association. A critical feature of this work is the inclusion of at least one heterogeneity parameter when performing statistical power and sample size calculations for tests of genetic association. We anticipate that this book will be useful to researchers who want to estimate heterogeneity in their data, develop or apply genetic association statistics where heterogeneity exists, and accurately evaluate statistical power and sample size for genetic association through the application of robust experimental design.
Book Synopsis Modern Statistics for Modern Biology by : SUSAN. HUBER HOLMES (WOLFGANG.)
Download or read book Modern Statistics for Modern Biology written by SUSAN. HUBER HOLMES (WOLFGANG.) and published by Cambridge University Press. This book was released on 2018 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Fundamentals of Genetic Epidemiology by : Muin J. Khoury
Download or read book Fundamentals of Genetic Epidemiology written by Muin J. Khoury and published by Monographs in Epidemiology and. This book was released on 1993 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text integrates the principles, methods and approaches of epidemiology and genetics in the study of disease aetiology. The authors define the central theme of genetic epidemiology as the study of the role of genetic factors and their interaction with environmental factors in the occurrence of disease in populations.
Book Synopsis Handbook of Statistical Genetics by : David J. Balding
Download or read book Handbook of Statistical Genetics written by David J. Balding and published by John Wiley & Sons. This book was released on 2008-06-10 with total page 1616 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Handbook for Statistical Genetics is widely regarded as the reference work in the field. However, the field has developed considerably over the past three years. In particular the modeling of genetic networks has advanced considerably via the evolution of microarray analysis. As a consequence the 3rd edition of the handbook contains a much expanded section on Network Modeling, including 5 new chapters covering metabolic networks, graphical modeling and inference and simulation of pedigrees and genealogies. Other chapters new to the 3rd edition include Human Population Genetics, Genome-wide Association Studies, Family-based Association Studies, Pharmacogenetics, Epigenetics, Ethic and Insurance. As with the second Edition, the Handbook includes a glossary of terms, acronyms and abbreviations, and features extensive cross-referencing between the chapters, tying the different areas together. With heavy use of up-to-date examples, real-life case studies and references to web-based resources, this continues to be must-have reference in a vital area of research. Edited by the leading international authorities in the field. David Balding - Department of Epidemiology & Public Health, Imperial College An advisor for our Probability & Statistics series, Professor Balding is also a previous Wiley author, having written Weight-of-Evidence for Forensic DNA Profiles, as well as having edited the two previous editions of HSG. With over 20 years teaching experience, he’s also had dozens of articles published in numerous international journals. Martin Bishop – Head of the Bioinformatics Division at the HGMP Resource Centre As well as the first two editions of HSG, Dr Bishop has edited a number of introductory books on the application of informatics to molecular biology and genetics. He is the Associate Editor of the journal Bioinformatics and Managing Editor of Briefings in Bioinformatics. Chris Cannings – Division of Genomic Medicine, University of Sheffield With over 40 years teaching in the area, Professor Cannings has published over 100 papers and is on the editorial board of many related journals. Co-editor of the two previous editions of HSG, he also authored a book on this topic.
Book Synopsis Modern Statistical Methods for Astronomy by : Eric D. Feigelson
Download or read book Modern Statistical Methods for Astronomy written by Eric D. Feigelson and published by Cambridge University Press. This book was released on 2012-07-12 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern Statistical Methods for Astronomy: With R Applications.
Download or read book The R Book written by Michael J. Crawley and published by John Wiley & Sons. This book was released on 2007-06-13 with total page 953 pages. Available in PDF, EPUB and Kindle. Book excerpt: The high-level language of R is recognized as one of the mostpowerful and flexible statistical software environments, and israpidly becoming the standard setting for quantitative analysis,statistics and graphics. R provides free access to unrivalledcoverage and cutting-edge applications, enabling the user to applynumerous statistical methods ranging from simple regression to timeseries or multivariate analysis. Building on the success of the author’s bestsellingStatistics: An Introduction using R, The R Book ispacked with worked examples, providing an all inclusive guide to R,ideal for novice and more accomplished users alike. The bookassumes no background in statistics or computing and introduces theadvantages of the R environment, detailing its applications in awide range of disciplines. Provides the first comprehensive reference manual for the Rlanguage, including practical guidance and full coverage of thegraphics facilities. Introduces all the statistical models covered by R, beginningwith simple classical tests such as chi-square and t-test. Proceeds to examine more advance methods, from regression andanalysis of variance, through to generalized linear models,generalized mixed models, time series, spatial statistics,multivariate statistics and much more. The R Book is aimed at undergraduates, postgraduates andprofessionals in science, engineering and medicine. It is alsoideal for students and professionals in statistics, economics,geography and the social sciences.
Book Synopsis Handbook of Statistical Genetics by : David J. Balding
Download or read book Handbook of Statistical Genetics written by David J. Balding and published by Wiley. This book was released on 2003-09-19 with total page 1308 pages. Available in PDF, EPUB and Kindle. Book excerpt: From the Reviews of the First Edition: "This magnificent book attempts to catalogue and introduce all aspects of modern statistical genetics...I can thoroughly recommend it." Short Book Reviews of ISI "...extremely well written and referenced work, which must come highly recommended..." Statistical Methods in Medical Research Provides comprehensive coverage of a thriving area of research Features nine newly commissioned chapters All existing chapters have been fully updated with new advances in the field and new references Now includes a glossary of terms, and a list of acronyms and abbreviations. Features extensive cross-referencing between chapters. Each chapter is written by a leading international authority from the field. Complemented by examples, case studies, and references to useful resources on the web.
