The Feasibility Of Plants In The Manufacturing Of Protein Therapeutics

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Plants as Factories for Protein Production

Author : Elizabeth E. Hood
Publisher : Springer Science & Business Media
ISBN 13 : 9401726930
Total Pages : 232 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Plants as Factories for Protein Production by : Elizabeth E. Hood

Download or read book Plants as Factories for Protein Production written by Elizabeth E. Hood and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: This exciting volume Plants as Factories for Protein Production, edited by Drs. Elizabeth E. Hood and John A. Howard, contains chapters by experts in the field of molecular farming. The information within addresses the leading plant systems for recombinant protein production, as well as the progress being made in leading product categories - human pharmaceuticals, animal health, and industrial enzymes. More importantly, the book includes chapters that address the hot topics of production, containment, regulatory, and legal aspects that are quickly coming to the forefront of the industry. This most timely text is appropriate for graduate students and post-doctoral fellows, as well as being a key text for faculty, pharmaceutical producers, and industrial enzyme users.

Engineering the Plant Factory for the Production of Biologics and Small-Molecule Medicines

Author : Domenico De Martinis
Publisher : Frontiers Media SA
ISBN 13 : 2889450511
Total Pages : 379 pages
Book Rating : 4.8/5 (894 download)

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Book Synopsis Engineering the Plant Factory for the Production of Biologics and Small-Molecule Medicines by : Domenico De Martinis

Download or read book Engineering the Plant Factory for the Production of Biologics and Small-Molecule Medicines written by Domenico De Martinis and published by Frontiers Media SA. This book was released on 2017-04-27 with total page 379 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant gene transfer achieved in the early ‘80s paved the way for the exploitation of the potential of gene engineering to add novel agronomic traits and/or to design plants as factories for high added value molecules. For this latter area of research, the term "Molecular Farming" was coined in reference to agricultural applications in that major crops like maize and tobacco were originally used basically for pharma applications. The concept of the “green biofactory” implies different advantages over the typical cell factories based on animal cell or microbial cultures already when considering the investment and managing costs of fermenters. Although yield, stability, and quality of the molecules may vary among different heterologous systems and plants are competitive on a case-to-case basis, still the “plant factory” attracts scientists and technologists for the challenging features of low production cost, product safety and easy scale up. Once engineered, a plant is among the cheapest and easiest eukaryotic system to be bred with simple know-how, using nutrients, water and light. Molecules that are currently being produced in plants vary from industrial and pharmaceutical proteins, including medical diagnostics proteins and vaccine antigens, to nutritional supplements such as vitamins, carbohydrates and biopolymers. Convergence among disciplines as distant as plant physiology and pharmacology and, more recently, as omic sciences, bioinformatics and nanotechnology, increases the options of research on the plant cell factory. “Farming for Pharming” biologics and small-molecule medicines is a challenging area of plant biotechnology that may break the limits of current standard production technologies. The recent success on Ebola fighting with plant-made antibodies put a spotlight on the enormous potential of next generation herbal medicines made especially in the name of the guiding principle of reduction of costs, hence reduction of disparities of health rights and as a tool to guarantee adequate health protection in developing countries.

Multidisciplinary International Conference on Innovations in Education Science & Technology ICIEST-2023

Author : Prof. (Dr.) B.K Sarkar
Publisher : GEH PRESS
ISBN 13 :
Total Pages : 393 pages
Book Rating : 4.9/5 (898 download)

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Book Synopsis Multidisciplinary International Conference on Innovations in Education Science & Technology ICIEST-2023 by : Prof. (Dr.) B.K Sarkar

