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The ESCRT Complexes

Author : Emmanuel Culetto
Publisher : Springer Nature
ISBN 13 : 1493994921
Total Pages : 328 pages
Book Rating : 4.4/5 (939 download)

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Book Synopsis The ESCRT Complexes by : Emmanuel Culetto

Download or read book The ESCRT Complexes written by Emmanuel Culetto and published by Springer Nature. This book was released on 2019-06-27 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: This detailed collection gathers both established and recent technical procedures to study the Endosomal Sorting Complex Required for Transport (ESCRT) complexes in a wide range of biological systems: Archaea, A. thaliana, U. maydis, S. cerevisiae, S. pombe, C. elegans, D. melanogaster, and mammalian cells. Opening with a section on imaging techniques, the book continues with chapters covering biochemical approaches presenting strategies for production and characterization of recombinant ESCRT proteins, or of specific ESCRT protein domains, as well as genetic and proteomic experimental approaches. Written for the highly successful Methods in Molecular Biology series, chapters include introduction to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, The ESCRT Complexes: Methods and Protocols serves as a compact guide for researchers interested in establishing an integrated approach to investigate the ESCRT machinery functions in cell biology.

Encyclopedia of Cell Biology

Author :
Publisher : Academic Press
ISBN 13 : 0123947960
Total Pages : 2972 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Encyclopedia of Cell Biology by :

Download or read book Encyclopedia of Cell Biology written by and published by Academic Press. This book was released on 2015-08-07 with total page 2972 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Encyclopedia of Cell Biology, Four Volume Set offers a broad overview of cell biology, offering reputable, foundational content for researchers and students across the biological and medical sciences. This important work includes 285 articles from domain experts covering every aspect of cell biology, with fully annotated figures, abundant illustrations, videos, and references for further reading. Each entry is built with a layered approach to the content, providing basic information for those new to the area and more detailed material for the more experienced researcher. With authored contributions by experts in the field, the Encyclopedia of Cell Biology provides a fully cross-referenced, one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences. Fully annotated color images and videos for full comprehension of concepts, with layered content for readers from different levels of experience Includes information on cytokinesis, cell biology, cell mechanics, cytoskeleton dynamics, stem cells, prokaryotic cell biology, RNA biology, aging, cell growth, cell Injury, and more In-depth linking to Academic Press/Elsevier content and additional links to outside websites and resources for further reading A one-stop resource for students, researchers, and teaching faculty across the biological and medical sciences

Exosomes and MicroRNAs in Biomedical Science

Author : Hamed Mirzaei
Publisher : Springer Nature
ISBN 13 : 3031791770
Total Pages : 171 pages
Book Rating : 4.0/5 (317 download)

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Book Synopsis Exosomes and MicroRNAs in Biomedical Science by : Hamed Mirzaei

Download or read book Exosomes and MicroRNAs in Biomedical Science written by Hamed Mirzaei and published by Springer Nature. This book was released on 2022-06-06 with total page 171 pages. Available in PDF, EPUB and Kindle. Book excerpt: MicroRNAs (miRNAs) are a member of the family of non-coding RNA molecules, and consist of small conserved sequences between 19–25 nucleotides in length that are responsible for regulating many cellular functions by affecting a wide range of messenger RNAs in a sequence specific manner. Fundamental biological processes like cell proliferation and growth, stress resistance, tumorigenesis, fat metabolism, and neural development have all been shown to be governed by miRNAs. miRNAs carry out the post-transcriptional silencing of gene expression via targeting the 30-untranslated region (UTR) of the complementary mRNA sequence. The dysregulation of the expression levels of various miRNAs is typical of tumor cells, and has been associated with tumor progression and poor prognosis. Many miRNAs are up-regulated in cancer, where they can silence tumor suppressor genes such as apoptosis and immune response associated genes. Therefore, it is possible to profile the expression levels of miRNAs as biomarkers, in order to diagnose cancer and noncancerous diseases. Moreover, cancer detection in the early stages is crucial in clinical situations. Characterization of miRNAs in serum, plasma, and other bodily fluids, and understanding their stability against RNase degradation, is important to assess their suitability as biomarkers and diagnostic tools. Exosomes play an important role in inter-cellular communications, and these nanosized particles have various functions in diverse physiological pathways, in normal as well as abnormal cells. Exosomes can carry diverse cargos such as mRNAs, miRNAs, and proteins that transfer information between donor and recipient cells. Furthermore, uptake of exosomes and their cargos may promote or suppress various molecular and cellular pathways, which alter the cellular behavior. Many reports have discussed the role of exosomes released from cancer cells on the progression of cancer at various stages. Exosomes and their cargos may affect the growth of the tumor, metastasis, drug resistance, immune system function, as well as angiogenesis. Therefore, exosomes have been explored as diagnostic biomarkers in many cancers. Moreover, exosomes can be used as biological vehicles to deliver different drugs and agents like doxorubicin (DOX), miRNAs, and siRNAs. The present book covers the role of exosomes and micro-RNAs in the pathogenesis and treatment of various diseases.