Book Synopsis Understanding Statistics and Experimental Design by : Michael H. Herzog
Download or read book Understanding Statistics and Experimental Design written by Michael H. Herzog and published by Springer. This book was released on 2019-08-13 with total page 146 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access textbook provides the background needed to correctly use, interpret and understand statistics and statistical data in diverse settings. Part I makes key concepts in statistics readily clear. Parts I and II give an overview of the most common tests (t-test, ANOVA, correlations) and work out their statistical principles. Part III provides insight into meta-statistics (statistics of statistics) and demonstrates why experiments often do not replicate. Finally, the textbook shows how complex statistics can be avoided by using clever experimental design. Both non-scientists and students in Biology, Biomedicine and Engineering will benefit from the book by learning the statistical basis of scientific claims and by discovering ways to evaluate the quality of scientific reports in academic journals and news outlets.
Book Synopsis Basics of Modern Statistical Genetics by : Linda Lait
Download or read book Basics of Modern Statistical Genetics written by Linda Lait and published by Delve Publishing. This book was released on 2016-11-30 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Examines a number of novel techniques used to study populations, phenotypes, and gene expression in organisms as diverse as humans and plants. The book ends with three case studies applying statistical genetics to identify genes associated with human diseases.
Book Synopsis Fundamentals of Mathematical Statistics by : S.C. Gupta
Download or read book Fundamentals of Mathematical Statistics written by S.C. Gupta and published by Sultan Chand & Sons. This book was released on 2020-09-10 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge updating is a never-ending process and so should be the revision of an effective textbook. The book originally written fifty years ago has, during the intervening period, been revised and reprinted several times. The authors have, however, been thinking, for the last few years that the book needed not only a thorough revision but rather a substantial rewriting. They now take great pleasure in presenting to the readers the twelfth, thoroughly revised and enlarged, Golden Jubilee edition of the book. The subject-matter in the entire book has been re-written in the light of numerous criticisms and suggestions received from the users of the earlier editions in India and abroad. The basis of this revision has been the emergence of new literature on the subject, the constructive feedback from students and teaching fraternity, as well as those changes that have been made in the syllabi and/or the pattern of examination papers of numerous universities. Knowledge updating is a never-ending process and so should be the revision of an effective textbook. The book originally written fifty years ago has, during the intervening period, been revised and reprinted several times. The authors have, however, been thinking, for the last few years that the book needed not only a thorough revision but rather a substantial rewriting. They now take great pleasure in presenting to the readers the twelfth, thoroughly revised and enlarged, Golden Jubilee edition of the book. The subject-matter in the entire book has been re-written in the light of numerous criticisms and suggestions received from the users of the earlier editions in India and abroad. The basis of this revision has been the emergence of new literature on the subject, the constructive feedback from students and teaching fraternity, as well as those changes that have been made in the syllabi and/or the pattern of examination papers of numerous universities. Knowledge updating is a never-ending process and so should be the revision of an effective textbook. The book originally written fifty years ago has, during the intervening period, been revised and reprinted several times. The authors have, however, been thinking, for the last few years that the book needed not only a thorough revision but rather a substantial rewriting. They now take great pleasure in presenting to the readers the twelfth, thoroughly revised and enlarged, Golden Jubilee edition of the book. The subject-matter in the entire book has been re-written in the light of numerous criticisms and suggestions received from the users of the earlier editions in India and abroad. The basis of this revision has been the emergence of new literature on the subject, the constructive feedback from students and teaching fraternity, as well as those changes that have been made in the syllabi and/or the pattern of examination papers of numerous universities. Some prominent additions are given below: 1. Variance of Degenerate Random Variable 2. Approximate Expression for Expectation and Variance 3. Lyapounov’s Inequality 4. Holder’s Inequality 5. Minkowski’s Inequality 6. Double Expectation Rule or Double-E Rule and many others
Book Synopsis An Introduction to Statistical Genetic Data Analysis by : Melinda C. Mills
Download or read book An Introduction to Statistical Genetic Data Analysis written by Melinda C. Mills and published by MIT Press. This book was released on 2020-02-18 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive introduction to modern applied statistical genetic data analysis, accessible to those without a background in molecular biology or genetics. Human genetic research is now relevant beyond biology, epidemiology, and the medical sciences, with applications in such fields as psychology, psychiatry, statistics, demography, sociology, and economics. With advances in computing power, the availability of data, and new techniques, it is now possible to integrate large-scale molecular genetic information into research across a broad range of topics. This book offers the first comprehensive introduction to modern applied statistical genetic data analysis that covers theory, data preparation, and analysis of molecular genetic data, with hands-on computer exercises. It is accessible to students and researchers in any empirically oriented medical, biological, or social science discipline; a background in molecular biology or genetics is not required. The book first provides foundations for statistical genetic data analysis, including a survey of fundamental concepts, primers on statistics and human evolution, and an introduction to polygenic scores. It then covers the practicalities of working with genetic data, discussing such topics as analytical challenges and data management. Finally, the book presents applications and advanced topics, including polygenic score and gene-environment interaction applications, Mendelian Randomization and instrumental variables, and ethical issues. The software and data used in the book are freely available and can be found on the book's website.