Download or read book Multidisciplinary International Conference on Innovations in Education Science & Technology ICIEST-2023 written by Prof. (Dr.) B.K Sarkar and published by GEH PRESS . This book was released on 2023-12-15 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The central motive of the International Conference is to throw up a number of new ideas and solutions to address the present-day challenges in the fields of 1: Science, Technology, Engineering and Mathematics. 2: Economics / Accounts. 3: Architecture and Design, Business, Divinity, Education, Engineering, Environmental Studies and Forestry, Family and Consumer Science, Health Sciences ,Human Physical Performance and Recreation, Journalism, Media Studies and Communication ,Law ,Library and Museum Studies ,Military Sciences ,Public Administration ,Social Work ,Transportation, Fine arts, Agricultural education, Management ,Social sciences , Physics, Chemistry, Business and commerce. 4: Health oriented education, Medical, Pharmacy, Dentel, Ayurveda, and Yoga. 5: English, Regional Language(s), Maths, Science, Social Sciences, Physical Education Computer Basics, Arts (Drawing) 6: History, Languages and linguistics, Literature, Performing arts, Philosophy, Religion and Religious studies, Visual arts. 7: Anthropology, Archaeology, Area Studies, Cultural and Ethnic Studies, Economics Gender and Sexuality Studies, Geography, Political Science, Psychology, Sociology. 8: Chemistry, Earth Sciences, Life Sciences, Physics, Space Sciences. 9: Computer Sciences, Logic, Mathematics, Statistics, Systems Science. The scope of the conference is broad and covers many aspects of international research prospective. This conference aims to provide a scholarly platform for participants to publish their research in reputed International Journals. The authors have incredible opportunity to present/5- Minute Video their research virtually and present findings worldwide that will not only help them gain the necessary exposure that they need to make their research work known in global scientific circles but also open the door to incredible opportunities for collaboration and conducting further research.

Molecular Farming in Plants: Recent Advances and Future Prospects

Author : Aiming Wang
Publisher : Springer Science & Business Media
ISBN 13 : 9400722176
Total Pages : 284 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Molecular Farming in Plants: Recent Advances and Future Prospects by : Aiming Wang

Download or read book Molecular Farming in Plants: Recent Advances and Future Prospects written by Aiming Wang and published by Springer Science & Business Media. This book was released on 2011-10-14 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular farming in plants is a relatively young subject of sciences. As plants can offer an inexpensive and convenient platform for the large-scale production of recombinant proteins with various functions, the driven force from the giant market for recombinant protein pharmaceuticals and industrial enzymes makes this subject grow and advance very quickly. To summarize recent advances, current challenges and future directions in molecular farming, international authorities were invited to write this book for researchers, teachers and students who are interested in this subject. This book, with the focus on the most advanced cutting-edge breakthroughs, covers all the essential aspects of the field of molecular farming in plants: from expression technologies to downstream processing, from products to safety issues, and from current advances and holdups to future developments.

New and Future Developments in Catalysis

Author : Steven L Suib
Publisher : Newnes
ISBN 13 : 0444538798
Total Pages : 413 pages
Book Rating : 4.4/5 (445 download)

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Book Synopsis New and Future Developments in Catalysis by : Steven L Suib

Download or read book New and Future Developments in Catalysis written by Steven L Suib and published by Newnes. This book was released on 2013-07-17 with total page 413 pages. Available in PDF, EPUB and Kindle. Book excerpt: New and Future Developments in Catalysis is a package of books that compile the latest ideas concerning alternate and renewable energy sources and the role that catalysis plays in converting new renewable feedstock into biofuels and biochemicals. Both homogeneous and heterogeneous catalysts and catalytic processes will be discussed in a unified and comprehensive approach. There will be extensive cross-referencing within all volumes. This volume covers all the biomass sources and gives detailed and in-depth coverage of all current chemical/catalytic conversion processes of biomass into liquid hydrocarbons to be further used as a feedstock for the production of not only biofuels but a large array of chemicals. - Offers an in-depth coverage of all catalytic topics of current interest and outlines the future challenges and research areas - A clear and visual description of all parameters and conditions enables the reader to draw conclusions for a particular case - Outline the catalytic processes applicable to energy generation and design of green processes

Advanced Molecular Plant Breeding

Author : D.N. Bharadwaj
Publisher : CRC Press
ISBN 13 : 1351358464
Total Pages : 615 pages
Book Rating : 4.3/5 (513 download)

