The Chemical Biology Of Thrombin

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The Chemical Biology of Thrombin

Author : Roger L. Lundblad
Publisher : CRC Press
ISBN 13 : 1351677721
Total Pages : 308 pages
Book Rating : 4.3/5 (516 download)

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Book Synopsis The Chemical Biology of Thrombin by : Roger L. Lundblad

Download or read book The Chemical Biology of Thrombin written by Roger L. Lundblad and published by CRC Press. This book was released on 2022-05-01 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a comprehensive review of thrombin, especially as regulatory protease. The ready availability of highly purified thrombin has stimulated rapid advances in the cell biology of this important macromolecule. The text focuses on research findings from the discovery of thrombin by Andrew Buchanan in 1842 to the present. A substantial amount of this work was conducted by the author and his colleagues. His work on the purification of thrombin was seminal to much subsequent work on thrombin. This volume provides a framework for future studies now made possible by the discovery of the importance of exosites in the physiology of thrombin function. The current work describes the process of the development of an oral inhibitor of thrombin used in the prevention of thrombosis. Key Features Reviews the history of Thrombin (Fibrin Ferment) Documents the relation of protein engineering and chemical modification in the study of thrombin Summarizes the interaction of thrombin with fibrinogen and fibrin Outlines the role of exosites in thrombin function Describes the development of an oral inhibitor for thrombin

Chemistry and Biology of Thrombin

Author : Roger L. Lundblad
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 584 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Chemistry and Biology of Thrombin by : Roger L. Lundblad

Download or read book Chemistry and Biology of Thrombin written by Roger L. Lundblad and published by Butterworth-Heinemann. This book was released on 1977 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Thrombin

Author : Lawrence J. Berliner
Publisher : Springer Science & Business Media
ISBN 13 : 1461532965
Total Pages : 445 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Thrombin by : Lawrence J. Berliner

Download or read book Thrombin written by Lawrence J. Berliner and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Research on thrombin structure and function has progressed significantly over the past three decades. We are continually discovering new functions f()r this enzyme in biology. Yet, until quite recently, a full, detailed, three dimensional picture of its structure was difficult to attain. We believe that this text represents a turning point and, more appropriately, a new start ing point for thrombin studies. Our goal for this text is to present a thorough and rounded-out coverage of thrombin chemistry and biochem istry in order to provide the biochemist and physiologist with an excellent desk reference on almost any thrombin-related problem. This volume is organized into three general thrombin topic areas: Structure, Biochemistry, and Physiology. In Part 1, Structure, we open with the complete three-dimensional x-ray structures of two inhibited human thrombin complexes, one of which is the thrombin-hirudin com plex. These complexes are also addressed in the chapter on structural studies in solution, which include NMR, ESR, and fluorescence. Part 2, Biochemistry, includes chapters on synthetic thrombin inhibitors, protein inhibitors (e.g., antithrombin III, hirudin), and thrombin interactions with factor XIII. Part 3, Physiology, covers such topics as chemotactic activities, interactions with cell surfaces, and the vascular endothelium.

The Design of Synthetic Inhibitors of Thrombin

Author : Goran Claeson
Publisher : Springer Science & Business Media
ISBN 13 : 1489924183
Total Pages : 245 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis The Design of Synthetic Inhibitors of Thrombin by : Goran Claeson