Author : Taylor & Francis Group
Publisher : Garland Science
ISBN 13 : 9780815341
Total Pages : pages
Book Rating : 4.7/5 (88 download)

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Book Synopsis by : Taylor & Francis Group

Download or read book written by Taylor & Francis Group and published by Garland Science. This book was released on 2010-12-31 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Sorting and Recycling Endosomes

Author :
Publisher : Academic Press
ISBN 13 : 0128028718
Total Pages : 416 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Sorting and Recycling Endosomes by :

Download or read book Sorting and Recycling Endosomes written by and published by Academic Press. This book was released on 2015-09-14 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sorting and Recycling Endosomes provides the latest information on endosomes, the receiving compartment for endocytosed cargos, and the donor compartment and sorting station for cargos designated to lysosomes, Golgi, or plasma membrane. In recent years, the importance of endosomes as a sorting and recycling compartment has become increasingly appreciated. As such, scientists from various fields of cell biology, membrane traffic, and beyond, see the needs to communicate and learn about the methods used to investigate the dynamics and functions of endosomes. This book brings together specialists from the field who contribute their expertise on a broad range of biomedical topics that will provide ideal reading for researchers interested in endosomal sorting and recycling. This volume covers the approaches necessary to study the key components that mediate the generation and transport of membrane-bounded carriers from the endosomes, and how membrane trafficking machinery is coordinated with cytoskeletons during these processes. In addition to studies carried out in mammalian cells, other model systems such as worm and yeast are also included. Provides the latest information on endosomes, the receiving compartment for endocytosed cargos, and the donor compartment and sorting station for cargos designated to lysosomes, Golgi, or plasma membrane. Covers an increasingly appreciated field in cell biology Includes both established and new technologies Brings together specialists from the field who contribute their expertise on a broad range of biomedical topics that will provide ideal reading for researchers interested in endosomal sorting and recycling

Current Topics in Membranes

Author :
Publisher : Academic Press
ISBN 13 : 9780080585109
Total Pages : 453 pages
Book Rating : 4.5/5 (851 download)

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Book Synopsis Current Topics in Membranes by :

Download or read book Current Topics in Membranes written by and published by Academic Press. This book was released on 1992-01-08 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: Current Topics in Membranes

Cell Press Reviews: Core Concepts in Cell Biology

Author : Cell Press
Publisher : Elsevier
ISBN 13 : 0127999183
Total Pages : 485 pages
Book Rating : 4.1/5 (279 download)

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Book Synopsis Cell Press Reviews: Core Concepts in Cell Biology by : Cell Press

Download or read book Cell Press Reviews: Core Concepts in Cell Biology written by Cell Press and published by Elsevier. This book was released on 2013-11-29 with total page 485 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by leading cell biologists and curated by Cell Press editors, reviews in the Cell Press Reviews: Core Concepts in Cell Biology publication informs, inspires, and connects cell biologists at all stages in their careers with timely, comprehensive insight into the most recent exciting developments across cell biology and hot topics within core areas of the field including: Signaling mechanisms and membrane biology Cytoskeletal self-organization and cell polarity Organelle dynamics and biogenesis Morphogenesis and cell motility Chromatin and genome organization in nuclear function Contributions come from leading voices in cell biology, who are defining the future of their field, including: - Tom Misteli, National Cancer Institute - Galit Lahav, Harvard Medical School - Scott D. Emr, Cornell University - David G. Drubin, University of California, Berkeley - Tom Rapoport, Harvard Medical School - Anthony A. Hyman, Max Planck Institute of Molecular and Cell Biology, Dresden This publication is part of the Cell Press Reviews series, which features reviews published in Cell Press primary research and Trends reviews journals. Provides timely, comprehensive coverage across a broad range of cell biological topics Offers foundational knowledge and expert insights to students and others new to the field Features reviews from leaders in cell biology research and discussion of future directions for the field Includes articles originally published in Cell, Current Biology, Developmental Cell, and Trends in Cell Biology