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Book Synopsis Advanced Molecular Plant Breeding by : D.N. Bharadwaj

Download or read book Advanced Molecular Plant Breeding written by D.N. Bharadwaj and published by CRC Press. This book was released on 2018-10-29 with total page 615 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new volume provides a better understanding of molecular plant breeding in order to boost the quality of agriculture produce, to increase crop yields and to provide nutritious food for everyone by 2050. Scientists believe the challenge can be met by implementing new and improved techniques of quantitative trait inheritance in plant breeding. Integrating genomics and molecular biology into appropriate tools and methodologies can help to create genetically engineered plants, such as by using biotic and abiotic stress tolerance, molecular markers, ‘-omics’ technology, and genome editing.

Transgenic Plants

Author : Meran R. L. Owen
Publisher : John Wiley & Sons
ISBN 13 : 9780471964438
Total Pages : 378 pages
Book Rating : 4.9/5 (644 download)

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Book Synopsis Transgenic Plants by : Meran R. L. Owen

Download or read book Transgenic Plants written by Meran R. L. Owen and published by John Wiley & Sons. This book was released on 1997-01-23 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transgenic Plants: A Production System for Industrial andPharmaceutical Proteins provides a detailed guide to the principlesand practice of using transgenic plants as a system for theproduction of heterologous proteins. It is unique in that it coversthe complete process of heterologous protein production in plants,from the initial transformation of the plant, through totranscription, transgene stability and finally the downstreamingprocessing events for protein purification. Written by aninternational team of industrialists and academics, this bookdescribes: * the fundamental issues associated with expressing heterologousproteins in plants; * a number of detailed examples of the successful small-andlarge-scale production of proteins; * the essentials of patenting; and * the commercial exploitation. Transgenic Plants: A Production System for Industrial andPharmaceutical Proteins will be of interest to plantbiotechnologists, molecular biologists and protein biochemists inthe biotechnology and pharmaceutical industries.

Encyclopedia of Plant and Crop Science (Print)

Author : Robert M. Goodman
Publisher : Routledge
ISBN 13 : 1000031586
Total Pages : 1365 pages
Book Rating : 4.0/5 ( download)

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Book Synopsis Encyclopedia of Plant and Crop Science (Print) by : Robert M. Goodman

Download or read book Encyclopedia of Plant and Crop Science (Print) written by Robert M. Goodman and published by Routledge. This book was released on 2004-02-27 with total page 1365 pages. Available in PDF, EPUB and Kindle. Book excerpt: Encyclopedia of Plant and Crop Science is the first-ever single-source reference work to inclusively cover classic and modern studies in plant biology in conjunction with research, applications, and innovations in crop science and agriculture. From the fundamentals of plant growth and reproduction to developments in agronomy and agricultural science, the encyclopedia's authoritative content nurtures communication between these academically distinct yet intrinsically related fields-offering a spread of clear, descriptive, and concise entries to optimally serve scientists, agriculturalists, policy makers, students, and the general public.

Biopharmaceuticals

Author : Basanta Kumara Behera
Publisher : CRC Press
ISBN 13 : 1351013130
Total Pages : 300 pages
Book Rating : 4.3/5 (51 download)

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Book Synopsis Biopharmaceuticals by : Basanta Kumara Behera