Download or read book The Design of Synthetic Inhibitors of Thrombin written by Goran Claeson and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 245 pages. Available in PDF, EPUB and Kindle. Book excerpt: In one generation, the numerous factors involved in blood coagulation have become real protein entities, isolated in pure form, expressed by recombinant DNA techniques, and subjected to structure elucidation by the modem methods of physical chemistry, viz. , X-ray diffraction, and NMR, ESR and fluorescence spectroscopy. The major milestone in this field was the breakthrough achieved by W. Bode, R. Huber and their colleagues in 1989 in of human a-thrombin, inhibited with D-Phe-Pro-Arg determining the crystal structure chioromethyl ketone. The availability of this structure will greatly facilitate the interpretation of experiments designed to gain an understanding of the interatomic interactions between this enzyme and fibrinogen and its other substrates. At the same time, it provides a rational basis for the design and synthesis of inhibitors of thrombin, the subject of this symposium. The symposium was organized in four sessions: (1) Structural features of the interaction of thrombin with substrates and inhibitors, (2) Synthetic inhibitors, (3) Hirudin and its analogues, and (4) Pharmacological and clinical considerations. This book contains summaries of most of the papers presented, and takes its rigbful place among two others that provide a comprehensive picture of our current knowledge about thrombin, viz. the 1977 volume entitled "Chemistry and Biology of Thrombin", edited by R. L. Lundblad, J. W. Fenton II, and K. G. Mann, and the 1992 volume entitled "Thrombin: Structure and Function", edited by L. J. Berliner.

Thrombin

Author : Michael E. Maragoudakis
Publisher : Springer Science & Business Media
ISBN 13 : 038709637X
Total Pages : 272 pages
Book Rating : 4.3/5 (87 download)

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Book Synopsis Thrombin by : Michael E. Maragoudakis

Download or read book Thrombin written by Michael E. Maragoudakis and published by Springer Science & Business Media. This book was released on 2010-04-02 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields. This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

Thrombin

Author : Michael E. Maragoudakis
Publisher : Springer
ISBN 13 : 9780387096360
Total Pages : 0 pages
Book Rating : 4.0/5 (963 download)

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Book Synopsis Thrombin by : Michael E. Maragoudakis

Download or read book Thrombin written by Michael E. Maragoudakis and published by Springer. This book was released on 2008-12-02 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In addition to its central role in blood coagulation, it has become increasingly apparent that thrombin and thrombin receptors are involved in many other physiological processes and can contribute to a variety of disease states such as tumor progression and metastasis, inflammation, neurological disorders and cardiovascular complications. This book is a collection of reviews of up-to-date information on the above topics by leaders in these fields. This book will be of value to researchers and academic professionals both in basic and clinical science who are interested in the fields of biochemistry, biophysics, cell biology, pharmacology, cancer, inflammation, angiogenesis, cardiovascular system and neuronal system. These areas of research are prime target areas for drug development by many pharmaceutical and biotechnology companies.

Chemistry and Biology of Heparin and Heparan Sulfate

Author : Hari G. Garg
Publisher : Elsevier
ISBN 13 : 9780080529059
Total Pages : 792 pages
Book Rating : 4.5/5 (29 download)

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Book Synopsis Chemistry and Biology of Heparin and Heparan Sulfate by : Hari G. Garg

Download or read book Chemistry and Biology of Heparin and Heparan Sulfate written by Hari G. Garg and published by Elsevier. This book was released on 2011-10-10 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemistry, biochemistry and pharmacology of heparin and heparan sulfate have been and continue to be a major scientific undertaking - heparin and its derivative remain important drugs in clinical practice. Chemistry and Biology of Heparin and Heparan Sulfate provides readers with an insight into the chemistry, biology and clinical applications of heparin and heparan sulfate and examines their function in various physiological and pathological conditions. Providing a wealth of useful information, no other tome covers the diversity of topics in the field. Students, doctors, chemists, biochemists, and research scientists will find this book an invaluable source for updating their current knowledge of developments in this area. Comprehensively reviews all aspects of heparin and heparan sulfate research Uniquely describes the chemistry, biology and clinical application of heparins and heparan sulfates in one work Provides an invaluable source of knowledge of current developments for chemists, biochemists, medical doctors, researchers, students and practitioners

Hemostasis and Thrombosis

Author : Robert W. Colman
Publisher : Lippincott Williams & Wilkins
ISBN 13 : 0781749964
Total Pages : 1903 pages
Book Rating : 4.7/5 (817 download)

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Book Synopsis Hemostasis and Thrombosis by : Robert W. Colman

