The Biology Of Human Longevity

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The Biology of Human Longevity

Author : Caleb E. Finch
Publisher : Elsevier
ISBN 13 : 9780080545943
Total Pages : 640 pages
Book Rating : 4.5/5 (459 download)

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Book Synopsis The Biology of Human Longevity by : Caleb E. Finch

Download or read book The Biology of Human Longevity written by Caleb E. Finch and published by Elsevier. This book was released on 2010-07-28 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by Caleb Finch, one of the leading scientists of our time, The Biology of Human Longevity: Inflammation, Nutrition, and Aging in the Evolution of Lifespans synthesizes several decades of top research on the topic of human aging and longevity particularly on the recent theories of inflammation and its effects on human health. The book expands a number of existing major theories, including the Barker theory of fetal origins of adult disease to consider the role of inflammation and Harmon's free radical theory of aging to include inflammatory damage. Future increases in lifespan are challenged by the obesity epidemic and spreading global infections which may reverse the gains made in lowering inflammatory exposure. This timely and topical book will be of interest to anyone studying aging from any scientific angle. Author Caleb Finch is a highly influential and respected scientist, ranked in the top half of the 1% most cited scientists Provides a novel synthesis of existing ideas about the biology of longevity and aging Incorporates important research findings from several disciplines, including Gerontology, Genomics, Neuroscience, Immunology, Nutrition

The Quest for Human Longevity

Author : Lewis D. Solomon
Publisher : Routledge
ISBN 13 : 1351475592
Total Pages : 220 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis The Quest for Human Longevity by : Lewis D. Solomon

Download or read book The Quest for Human Longevity written by Lewis D. Solomon and published by Routledge. This book was released on 2017-12-02 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Many scientists today are working to retard the aging process in humans so as to increase both life expectancy and the quality of life. Over the past decade impressive results have been achieved in targeting the mechanisms and pathways of aging. In The Quest for Human Longevity, Lewis D. Solomon considers these scientific studies by exploring the principal biomedical anti-aging techniques. The book also considers cutting edge research on mental enhancements and assesses the scientific doubts of skeptics. The Quest for Human Longevity is also about business. Solomon examines eight corporations pursuing various age-related interventions, profiling their scientific founders and top executives, and examining personnel, intellectual property, and financing for each firm. Academic scientists form the link between research and commerce. Solomon notes that the involvement of university scientists and researchers follows one of two models. The first is a traditional model in which scientists leave academia to work for a corporation or remain in academia and obtain business support for their research. The second is a modern model in which scientists use their intellectual property as a catalyst for acquiring equity interests in the firms they organize. Critics have pointed to the dangers of commercialized science, but Solomon's analysis, on balance, finds that the benefits outweigh the costs and that problems of secrecy and conflicts of interest can be addressed. If scientists succeed in unlocking the secrets of aging and developing drugs or therapies that will allow us to live decades longer, the consequences for society will include profound social, political, economic, and ethical questions. Solomon deals with the public policy aspects of significant life extension and looks at the conflict between those who advocate the acceptance of mortality and the partisans of life. The Quest for Human Longevity will be of interest to policymakers, sociologists, scientists, and studen"

Human Longevity, Individual Life Duration, and the Growth of the Oldest-Old Population

Author : Jean-Marie Robine
Publisher : Springer Science & Business Media
ISBN 13 : 1402048483
Total Pages : 443 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Human Longevity, Individual Life Duration, and the Growth of the Oldest-Old Population by : Jean-Marie Robine

Download or read book Human Longevity, Individual Life Duration, and the Growth of the Oldest-Old Population written by Jean-Marie Robine and published by Springer Science & Business Media. This book was released on 2007-03-21 with total page 443 pages. Available in PDF, EPUB and Kindle. Book excerpt: Old-age survival has considerably improved in the second half of the twentieth century. Why has such a substantial extension of human lifespan occurred? How long can we live? In this book, these fundamental questions are explored by experts from diverse fields. They report on recent cutting-edge studies about essential issues of human longevity and social factors of long survival in old age.

