Chemical Biology Of Nucleic Acids

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Nucleic Acids in Chemistry and Biology

Author : G Michael Blackburn
Publisher : Royal Society of Chemistry
ISBN 13 : 1782625771
Total Pages : 824 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Nucleic Acids in Chemistry and Biology by : G Michael Blackburn

Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2015-11-09 with total page 824 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and are crucial for the understanding of complex biological processes involved. Revised and updated Nucleic Acids in Chemistry and Biology 3rd Edition discusses in detail, both the chemistry and biology of nucleic acids and brings RNA into parity with DNA. Written by leading experts, with extensive teaching experience, this new edition provides some updated and expanded coverage of nucleic acid chemistry, reactions and interactions with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecularly based introduction to the structure and biological roles of DNA and RNA. Key chapters are devoted to the chemical synthesis of nucleosides and nucleotides, oligonucleotides and their analogues and to analytical techniques applied to nucleic acids. The text is supported by an extensive list of references, making it a definitive reference source. This authoritative book presents topics in an integrated manner and readable style. It is ideal for graduate and undergraduates students of chemistry and biochemistry, as well as new researchers to the field.

The Chemical Biology of Nucleic Acids

Author : Günter Mayer
Publisher : John Wiley & Sons
ISBN 13 : 1119957265
Total Pages : 595 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis The Chemical Biology of Nucleic Acids by : Günter Mayer

Download or read book The Chemical Biology of Nucleic Acids written by Günter Mayer and published by John Wiley & Sons. This book was released on 2011-06-17 with total page 595 pages. Available in PDF, EPUB and Kindle. Book excerpt: With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Nucleic Acids in Medicinal Chemistry and Chemical Biology

Author : Lihe Zhang
Publisher : John Wiley & Sons
ISBN 13 : 1119692784
Total Pages : 564 pages
Book Rating : 4.1/5 (196 download)

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Book Synopsis Nucleic Acids in Medicinal Chemistry and Chemical Biology by : Lihe Zhang

Download or read book Nucleic Acids in Medicinal Chemistry and Chemical Biology written by Lihe Zhang and published by John Wiley & Sons. This book was released on 2022-12-15 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Nucleic Acids in Chemistry and Biology

Author : G. Michael Blackburn
Publisher : Irl Press
ISBN 13 : 9780199635337
Total Pages : 528 pages
Book Rating : 4.6/5 (353 download)

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Book Synopsis Nucleic Acids in Chemistry and Biology by : G. Michael Blackburn

Download or read book Nucleic Acids in Chemistry and Biology written by G. Michael Blackburn and published by Irl Press. This book was released on 1996 with total page 528 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the discovery of the DNA double helix in 1953, nucleic acids have formed the central theme of much of contemporary molecular science. Nowhere is this more apparent than in the increasing efforts to determine the DNA sequence of the human genome and the development of new diagnostics of genetic disease. Recent sophistication of nucleic acids synthesis has been key to the establishment of the biotechnology industry and our improving knowledge of nucleic acid structures and interactions is noticeably influencing the design of novel drugs.This second and completely revised edition draws on the expertise of the same international group of authors to set the basics of the nucleic acids in the context of the expanding horizons set by modern structural biology, RNA enzymology, drug discovery and biotechnology.

Chemical Biology of Nucleic Acids

Author : Volker A. Erdmann
Publisher : Springer Science & Business
ISBN 13 : 3642544525
Total Pages : 599 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Chemical Biology of Nucleic Acids by : Volker A. Erdmann

Download or read book Chemical Biology of Nucleic Acids written by Volker A. Erdmann and published by Springer Science & Business. This book was released on 2014-04-22 with total page 599 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains 29 engrossing chapters contributed by worldwide, leading research groups in the field of chemical biology. Topics include pre-biology; the establishment of the genetic code; isomerization of RNA; damage of nucleobases in RNA; the dynamic structure of nucleic acids and their analogs in DNA replication, extra- and intra-cellular transport; molecular crowding by the use of ionic liquids; new technologies enabling the modification of gene expression via editing of therapeutic genes; the use of riboswitches; the modification of mRNA cap regions; new approaches to detect appropriately modified RNAs with EPR spectroscopy and the use of parallel and high-throughput techniques for the analysis of the structure and new functions of nucleic acids. This volume discusses how chemistry can add new frontiers to the field of nucleic acids in molecular medicine, biotechnology and nanotechnology and is not only an invaluable source of information to chemists, biochemists and life scientists but will also stimulate future research.

