The Evolutionary Dynamics Of Cancer

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Dynamics of Cancer

Author : Steven A. Frank
Publisher : Princeton University Press
ISBN 13 : 0691186863
Total Pages : 393 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis Dynamics of Cancer by : Steven A. Frank

Download or read book Dynamics of Cancer written by Steven A. Frank and published by Princeton University Press. This book was released on 2018-06-05 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The onset of cancer presents one of the most fundamental problems in modern biology. In Dynamics of Cancer, Steven Frank produces the first comprehensive analysis of how particular genetic and environmental causes influence the age of onset. The book provides a unique conceptual and historical framework for understanding the causes of cancer and other diseases that increase with age. Using a novel quantitative framework of reliability and multistage breakdown, Frank unifies molecular, demographic, and evolutionary levels of analysis. He interprets a wide variety of observations on the age of cancer onset, the genetic and environmental causes of disease, and the organization of tissues with regard to stem cell biology and somatic mutation. Frank uses new quantitative methods to tackle some of the classic problems in cancer biology and aging: how the rate of increase in the incidence of lung cancer declines after individuals quit smoking, the distinction between the dosage of a chemical carcinogen and the time of exposure, and the role of inherited genetic variation in familial patterns of cancer. This is the only book that presents a full analysis of the age of cancer onset. It is a superb teaching tool and a rich source of ideas for new and experienced researchers. For cancer biologists, population geneticists, evolutionary biologists, and demographers interested in aging, this book provides new insight into disease progression, the inheritance of predisposition to disease, and the evolutionary processes that have shaped organismal design.

Dynamics Of Cancer: Mathematical Foundations Of Oncology

Author : Dominik Wodarz
Publisher : World Scientific
ISBN 13 : 9814566381
Total Pages : 533 pages
Book Rating : 4.8/5 (145 download)

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Book Synopsis Dynamics Of Cancer: Mathematical Foundations Of Oncology by : Dominik Wodarz

Download or read book Dynamics Of Cancer: Mathematical Foundations Of Oncology written by Dominik Wodarz and published by World Scientific. This book was released on 2014-04-24 with total page 533 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book aims to provide an introduction to mathematical models that describe the dynamics of tumor growth and the evolution of tumor cells. It can be used as a textbook for advanced undergraduate or graduate courses, and also serves as a reference book for researchers. The book has a strong evolutionary component and reflects the viewpoint that cancer can be understood rationally through a combination of mathematical and biological tools. It can be used both by mathematicians and biologists. Mathematically, the book starts with relatively simple ordinary differential equation models, and subsequently explores more complex stochastic and spatial models. Biologically, the book starts with explorations of the basic dynamics of tumor growth, including competitive interactions among cells, and subsequently moves on to the evolutionary dynamics of cancer cells, including scenarios of cancer initiation, progression, and treatment. The book finishes with a discussion of advanced topics, which describe how some of the mathematical concepts can be used to gain insights into a variety of questions, such as epigenetics, telomeres, gene therapy, and social interactions of cancer cells.

Evolutionary Dynamics

Author : Martin A. Nowak
Publisher : Harvard University Press
ISBN 13 : 0674417755
Total Pages : 390 pages
Book Rating : 4.6/5 (744 download)

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Book Synopsis Evolutionary Dynamics by : Martin A. Nowak

