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The Effect Of Conjugated Linoleic Acid Cla Isomers On Hepatic Lipid Droplets And Lipid Droplet Proteins In Fa Fa Zucker Rats
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Book Synopsis The Effect of Conjugated Linoleic Acid (CLA) Isomers on Hepatic Lipid Droplets and Lipid Droplet Proteins in Fa/fa Zucker Rats by : Nazanin Kazem Moosavi
Download or read book The Effect of Conjugated Linoleic Acid (CLA) Isomers on Hepatic Lipid Droplets and Lipid Droplet Proteins in Fa/fa Zucker Rats written by Nazanin Kazem Moosavi and published by . This book was released on 2010 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism by : Amy Dianne Noto
Download or read book Conjugated Linoleic Acid (CLA) in Liver and Adipose Metabolism written by Amy Dianne Noto and published by . This book was released on 2005 with total page 294 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Investigating the Isomer-specific Effects of Conjugated Linoleic Acid on Metabolic Syndrome, Hepatic Steatosis and Selected Mediators of Hepatic Lipid Metabolism in the Fa/fa Zucker Rat by : Danielle Marie Stringer
Download or read book Investigating the Isomer-specific Effects of Conjugated Linoleic Acid on Metabolic Syndrome, Hepatic Steatosis and Selected Mediators of Hepatic Lipid Metabolism in the Fa/fa Zucker Rat written by Danielle Marie Stringer and published by . This book was released on 2006 with total page 540 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-[alpha]) in Fa/fa and Lean Zucker Rats by : Robert Peter Diakiw
Download or read book Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-[alpha]) in Fa/fa and Lean Zucker Rats written by Robert Peter Diakiw and published by . This book was released on 2006 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-α) in Fa/fa and Lean Zucker Rats by : Robert Peter Diakiw
Download or read book Effects of Specific Conjugated Linoleic Acid (CLA) Isomers on Insulin Resistance, and Skeletal Muscle AMP-activated Protein Kinase-alpha (AMPK-α) in Fa/fa and Lean Zucker Rats written by Robert Peter Diakiw and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Conjugated Linoleic Acid Research by : Jean-Louis Sebedio
Download or read book Advances in Conjugated Linoleic Acid Research written by Jean-Louis Sebedio and published by CRC Press. This book was released on 2020-03-05 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Conjugated Linoleic Acid Research, Volume 2 is the second book in a series devoted entirely to conjugated linoleic acid. This book has updated information on the analysis, biochemistry and applications of conjugated fatty acids in an attempt to make Volume 2, in conjunction with Volume 1 (published in 1999), the most comprehensive, up-to-date sources of CLA-related information available today. Both scientific and commercial views are presented, with the same data sometimes interpreted differently.
Book Synopsis Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity by : Angela Ann Wendel
Download or read book Mechanisms of Conjugated Linoleic Acid on Insulin Resistance, Hepatic Steatosis, and Adiposity written by Angela Ann Wendel and published by . This book was released on 2007 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt: The significant depletion of adipose in mice by CLA may contribute to the lipodystrophic-like effects that accompany. The final objective of this research was to determine mechanisms by which CLA reduces adipose mass. Six-week old, male ob/ob mice were fed either a control diet (CON) or a diet supplemented with 1.5% mixed isomer CLA (CLA) for 4 weeks. A third group of mice (LEPTIN) were fed the control diet and received daily, intraperitoneal injections of 1 mg/kg BW recombinant leptin as a positive control for adipose depletion in ob/ob mice. The depletion of adipose tissue by CLA was accompanied by the acquirement of brown adipose-like characteristics, such as increased CPT-1b, PGC-1alpha, and UCP-1, in the white adipose of CLA-fed mice. This alteration may facilitate the reduction of adipose mass by increasing mitochondrial oxidation and energy dissipation. However, it appears that CLA does not increase UCP-1 through beta3AR signaling.
Book Synopsis Effects of Conjugated Linoleic Acid Isomers on Eicosanoid Metabolism in Kidney and Liver Tissues of Obese Zucker Rats by : Hong Shi
Download or read book Effects of Conjugated Linoleic Acid Isomers on Eicosanoid Metabolism in Kidney and Liver Tissues of Obese Zucker Rats written by Hong Shi and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: CLA -- Zucker rat -- eicosanoids -- tissues.
