The Crispr Cas9 System

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Genome Engineering via CRISPR-Cas9 System

Author : Vijai Singh
Publisher : Academic Press
ISBN 13 : 9780128181409
Total Pages : 0 pages
Book Rating : 4.1/5 (814 download)

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Book Synopsis Genome Engineering via CRISPR-Cas9 System by : Vijai Singh

Download or read book Genome Engineering via CRISPR-Cas9 System written by Vijai Singh and published by Academic Press. This book was released on 2020-02-21 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields.

CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases

Author : Luis María Vaschetto
Publisher : CRC Press
ISBN 13 : 1000540812
Total Pages : 268 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases by : Luis María Vaschetto

Download or read book CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases written by Luis María Vaschetto and published by CRC Press. This book was released on 2022-01-31 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.

CRISPR-Cas Systems

Author : Rodolphe Barrangou
Publisher : Springer Science & Business Media
ISBN 13 : 364234657X
Total Pages : 300 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis CRISPR-Cas Systems by : Rodolphe Barrangou

Download or read book CRISPR-Cas Systems written by Rodolphe Barrangou and published by Springer Science & Business Media. This book was released on 2012-12-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: CRISPR/Cas is a recently described defense system that protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR/Cas systems has been identified in at least half of the available prokaryotic genomes. On-going structural and functional analyses have resulted in a far greater insight into the functions and possible applications of these systems, although many secrets remain to be discovered. In this book, experts summarize the state of the art in this exciting field.

Genome Engineering via CRISPR-Cas9 System

Author : Vijai Singh
Publisher : Academic Press
ISBN 13 : 0128181419
Total Pages : 386 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Genome Engineering via CRISPR-Cas9 System by : Vijai Singh

Download or read book Genome Engineering via CRISPR-Cas9 System written by Vijai Singh and published by Academic Press. This book was released on 2020-02-18 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome Engineering via CRISPR-Cas9 Systems presents a compilation of chapters from eminent scientists from across the globe who have established expertise in working with CRISPR-Cas9 systems. Currently, targeted genome engineering is a key technology for basic science, biomedical and industrial applications due to the relative simplicity to which they can be designed, used and applied. However, it is not easy to find relevant information gathered in a single source. The book contains a wide range of applications of CRISPR in research of bacteria, virus, algae, plant and mammalian and also discusses the modeling of drosophila, zebra fish and protozoan, among others. Other topics covered include diagnosis, sensor and therapeutic applications, as well as ethical and regulatory issues. This book is a valuable source not only for beginners in genome engineering, but also researchers, clinicians, stakeholders, policy makers, and practitioners interested in the potential of CRISPR-Cas9 in several fields. Provides basic understanding and a clear picture on how to design, use and implement the CRISPR-Cas9 system in different organisms Explains how to create an animal model for disease research and screening purposes using CRISPR Discusses the application of CRISPR-Cas9 systems in basic sciences, biomedicine, virology, bacteriology, molecular biology, neurology, cancer, industry, and many more

CRISPR and RNAi Systems

Author : Kamel A Abd-Elsalam
Publisher : Elsevier
ISBN 13 : 0128219114
Total Pages : 842 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis CRISPR and RNAi Systems by : Kamel A Abd-Elsalam

Download or read book CRISPR and RNAi Systems written by Kamel A Abd-Elsalam and published by Elsevier. This book was released on 2021-02-27 with total page 842 pages. Available in PDF, EPUB and Kindle. Book excerpt: Plants are vulnerable to pathogens including fungi, bacteria, and viruses, which cause critical problems and deficits. Crop protection by plant breeding delivers a promising solution with no obvious effect on human health or the local ecosystem. Crop improvement has been the most powerful approach for producing unique crop cultivars since domestication occurred, making possible the main innovations in feeding the globe and community development. Genome editing is one of the genetic devices that can be implemented, and disease resistance is frequently cited as the most encouraging application of CRISPR/Cas9 technology in agriculture. Nanobiotechnology has harnessed the power of genome editing to develop agricultural crops. Nanosized DNA or RNA nanotechnology approaches could contribute to raising the stability and performance of CRISPR guide RNAs. This book brings together the latest research in these areas. CRISPR and RNAi Systems: Nanobiotechnology Approaches to Plant Breeding and Protection presents a complete understanding of the RNAi and CRISPR/Cas9 techniques for controlling mycotoxins, fighting plant nematodes, and detecting plant pathogens. CRISPR/Cas genome editing enables efficient targeted modification in most crops, thus promising to accelerate crop improvement. CRISPR/Cas9 can be used for management of plant insects, and various plant pathogens. The book is an important reference source for both plant scientists and environmental scientists who want to understand how nano biotechnologically based approaches are being used to create more efficient plant protection and plant breeding systems. Shows how nanotechnology is being used as the basis for new solutions for more efficient plant breeding and plant protection Outlines the major techniques and applications of both CRISPR and RNAi technologies Assesses the major challenges of escalating these technologies on a mass scale