Download or read book Evolutionary Dynamics written by Martin A. Nowak and published by Harvard University Press. This book was released on 2006-09-29 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: At a time of unprecedented expansion in the life sciences, evolution is the one theory that transcends all of biology. Any observation of a living system must ultimately be interpreted in the context of its evolution. Evolutionary change is the consequence of mutation and natural selection, which are two concepts that can be described by mathematical equations. Evolutionary Dynamics is concerned with these equations of life. In this book, Martin A. Nowak draws on the languages of biology and mathematics to outline the mathematical principles according to which life evolves. His work introduces readers to the powerful yet simple laws that govern the evolution of living systems, no matter how complicated they might seem. Evolution has become a mathematical theory, Nowak suggests, and any idea of an evolutionary process or mechanism should be studied in the context of the mathematical equations of evolutionary dynamics. His book presents a range of analytical tools that can be used to this end: fitness landscapes, mutation matrices, genomic sequence space, random drift, quasispecies, replicators, the Prisoner’s Dilemma, games in finite and infinite populations, evolutionary graph theory, games on grids, evolutionary kaleidoscopes, fractals, and spatial chaos. Nowak then shows how evolutionary dynamics applies to critical real-world problems, including the progression of viral diseases such as AIDS, the virulence of infectious agents, the unpredictable mutations that lead to cancer, the evolution of altruism, and even the evolution of human language. His book makes a clear and compelling case for understanding every living system—and everything that arises as a consequence of living systems—in terms of evolutionary dynamics.

Ecology and Evolution of Cancer

Author : Beata Ujvari
Publisher : Academic Press
ISBN 13 : 0128043806
Total Pages : 292 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Ecology and Evolution of Cancer by : Beata Ujvari

Download or read book Ecology and Evolution of Cancer written by Beata Ujvari and published by Academic Press. This book was released on 2017-02-08 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ecology and Evolution of Cancer is a timely work outlining ideas that not only represent a substantial and original contribution to the fields of evolution, ecology, and cancer, but also goes beyond by connecting the interfaces of these disciplines. This work engages the expertise of a multidisciplinary research team to collate and review the latest knowledge and developments in this exciting research field. The evolutionary perspective of cancer has gained significant international recognition and interest, which is fully understandable given that somatic cellular selection and evolution are elegant explanations for carcinogenesis. Cancer is now generally accepted to be an evolutionary and ecological process with complex interactions between tumor cells and their environment sharing many similarities with organismal evolution. As a critical contribution to this field of research the book is important and relevant for the applications of evolutionary biology to understand the origin of cancers, to control neoplastic progression, and to prevent therapeutic failures. Covers all aspects of the evolution of cancer, appealing to researchers seeking to understand its origins and effects of treatments on its progression, as well as to lecturers in evolutionary medicine Functions as both an introduction to cancer and evolution and a review of the current research on this burgeoning, exciting field, presented by an international group of leading editors and contributors Improves understanding of the origin and the evolution of cancer, aiding efforts to determine how this disease interferes with biotic interactions that govern ecosystems Highlights research that intends to apply evolutionary principles to help predict emergence and metastatic progression with the aim of improving therapies

Evolutionary Dynamics of Cancer

Author : Franziska Michor
Publisher :
ISBN 13 :
Total Pages : 326 pages
Book Rating : 4.:/5 (122 download)

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Book Synopsis Evolutionary Dynamics of Cancer by : Franziska Michor

Download or read book Evolutionary Dynamics of Cancer written by Franziska Michor and published by . This book was released on 2005 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Evolutionary Dynamics of Malignancy

Author : Robert C. Jackson
Publisher : Springer Nature
ISBN 13 : 3031325737
Total Pages : 271 pages
Book Rating : 4.0/5 (313 download)

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Book Synopsis Evolutionary Dynamics of Malignancy by : Robert C. Jackson

