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The Design Synthesis And Evaluation Of Guanidine Based Molecular Transporters
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Book Synopsis The Design, Synthesis and Evaluation of Guanidine-based Molecular Transporters by : Kanaka Pattabiraman
Download or read book The Design, Synthesis and Evaluation of Guanidine-based Molecular Transporters written by Kanaka Pattabiraman and published by . This book was released on 2004 with total page 492 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis and Evaluation of Guanidinium-rich Molecular Transporters for the Delivery of Antibiotics and Oligonucleotides by : Melanie Ann Huttner
Download or read book The Design, Synthesis and Evaluation of Guanidinium-rich Molecular Transporters for the Delivery of Antibiotics and Oligonucleotides written by Melanie Ann Huttner and published by . This book was released on 2018 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The delivery of cell-impenetrable therapeutic agents across biological barriers represents a challenging problem in the field of life science research and medicine. Many bacterial pathogens are inherently resistant to glycopeptide antibiotics such as vancomycin due to the antibiotic's relatively large size and mode of action, which requires actively growing cells. Recently, genetically-resistant vancomycin strains have emerged, adding to vancomycin's inefficaciousness against certain bacterial populations. The emergence and understanding of phenotypically and genetically resistant bacteria coupled to a declining pipeline of antibiotic development necessitates new strategies to combat bacterial infections. As part of a collaboration between the Wender and Cegelski labs, we have designed, synthesized and evaluated a novel vancomycin cell-penetrating peptide conjugate. We have shown that this new conjugate exhibits a unique mode of action compared to vancomycin, allowing it to be extremely effective against vancomycin-insensitive bacterial populations.
Book Synopsis Design, Synthesis, and Evaluation of Molecular Transporters for Probe, Drug, and SiRNA Delivery by : Christina Barnes Cooley
Download or read book Design, Synthesis, and Evaluation of Molecular Transporters for Probe, Drug, and SiRNA Delivery written by Christina Barnes Cooley and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: My graduate studies have focused on the design, synthesis, and biological evaluation of novel probe and drug delivery technologies. This research has explored the development of new molecular transporter scaffolds with a focus on step economy and translational costs as well as evaluation of their uptake and delivery properties in cells and animals. Chapter 1 provides a historical context and overview of guanidinium-rich molecular transporter technology. Chapter 2 describes the development of a new family of guanidinium-rich oligocarbonate molecular transporter which are flexibly and efficiently assembled by a one-step oligomerization strategy. These novel oligocarbonate transporters were shown to exhibit excellent uptake properties both in cells and animal models. Chapter 3 is directed at the utility of an oligomerization approach to generate molecular transporters by the design, synthesis, and evaluation of new aphipathic co-oligomers for the delivery of siRNA, an oligonucleotide cargo of intense therapeutic interest. Amphipathic carbonate co-oligomers were prepared by an oligomerization strategy and demonstrated to effectively package, deliver, and release functional siRNA in cells. Chapter 4 describes the effects of a branched guanidinium array on the transport and delivery efficiency of releasable dendrimeric guanidinium-rich transporters. These transporters were synthesized and demonstrated to deliver and release a small molecule for turnover by its intracellular target enzyme by bioluminescence assays in cells and transgenic animal models. Chapter 5 describes the design, synthesis, and preliminary biological evaluation of lipidated molecular transporter derivatives of the immunosuppressant drug rapamycin for topical delivery.