Targeted Genome Editing Using Site-Specific Nucleases

Author : Takashi Yamamoto
Publisher : Springer
ISBN 13 : 4431552278
Total Pages : 205 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Targeted Genome Editing Using Site-Specific Nucleases by : Takashi Yamamoto

Download or read book Targeted Genome Editing Using Site-Specific Nucleases written by Takashi Yamamoto and published by Springer. This book was released on 2015-01-05 with total page 205 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book serves as an introduction to targeted genome editing, beginning with the background of this rapidly developing field and methods for generation of engineered nucleases. Applications of genome editing tools are then described in detail, in iPS cells and diverse organisms such as mice, rats, marine invertebrates, fish, frogs, and plants. Tools that are mentioned include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and CRISPR/Cas9, all of which have received much attention in recent years as breakthrough technologies. Genome editing with engineered nucleases allows us to precisely change the target genome of living cells and is a powerful way to control functional genes. It is feasible in almost all organisms ranging from bacteria to plants and animals, as well as in cultured cells such as ES and iPS cells. Various genome modifications have proven successful, including gene knockout and knock-in experiments with targeting vectors and chromosomal editing. Genome editing technologies hold great promise for the future, for example in biomedical research, clinical medicine, and generation of crops and livestock with desirable traits. A wide range of readers will find this book interesting, and with its focus on applications in a variety of organisms and cells, the book will be valuable for life scientists in all fields.

The CRISPR/Cas9 System

Author : Alfred A. Bertelsen
Publisher :
ISBN 13 : 9781536164268
Total Pages : 0 pages
Book Rating : 4.1/5 (642 download)

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Book Synopsis The CRISPR/Cas9 System by : Alfred A. Bertelsen

Download or read book The CRISPR/Cas9 System written by Alfred A. Bertelsen and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This compilation focuses on the CRISPR/Cas9 system, a genome editing tool that has been hailed as the most profound molecular biology discovery in the past decade. By employing the natural process of bacterial immunity towards bacteriophages, the tool allows researchers to precisely excise and edit parts of the genetic sequence to modify them.The authors summarize the molecular pathogenesis of hepatocellular carcinoma, available treatments/drugs and their limitations, the landscape of CRISPR targeting hepatocellular carcinoma, limitations and potential targets in future.The closing review summarises the use of CRISPR/Cas9 gene editing in ophthalmology and focuses on the advancement of gene editing in the cornea. The majority of corneal dystrophies are the result an autosomal dominant inheritance pattern within the TGFBI gene, which presents an ideal model suited for a CRISPR/Cas9 knock out methodology.

CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases

Author : Luis María Vaschetto
Publisher : CRC Press
ISBN 13 : 1000540839
Total Pages : 315 pages
Book Rating : 4.0/5 (5 download)

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Book Synopsis CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases by : Luis María Vaschetto

Download or read book CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases written by Luis María Vaschetto and published by CRC Press. This book was released on 2022-01-31 with total page 315 pages. Available in PDF, EPUB and Kindle. Book excerpt: The CRISPR-Cas9 genome-editing system is creating a revolution in the science world. In the laboratory, CRISPR-Cas9 can efficiently be used to target specific genes, correct mutations and regulate gene expression of a wide array of cells and organisms, including human cells. CRISPR-/Cas9 Based Genome Editing for Treating Genetic Disorders and Diseases is a unique reading material for college students, academicians, and other health professionals interested in learning about the broad range of applications of CRISPR/Cas9 genetic scissors. Some topics included in this book are: the role of the CRISPR/Cas9 system in neuroscience, gene therapy, epigenome editing, genome mapping, cancer, virus infection control strategies, regulatory challenges and bioethical considerations.

The CRISPR/Cas System

Author : Muhammad Jamal
Publisher : Caister Academic Press Limited
ISBN 13 : 9781910190630
Total Pages : 0 pages
Book Rating : 4.1/5 (96 download)

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Book Synopsis The CRISPR/Cas System by : Muhammad Jamal

Download or read book The CRISPR/Cas System written by Muhammad Jamal and published by Caister Academic Press Limited. This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of CRISPR/Cas technology for genome editing suggests many potential applications, including the alteration of the germline of humans, animals and food crops. The speed and efficiency of the CRISPR/Cas system make it a potentially useful system for gene therapy. In this volume expert international authors provide a useful and timely review of the applications of the CRISPR/Cas system across diverse fields and explore further avenues and research directions of this novel and powerful editing technology. The technology and its application are reviewed with respect to reproduction and development, immunity and genetic diseases, system structure and system specificity. Some of the potential problems of the CRISPR/Cas system are also discussed, in particular the specificity of the system: this remains an important topic as improvement could lead to the more direct and efficient use of the CRISPR/Cas system in clinical settings. The authors also debate ethical concerns associated with this powerful new technology. This volume is a rigorous review of the applications and new opportunities for the CRISPR/Cas system and provides a stimulus for current and future research. An invaluable guide for all scientists working in the fields of genome editing and gene therapy the book is also recommended for all life sciences libraries.