Download or read book Hemostasis and Thrombosis written by Robert W. Colman and published by Lippincott Williams & Wilkins. This book was released on 2006 with total page 1903 pages. Available in PDF, EPUB and Kindle. Book excerpt: The pre-eminent reference on coagulation disorders is now in its thoroughly updated Fifth Edition. Written by more than 160 of the world's foremost authorities, this encyclopedic volume integrates basic science and clinical practice and details all that is currently known about blood clotting disorders and how to manage patients with these and related problems. This edition has been reorganized into smaller, more tightly focused chapters to help readers find information easily. A new co-editor, Samuel Z. Goldhaber, MD, has expanded the cardiology portion of the book. Other new features include a two-color page design and more than 100 full-color illustrations.

Advances in Enzymology and Related Areas of Molecular Biology

Author : Alton Meister
Publisher : John Wiley & Sons
ISBN 13 : 0470123389
Total Pages : 595 pages
Book Rating : 4.4/5 (71 download)

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Book Synopsis Advances in Enzymology and Related Areas of Molecular Biology by : Alton Meister

Download or read book Advances in Enzymology and Related Areas of Molecular Biology written by Alton Meister and published by John Wiley & Sons. This book was released on 2009-09-10 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in Enzymology and Related Areas of Molecular Biology is a seminal series in the field of biochemistry, offering researchers access to authoritative reviews of the latest discoveries in all areas of enzymology and molecular biology. These landmark volumes date back to 1941, providing an unrivaled view of the historical development of enzymology. The series offers researchers the latest understanding of enzymes, their mechanisms, reactions and evolution, roles in complex biological process, and their application in both the laboratory and industry. Each volume in the series features contributions by leading pioneers and investigators in the field from around the world. All articles are carefully edited to ensure thoroughness, quality, and readability. With its wide range of topics and long historical pedigree, Advances in Enzymology and Related Areas of Molecular Biology can be used not only by students and researchers in molecular biology, biochemistry, and enzymology, but also by any scientist interested in the discovery of an enzyme, its properties, and its applications.

Handbook of Chemical Biology of Nucleic Acids

Author : Naoki Sugimoto
Publisher : Springer Nature
ISBN 13 : 9811997764
Total Pages : 2847 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Handbook of Chemical Biology of Nucleic Acids by : Naoki Sugimoto

Download or read book Handbook of Chemical Biology of Nucleic Acids written by Naoki Sugimoto and published by Springer Nature. This book was released on 2023-07-29 with total page 2847 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.

Chemical Biology

Author : Herbert Waldmann
Publisher : Wiley-VCH
ISBN 13 :
Total Pages : 240 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Chemical Biology by : Herbert Waldmann

Download or read book Chemical Biology written by Herbert Waldmann and published by Wiley-VCH. This book was released on 2004-08-06 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: Take your first steps in combinatorial synthesis or synthesize bioactive molecules such as antibiotics. Search for mutations in DNA using chemical probes or perform a proteome analysis in yeast. The present selection of 12 inspiring experiments is tailored for maximum learning effect at minimal expense of time and equipment. Almost all currently used laboratory techniques in synthesis and analysis of bioactive compounds are represented at least once. Abundant practical hints are complemented by a thorough treatment of the underlying theory and mechanisms.

Chemical Biology of Nucleic Acids

Author : Volker A. Erdmann
Publisher : Springer Science & Business
ISBN 13 : 3642544525
Total Pages : 599 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Chemical Biology of Nucleic Acids by : Volker A. Erdmann

Download or read book Chemical Biology of Nucleic Acids written by Volker A. Erdmann and published by Springer Science & Business. This book was released on 2014-04-22 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

The Chemical Biology of Nucleic Acids

Author : Günter Mayer
Publisher : John Wiley & Sons
ISBN 13 : 1119957265
Total Pages : 595 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis The Chemical Biology of Nucleic Acids by : Günter Mayer