Trafficking Inside Cells

Author : Nava Segev
Publisher : Springer Science & Business Media
ISBN 13 : 038793877X
Total Pages : 459 pages
Book Rating : 4.3/5 (879 download)

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Book Synopsis Trafficking Inside Cells by : Nava Segev

Download or read book Trafficking Inside Cells written by Nava Segev and published by Springer Science & Business Media. This book was released on 2010-05-30 with total page 459 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers the past, present and future of the intra-cellular trafficking field, which has made a quantum leap in the last few decades. It details how the field has developed and evolved as well as examines future directions.

Crosstalk and Integration of Membrane Trafficking Pathways

Author : Roberto Weigert
Publisher : BoD – Books on Demand
ISBN 13 : 9535105159
Total Pages : 262 pages
Book Rating : 4.5/5 (351 download)

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Book Synopsis Crosstalk and Integration of Membrane Trafficking Pathways by : Roberto Weigert

Download or read book Crosstalk and Integration of Membrane Trafficking Pathways written by Roberto Weigert and published by BoD – Books on Demand. This book was released on 2012-04-11 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane traffic is a broad field that studies the complex exchange of membranes that occurs inside the cell. Protein, lipids and other molecules traffic among intracellular organelles, and are delivered to, or transported from the cell surface by virtue of membranous carriers generally referred as "transport intermediates". These carriers have different shapes and sizes, and their biogenesis, modality of transport, and delivery to the final destination are regulated by a multitude of very complex molecular machineries. A concept that has clearly emerged in the last decade is that each membrane pathway does not represent a close system, but is fully integrated with all the other trafficking pathways. The aim of this book is to provide a general overview of the extent of this crosstalk.

HIV Interactions with Host Cell Proteins

Author : Paul Spearman
Publisher : Springer Science & Business Media
ISBN 13 : 3642021751
Total Pages : 210 pages
Book Rating : 4.6/5 (42 download)

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Book Synopsis HIV Interactions with Host Cell Proteins by : Paul Spearman

Download or read book HIV Interactions with Host Cell Proteins written by Paul Spearman and published by Springer Science & Business Media. This book was released on 2009-12-11 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study of viruses necessarily involves dissecting the intimate details of cellular pathways. Viruses have often been employed as tools in studying cellular pathways, as was done by early retrovirologists such as Peyton Rous in attempting to understand the mechanism of cellular transformation and oncogenesis. On the other side of the coin, virologists seek to de?ne those cellular elements interacting intimatelywiththeir virus ofinterestinorder to better understand viral replication itself, and in some cases to develop antiviral strategies. It is in the intersection of virology and cell biology that many of us ?nd the most rewarding aspects of our research. When a new discovery yields insights into basic cellular mechanisms and presents new targets for int- vention to ?ght a serious pathogen, the impact can be high and the excitement intense. HIV has been no exception to the rule that viruses reveal many basic aspects of cellular biology. In recent years, in part because of the importance of HIV as a major cause of human suffering, numerous cellular processes have been elucidated through work on processes or proteins of this human retrovirus. The excitement in this ?eld is especially well illustrated by the discovery of new innate means of resisting viral replication, such as the work on APOBEC3G, TRIM5a, and BST-2/ tetherin presented in this volume.