Human Longevity

Author : Raymond C. Valentine
Publisher : CRC Press
ISBN 13 : 146659487X
Total Pages : 259 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Human Longevity by : Raymond C. Valentine

Download or read book Human Longevity written by Raymond C. Valentine and published by CRC Press. This book was released on 2014-09-18 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 7 billion people inhabit the earth and all of them are subject to aging. This book is aimed at persons interested in a molecular explanation of how our cells age. Human Longevity: Omega-3 Fatty Acids, Bioenergetics, Molecular Biology, and Evolution is built on the proposition that we age as our mitochondria age. It suggests a revised version of Harman’s famous hypothesis featuring mitochondrial oxidative and energy stresses as the root causes of aging. Human cells are protected from the ravages of aging by a battery of defensive systems including some novel mechanisms against membrane oxidation introduced in this book. This concept is consistent with recent discoveries showing that mitochondria-targeted antioxidants prevent Huntington’s disease, Parkinson’s disease, and traumatic brain disease in animal models of neurodegeneration. This book explores a unified theory of aging based on bioenergetics. It covers a variety of topics including an introduction to the science of human aging, the Darwinian selection of membranes enabling longevity, a revised mitochondrial membrane hypothesis of aging, and various mechanisms that protect human mitochondrial membranes, thereby enabling longevity.

Longevity

Author : James R. Carey
Publisher : Princeton University Press
ISBN 13 : 0691224080
Total Pages : 305 pages
Book Rating : 4.6/5 (912 download)

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Book Synopsis Longevity by : James R. Carey

Download or read book Longevity written by James R. Carey and published by Princeton University Press. This book was released on 2021-01-12 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite our deep interest in mortality, little is known about why some individuals live to middle age and others to extreme old age. Life span, mortality, and aging present some of the most profound mysteries in biology. In Longevity, James Carey draws on unprecedented data to develop a biological and demographic framework for identifying the key factors that govern aging, life span, and mortality in humans and other animals. Carey presents the results of a monumental, twelve-year, National Institute on Aging-funded research project on the determinants of longevity using data from the life tables of five million Mediterranean fruit flies, the most comprehensive set of life table studies ever on the mortality dynamics of a single species. He interprets the fruit fly data within the context of human aging and the aging process in general to identify the determinants of mortality. Three key themes emerge: the absence of species-specific life span limits, the context-specific nature of the mortality rate, and biodemographic linkages between longevity and reproduction. A powerful foundation for the emerging field of biodemography and a rich framework for considering the future of human life span, Longevity will be an indispensable resource for readers from a range of fields including population biology, demography, gerontology, ecology, evolutionary biology, and medical research.

Biology of Aging

Author : Robert Arking
Publisher : Oxford University Press
ISBN 13 : 9780199727629
Total Pages : 624 pages
Book Rating : 4.7/5 (276 download)

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Book Synopsis Biology of Aging by : Robert Arking

Download or read book Biology of Aging written by Robert Arking and published by Oxford University Press. This book was released on 2006-02-02 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Robert Arking's Biology of Aging, 3rd edition, is an introductory text to the biology of aging which gives advanced undergraduate and graduate students a thorough review of the entire field. His prior two editions have also served admirably as a reference text for clinicians and scientists. This new edition captures the extraordinary recent advances in our knowledge of the ultimate and proximal mechanisms underlying the phenomenon of aging. As a result, six important conceptual changes are included here: ? Clarified distinctions between the biological mechanisms involved in longevity determination and those involved in senescent processes. ? A new conceptual framework around which we can organize all the new facts about aging. This will assist readers to make sense of the information and use the data to form their own ideas. ? Increased knowledge of aging cells has lead to new ideas on how a cell transits from a healthy state to a senescent state, while still allowing for high levels of intra- and inter-specific variability. ? Discussion of senescent mechanisms assists the reader to understand that aging is a non-programmatic loss of function, likely arising from the loss of regulatory signals, and so is modifiable in the laboratory. ? Because the standard evolutionary story does not fully explain the evolution of social organisms, this edition also includes recent work dealing with intergenerational resource transfers. ? Lastly, if aging mechanisms are plastic, then the demand to move these anti-aging interventions into the human arena will inevitably grow. A discussion of the biological and ethical arguments on both sides of the question frames the question in an appropriate manner. The mass of data related to aging is summarized into fifteen focused chapters, each dealing with some particular aspect of the problem. The last two chapters integrate all this material into a coherent view of how the relevant biological processes change over the life span. This view is expressed in two non-technical figures (you might say that the whole book exists to fully support Figs 9-4 & 14-9), whose meanings are elucidated as the reader progresses through the book.

