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The Biology Of The Mycobacteria
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Book Synopsis Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions by : Seyed Ehtesham Hasnain
Download or read book Mycobacterium Tuberculosis: Molecular Infection Biology, Pathogenesis, Diagnostics and New Interventions written by Seyed Ehtesham Hasnain and published by Springer. This book was released on 2019-12-11 with total page 514 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews recent advances in the molecular and infection biology, pathology, and molecular epidemiology of Mycobacterium tuberculosis, as well as the identification and validation of novel molecular drug targets for the treatment of this mycobacterial disease. Despite being completely curable, tuberculosis is still one of the leading global causes of death. M. tuberculosis, the causative organism – one of the smartest pathogens known – adopts highly intelligent strategies for survival and pathogenesis. Presenting a wealth of information on the molecular infection biology of M. tuberculosis, as well as nontuberculous mycobacteria (NTM), the book provides an overview of the functional role of the PE/PPE group of proteins, which is exclusive to the genus Mycobacteria, of host-pathogen interactions, and virulence. It also explores the pathogenesis of the infection, pathology, epidemiology, and diagnosis of NTM. Finally it discusses current and novel approaches in vaccine development against tuberculosis, including the role of nanotechnology. With state-of-the-art contributions from experts in the respective domains, this book is an informative resource for practitioners as well as medical postgraduate students and researchers.
Download or read book Tuberculosis written by Barry R. Bloom and published by . This book was released on 1994 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: The authors discuss fundamental questions about the biology, genetics, mechanisms of pathogenicity, mechanisms of resistance, and drug development strategies that are likely to provide important new knowledge about TB and new interventions to prevent and treat this disease.
Book Synopsis Mycobacterium Tuberculosis Protocols by : Tanya Parish
Download or read book Mycobacterium Tuberculosis Protocols written by Tanya Parish and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide detailed protocols for studying the molecular biology of the pathogen Mycobacterium tuberculosis, and its int- actions with host cells. As established mycobacterial laboratories move - wards exploiting the genome, and laboratories with expertise in other fields apply them to mycobacteria, both traditional and novel methodologies need to be reviewed. Thus the chapters in Mycobacterium tuberculosis Protocols range from perspectives on storage of strains and safety issues to the application of the latest functional genomics technologies. The last few years have been remarkable ones for research into M. tuber- losis. The most important landmark by far has been the completion of the genome sequence of the widely studied H37Rv strain (1). We can now predict every protein and RNA molecule made by the pathogen. This information is or will soon be enriched by the addition of genome sequences of other strains from the M. tuberculosis complex: a second strain of M. tuberculosis, My- bacterium bovis, and the vaccine strain, M. bovis BCG. Valuable comparative data will also be provided by the genome sequences of Mycobacterium leprae, Mycobacterium avium, and Streptomyces coelicolor. Another recent milestone for M. tuberculosis has been the development of efficient mutagenesis me- odologies, the lack of which has been a major handicap in functional studies.
Book Synopsis The Mycobacterial Cell Envelope by : Mamadou Daffé
Download or read book The Mycobacterial Cell Envelope written by Mamadou Daffé and published by . This book was released on 2008 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Explains the unique characteristics that cause this large group of bacteria responsible for tuberculosis and leprosy to function differently; serves as a valuable reference for those working in the areas of biochemistry, genetics, genomics, and immunology.