Download or read book Evolutionary Dynamics of Malignancy written by Robert C. Jackson and published by Springer Nature. This book was released on 2023-06-24 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in cancer genomics are transforming our understanding of cancer, and have profound implications for its prevention, diagnosis, and treatment. Evolutionary dynamics suggests that as few as two mutations can cause transformation of normal cells into cancer stem cells. A process of Darwinian selection, involving a further three or more mutations, taking place over a period of years, can then result in progression to a life-threatening tumour. In many cases the immune response can recognise and eliminate the mutant cells, but most advanced tumours have mutations that activate immune checkpoints and enable the tumour to hide from the immune system. For the most hard-to-treat tumours, future progress will require molecular diagnostics to detect cancer-causing mutations in healthy subjects, and new drugs or vaccines that prevent the progression process. Chapters of this book deal with the signalling pathways that control cell division, and changes in these pathways in cancer cells. Three cell cycle checkpoints that are often mutated in cancer are analysed in detail. A discussion of chronic myeloid leukaemia illustrates the role of reactive oxygen species in driving progression from a chronic to an acute condition. A single drug that suppresses reactive oxygen can prevent disease progression and turn an otherwise deadly disease into a condition that can be managed to enable many years of normal life. Another chapter discusses chronic myelomonocytic leukaemia, a disease that involves both genetic and epigenetic change. Tumour progression is discussed as a multi-stage process in which cancer stem cells evolve into genetically unstable, invasive, metastatic, drug-resistant growths. Each of these stages can act as targets for drugs or immunomodulators, but the future of cancer treatment lies in understanding tumour dynamics, and arresting malignancy at the earliest possible stage. Evolutionary dynamics is a primarily mathematical technique, but the target readership will be tumour biologists, clinicians, and drug developers. Computational detail is provided in an online supplement, but the main text emphasises the implications of the dynamics for an understanding of tumour biology and does not require mathematical expertise.

Evolutionary Dynamics of Cancer

Author : Ali Mahdipour Shirayeh
Publisher :
ISBN 13 :
Total Pages : 163 pages
Book Rating : 4.:/5 (1 download)

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Book Synopsis Evolutionary Dynamics of Cancer by : Ali Mahdipour Shirayeh

Download or read book Evolutionary Dynamics of Cancer written by Ali Mahdipour Shirayeh and published by . This book was released on 2017 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite significant advances in the study of cancer and associated combination therapeutic treatments, cancer still remains one of the most common and complex often-terminal diseases. Acquisition of high-throughput experimental data from diverse cellular perspectives has thrown light on some of the regulatory mechanisms underlying the development of cancer. However, in general there is a lack of a general pattern and coherent model which can explain the development and evolution of the disease. To this end, evolutionary dynamics has been used, as a mathematical tool, in numerous studies to model various aspects of cancer over time periods. Our main focus in this thesis is on the use of stochastic and statistic methods to study cellular interactions within cancer tissues in order to understand the role of spatial structure, heterogeneity, and the microenvironment in cancer development. By constructing multi-cellular structures and using both analytic calculations and stochastic simulations, we have investigated the phenotypic hierarchy of stem cells within a heterogeneous system and in the presence of environmentally induced plasticity. Moreover, the effect of a random environment on the development of cancer has been explored in a general framework. As an important application of the multi-stage hierarchical model, the structure of the colonic/intestinal crypt has been taken into account to show the crucial role of these stem cells in the initiation and progression of colorectal/intestinal cancer. From an alternative viewpoint, we have envisaged the hierarchy of mutations as an evolutionary mechanism in the context of acute myeloid leukemia and carried out a statistical analysis of genetic data. Our findings in this thesis are general and most likely have many implications across a wide array of fields including different blood and solid cancers, bacterial growth, drug resistance and social networks. Moreover, the introduced methods and analyses should have important applications in diverse branches of evolution, ecology, and population genetics.

Cancer

Author : Melvyn F. Greaves
Publisher :
ISBN 13 : 9780192628343
Total Pages : 294 pages
Book Rating : 4.6/5 (283 download)

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Book Synopsis Cancer by : Melvyn F. Greaves