Book Synopsis Conjugated Linoleic Acids and Conjugated Vegetable Oils by : Bert Sels
Download or read book Conjugated Linoleic Acids and Conjugated Vegetable Oils written by Bert Sels and published by Royal Society of Chemistry. This book was released on 2014-07-11 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conjugated linoleic acids (CLA) isomers of linoleic acid – a compound derived from meat and dairy products. Attention was first drawn to their potential anti-carcinogen properties in the 1980’s; since then further health benefits have been reported, and applications in the glue and paint industries as a renewable resource have been explored. This comprehensive book presents an overview of the background and research into CLA and examines each of their applications in the context of the chemistry surrounding them and CLA-enriched oils. The biosynthesis of CLA is presented, with a discussion on how animal husbandry could promote CLA production. Other chapters examine the current strategies for their synthesis using bespoke catalysts and enzymes. Readers from academia and industry will find the layout of the book highly accessible, with sections for each application. The editors are both active researchers in the field, and have brought together a wealth of expertise from across the globe, presenting a comprehensive guide to this valuable group of compounds and their potential applications.
Book Synopsis Conjugated Linoleic Acid and Lipid Metabolism by : Kisun Nam Lee
Download or read book Conjugated Linoleic Acid and Lipid Metabolism written by Kisun Nam Lee and published by . This book was released on 1996 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :Martin P. Yurawecz Publisher :The American Oil Chemists Society ISBN 13 :9781893997875 Total Pages :284 pages Book Rating :4.9/5 (978 download)
Book Synopsis Advances in Conjugated Linoleic Acid Research, Volume 3 by : Martin P. Yurawecz
Download or read book Advances in Conjugated Linoleic Acid Research, Volume 3 written by Martin P. Yurawecz and published by The American Oil Chemists Society. This book was released on 2006-09-29 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in the chemistry, biological properties and healthful benefits of conjugated linoleic acid (CLA) continues to grow. The number of peer reviewed publications produced on CLA since the 2003 publication of Advances in Conjugated Linoleic Acid Research, Volume 2, has more than doubled. It is likely that CLA will be used in the future in many more studies related to diseases such as cancer, atherosclerosis, and diabetes. This text provides comprehensive coverage of this area of research. Sections include material on biosynthesis and metabolic processes, techniques of determination of individual isomers, diversity of CLA, and effects of CLA isomers in humans.
Book Synopsis The Effects of Dietary Conjugated Linoleic Acid on Avian Lipid Metalbolism by : Rahim Aydin
Download or read book The Effects of Dietary Conjugated Linoleic Acid on Avian Lipid Metalbolism written by Rahim Aydin and published by . This book was released on 2000 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Mechanisms by which Conjugated Linoleic Acid Causes Human Adipocyte Delipidation by : Soonkyu Chung
Download or read book Mechanisms by which Conjugated Linoleic Acid Causes Human Adipocyte Delipidation written by Soonkyu Chung and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: "Obesity is an important health issue, having risen to epidemic proportions in the U.S. Use of conjugated linoleic acid (CLA), positional and geometric isomers of linoleic acid, has received recent attention due to its potential health benefits including the reduction of fat mass in animals. However, the effectiveness and safety of CLA consumption in humans remains unclear. Our group previously reported that trans-10, cis-12 CLA impaired the conversion of preadipocytes into lipid-filled adipocytes (e.g., differentiation) and caused adipocyte delipidation that involved inflammatory cytokines in a human cell model. However, the isomer-specific mechanism for these events was unknown. Thus, this research examined mechanisms by which trans-10, cis-12 CLA induced adipocyte delipidation, inflammation, and insulin resistance in primary cultures of human adipocytes. Delipidation of adipocytes by trans-10, cis-12 CLA was accompanied by increased lipolysis and changes in the morphology of lipid droplets and the expression and localization of proteins regulating lipid droplet metabolism. This process involved the translational control of adipose differentiated related protein (ADRP) through activation of mTOR/p70S6K/S6 signaling and transcriptional control of perilipin A. Prior to these morphological changes, it was shown that trans-10, cis-12 CLA promoted nuclear factor κB (NFκB) and mitogen activated protein kinase (MAPK) activation and subsequent induction of interleukin (IL)-6 which were, at least in part, responsible for trans-10, cis-12 CLA-mediated suppression of peroxisome proliferator activated receptor gamma (PPAR)γ target gene expression and insulin sensitivity in human adipocytes. The essential role of NFκB on CLA-induced inflammation was confirmed by using RNA interference. Further studies were conducted examining the localization and characterization of the inflammatory response, including the type of cells involved, using lipopolysaccharide (LPS) as the inflammatory agent. It was demonstrated that LPS-induced, NFκB-dependent proinflammatory cytokine expression was predominantly from preadipocytes, which led to, at least in part, the suppression of PPAR activity and adipogenic gene expression and insulin sensitivity. Collectively, these data support the emerging concept that adipose tissue is a dynamic endocrine organ with the capacity to generate inflammatory signals that impact glucose and lipid metabolism. Furthermore, human preadipocytes have the capacity to generate these inflammatory signals induced by trans-10, cis-12 CLA and LPS, subsequently causing insulin resistance in neighboring adipocytes. These studies also revealed that NFκB- and MAPK-signaling mediate inflammation and insulin resistance induced by CLA and LPS. Thus, although the trans-10, cis-12 isomer of CLA may decrease the size and lipid content of human adipocytes, it may also cause insulin resistance, which is a hallmark of type 2 diabetes."--Abstract from author supplied metadata.