Book Synopsis The Travel and Tropical Medicine Manual E-Book by : Christopher A. Sanford
Download or read book The Travel and Tropical Medicine Manual E-Book written by Christopher A. Sanford and published by Elsevier Health Sciences. This book was released on 2016-08-07 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prevent, evaluate, and manage diseases that can be acquired in tropical environments and foreign countries with The Travel and Tropical Medicine Manual. This pragmatic resource equips medical providers with the knowledge they need to offer effective aid, covering key topics in pre- and post-travel medicine, caring for immigrants and refugees, and working in low-resource settings. It's also the perfect source for travelers seeking quick, easy access to the latest travel medicine information. - Dynamic images illustrate key concepts for an enhanced visual understanding. - Evidence-based treatment recommendations enable you to manage diseases confidently. - Expert Consult eBook version included with purchase. This enhanced eBook experience allows you to search all of the text, figures, images, and references from the book on a variety of devices. - Evidence-based appendix, available at Expert Consult, helps to validate treatments. - Highlights new evidence and content surrounding mental health and traveling. - Covers emerging hot topics such as Ebola virus disease, viral hemorrhagic fevers, the role of point-of-care testing in travel medicine, and antibiotic-resistant bacteria in returning travelers and students traveling abroad. - Includes an enhanced drug appendix in the back of the book.
Download or read book Mycobacterium written by Tanya Parish and published by Caister Academic Press Limited. This book was released on 2009 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this book, expert scientists critically review the current and most recent advances in the genomics and molecular biology of mycobacteria. With the focus being on the topical and most relevant aspects, the contributors provide insight into the current understanding of the subject and the future direction of research. Topics covered include strain variation and evolution, hypervirulent strains, electron transport and respiration, lipid biosynthesis, DNA repair, oxygen signaling, sulphur metabolism, protein secretion, the protein kinase family, and much more. This is a valuable reference text for all microbiology laboratories and is essential reading for all scientists and researchers involved with mycobacteria.
Book Synopsis Biological Sequence Analysis by : Richard Durbin
Download or read book Biological Sequence Analysis written by Richard Durbin and published by Cambridge University Press. This book was released on 1998-04-23 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: Probabilistic models are becoming increasingly important in analysing the huge amount of data being produced by large-scale DNA-sequencing efforts such as the Human Genome Project. For example, hidden Markov models are used for analysing biological sequences, linguistic-grammar-based probabilistic models for identifying RNA secondary structure, and probabilistic evolutionary models for inferring phylogenies of sequences from different organisms. This book gives a unified, up-to-date and self-contained account, with a Bayesian slant, of such methods, and more generally to probabilistic methods of sequence analysis. Written by an interdisciplinary team of authors, it aims to be accessible to molecular biologists, computer scientists, and mathematicians with no formal knowledge of the other fields, and at the same time present the state-of-the-art in this new and highly important field.
Book Synopsis Disease Control Priorities, Third Edition (Volume 6) by : King K. Holmes
Download or read book Disease Control Priorities, Third Edition (Volume 6) written by King K. Holmes and published by World Bank Publications. This book was released on 2017-11-06 with total page 1027 pages. Available in PDF, EPUB and Kindle. Book excerpt: Infectious diseases are the leading cause of death globally, particularly among children and young adults. The spread of new pathogens and the threat of antimicrobial resistance pose particular challenges in combating these diseases. Major Infectious Diseases identifies feasible, cost-effective packages of interventions and strategies across delivery platforms to prevent and treat HIV/AIDS, other sexually transmitted infections, tuberculosis, malaria, adult febrile illness, viral hepatitis, and neglected tropical diseases. The volume emphasizes the need to effectively address emerging antimicrobial resistance, strengthen health systems, and increase access to care. The attainable goals are to reduce incidence, develop innovative approaches, and optimize existing tools in resource-constrained settings.