Book Synopsis Guanidine Based Molecular Transporters for Drug Delivery by : Christopher L. VanDeusen
Download or read book Guanidine Based Molecular Transporters for Drug Delivery written by Christopher L. VanDeusen and published by . This book was released on 2003 with total page 802 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis, and Evaluation of Novel Bryostatin Analogs by : Vishal Anil Verma
Download or read book The Design, Synthesis, and Evaluation of Novel Bryostatin Analogs written by Vishal Anil Verma and published by . This book was released on 2008 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis, and Biological Evaluation of Structurally Simplified Bryostatin and Laulimalide Analogues by : Michael Kenneth Hilinski
Download or read book The Design, Synthesis, and Biological Evaluation of Structurally Simplified Bryostatin and Laulimalide Analogues written by Michael Kenneth Hilinski and published by . This book was released on 2006 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Synthesis, and Biological Evaluation of Molecular Transporter Conjugates and Their Encapsulation Inside Nanoparticles for Drug Delivery Applications by : Wesley Charles Galliher
Download or read book The Design, Synthesis, and Biological Evaluation of Molecular Transporter Conjugates and Their Encapsulation Inside Nanoparticles for Drug Delivery Applications written by Wesley Charles Galliher and published by . This book was released on 2010 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological barriers prevent the uptake of many potentially harmful xenobiotics yet also limit the delivery and cellular entry of a variety of drugs to their targets. One approach to this problem selects only those compounds with appropriate properties, namely solubility in polar biological fluids yet also able to pass through the nonpolar cellular membrane. This restriction would therefore preclude the use of many polar (e.g. siRNA) and nonpolar (e.g. Taxol) compounds whose inherent physical properties cause problems with formulation, distribution or bioavailability. The research described herein utilizes an alternative strategy that involves molecular transporters, which are agents that, when attached to poorly soluble or poorly bioavailable drugs, produce conjugates that exhibit excellent water solubility and simultaneously an increased ability to cross tissue and cell barriers. Bioactivatable molecular transporter conjugates of the immunosuppressant drug Cyclosporin A incorporating disulfide linkers were developed, evaluated for their biological activity in vitro, and administered topically in an in vivo mouse model. In addition to the inherent physical properties limitation that prevents drug passage across the cell membrane, another significant contributor to the failure of many therapeutics is the overexpression of membrane proteins (e.g. P-glycoprotein or Pgp) that mediate the unidirectional efflux of drugs out of target cells, often doing so prior to the drug reaching its intracellular target. Bioactivatable oligoarginine transporter conjugates of Taxol, a substrate for Pgp, were prepared and shown to overcome efflux-mediated resistance in primary human ovarian cancer tissue ex vivo. The encapsulation of transporter conjugates inside biodegradable polymeric nanoparticles was also investigated as a way to achieve sustained release of transporter drug conjugates over extended periods of time, thereby avoiding metabolism or toxicity problems associated with a bolus administration of therapeutic agents. Nanoparticles encapsulating transporter-probe conjugates were formed using two different methods, and shown to release their encapsulated cargo over time under biologically relevant conditions.
Book Synopsis I. Guanidinium Rich Molecular Transporters by : Lisa Renee Jones
Download or read book I. Guanidinium Rich Molecular Transporters written by Lisa Renee Jones and published by . This book was released on 2008 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Design, Syntheis, and Preliminary Biological Evaluation of Structurally Simplified Bryostatin Analogs by : Joshua Courtney Hora
Download or read book The Design, Syntheis, and Preliminary Biological Evaluation of Structurally Simplified Bryostatin Analogs written by Joshua Courtney Hora and published by . This book was released on 2005 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Discovery Research by : Ziwei Huang
Download or read book Drug Discovery Research written by Ziwei Huang and published by John Wiley & Sons. This book was released on 2007-06-11 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Post Genomics Drug Discovery and Research explores and discusses some of the most important topics in post-genomics life and biopharmaceutical sciences. It provides an introduction to the field, outlining examples of many techniques currently used, as well as those still under development, which are important for the research of biopharmaceutical discovery in the post-genomics era. Integrates several developing and cutting-edge technologies and methods like bioinformatics, experimental therapeutics, and molecular recognition Includes discussion on topics such as: computer-aided ligand design; peptide and protein chemistry and synthesis; synthesis of active natural products; and the use of emerging technologies like proteomics, nanotechnology, or bioengineering.
Book Synopsis Journal by : American Chemical Society
Download or read book Journal written by American Chemical Society and published by . This book was released on 2002 with total page 1448 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Molecular Transporters for Drug Delivery by : Theodore C. Jessop
Download or read book Molecular Transporters for Drug Delivery written by Theodore C. Jessop and published by . This book was released on 2005 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Directory of Graduate Research by : American Chemical Society. Committee on Professional Training
Download or read book Directory of Graduate Research written by American Chemical Society. Committee on Professional Training and published by . This book was released on 2005 with total page 1932 pages. Available in PDF, EPUB and Kindle. Book excerpt: Faculties, publications and doctoral theses in departments or divisions of chemistry, chemical engineering, biochemistry and pharmaceutical and/or medicinal chemistry at universities in the United States and Canada.
Book Synopsis Contributions by : Stanford University. Department of Chemistry
Download or read book Contributions written by Stanford University. Department of Chemistry and published by . This book was released on 2002 with total page 1062 pages. Available in PDF, EPUB and Kindle. Book excerpt: Contains reprints of articles published by members of the department.
Book Synopsis Annual Commencement by : Stanford University
Download or read book Annual Commencement written by Stanford University and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis American Doctoral Dissertations by :
Download or read book American Doctoral Dissertations written by and published by . This book was released on 2002 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Cell-Penetrating Peptides by : Ulo Langel
Download or read book Cell-Penetrating Peptides written by Ulo Langel and published by CRC Press. This book was released on 2002-05-29 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major problems with drug delivery is the inability of large hydrophilic compounds to pass through the lipid membrane of the cell, thus making drugs such as polypeptides and oligonucleotides of limited therapeutic value. Until recently, the transport of such molecules into the cytoplasmic and nuclear compartments of living cells seemed a