Book Synopsis Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition by : Madhuri Vemuri
Download or read book Effect of Omega-3 Fatty Acids on T10, C12-conjugated Linoleic Acid Induced Insulin Resistance, Non Alcoholic Fatty Liver Disease and Tissue Fatty Acid Composition written by Madhuri Vemuri and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Conjugated linoleic acid (CLA) refers to all the positional and geometric isomers of linoleic acid. The two most studied isomers are cis9, trans11-CLA and trans10, cis12-CLA. CLA supplements, often a mixture of the two isomers, have been popularly used for weight loss and other claimed health benefits. However supplementing CLA isomers, especially trans10, cis12-CLA has been shown to cause non alcoholic fatty liver disease (NAFLD) and insulin resistance (IR) in several animal models. Here we have confirmed that supplementing 0.5% trans10, cis12-CLA to C57BL/6 mice for 8 weeks causes NAFLD and IR. When CLA diets were concomitantly supplemented with omega-3 fatty acids docosahexaenoic acid (DHA) or eicosapentaenoic acid (EPA) at 1.5% (w/w) for 8 weeks, DHA prevented CLA induced IR, while EPA was ineffective. Both EPA and DHA prevented CLA induced fatty liver. CLA also reduced the plasma leptin and adiponectin concentrations, and both EPA and DHA partially restored plasma leptin, but only DHA partially restored the plasma adiponectin. In another experiment, concomitant supplementation of CLA diets with 0.5% of flaxseed oil (rich in alpha linolenic acid) also prevented IR and decreased liver weights and lipids compared with those in CLA group. CLA supplementation also altered lipid profile in liver, decreasing n-6 and n-3 wt% and increasing n-6:n-3 ratio. Concomitant supplementation with flaxseed oil increased n-6 and n-3 polyunsaturated (PUFA) in liver lipids and decreased the n-6:n-3 ratio compared to that in CLA group. Supplementing 0.5% (w/w) of purified c9, t11- or trans10, cis12-CLA to mice for 8 weeks altered fatty acid profile of tissues differently. c9, t11-CLA diet reduced MUFA wt% in liver, adipose tissue, and spleen, and reduced the spleen n-3 PUFAs significantly while increasing the n-6 PUFA wt% in all tissues except heart. In contrast, trans10, cis12-CLA reduced both the n-6 and n-3 PUFA wt% in liver and heart however increased the wt% of n-3 PUFAs in spleen. Considering the adverse health effects of trans10, cis12-CLA and of mixtures of CLA isomers on NAFLD, IR and tissue fatty acids, human use of CLA supplements should not be recommended.
Book Synopsis Role of Trans-10, Cis-12 Conjugated Linoleic Acid (CLA) and Other CLA Isomers in the Regulation of Milk Fat Synthesis and Lipid Metabolism by : James W. Perfield
Download or read book Role of Trans-10, Cis-12 Conjugated Linoleic Acid (CLA) and Other CLA Isomers in the Regulation of Milk Fat Synthesis and Lipid Metabolism written by James W. Perfield and published by . This book was released on 2006 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Effects of Dietary Conjugated Linoleic Acid (CLA) as Single Or Mixed Isomers on the Expression of Genes Encoding for Proteins Involved in Cardiac Calcium Homeostasis in Male and Female Rats by : Cindy A. M. Gabriel
Download or read book Effects of Dietary Conjugated Linoleic Acid (CLA) as Single Or Mixed Isomers on the Expression of Genes Encoding for Proteins Involved in Cardiac Calcium Homeostasis in Male and Female Rats written by Cindy A. M. Gabriel and published by . This book was released on 2006 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Advances in Conjugated Linoleic Acid Research by : Martin P. Yurawecz
Download or read book Advances in Conjugated Linoleic Acid Research written by Martin P. Yurawecz and published by The American Oil Chemists Society. This book was released on 1999 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interest in conjugated linoleic acid (CLA) has increased substantially in recent years. As one would expect with any evolving scientific area, research to date has provided more questions than answers. This book provides an up-to-date report of work that is still in progress. The editors document the state of knowledge about CLA as the twentieth century draws to a close.
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