Book Synopsis Pathology of the Lungs E-Book by : Bryan Corrin
Download or read book Pathology of the Lungs E-Book written by Bryan Corrin and published by Elsevier Health Sciences. This book was released on 2011-02-25 with total page 785 pages. Available in PDF, EPUB and Kindle. Book excerpt: With an emphasis on practical diagnostic problem solving, Pathology of the Lungs, 3rd Edition provides the pulmonary pathologist and the general surgical pathologist with an accessible, comprehensive guide to the recognition and interpretation of common and rare neoplastic and non-neoplastic lung conditions. The text is written by two authors and covers all topics in a consistent manner without the redundancies or lapses that are common in multi-authored texts. The text is lavishly illustrated with the highest quality illustrations which accurately depict the histologic, immunohistochemical and cytologic findings under consideration and it is supplemented throughout with practical tips and advice from two internationally respected experts. The user-friendly design and format allows rapid access to essential information and the incorporation throughout of relevant clinical and radiographic information makes it a complete diagnostic resource inside the reporting room. Approximately 1,000 high quality full color illustrations.Provides the user with a complete visual guide to each specimen and assists in the recognition and diagnosis of any slide looked at under the microscope. Comprehensive coverage of both common and rare lung diseases and disorders. One stop consultation resource for the reporting room or study, no need to go further to get questions answered. Clinical background and ancillary radiographs incorporated throughout.Provides the user with all of the necessary diagnostic tools to make a complete and accurate pathologic report. Practical advice and tips from two of the world’s recognized experts. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Consistent and uniform approach incorporated for each disease and disorder (Etiology, pathogenesis, clinical features, pathologic features, differential diagnosis) User-friendly format enables quick and easy navigation to the key information required. Extensive use of summary tables, charts and graphs throughout the text. Helps simplify and clarify complex concepts and facilitates “at a glance comparisons between entities. Extensive reference list highlights landmark articles as well as including most up-to-date citations. Directs the trainee and practitioner to the most recent and authoritative sources for further reading and investigation
Book Synopsis Biogenesis of Fatty Acids, Lipids and Membranes by : Otto Geiger
Download or read book Biogenesis of Fatty Acids, Lipids and Membranes written by Otto Geiger and published by Springer. This book was released on 2019-01-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Concise chapters, written by experts in the field, cover a wide spectrum of topics on lipid and membrane formation in microbes (Archaea, Bacteria, eukaryotic microbes).All cells are delimited by a lipid membrane, which provides a crucial boundary in any known form of life. Readers will discover significant chapters on microbial lipid-carrying biomolecules and lipid/membrane-associated structures and processes.
Book Synopsis Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control by : Sebastien Gagneux
Download or read book Strain Variation in the Mycobacterium tuberculosis Complex: Its Role in Biology, Epidemiology and Control written by Sebastien Gagneux and published by Springer. This book was released on 2018-08-31 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt: Until about 10 years ago, the general view in the field was that Mycobacterium tuberculosis, the causative agent of human tuberculosis was a “clone” with insufficient natural sequence variation between clinical strains to be considered biologically and epidemiologically “relevant”. This view has now changed quite dramatically thanks to the –omics revolution, particularly the advent of next generation DNA sequencing. Large-scale comparative genomic studies over the last few years have revealed that M. tuberculosis clinical strains are more genetically diverse than appreciated previously. Moreover, an increasing number of experimental and epidemiological studies are showing that this genetic diversity also translates into important phenotypic variation. Taken together, these findings have led to a paradigm shift, such that currently phylogenetic diversity among M. tuberculosis clinical strains is being considered in the development of new tools to combat tuberculosis. The purpose of this book is to bring together a series of contributions from some of the most influential groups working on various aspects of M. tuberculosis diversity, and which through their work have contributed to the this paradigm shift. This includes authors focusing on the evolution of M. tuberculosis in relation to other members of the M. tuberculosis complex adapted to animals, the co-evolution between M. tuberculosis and humans, the phenotypic consequences of strains diversity both from an experimental and epidemiological point of view, the ecology and evolution of drug resistant tuberculosis, the diversity and evolution of the BCG vaccine strains, and the use of mathematical modelling to study strain diversity and drug resistance in human tuberculosis. No such book has ever been published, and given the paradigm shift described above, this book will be a valuable resource both for established researchers as well as new scientists, clinicians and public health officials joining the growing field of tuberculosis research.