Download or read book Biopharmaceuticals written by Basanta Kumara Behera and published by CRC Press. This book was released on 2020-12-07 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biopharmaceuticals: Challenges and Opportunities This book highlights how the traditional microbial process technology has been upgraded for the production of biologic drugs how manufacturing processes have evolved to meet the global market demand with quality products under the guidelines of internally recognized regulatory bodies. It also carries information on how, armed with a deeper understanding of life-threatening diseases, biopharmaceutical companies and the life sciences industry have developed formal and informal partnerships with researchers in institutes, universities, and other R&D organizations to fulfil timely, quality production with perfect safety and security. One of the most interesting aspects of this book is the conceptual development of personalized medicine (or precision medicine) to provide the right treatment to the right patient, at the right dose at an earlier stage of development, for genetic diseases. Besides this, it also highlights the most challenging aspects of modern biopharmaceutical science, focusing on the hot topics such as design and development of biologic drugs; the use of diversified groups of host cells belonging to animals, plants, microbes, insects, and mammals; stem cell therapy and gene therapy; supply chain management of biopharmaceuticals; and the future scope of biopharmaceutical industry development. This book is the latest resource for a wide circle of scientists, students, and researchers involved in understanding and implementing the knowledge of biopharmaceuticals to develop life-saving biologic drugs and to bring awareness to the development of personalized treatment that can potentially offer patients a faster diagnosis, fewer side effects, and better outcomes. Features: Explains how the traditional cell culture methodology has been changed to a fully continuous or partially continuous process Explains how to design and fabricate living organs of body by 3D bioprinting technology Focuses on how a biopharmaceutical company deals with various problems of regulatory bodies and develops innovative biologic drugs Narrates in detail the updated information on stem cell therapy and gene therapy Explains the development strategies and clinical significance of biosimilars and biobetters Highlights the supply chain management of biopharmaceuticals

Plants as Bioreactors for Industrial Molecules

Author : Santosh Kumar Upadhyay
Publisher : John Wiley & Sons
ISBN 13 : 1119875102
Total Pages : 548 pages
Book Rating : 4.1/5 (198 download)

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Book Synopsis Plants as Bioreactors for Industrial Molecules by : Santosh Kumar Upadhyay

Download or read book Plants as Bioreactors for Industrial Molecules written by Santosh Kumar Upadhyay and published by John Wiley & Sons. This book was released on 2023-02-03 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: PLANTS AS BIOREACTORS FOR INDUSTRIAL MOLECULES An incisive and practical discussion of how to use plants as bioreactors In Plants as Bioreactors for Industrial Molecules, a team of distinguished researchers delivers an insightful and global perspective on the use of plants as bioreactors. In the book, you’ll find coverage of the basic, applied, biosynthetic, and translational approaches to the exploitation of plant technology in the production of high-value biomolecules. The authors focus on the yield and quality of amino acids, vitamins, and carbohydrates. The authors explain how high-value biomolecules enable developers to create cost-effective biological systems for the production of biomolecules useful in a variety of sectors. They provide a holistic approach to plant-based biological devices to produce natural molecules of relevance to the health and agriculture industries. Readers will also find: A thorough overview of plants as bioreactors and discussions of molecular farming for the production of pharmaceutical proteins in plants Comprehensive explorations of plants as edible vaccines and plant cell culture for biopharmaceuticals Practical discussions of the production of attenuated viral particles as vaccines in plants and insecticidal protein production in transgenic plants Extensive treatment of the regulatory challenges involved in using plants as bioreactors Perfect for academics, scientists, and researchers in industrial microbiology and biotechnology, Plants as Bioreactors for Industrial Molecules will also earn a place in the libraries of biotechnology company professionals in applied product development.

Production of Plasma Proteins for Therapeutic Use

Author : Joseph Bertolini
Publisher : John Wiley & Sons
ISBN 13 : 0470924314
Total Pages : 518 pages
Book Rating : 4.4/5 (79 download)

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Book Synopsis Production of Plasma Proteins for Therapeutic Use by : Joseph Bertolini