Download or read book The Chemical Biology of Nucleic Acids written by Günter Mayer and published by John Wiley & Sons. This book was released on 2011-06-17 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Nucleic Acids in Medicinal Chemistry and Chemical Biology

Author : Lihe Zhang
Publisher : John Wiley & Sons
ISBN 13 : 1119692741
Total Pages : 564 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Nucleic Acids in Medicinal Chemistry and Chemical Biology by : Lihe Zhang

Download or read book Nucleic Acids in Medicinal Chemistry and Chemical Biology written by Lihe Zhang and published by John Wiley & Sons. This book was released on 2023-01-05 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Introduction to Bioorganic Chemistry and Chemical Biology

Author : David Van Vranken
Publisher : Garland Science
ISBN 13 : 1135054827
Total Pages : 504 pages
Book Rating : 4.1/5 (35 download)

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Book Synopsis Introduction to Bioorganic Chemistry and Chemical Biology by : David Van Vranken

Download or read book Introduction to Bioorganic Chemistry and Chemical Biology written by David Van Vranken and published by Garland Science. This book was released on 2018-10-08 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to Bioorganic Chemistry and Chemical Biology is the first textbook to blend modern tools of organic chemistry with concepts of biology, physiology, and medicine. With a focus on human cell biology and a problems-driven approach, the text explains the combinatorial architecture of biooligomers (genes, DNA, RNA, proteins, glycans, lipids, and terpenes) as the molecular engine for life. Accentuated by rich illustrations and mechanistic arrow pushing, organic chemistry is used to illuminate the central dogma of molecular biology. Introduction to Bioorganic Chemistry and Chemical Biology is appropriate for advanced undergraduate and graduate students in chemistry and molecular biology, as well as those going into medicine and pharmaceutical science.

Fluorine in Medicinal Chemistry and Chemical Biology

Author : Iwao Ojima
Publisher : John Wiley & Sons
ISBN 13 : 9780470744086
Total Pages : 640 pages
Book Rating : 4.7/5 (44 download)

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Book Synopsis Fluorine in Medicinal Chemistry and Chemical Biology by : Iwao Ojima

Download or read book Fluorine in Medicinal Chemistry and Chemical Biology written by Iwao Ojima and published by John Wiley & Sons. This book was released on 2009-03-23 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary potential of fluorine-containing molecules in medicinal chemistry and chemical biology has been recognized by researchers outside of the traditional fluorine chemistry field, and thus a new wave of fluorine chemistry is rapidly expanding its biomedical frontiers. With several of the best selling drugs in the world crucially containing fluorine atoms, the incorporation of fluorine to drug leads has become an essential practice in biomedical research, especially for drug design and discovery as well as development. Focusing on the unique and significant roles that fluorine plays in medicinal chemistry and chemical biology, this book reviews recent advances and future prospects in this rapidly developing field. Topics covered include: Discovery and development of fluorine containing drugs and drug candidates. New and efficient synthetic methods for medicinal chemistry and the optimisation of fluorine-containing drug candidates. Structural and chemical biology of fluorinated amino acids and peptides. Fluorine labels as probes in metabolic study, protein engineering and clinical diagnosis. Applications of 19F NMR spectroscopy in biomedical research. An appendix presents an invaluable index of all fluorine-containing drugs that have been approved by the US Food and Drug Administration, including information on structure and pharmaceutical action. Fluorine in Medicinal Chemistry and Chemical Biology will serve as an excellent reference source for graduate students as well as academic and industrial researchers who want to take advantage of fluorine in biomedical research.

Water in Biological and Chemical Processes

Author : Biman Bagchi
Publisher : Cambridge University Press
ISBN 13 : 1107037298
Total Pages : 383 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Water in Biological and Chemical Processes by : Biman Bagchi

Download or read book Water in Biological and Chemical Processes written by Biman Bagchi and published by Cambridge University Press. This book was released on 2013-11-14 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: A unified overview of the dynamical properties of water and its unique and diverse role in biological and chemical processes.