Book Synopsis Bacterial Cell Wall by : J.-M. Ghuysen
Download or read book Bacterial Cell Wall written by J.-M. Ghuysen and published by Elsevier. This book was released on 1994-02-09 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of the bacterial cell wall emerged as a new field of research in the early 1950s, and has flourished in a multitude of directions. This excellent book provides an integrated collection of contributions forming a fundamental reference for researchers and of general use to teachers, advanced students in the life sciences, and all scientists in bacterial cell wall research. Chapters include topics such as: Peptidoglycan, an essential constituent of bacterial endospores; Teichoic and teichuronic acids, lipoteichoic acids, lipoglycans, neural complex polysaccharides and several specialized proteins are frequently unique wall-associated components of Gram-positive bacteria; Bacterial cells evolving signal transduction pathways; Underlying mechanisms of bacterial resistance to antibiotics.
Book Synopsis The Bacterial Cell Wall by : Guntram Seltmann
Download or read book The Bacterial Cell Wall written by Guntram Seltmann and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bacterial cell wall represents a very complex structure disconnecting the interior of single-cell organisms from the environment, thus protecting, but also enabling, them to interact with the surrounding milieu and to exchange both substances and information. Knowledge of the biochemistry of the cell wall (components) and the genetic background helps to understand their significance with regard to microbiology and immunology of bacteria. This book represents the second edition of a publication which was presented nearly 20 years ago in the German language (Die bakterielle Zellwand). Since that time our knowledge in this field has been significantly enlarged. Therefore, the manuscript had to be completely revised and updated. To maintain both the size and the introductory character of the book at least to a great extent, the authors had to restrict the presented material to that which appears basic and most important. This requirement must inevitably bring about many subjective factors. As pointed out in the first edition, the term cell wall was not taken too strictly. Since the constituents located outside the cytoplasmic membrane are frequently difficult to divide in structure, localisation, and/or function into true cell wall components and supplementary substances, they are all at least briefly mentioned.
Book Synopsis Atlas of Mycobacterium Tuberculosis by : Ali Akbar Velayati
Download or read book Atlas of Mycobacterium Tuberculosis written by Ali Akbar Velayati and published by Academic Press. This book was released on 2016-09-30 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: Atlas of Mycobacterium Tuberculosis reveals in-depth information about mycobacterium tuberculosis which has never before been reported. Using atomic force microscopy (AFM), the in-depth phenotypic interaction that occurs in different stages of the tuberculosis lifecycle is illustrated, including resting, exponential, and dormant states. Coverage also includes the macroscopic and microscopic anatomy of mycobacterium, including pigmentation, morphology of colonies, size and shape, and the phenotypic changes from susceptible to resistant, all shown with images from electronic and atomic force microscopes. This book will open a new window into the results of molecular changes at the cellular level, guiding researchers and scientists to think in new ways about the area of cell wall and the reproductive and drug resistance phenomena surrounding tuberculosis. - Identifies the different stages and morphological aspects of mycobacterium tuberculosis with the use of new microscopy techniques - Includes never-before-seen photographs from the personal collection and scientific achievement of the authors - Outlines the nature of the lifecycle of mycobacterium tuberculosis in relation to adaptation in humans
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis by :
Download or read book Medicinal Chemistry Approaches to Tuberculosis and Trypanosomiasis written by and published by Academic Press. This book was released on 2019-09-07 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some of the more recent efforts in tuberculosis (TB) and trypanosomiasis drug discovery from both Product Development Partnerships (PDPs) and academia are highlighted in this this volume. Drug discovery approaches include both target- and phenotypic whole cell screening- approaches. Regarding the latter, mechanism of action studies through target identification are also illustrated.
Download or read book Buruli Ulcer written by Gerd Pluschke and published by Springer. This book was released on 2019-04-29 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: A major objective of this open access book is to summarize the current status of Buruli Ulcer (BU) research for the first time. It will identify gaps in our knowledge, stimulate research and support control of the disease by providing insight into approaches for surveillance, diagnosis, and treatment of Buruli Ulcer. Book chapters will cover the history, epidemiology diagnosis, treatment and disease burden of BU and provide insight into the microbiology, genomics, transmission and virulence of Mycobacterium ulcerans.