Handbook of the Biology of Aging

Author : Matt Kaeberlein
Publisher : Academic Press
ISBN 13 : 0124116205
Total Pages : 576 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Handbook of the Biology of Aging by : Matt Kaeberlein

Download or read book Handbook of the Biology of Aging written by Matt Kaeberlein and published by Academic Press. This book was released on 2015-08-20 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of the Biology of Aging, Eighth Edition, provides readers with an update on the rapid progress in the research of aging. It is a comprehensive synthesis and review of the latest and most important advances and themes in modern biogerontology, and focuses on the trend of ‘big data’ approaches in the biological sciences, presenting new strategies to analyze, interpret, and understand the enormous amounts of information being generated through DNA sequencing, transcriptomic, proteomic, and the metabolomics methodologies applied to aging related problems. The book includes discussions on longevity pathways and interventions that modulate aging, innovative new tools that facilitate systems-level approaches to aging research, the mTOR pathway and its importance in age-related phenotypes, new strategies to pharmacologically modulate the mTOR pathway to delay aging, the importance of sirtuins and the hypoxic response in aging, and how various pathways interact within the context of aging as a complex genetic trait, amongst others. Covers the key areas in biological gerontology research in one volume, with an 80% update from the previous edition Edited by Matt Kaeberlein and George Martin, highly respected voices and researchers within the biology of aging discipline Assists basic researchers in keeping abreast of research and clinical findings outside their subdiscipline Presents information that will help medical, behavioral, and social gerontologists in understanding what basic scientists and clinicians are discovering New chapters on genetics, evolutionary biology, bone aging, and epigenetic control Provides a close examination of the diverse research being conducted today in the study of the biology of aging, detailing recent breakthroughs and potential new directions

Aging and Human Longevity

Author : M.-F. Schulz-Aellen
Publisher : Springer Science & Business Media
ISBN 13 : 1461220068
Total Pages : 291 pages
Book Rating : 4.4/5 (612 download)

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Book Synopsis Aging and Human Longevity by : M.-F. Schulz-Aellen

Download or read book Aging and Human Longevity written by M.-F. Schulz-Aellen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.

Human Longevity

Author : David W. E. Smith
Publisher : Oxford University Press, USA
ISBN 13 :
Total Pages : 200 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Human Longevity by : David W. E. Smith

Download or read book Human Longevity written by David W. E. Smith and published by Oxford University Press, USA. This book was released on 1993 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: This absorbing, balanced account of human longevity draws together information from the fields of medicine, biology, demography, epidemiology, gerontology, and sociology. It describes the history and present status of human longevity and deals in logical sequence with the questions this subject raises. The book illustrates how life expectancy has increased in most countries due, in part, to changing causes of death. It examines the biological determinants of longevity and analyzes social and behavioral factors that may reduce longevity. The book covers the reasons why women live longer than men. It asks why the maximum human life span is nearly twice that of any other warm-blooded animal and much longer than required for reproductive success, and it discusses factors that were involved in the evolution of longevity. It presents predictable increases in human life expectancy and explores the possibility that the maximum human life expectancy may become even longer. Accessible, comprehensive, and original, this book provides a multidisciplinary synthesis of ideas and conclusions about human longevity. It will have wide appeal to professionals in the many areas concerned with longevity as well as lay readers.

The Long and the Short of It

Author : Jonathan Silvertown
Publisher : University of Chicago Press
ISBN 13 : 022607210X
Total Pages : 203 pages
Book Rating : 4.2/5 (26 download)

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Book Synopsis The Long and the Short of It by : Jonathan Silvertown

Download or read book The Long and the Short of It written by Jonathan Silvertown and published by University of Chicago Press. This book was released on 2013-11-01 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: “[A] whimsical book on aging . . . the author mixes art, science, and humor to brew a highly readable concoction, presenting one aging theory after another.” —Publishers Weekly Everything that lives will die. That’s the fundamental fact of life. But not everyone dies at the same age: people vary wildly in their patterns of aging and their life spans—and that variation is nothing compared to what’s found in other animal and plant species. With The Long and the Short of It, biologist and writer Jonathan Silvertown offers readers a witty and fascinating tour through the scientific study of longevity and aging. Dividing his daunting subject by theme—death, life span, aging, heredity, evolution, and more—Silvertown draws on the latest scientific developments to paint a picture of what we know about how life span, senescence, and death vary within and across species. At every turn, he addresses fascinating questions that have far-reaching implications: What causes aging, and what determines the length of an individual life? What changes have caused the average human life span to increase so dramatically—fifteen minutes per hour—in the past two centuries? If evolution favors those who leave the most descendants, why haven’t we evolved to be immortal? The answers to these puzzles and more emerge from close examination of the whole natural history of life span and aging, from fruit flies, nematodes, redwoods, and much more. The Long and the Short of It pairs a perpetually fascinating topic with a wholly engaging writer, and the result is a supremely accessible book that will reward curious readers of all ages. “Captivating and enlightening.” —The New York Times Well Blog