Download or read book Cancer written by Melvyn F. Greaves and published by . This book was released on 2001 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt: Every day, 1500 Americans die of cancer, and yet for most of us this deadly disease remains mysterious. Why is it so common? Why are there so many different causes? Why does treatment so often fail? What, ultimately, is cancer? In this fascinating new book, a leading cancer researcher offers general readers clear and convincing answers to these and many other questions. Mel Greaves places cancer in its evolutionary context, arguing that we can best answer the big questions about cancer by looking through a Darwinian lens. Drawing on both ancient and more modern evolutionary legacies, he shows how human development has changed the rules of evolutionary games, trapping us in a nature-nurture mismatch. Compelling examples, from the King of Naples intestinal tumor in the 15th century, through the epidemic of scrotal skin cancer in 18th-century chimney sweeps, to the current surge of cases of prostate cancer illustrate his thesis. He also shows why the old paradigms of infectious diseases or genetic disorders have proved fruitless when trying to explain this complex and elusive disease. And finally, he looks at the implications for research, prevention, and treatment of cancer that an evolutionary perspective provides. Drawing on the most recent research, this is the first book to put cancer in its evolutionary framework. At a time when Darwinian perspectives on everything from language acquisition to economics are providing new breakthroughs in understanding, medicine seems to have much to gain from the insights provided by evolutionary biology. Written in an exceptionally lucid and entertaining style, this book will be of broad interest to all those who wish to know more about this dread disease.

Cancer Evolution

Author : Charles Swanton
Publisher : Perspectives Cshl
ISBN 13 : 9781621821434
Total Pages : 350 pages
Book Rating : 4.8/5 (214 download)

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Book Synopsis Cancer Evolution by : Charles Swanton

Download or read book Cancer Evolution written by Charles Swanton and published by Perspectives Cshl. This book was released on 2017 with total page 350 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor progression is driven by mutations that confer growth advantages to different subpopulations of cancer cells. As a tumor grows, these subpopulations expand, accumulate new mutations, and are subjected to selective pressures from the environment, including anticancer interventions. This process, termed clonal evolution, can lead to the emergence of therapy-resistant tumors and poses a major challenge for cancer eradication efforts. Written and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Medicine examines cancer progression as an evolutionary process and explores how this way of looking at cancer may lead to more effective strategies for managing and treating it. The contributors review efforts to characterize the subclonal architecture and dynamics of tumors, understand the roles of chromosomal instability, driver mutations, and mutation order, and determine how cancer cells respond to selective pressures imposed by anticancer agents, immune cells, and other components of the tumor microenvironment. They compare cancer evolution to organismal evolution and describe how ecological theories and mathematical models are being used to understand the complex dynamics between a tumor and its microenvironment during cancer progression. The authors also discuss improved methods to monitor tumor evolution (e.g., liquid biopsies) and the development of more effective strategies for managing and treating cancers (e.g., immunotherapies). This volume will therefore serve as a vital reference for all cancer biologists as well as anyone seeking to improve clinical outcomes for patients with cancer.

The Evolutionary Dynamics of Cancer

Author :
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (727 download)

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Book Synopsis The Evolutionary Dynamics of Cancer by :

Download or read book The Evolutionary Dynamics of Cancer written by and published by . This book was released on 2000 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: We hypothesized that a subset of the mutations observed in the progression to cancer confer beneficial selective effects on the cell. Our aim was to identify these selective mutations and to infer the interactions between the mutant clones in Barrett's esophagus (BE) that eventually lead to the development of esophageal adenocarcinoma. The results were to be a set of predictions about the roles of specific mutations in the progression to cancer.

Genome Chaos

Author : Henry H. Heng
Publisher : Academic Press
ISBN 13 : 0128136367
Total Pages : 556 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genome Chaos by : Henry H. Heng

Download or read book Genome Chaos written by Henry H. Heng and published by Academic Press. This book was released on 2019-05-25 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Chaos: Rethinking Genetics, Evolution, and Molecular Medicine transports readers from Mendelian Genetics to 4D-genomics, building a case for genes and genomes as distinct biological entities, and positing that the genome, rather than individual genes, defines system inheritance and represents a clear unit of selection for macro-evolution. In authoring this thought-provoking text, Dr. Heng invigorates fresh discussions in genome theory and helps readers reevaluate their current understanding of human genetics, evolution, and new pathways for advancing molecular and precision medicine. Bridges basic research and clinical application and provides a foundation for re-examining the results of large-scale omics studies and advancing molecular medicine Gathers the most pressing questions in genomic and cytogenomic research Offers alternative explanations to timely puzzles in the field Contains eight evidence-based chapters that discuss 4d-genomics, genes and genomes as distinct biological entities, genome chaos and macro-cellular evolution, evolutionary cytogenetics and cancer, chromosomal coding and fuzzy inheritance, and more