A Crack In Creation

Author : Jennifer A. Doudna
Publisher : HarperCollins
ISBN 13 : 0544716965
Total Pages : 307 pages
Book Rating : 4.5/5 (447 download)

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Book Synopsis A Crack In Creation by : Jennifer A. Doudna

Download or read book A Crack In Creation written by Jennifer A. Doudna and published by HarperCollins. This book was released on 2017-06-13 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: BY THE WINNER OF THE 2020 NOBEL PRIZE IN CHEMISTRY | Finalist for the Los Angeles Times Book Prize “A powerful mix of science and ethics . . . This book is required reading for every concerned citizen—the material it covers should be discussed in schools, colleges, and universities throughout the country.”— New York Review of Books Not since the atomic bomb has a technology so alarmed its inventors that they warned the world about its use. That is, until 2015, when biologist Jennifer Doudna called for a worldwide moratorium on the use of the gene-editing tool CRISPR—a revolutionary new technology that she helped create—to make heritable changes in human embryos. The cheapest, simplest, most effective way of manipulating DNA ever known, CRISPR may well give us the cure to HIV, genetic diseases, and some cancers. Yet even the tiniest changes to DNA could have myriad, unforeseeable consequences, to say nothing of the ethical and societal repercussions of intentionally mutating embryos to create “better” humans. Writing with fellow researcher Sam Sternberg, Doudna—who has since won the Nobel Prize for her CRISPR research—shares the thrilling story of her discovery and describes the enormous responsibility that comes with the power to rewrite the code of life. “The future is in our hands as never before, and this book explains the stakes like no other.” — George Lucas “An invaluable account . . . We owe Doudna several times over.” — Guardian

Plant Genome Editing – Policies and Governance

Author : Thorben Sprink
Publisher : Frontiers Media SA
ISBN 13 : 2889636704
Total Pages : 252 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Plant Genome Editing – Policies and Governance by : Thorben Sprink

Download or read book Plant Genome Editing – Policies and Governance written by Thorben Sprink and published by Frontiers Media SA. This book was released on 2020-04-22 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Plant Genome Editing with CRISPR Systems

Author : Yiping Qi
Publisher : Humana
ISBN 13 : 9781493989904
Total Pages : 0 pages
Book Rating : 4.9/5 (899 download)

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Book Synopsis Plant Genome Editing with CRISPR Systems by : Yiping Qi

Download or read book Plant Genome Editing with CRISPR Systems written by Yiping Qi and published by Humana. This book was released on 2019-01-05 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume provides readers with wide-ranging coverage of CRISPR systems and their applications in various plant species. The chapters in this book discuss topics such as plant DNA repair and genome editing; analysis of CRISPR-induced mutations; multiplexed CRISPR/Cas9 systems; CRISPR-Cas12a (Cpf1) editing systems; and non-agrobacterium based CRISPR delivery systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Comprehensive and thorough, Plant Genome Editing with CRISPR Systems: Methods and Protocols is a valuable resource for any researcher interested in learning about and using CRISPR systems in plants.

Next Generation Plant Breeding

Author : Yelda Ozden Çiftçi
Publisher : BoD – Books on Demand
ISBN 13 : 1789239257
Total Pages : 162 pages
Book Rating : 4.7/5 (892 download)

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Book Synopsis Next Generation Plant Breeding by : Yelda Ozden Çiftçi

Download or read book Next Generation Plant Breeding written by Yelda Ozden Çiftçi and published by BoD – Books on Demand. This book was released on 2018-09-26 with total page 162 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following the green revolution and transgenic crop development, another revolutionary progress has been experienced in plant breeding in the last decade with the application of marker-assisted selection (MAS), next-generation sequencing (NGS), and gene editing techniques together with omic technologies, including genomics, transcriptomics, proteomics, and phenomics. Thus, this book is structured into two sections: "Marker-Assisted Breeding" and "RNA-seq and Gene Editing in Plants," which aim to provide a reference for students, instructors, and scientists on recent innovative advances in plant-breeding programs to cultivate crops for tomorrow.