Mesenchymal Stromal Cells as Tumor Stromal Modulators

Author : Marcela Bolontrade
Publisher : Academic Press
ISBN 13 : 0128031034
Total Pages : 642 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Mesenchymal Stromal Cells as Tumor Stromal Modulators by : Marcela Bolontrade

Download or read book Mesenchymal Stromal Cells as Tumor Stromal Modulators written by Marcela Bolontrade and published by Academic Press. This book was released on 2016-10-24 with total page 642 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesenchymal stromal/ stem cells (MSCs) represent a heterogeneous cell population with immunomodulating, tissue repairing, differentiating, migratory and angiogenic abilities, making them important tools for clinical and translational research. An understanding of the role of MSCs in modulating tumor growth provides a glimpse into their role in non-pathological tissue remodeling and potential regenerative tissue therapies. Mesenchymal Stromal Cells as Tumor Stromal Modulators is a comprehensive source for the understanding of the role of MSCs as ubiquitous connective tissue cell components, which may have both direct and indirect effects on the tumor microenvironment and potential for regenerative therapeutics for various diseases. Using cancer as a model disease, this book explores the transformative role MSCs play in the recruitment of disease cells, cell repair and immunological defenses. Explores the biology of mesenchymal stromal cells (MSCs) and tissue related function Discusses the bidirectional communication between tumor stroma and MSCs derived from bone marrow, from adipose tissue and from other tissue types Provides in-depth analysis of the effects of MSCs on key processes that regulate disease progression, such as angiogenesis, metastatic potential, invasion, proliferation, tumor immune privileges

Molecular Mechanisms of Notch Signaling

Author : Tilman Borggrefe
Publisher : Springer
ISBN 13 : 3319895125
Total Pages : 417 pages
Book Rating : 4.3/5 (198 download)

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Book Synopsis Molecular Mechanisms of Notch Signaling by : Tilman Borggrefe

Download or read book Molecular Mechanisms of Notch Signaling written by Tilman Borggrefe and published by Springer. This book was released on 2018-07-20 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes the Notch signaling pathway with a focus on molecular mechanisms. The Notch signaling pathway is a seemingly simple pathway that does not involve any second messenger. Upon ligand binding two consecutive proteolytic cleavages of the NOTCH receptor release the Notch intracellular domain from the membrane. The Notch intracellular domain migrates into the nucleus and activates gene expression. Recently, new technologies allowed us to better understand this pivotal signaling cascade and revealed new regulatory mechanisms. The different chapters cover many aspects of the Notch signaling focusing on the mechanisms governing the receptor/ligand interaction as well as on the downstream intracellular signaling events. Aspects of both canonical and non-canonical signaling are discussed and the function of Notch signaling in physiological and pathological contexts are elucidated. This book is not only intended for experts but it should also be a useful resource for young, sprouting scientists or interested scientists from other research areas, who may use this book as a stimulating starting point for further discoveries and developments.

Phosphoinositides II: The Diverse Biological Functions

Author : Tamas Balla
Publisher : Springer Science & Business Media
ISBN 13 : 9400730144
Total Pages : 467 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Phosphoinositides II: The Diverse Biological Functions by : Tamas Balla

Download or read book Phosphoinositides II: The Diverse Biological Functions written by Tamas Balla and published by Springer Science & Business Media. This book was released on 2012-02-29 with total page 467 pages. Available in PDF, EPUB and Kindle. Book excerpt: Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field. Volume II extends into the role of phosphoinositides in membrane organization and vesicular traffic. Endocytosis and exocytosis are modulated by phosphoinositides, which determine the fate and activity of integral membrane proteins. Phosphatidylinositol(4,5)-bisphosphate is a prominent flag in the plasma membrane, while phosphatidylinositol-3-phosphate decorates early endosomes. The Golgi apparatus is rich in phosphatidylinositol-4-phosphate, stressed cells increase phosphatidylinositol(3,5)-bisphosphate, and the nucleus has a phosphoinositide metabolism of its own. Phosphoinositide-dependent signaling cascades and the spatial organization of distinct phosphoinositide species are required in organelle function, fission and fusion, membrane channel regulation, cytoskeletal rearrangements, adhesion processes, and thus orchestrate complex cellular responses including growth, proliferation, differentiation, cell motility, and cell polarization. The two volumes on “Phosphoinositides” provide a concise overview of the latest developments in the field of phosphoinositide hemostasis and function, and provide introductory background and extensions into unexplored territory.