SuperCooperators

Author : Martin Nowak
Publisher : Simon and Schuster
ISBN 13 : 1451626630
Total Pages : 354 pages
Book Rating : 4.4/5 (516 download)

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Book Synopsis SuperCooperators by : Martin Nowak

Download or read book SuperCooperators written by Martin Nowak and published by Simon and Schuster. This book was released on 2012-03-27 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt: Looks at the importance of cooperation in human beings and in nature, arguing that this social tool is as important an aspect of evolution as mutation and natural selection.

The Cheating Cell

Author : Athena Aktipis
Publisher : Princeton University Press
ISBN 13 : 0691163847
Total Pages : 256 pages
Book Rating : 4.6/5 (911 download)

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Book Synopsis The Cheating Cell by : Athena Aktipis

Download or read book The Cheating Cell written by Athena Aktipis and published by Princeton University Press. This book was released on 2020-03-24 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: A fundamental and groundbreaking reassessment of how we view and manage cancer When we think of the forces driving cancer, we don’t necessarily think of evolution. But evolution and cancer are closely linked because the historical processes that created life also created cancer. The Cheating Cell delves into this extraordinary relationship, and shows that by understanding cancer’s evolutionary origins, researchers can come up with more effective, revolutionary treatments. Athena Aktipis goes back billions of years to explore when unicellular forms became multicellular organisms. Within these bodies of cooperating cells, cheating ones arose, overusing resources and replicating out of control, giving rise to cancer. Aktipis illustrates how evolution has paved the way for cancer’s ubiquity, and why it will exist as long as multicellular life does. Even so, she argues, this doesn’t mean we should give up on treating cancer—in fact, evolutionary approaches offer new and promising options for the disease’s prevention and treatments that aim at long-term management rather than simple eradication. Looking across species—from sponges and cacti to dogs and elephants—we are discovering new mechanisms of tumor suppression and the many ways that multicellular life-forms have evolved to keep cancer under control. By accepting that cancer is a part of our biological past, present, and future—and that we cannot win a war against evolution—treatments can become smarter, more strategic, and more humane. Unifying the latest research from biology, ecology, medicine, and social science, The Cheating Cell challenges us to rethink cancer’s fundamental nature and our relationship to it.

Explaining Cancer

Author : Anya Plutynski
Publisher : Oxford University Press
ISBN 13 : 0199967466
Total Pages : 281 pages
Book Rating : 4.1/5 (999 download)

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Book Synopsis Explaining Cancer by : Anya Plutynski

Download or read book Explaining Cancer written by Anya Plutynski and published by Oxford University Press. This book was released on 2018-07-18 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: In Explaining Cancer, Anya Plutynski addresses a variety of philosophical questions that arise in the context of cancer science and medicine. She begins with the following concerns: · How do scientists classify cancer? Do these classifications reflect nature's "joints"? · How do cancer scientists identify and classify early stage cancers? · What does it mean to say that cancer is a "genetic" disease? What role do genes play in "mechanisms for" cancer? · What are the most important environmental causes of cancer, and how do epidemiologists investigate these causes? · How exactly has our evolutionary history made us vulnerable to cancer? Explaining Cancer uses these questions as an entrée into a family of philosophical debates. It uses case studies of scientific practice to reframe philosophical debates about natural classification in science and medicine, the problem of drawing the line between disease and health, mechanistic reasoning in science, pragmatics and evidence, the roles of models and modeling in science, and the nature of scientific explanation.