Chemistry and Biology of Artificial Nucleic Acids

Author : Martin Egli
Publisher : Wiley-VCH
ISBN 13 : 9783906390673
Total Pages : 0 pages
Book Rating : 4.3/5 (96 download)

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Book Synopsis Chemistry and Biology of Artificial Nucleic Acids by : Martin Egli

Download or read book Chemistry and Biology of Artificial Nucleic Acids written by Martin Egli and published by Wiley-VCH. This book was released on 2012-04-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to provide a comprehensive overview of the field of artificial nucleic acids. Covering a tremendous amount of literature on the chemistry, biology, and structure of artificial nucleic acids, it will constitute an invaluable source of information for the specialist and for young researchers interested in starting a career in this fascinating field of research alike. This book combines the contributions of many of the major players in this research field, and covers the synthesis of sugar-, base- and backbone-modified nucleic acids, their structural characteristics studied by X-ray crystallography, and NMR in solution as well as their chemical and biological properties.

The Chemical Biology of Nucleic Acids

Author : Günter Mayer
Publisher : Wiley
ISBN 13 : 9780470519745
Total Pages : 478 pages
Book Rating : 4.5/5 (197 download)

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Book Synopsis The Chemical Biology of Nucleic Acids by : Günter Mayer

Download or read book The Chemical Biology of Nucleic Acids written by Günter Mayer and published by Wiley. This book was released on 2010-07-13 with total page 478 pages. Available in PDF, EPUB and Kindle. Book excerpt: With extensive coverage of synthesis techniques and applications, this text describes chemical biology techniques which have gained significant impetus during the last five years. It focuses on the methods for obtaining modified and native nucleic acids, and their biological applications. Topics covered include: chemical synthesis of modified RNA expansion of the genetic alphabet in nucleic acids by creating new base pairs chemical biology of DNA replication: probing DNA polymerase selectivity mechanisms with modified nucleotides nucleic-acid-templated chemistry chemical biology of peptide nucleic acids (PNA) the interactions of small molecules with DNA and RNA the architectural modules of folded RNAs genesis and biological applications of locked nucleic acid (LNA) small non-coding RNA in bacteria microRNA-guided gene silencing nucleic acids based therapies innate immune recognition of nucleic acid light-responsive nucleic acids for the spatiotemporal control of biological processes DNA methylation frameworks for programming RNA devices RNA as a catalyst: The Diels-Alderase-Ribozyme evolving an understanding of RNA function by in vitro approaches the chemical biology of aptamers: synthesis and applications nucleic acids as detection tools bacterial riboswitch discovery and analysis The Chemical Biology of Nucleic Acids is an essential compendium of the synthesis of nucleic acids and their biological applications for bioorganic chemists, chemical biologists, medicinal chemists, cell biologists, and molecular biologists.

Computational Tools for Chemical Biology

Author : Sonsoles Martín-Santamaría
Publisher : Royal Society of Chemistry
ISBN 13 : 1782627006
Total Pages : 392 pages
Book Rating : 4.7/5 (826 download)

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Book Synopsis Computational Tools for Chemical Biology by : Sonsoles Martín-Santamaría

Download or read book Computational Tools for Chemical Biology written by Sonsoles Martín-Santamaría and published by Royal Society of Chemistry. This book was released on 2017-11-01 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers a fresh perspective on how computational tools can aid the chemical biology research community and drive new research.