Bioinformatics

Author : Mahmood A. Mahdavi
Publisher : BoD – Books on Demand
ISBN 13 : 9533072822
Total Pages : 740 pages
Book Rating : 4.5/5 (33 download)

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Book Synopsis Bioinformatics by : Mahmood A. Mahdavi

Download or read book Bioinformatics written by Mahmood A. Mahdavi and published by BoD – Books on Demand. This book was released on 2011-11-02 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioinformatics - Trends and Methodologies is a collection of different views on most recent topics and basic concepts in bioinformatics. This book suits young researchers who seek basic fundamentals of bioinformatic skills such as data mining, data integration, sequence analysis and gene expression analysis as well as scientists who are interested in current research in computational biology and bioinformatics including next generation sequencing, transcriptional analysis and drug design. Because of the rapid development of new technologies in molecular biology, new bioinformatic techniques emerge accordingly to keep the pace of in silico development of life science. This book focuses partly on such new techniques and their applications in biomedical science. These techniques maybe useful in identification of some diseases and cellular disorders and narrow down the number of experiments required for medical diagnostic.

Endocytosis and Signaling

Author : Christophe Lamaze
Publisher : Springer
ISBN 13 : 3319967045
Total Pages : 329 pages
Book Rating : 4.3/5 (199 download)

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Book Synopsis Endocytosis and Signaling by : Christophe Lamaze

Download or read book Endocytosis and Signaling written by Christophe Lamaze and published by Springer. This book was released on 2018-08-10 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.

Vesicular Transport in the Secretory and Endocytic Pathways

Author : Anne Müsch
Publisher : Biota Publishing
ISBN 13 : 1615046593
Total Pages : 136 pages
Book Rating : 4.6/5 (15 download)

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Book Synopsis Vesicular Transport in the Secretory and Endocytic Pathways by : Anne Müsch

Download or read book Vesicular Transport in the Secretory and Endocytic Pathways written by Anne Müsch and published by Biota Publishing. This book was released on 2014-09-01 with total page 136 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of vesicular traffic as a means of protein transport in and out of cells and between membrane compartments has been established since the 1960s. Its basic principles are beautifully simple, yet the details of protein transport are complex enough to find novel classes of transport vesicles, and trafficking itineraries still being described to date. In this treatise, the reader will be introduced to mechanisms of vesicle sculpting, cargo selection, vesicle targeting, and vesicle consumption that have emerged as common characteristics of multiple transport steps in the exocytic and endocytic pathways. These fundamentals also reveal the basis for the specificity and selectivity of individual transport steps. We will further discuss how protein transport might lead to the establishment and maintenance of the endomembrane system of eukaryotic cells. The concepts for these mechanisms are based on experimental evidence combined with mathematical modeling that can disclose the minimal requirements for the generation of the distinct membrane compartments. Table of Contents: Compartmentalization Is a Hallmark of Eukaryotic Cells / Organelles Can Be Classified Based on Their Origin / There Are Multiple Entry Points Into the Endomembrane System and a Network of Connecting Trafficking Routes / There Are Exceptions and Extensions to the Classic Trafficking Itineraries / A Mathematical Model Can Explain How Organelle Size Is Established and Maintained / Coats and SNAREs Constitute the Core Machinery for Vesicle Budding and Fusion / A Mathematical Model Explains How Coats and SNAREs Are Sufficient to Generate Organelle Identity / How Vesicle Formation Is Linked to Cargo Incorporation / RabGTPases Are the Master Regulators of Vesicular Traffic / The Mechanisms and Physiological Roles of Endocytosis / Models for Protein Transport in the Golgi Apparatus / Summary / Acknowledgments / References / Author Biography

Lipids

Author : Gilbert Di Paolo
Publisher : Academic Press
ISBN 13 : 0123864879
Total Pages : 503 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Lipids by : Gilbert Di Paolo

Download or read book Lipids written by Gilbert Di Paolo and published by Academic Press. This book was released on 2012-02-16 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are a broad group of naturally occurring molecules which includes fats, waxes, sterols, fat-soluble vitamins (such as vitamins A, D, E and K), monoglycerides, diglycerides, phospholipids, and others. The main biological functions of lipids include energy storage, as structural components of cell membranes, and as important signaling molecules. This volume of Methods in Cell Biology covers such areas as Membrane structure and dynamics, Imaging, and Lipid Protein Interactions. It will be an essential tool for researchers and students alike. Covers such areas as membrane structure and dynamics, imaging, and lipid protein interactions An essential tool for researchers and students alike International authors Renowned editors