Human Genome Editing

Author : National Academies of Sciences, Engineering, and Medicine
Publisher : National Academies Press
ISBN 13 : 0309452880
Total Pages : 329 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Human Genome Editing by : National Academies of Sciences, Engineering, and Medicine

Download or read book Human Genome Editing written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2017-08-13 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genome editing is a powerful new tool for making precise alterations to an organism's genetic material. Recent scientific advances have made genome editing more efficient, precise, and flexible than ever before. These advances have spurred an explosion of interest from around the globe in the possible ways in which genome editing can improve human health. The speed at which these technologies are being developed and applied has led many policymakers and stakeholders to express concern about whether appropriate systems are in place to govern these technologies and how and when the public should be engaged in these decisions. Human Genome Editing considers important questions about the human application of genome editing including: balancing potential benefits with unintended risks, governing the use of genome editing, incorporating societal values into clinical applications and policy decisions, and respecting the inevitable differences across nations and cultures that will shape how and whether to use these new technologies. This report proposes criteria for heritable germline editing, provides conclusions on the crucial need for public education and engagement, and presents 7 general principles for the governance of human genome editing.

CRISPR-Cas

Author : Jennifer A. Doudna
Publisher :
ISBN 13 : 9781621821304
Total Pages : 0 pages
Book Rating : 4.8/5 (213 download)

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Book Synopsis CRISPR-Cas by : Jennifer A. Doudna

Download or read book CRISPR-Cas written by Jennifer A. Doudna and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: CRISPR/Cas-based techniques are revolutionizing the way geneticists and molecular biologists modify DNA sequences and modulate gene expression in cells and organisms. This laboratory manual presents step-by-step protocols for applying this cutting-edge technology to any system of interest. Contributors describe approaches for de.

Diversity and Evolution of Butterfly Wing Patterns

Author : Toshio Sekimura
Publisher : Springer
ISBN 13 : 9811049564
Total Pages : 321 pages
Book Rating : 4.8/5 (11 download)

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Book Synopsis Diversity and Evolution of Butterfly Wing Patterns by : Toshio Sekimura

Download or read book Diversity and Evolution of Butterfly Wing Patterns written by Toshio Sekimura and published by Springer. This book was released on 2017-08-29 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book facilitates an integrative understanding of the development, genetics and evolution of butterfly wing patterns. To develop a deep and realistic understanding of the diversity and evolution of butterfly wing patterns, it is essential and necessary to approach the problem from various kinds of key research fields such as “evo-devo,” “eco-devo,” ”developmental genetics,” “ecology and adaptation,” “food plants,” and “theoretical modeling.” The past decade-and-a-half has seen a veritable revolution in our understanding of the development, genetics and evolution of butterfly wing patterns. In addition, studies of how environmental and climatic factors affect the expression of color patterns has led to increasingly deeper understanding of the pervasiveness and underlying mechanisms of phenotypic plasticity. In recognition of the great progress in research on the biology, an international meeting titled “Integrative Approach to Understanding the Diversity of Butterfly Wing Patterns (IABP-2016)” was held at Chubu University, Japan in August 2016. This book consists of selected contributions from the meeting. Authors include main active researchers of new findings of corresponding genes as well as world leaders in both experimental and theoretical approaches to wing color patterns. The book provides excellent case studies for graduate and undergraduate classes in evolution, genetics/genomics, developmental biology, ecology, biochemistry, and also theoretical biology, opening the door to a new era in the integrative approach to the analysis of biological problems. This book is open access under a CC BY 4.0 license.

Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B

Author :
Publisher : Academic Press
ISBN 13 : 032385298X
Total Pages : 200 pages
Book Rating : 4.3/5 (238 download)

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Book Synopsis Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B by :

Download or read book Reprogramming the Genome: Applications of CRISPR-Cas in non-mammalian systems part B written by and published by Academic Press. This book was released on 2021-04-29 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reprogramming the Genome: Applications of CRISPR-Cas in Non-mammalian Systems Part B, represents the collation of chapters written by eminent scientists worldwide. CRISPR-Cas9 system is an RNA-mediated immune system of bacteria and archaea that protects from bacteriophage infections. It is one of the revolutionized technologies to uplift biology to the next stages. It is a simple, rapid, precise, and cost-effective tool for genome editing and regulation of a wide range of organisms. It has gained scientific and public attention worldwide. This volume mainly covers insect cell line, protozoans, zebrafish, drosophila, CRISPRi, patents as well as technology transfer, and many more. This book is a key source of information available in a single volume. This book will be useful for not only beginners in genome engineering, but also students, researchers, scientists, policymakers, and stakeholders interested in harnessing the potential of reprogramming of the genomes in several areas. Offers basic understanding and a clear picture of genome editing CRISPR-Cas systems in different organisms Explains how to create an animal model for disease diagnosis/research and reprogram CRISPR for insect cell line, protozoans, zebrafish, drosophila, and many more Discusses the advances, patents, applications, challenges and opportunities in CRISPR-Cas9 systems in basic sciences, biomedicine, molecular biology and many more