Nucleic Acids in Medicinal Chemistry and Chemical Biology

Author : Lihe Zhang
Publisher : John Wiley & Sons
ISBN 13 : 1119692741
Total Pages : 564 pages
Book Rating : 4.1/5 (196 download)

DOWNLOAD NOW!

Book Synopsis Nucleic Acids in Medicinal Chemistry and Chemical Biology by : Lihe Zhang

Download or read book Nucleic Acids in Medicinal Chemistry and Chemical Biology written by Lihe Zhang and published by John Wiley & Sons. This book was released on 2023-01-05 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nucleic Acids in Medicinal Chemistry and Chemical Biology An up-to-date and comprehensive exploration of nucleic acid medicinal chemistry and its applications In Nucleic Acids in Medicinal Chemistry and Chemical Biology: Drug Development and Clinical Applications, a team of distinguished researchers delivers a comprehensive overview of the chemistry and biology of nucleic acids and their therapeutic applications. The book emphasizes the latest research in the field, including new technologies like CRISPR that create novel possibilities to edit mutated genes at the genomic DNA level and to treat inherited diseases and cancers. The authors explore the application of modified nucleosides and nucleotides in medicinal chemistry, a variety of current topics on nucleic acid chemistry and biology, nucleic acid drugs used to treat disease, and more. They also probe new domains of pharmaceutical research, offering the reader a wealth of new drug discovery opportunities emerging in this dynamic field. Readers will also find: A thorough introduction to the basic terminology and knowledge of the field of nucleic acid medicinal chemistry Comprehensive explorations of the methods used to determine the development of nucleic acid drugs Practical discussions of new technologies, like CRISPR, nanotechnology-based delivery systems, synthetic biology, and DNA-encoded chemical libraries In-depth examinations of the latest, cutting-edge developments in nucleic acid medicinal chemistry Perfect for medicinal and nucleic acid chemists, Nucleic Acids in Medicinal Chemistry and Chemical Biology will also earn a place in the libraries of biochemists, chemical biologists, and pharmaceutical researchers.

Nucleic Acids in Chemistry and Biology

Author : G Michael Blackburn
Publisher : Royal Society of Chemistry
ISBN 13 : 1839163240
Total Pages : 774 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Nucleic Acids in Chemistry and Biology by : G Michael Blackburn

Download or read book Nucleic Acids in Chemistry and Biology written by G Michael Blackburn and published by Royal Society of Chemistry. This book was released on 2022-06-24 with total page 774 pages. Available in PDF, EPUB and Kindle. Book excerpt: The structure, function and reactions of nucleic acids are central to molecular biology and medicine and are crucial for understanding of the ever-expanding range of complex biological processes involved which are central to life. Revised, extended, updated and lavishly illustrated, this 4th Edition of Nucleic Acids in Chemistry and Biology is a long-awaited standard text for teaching and research in nucleic acids science. It maintains the close integration of chemistry and biology that characterised the earlier editions and contains a major expansion largely focused on the burgeoning growth of RNA science. Written by an international team of leading experts, all with extensive teaching experience, this 4th Edition provides up-to-date and extended coverage of the reactions and interactions of RNA and DNA with proteins and drugs. A brief history of the discovery of nucleic acids is followed by a molecule-based introduction to the structure and biological roles of DNA and RNA and the basics of Genes and Genomes. New key chapters are devoted to non-coding RNA, nucleic acids sequencing, nucleic acid therapeutics, in vitro evolution and aptamers, and protein-RNA interactions. The text is linked to an extensive list of references to make it a definitive reference source. This authoritative volume presents topics in an integrated manner and readable style with full colour illustrations throughout. It is ideal for graduate and undergraduate students of chemistry and biochemistry, biophysics and biotechnology, and molecular biology and medicine. It will be a guidebook for new researchers to the field of nucleic acids science.