Aging and Human Longevity

Author : Marie-Francoise Schulz-Aellen
Publisher : Birkhäuser
ISBN 13 : 9781461224488
Total Pages : 0 pages
Book Rating : 4.2/5 (244 download)

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Book Synopsis Aging and Human Longevity by : Marie-Francoise Schulz-Aellen

Download or read book Aging and Human Longevity written by Marie-Francoise Schulz-Aellen and published by Birkhäuser. This book was released on 1997 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The proportion of elderly people continues to increase in the western world-nearly a quarter of the population will be over 65 years by the year 2050. Since aging is accompanied by an increase in diseases and by a deterioration in well-being, finding solutions to these social, medical and psychological problems is necessarily a major goal for society. Scientists and medical practitioners are therefore faced with the urgent task of increasing basic knowledge of the biological processes that cause aging. More resources must be put into this research in order to achieve better understanding of the cellular mechanisms that underlie the differences in life span between species and to answer the difficult questions of why some individuals age more quickly than others, and why some develop liver problems, some have heart problems, and others brain problems. The results of such a wide program of research will provide important information about the causes of many life-threatening and/ or debilitating diseases of old age; it will help find ways to prevent some of the ailments that result from aging, and it may well lead to discoveries enabling the prolongation of human life.

Aging and Human Longevity

Author : Marie-Françoise Schulz-Aellen
Publisher : Birkhauser
ISBN 13 : 9783764339647
Total Pages : 283 pages
Book Rating : 4.3/5 (396 download)

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Book Synopsis Aging and Human Longevity by : Marie-Françoise Schulz-Aellen

Download or read book Aging and Human Longevity written by Marie-Françoise Schulz-Aellen and published by Birkhauser. This book was released on 1997-01-01 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book combines a scientific and medical description of aging with a critical review of ways to prolong life. The first part gives an overview of the complex biological mechanisms of aging and of the consequences of tissue and system aging in humans. The role of genetic and environmental factors that influence the rate of aging in several species is discussed. The second part of this book evaluates the various means, including life styles, behavioral variables, medical interventions and vitamin supplementation, that may slow down the physiological and psychological effects of aging. Biotechnology and gene therapy are also becoming a part of medical interventions to prolong life. This book is aimed at readers with some knowledge of biology and medicine, as well as to a larger audience eager to know more about how to live a healthy, happy and productive life in their old age.

Lifespan

Author : David A. Sinclair
Publisher : Atria Books
ISBN 13 : 1501191977
Total Pages : 432 pages
Book Rating : 4.5/5 (11 download)

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Book Synopsis Lifespan by : David A. Sinclair

Download or read book Lifespan written by David A. Sinclair and published by Atria Books. This book was released on 2019-09-10 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NEW YORK TIMES BESTSELLER “Brilliant and enthralling.” —The Wall Street Journal A paradigm-shifting book from an acclaimed Harvard Medical School scientist and one of Time’s most influential people. It’s a seemingly undeniable truth that aging is inevitable. But what if everything we’ve been taught to believe about aging is wrong? What if we could choose our lifespan? In this groundbreaking book, Dr. David Sinclair, leading world authority on genetics and longevity, reveals a bold new theory for why we age. As he writes: “Aging is a disease, and that disease is treatable.” This eye-opening and provocative work takes us to the frontlines of research that is pushing the boundaries on our perceived scientific limitations, revealing incredible breakthroughs—many from Dr. David Sinclair’s own lab at Harvard—that demonstrate how we can slow down, or even reverse, aging. The key is activating newly discovered vitality genes, the descendants of an ancient genetic survival circuit that is both the cause of aging and the key to reversing it. Recent experiments in genetic reprogramming suggest that in the near future we may not just be able to feel younger, but actually become younger. Through a page-turning narrative, Dr. Sinclair invites you into the process of scientific discovery and reveals the emerging technologies and simple lifestyle changes—such as intermittent fasting, cold exposure, exercising with the right intensity, and eating less meat—that have been shown to help us live younger and healthier for longer. At once a roadmap for taking charge of our own health destiny and a bold new vision for the future of humankind, Lifespan will forever change the way we think about why we age and what we can do about it.