Download or read book Production of Plasma Proteins for Therapeutic Use written by Joseph Bertolini and published by John Wiley & Sons. This book was released on 2012-12-26 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sets forth the state of the science and technology in plasma protein production With contributions from an international team of eighty leading experts and pioneers in the field, Production of Plasma Proteins for Therapeutic Use presents a comprehensive overview of the current state of knowledge about the function, use, and production of blood plasma proteins. In addition to details of the operational requirements for the production of plasma derivatives, the book describes the biology, development, research, manufacture, and clinical indications of essentially all plasma proteins with established clinical use or therapeutic potential. Production of Plasma Proteins for Therapeutic Use covers the key aspects of the plasma fractionation industry in five sections: Section 1: Introduction to Plasma Fractionation initially describes the history of transfusion and then covers the emergence of plasma collection and fractionation from its earliest days to the present time, with the commercial and not-for-profit sectors developing into a multi-billion dollar industry. Section 2: Plasma Proteins for Therapeutic Use contains 24 chapters dedicated to specific plasma proteins, including coagulation factors, albumin, immunoglobulin, and a comprehensive range of other plasma-derived proteins with therapeutic indications. Each chapter discusses the physiology, biochemistry, mechanism of action, and manufacture of each plasma protein including viral safety issues and clinical uses. Section 3: Pathogen Safety of Plasma Products examines issues and procedures for enhancing viral safety and reducing the risk of transmissible spongiform encephalopathy transmission. Section 4: The Pharmaceutical Environment Applied to Plasma Fractionation details the requirements and activities associated with plasma collection, quality assurance, compliance with regulatory requirements, provision of medical affairs support, and the manufacture of plasma products. Section 5: The Market for Plasma Products and the Economics of Fractionation reviews the commercial environment and economics of the plasma fractionation industry including future trends, highlighting regions such as Asia, which have the potential to exert a major influence on the plasma fractionation industry in the twenty-first century.

Microbial Biotechnology in Horticulture, Vol. 2

Author : R C Ray
Publisher : CRC Press
ISBN 13 : 1482280574
Total Pages : 367 pages
Book Rating : 4.4/5 (822 download)

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Book Synopsis Microbial Biotechnology in Horticulture, Vol. 2 by : R C Ray

Download or read book Microbial Biotechnology in Horticulture, Vol. 2 written by R C Ray and published by CRC Press. This book was released on 2008-01-01 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plant genetic engineering has revolutionized our ability to produce genetically improved plant varieties. Large proportions of our major crops have undergone genetic improvement through the use of recombinant DNA technology, and micro-organisms play an important role in this development. The book focuses on genetic engineering of plants for horticu

Plant Biotechnology and Transgenic Plants

Author : Kirsi-Marja Oksman-Caldentey
Publisher : CRC Press
ISBN 13 : 9780203910849
Total Pages : 746 pages
Book Rating : 4.9/5 (18 download)

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Book Synopsis Plant Biotechnology and Transgenic Plants by : Kirsi-Marja Oksman-Caldentey

Download or read book Plant Biotechnology and Transgenic Plants written by Kirsi-Marja Oksman-Caldentey and published by CRC Press. This book was released on 2002-08-14 with total page 746 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains case studies illustrating the cell culture production of pigments, flavors, and antineoplastic compounds Plant Biotechnology and Transgenic Plants covers topics that range from food to fragrances to fuel. It includes discussions of technologies and research on the engineering, synthesis, utilization, and control of primary and secondary plant metabolites such as carbohydrates, amino acids, lipids, polymers, proteins, and phytochemicals for industrial, pharmaceutical, and food and feed applications. The editors put the emphasis on recent methods in farming, plant propagation, and breeding and modern procedures to formulate more effective biopharmaceuticals.

Proceedings of ISPMF 2018 - Plant Molecular Farming

Author : Anneli Ritala
Publisher : Frontiers Media SA
ISBN 13 : 2889637948
Total Pages : 312 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Proceedings of ISPMF 2018 - Plant Molecular Farming by : Anneli Ritala

Download or read book Proceedings of ISPMF 2018 - Plant Molecular Farming written by Anneli Ritala and published by Frontiers Media SA. This book was released on 2020-06-16 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges

Author :
Publisher : Frontiers Media SA
ISBN 13 : 2832545661
Total Pages : 140 pages
Book Rating : 4.8/5 (325 download)

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Book Synopsis Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges by :