Bioorganic Chemistry: Nucleic Acids

Author : Sidney M. Hecht
Publisher : OUP USA
ISBN 13 : 9780195084672
Total Pages : 516 pages
Book Rating : 4.0/5 (846 download)

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Book Synopsis Bioorganic Chemistry: Nucleic Acids by : Sidney M. Hecht

Download or read book Bioorganic Chemistry: Nucleic Acids written by Sidney M. Hecht and published by OUP USA. This book was released on 1996-07-11 with total page 516 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of DNA and RNA including coverage of biosynthesis, stucture, and their functions in information storage and transmission. A review of fundamental material is presented in the first half of each chapter followed by a fairly detailed research example selected by the chapter author from current research.

Nucleic Acids

Author : Victor A. Bloomfield
Publisher : Sterling Publishing Company
ISBN 13 : 9780935702491
Total Pages : 854 pages
Book Rating : 4.7/5 (24 download)

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Book Synopsis Nucleic Acids by : Victor A. Bloomfield

Download or read book Nucleic Acids written by Victor A. Bloomfield and published by Sterling Publishing Company. This book was released on 2000-04-17 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive account of the structures and physical chemistry properties of nucleic acids, with special emphasis on biological function, this text has been organized to meet the needs of those who have only a basic understanding of physical chemistry and molecular biology.

Advanced Organic Chemistry of Nucleic Acids

Author : Zoe A. Shabarova
Publisher : John Wiley & Sons
ISBN 13 : 352761592X
Total Pages : 603 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Advanced Organic Chemistry of Nucleic Acids by : Zoe A. Shabarova

Download or read book Advanced Organic Chemistry of Nucleic Acids written by Zoe A. Shabarova and published by John Wiley & Sons. This book was released on 2008-07-11 with total page 603 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sequencing, cloning, transcription - these are but a few key techniques behind the current breathtaking advances in molecular biology and biochemistry. As these methods continuosly diversify, biochemists need a sound chemical understanding to keep the pace. Chemists beginning working in the molecular biology lab need an introduction to this field from their point of view. This book serves both: it describes most of the known chemical reactions of nucleosides, nucleotides, and nucleic acids in sufficient detail to provide the desired background, and additionally, the fundamental relations between sequence, structure and functionality of nucleic acids are presented. The first edition of this book, which was published in Russian, has immediately become a recognized standard reference. This second, thoroughly revised and updated edition, now published in English, is likely to achieve a similar position in the international scientific community.

New Frontiers in Chemical Biology

Author : Mark E. Bunnage
Publisher : Royal Society of Chemistry
ISBN 13 : 184973125X
Total Pages : 329 pages
Book Rating : 4.8/5 (497 download)

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Book Synopsis New Frontiers in Chemical Biology by : Mark E. Bunnage

Download or read book New Frontiers in Chemical Biology written by Mark E. Bunnage and published by Royal Society of Chemistry. This book was released on 2011 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the new frontiers in chemical biology and describes their impact and future potential in drug discovery.

Chemistry and Biology of Non-canonical Nucleic Acids

Author : Naoki Sugimoto
Publisher : John Wiley & Sons
ISBN 13 : 3527345213
Total Pages : 288 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Chemistry and Biology of Non-canonical Nucleic Acids by : Naoki Sugimoto