Concepts of Biology

Author : Samantha Fowler
Publisher :
ISBN 13 : 9789888407453
Total Pages : 618 pages
Book Rating : 4.4/5 (74 download)

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Book Synopsis Concepts of Biology by : Samantha Fowler

Download or read book Concepts of Biology written by Samantha Fowler and published by . This book was released on 2018-01-07 with total page 618 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concepts of Biology is designed for the single-semester introduction to biology course for non-science majors, which for many students is their only college-level science course. As such, this course represents an important opportunity for students to develop the necessary knowledge, tools, and skills to make informed decisions as they continue with their lives. Rather than being mired down with facts and vocabulary, the typical non-science major student needs information presented in a way that is easy to read and understand. Even more importantly, the content should be meaningful. Students do much better when they understand why biology is relevant to their everyday lives. For these reasons, Concepts of Biology is grounded on an evolutionary basis and includes exciting features that highlight careers in the biological sciences and everyday applications of the concepts at hand.We also strive to show the interconnectedness of topics within this extremely broad discipline. In order to meet the needs of today's instructors and students, we maintain the overall organization and coverage found in most syllabi for this course. A strength of Concepts of Biology is that instructors can customize the book, adapting it to the approach that works best in their classroom. Concepts of Biology also includes an innovative art program that incorporates critical thinking and clicker questions to help students understand--and apply--key concepts.

Molecular Biology of Mutagens and Carcinogens

Author : Beatrice Singer
Publisher : Springer Science & Business Media
ISBN 13 : 1461337720
Total Pages : 352 pages
Book Rating : 4.4/5 (613 download)

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Book Synopsis Molecular Biology of Mutagens and Carcinogens by : Beatrice Singer

Download or read book Molecular Biology of Mutagens and Carcinogens written by Beatrice Singer and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 352 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book originated in numerous Gordon Research Conferences and many other meetings of scientists working in chemistry, biophysics, biochemistry, and biology related to mutagenesis and carcinogenesis. It seemed the appro priate time to sit back and summarize the results of several decades of research in laboratories in different countries. We are very grateful to the Rockefeller Foundation for inviting us to formulate and begin writing the book at the Center for International Studies in Bellagio, Italy, where we were Resident Scholars. We are fortunate to have had the assistance of so many colleagues around the world who cheerfully sent original data, figures, and preprints and lis tened patiently to us as we worked out the various conflicting ideas in this fast-moving. field. The names of these scientists are found within the tables, figures, and references. There is one person whose contributions we especially wish to acknowl edge. Professor Heinz Fraenkel-Conrat was present at the inception of this book and throughout the writing encouraged and criticized in apprOximately equal proportion. Finally, his editing and amalgamation of our two styles gave us great comfort. B.S. D.G.

The Physics of Cancer

Author : Caterina A. M. La Porta
Publisher : Cambridge University Press
ISBN 13 : 1108150330
Total Pages : 187 pages
Book Rating : 4.1/5 (81 download)

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Book Synopsis The Physics of Cancer by : Caterina A. M. La Porta

Download or read book The Physics of Cancer written by Caterina A. M. La Porta and published by Cambridge University Press. This book was released on 2017-04-20 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed an increasing number of theoretical and experimental contributions to cancer research from different fields of physics, from biomechanics and soft-condensed matter physics to the statistical mechanics of complex systems. Reviewing these contributions and providing a sophisticated overview of the topic, this is the first book devoted to the emerging interdisciplinary field of cancer physics. Systematically integrating approaches from physics and biology, it includes topics such as cancer initiation and progression, metastasis, angiogenesis, cancer stem cells, tumor immunology, cancer cell mechanics and migration. Biological hallmarks of cancer are presented in an intuitive yet comprehensive way, providing graduate-level students and researchers in physics with a thorough introduction to this important subject. The impact of the physical mechanisms of cancer are explained through analytical and computational models, making this an essential reference for cancer biologists interested in cutting-edge quantitative tools and approaches coming from physics.