Download or read book Plant Molecular Farming for the Production of Next-Generation Vaccines and Biologics – Prospects and Challenges written by and published by Frontiers Media SA. This book was released on 2024-03-11 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are still a major threat to public health. The vaccine remains the most important and safer way of combating infectious diseases. Therefore, there is an urgent need to look for new ways of vaccine generation that can cut down production costs and processing time. The development of rDNA technology allows the expression and purification of proteins in unlimited quantity, thus opening an avenue for the development of protein-based vaccines as a prophylactic measure against infectious diseases. Recombinant therapeutic proteins derived from biological sources, including mammalian cells, microorganisms, suspension cultures, or genetically modified organisms by employing biotechnological processes, are widely used in clinical applications, especially for the treatment and prevention of human or veterinary infections. Since the development of human insulin by utilizing recombinant DNA technology in E. coli in the 1980s, the recombinant therapeutic protein production field has significantly grown and gained major attention. Plant molecular farming, the production of biologics in plant cells or transgenic plants, could offer a cost-effective adaptable strategy to produce biologics, particularly in low-resource settings. Molecular farming-based strategies could provide an alternative strategy to traditional biologics or vaccine production, enabling rapid development, effective deployment, and safe administration of vaccines. The concept of PMF was initially documented three decades back when recombinant growth hormone was produced in tobacco and sunflower plants. Even with such a long history of significant advantages and several proof-of-concept studies, very few plant-derived therapeutic products have been clinically translated. However, the recent progress around the approval of the plant-based biopharmaceutical ZMapp by the FDA, Medicago’s COVID-19 vaccine by Health Canada, and the safety of a few plant-derived vaccines in clinical trials have displayed the potential of a plant platform for biopharmaceutical production. Furthermore, constant efforts are being made with respect to the optimization of expression techniques, downstream processing, and defining standard guidelines for plant products to make an impact of plant-derived products on an array of applications.

Molecular Farming of Plants and Animals for Human and Veterinary Medicine

Author : L. Erickson
Publisher : Springer Science & Business Media
ISBN 13 : 9401723176
Total Pages : 381 pages
Book Rating : 4.4/5 (17 download)

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Book Synopsis Molecular Farming of Plants and Animals for Human and Veterinary Medicine by : L. Erickson

Download or read book Molecular Farming of Plants and Animals for Human and Veterinary Medicine written by L. Erickson and published by Springer Science & Business Media. This book was released on 2013-04-18 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: Molecular farming has been hailed as the "third wave" of genetically-modified organisms produced through biotechnology for the bio-based economy of the future. Unlike products of the first wave, such as herbicide resistant crop plants, which were perceived to benefit only the farmers who used them and the agrochemical companies who developed them, products of molecular farming are designed specifically for the benefit of the consumer. Such products could be purified from food or non-food organisms for a range of applications in industry, as well as animal and human health. Alternatively, the products of this technology could be consumed more directly in some edible format, such as milk, eggs, fruits or vegetables. There is a rapidly-growing interest Qn the part of the public as well as in the medical community in the role food plays in health, especially in the immunophysiological impact of food over and above the role of basic nutrition.

Genetically Engineered Food

Author : Knut J. Heller
Publisher : John Wiley & Sons
ISBN 13 : 9783527313938
Total Pages : 330 pages
Book Rating : 4.3/5 (139 download)

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Book Synopsis Genetically Engineered Food by : Knut J. Heller

Download or read book Genetically Engineered Food written by Knut J. Heller and published by John Wiley & Sons. This book was released on 2007-01-02 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Continuing the very successful first edition, this book reviews the most recent changes to the legal situation in Europe concerning genetically engineered food and labeling. Due to the extremely rapid developments in green biotechnology, all the chapters have been substantially revised and updated. Divided into three distinct parts, the text begins by covering applications and perspectives, including transgenic modification of production traits in farm animals, fermented food production and the production of food additives using filamentous fungi. The second section is devoted to legislation, while the final part examines methods of detection, such as DNA-based methods, and methods for detecting genetic engineering in composed and processed foods. From the reviews of the first edition: "This work promises to be a standard reference in the detection of genetically engineered food. I believe this work will find a valued place for any scientist, regulator or technical library that deals with biotechnology or detection of genetically engineered food organisms." —James J. Heinis, Journal of Agricultural & Food Information