Download or read book Chemistry and Biology of Non-canonical Nucleic Acids written by Naoki Sugimoto and published by John Wiley & Sons. This book was released on 2021-06-01 with total page 288 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover the fundamentals and intricacies of a subject at the interface of chemistry and biology with this authoritative resource Chemistry and Biology of Non-canonical Nucleic Acids delivers a comprehensive treatment of the chemistry and biology of non-canonical nucleic acids, including their history, structures, stabilities, properties, and functions. You'll learn about the role of these vital compounds in transcription, translation, regulation, telomeres, helicases, cancers, neurodegenerative diseases, therapeutic applications, nanotechnology, and more. An ideal resource for graduate students, researchers in physical, organic, analytical, and inorganic chemistry will learn about uncommon nucleic acids, become the common non-canonical nucleic acids that fascinate and engage academics and professionals in private industry. Split into 15 chapters covering a wide range of aspects of non-canonical nucleic acids, the book explains why these compounds exist at the forefront of a new research revolution at the intersection of chemistry and biology. Chemistry and Biology of Non-canonical Nucleic Acids also covers a broad range of topics critical to understanding these versatile and omnipresent chemicals, including: * A discussion of the dynamic regulation of biosystems by nucleic acids with non-canonical structures * The role played by nucleic acid structures in neurodegenerative diseases and various cancers * An exploration of the future outlook for the chemistry and biology of non-canonical nucleic acids * An introduction to the history of canonical and non-canonical structures of nucleic acids * An analysis of the physicochemical properties of non-canonical nucleic acids Perfect for biochemists, materials scientists, and bioengineers, Chemistry and Biology of Non-canonical Nucleic Acids will also earn a place in the libraries of medicinal and pharmaceutical chemists who wish to improve their understanding of life processes and the role that non-canonical nucleic acids play in them.

Modified Nucleic Acids

Author : Kazuhiko Nakatani
Publisher : Springer
ISBN 13 : 3319271113
Total Pages : 276 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Modified Nucleic Acids by : Kazuhiko Nakatani

Download or read book Modified Nucleic Acids written by Kazuhiko Nakatani and published by Springer. This book was released on 2016-04-04 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book spans diverse aspects of modified nucleic acids, from chemical synthesis and spectroscopy to in vivo applications, and highlights studies on chemical modifications of the backbone and nucleobases. Topics discussed include fluorescent pyrimidine and purine analogs, enzymatic approaches to the preparation of modified nucleic acids, emission and electron paramagnetic resonance (EPR) spectroscopy for studying nucleic acid structure and dynamics, non-covalent binding of low- and high-MW ligands to nucleic acids and the design of unnatural base pairs. This unique book addresses new developments and is designed for graduate level and professional research purposes.

Handbook of Chemical Biology of Nucleic Acids

Author : Naoki Sugimoto
Publisher : Springer Nature
ISBN 13 : 9811997764
Total Pages : 2847 pages
Book Rating : 4.8/5 (119 download)

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Book Synopsis Handbook of Chemical Biology of Nucleic Acids by : Naoki Sugimoto

Download or read book Handbook of Chemical Biology of Nucleic Acids written by Naoki Sugimoto and published by Springer Nature. This book was released on 2023-07-29 with total page 2847 pages. Available in PDF, EPUB and Kindle. Book excerpt: This handbook is the first to comprehensively cover nucleic acids from fundamentals to recent advances and applications. It is divided into 10 sections where authors present not only basic knowledge but also recent research. Each section consists of extensive review chapters covering the chemistry, biology, and biophysics of nucleic acids as well as their applications in molecular medicine, biotechnology and nanotechnology. All sections within this book are: Physical Chemistry of Nucleic Acids (Section Editor: Prof. Roland Winter), Structural Chemistry of Nucleic Acids (Section Editor: Prof. Janez Plavec), Organic Chemistry of Nucleic Acids (Section Editor: Prof. Piet Herdewijin), Ligand Chemistry of Nucleic Acids (Section Editor: Prof. Marie-Paule Teulade-Fichou), Nucleic Acids and Gene Expression (Section Editor: Prof. Cynthia Burrows), Analytical Methods and Applications of Nucleic Acids (Section Editor: Prof. Chaoyong Yang), Nanotechnology and Nanomaterial Biology of Nucleic Acids (Section Editor: Prof. Zhen Xi), Nucleic Acids Therapeutics (Section Editor: Prof. Katherine Seley-Radtke), Biotechnology and Synthetic Biology of Nucleic Acids (Section Editor: Prof. Eriks Rozners), Functional Nucleic Acids (Section Editor: Prof. Keith R. Fox). The handbook is edited by outstanding leaders with contributions written by international renowned experts. It is a valuable resource not only for researchers but also graduate students working in areas related to nucleic acids who would like to learn more about their important role and potential applications.