Age Later

Author : Nir Barzilai, M.D.
Publisher : St. Martin's Press
ISBN 13 : 1250230861
Total Pages : 320 pages
Book Rating : 4.2/5 (52 download)

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Book Synopsis Age Later by : Nir Barzilai, M.D.

Download or read book Age Later written by Nir Barzilai, M.D. and published by St. Martin's Press. This book was released on 2020-06-16 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: How do some people avoid the slowing down, deteriorating, and weakening that plagues many of their peers decades earlier? Are they just lucky? Or do they know something the rest of us don’t? Is it possible to grow older without getting sicker? What if you could look and feel fifty through your eighties and nineties? Founder of the Institute for Aging Research at the Albert Einstein College of Medicine and one of the leading pioneers of longevity research, Dr. Nir Barzilai’s life’s work is tackling the challenges of aging to delay and prevent the onset of all age-related diseases including “the big four”: diabetes, cancer, heart disease, and Alzheimer’s. One of Dr. Barzilai’s most fascinating studies features volunteers that include 750 SuperAgers—individuals who maintain active lives well into their nineties and even beyond—and, more importantly, who reached that ripe old age never having experienced cardiovascular disease, cancer, diabetes, or cognitive decline. In Age Later, Dr. Barzilai reveals the secrets his team has unlocked about SuperAgers and the scientific discoveries that show we can mimic some of their natural resistance to the aging process. This eye-opening and inspirational book will help you think of aging not as a certainty, but as a phenomenon—like many other diseases and misfortunes—that can be targeted, improved, and even cured.

Biology of Aging

Author : Roger B. McDonald
Publisher : Garland Science
ISBN 13 : 0429638191
Total Pages : 828 pages
Book Rating : 4.4/5 (296 download)

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Book Synopsis Biology of Aging by : Roger B. McDonald

Download or read book Biology of Aging written by Roger B. McDonald and published by Garland Science. This book was released on 2019-06-07 with total page 828 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology of Aging, Second Edition presents the biological principles that have led to a new understanding of the causes of aging and describes how these basic principles help one to understand the human experience of biological aging, longevity, and age-related disease. Intended for undergraduate biology students, it describes how the rate of biological aging is measured; explores the mechanisms underlying cellular aging; discusses the genetic pathways that affect longevity in various organisms; outlines the normal age-related changes and the functional decline that occurs in physiological systems over the lifespan; and considers the implications of modulating the rate of aging and longevity. The book also includes end-of-chapter discussion questions to help students assess their knowledge of the material. Roger McDonald received his Ph.D. from the University of Southern California and is Professor Emeritus in the Department of Nutrition at the University of California, Davis. Dr. McDonald’s research focused on mechanisms of cellular aging and the interaction between nutrition and aging. His research addressed two key topics in the field: the relationship between dietary restriction and lifespan, and the effect of aging on circadian rhythms and hypothalamic regulation. You can contact Dr. McDonald at [email protected]. Related Titles Ahmad, S. I., ed. Aging: Exploring a Complex Phenomenon (ISBN 978-1-1381-9697-1) Moody, H. R. & J. Sasser. Gerontology: The Basics (ISBN 978-1-1387-7582-4) Timiras, P. S. Physiological Basis of Aging and Geriatrics (ISBN 978-0-8493-7305-3)

The Longevity Seekers

Author : Ted Anton
Publisher : University of Chicago Press
ISBN 13 : 0226020932
Total Pages : 240 pages
Book Rating : 4.2/5 (26 download)

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Book Synopsis The Longevity Seekers by : Ted Anton

Download or read book The Longevity Seekers written by Ted Anton and published by University of Chicago Press. This book was released on 2013-05 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: People have searched for the fountain of youth everywhere from Bimini to St. Augustine. But for a steadfast group of scientists, the secret to a long life lies elsewhere: in the lowly lab worm. By suppressing the function of just a few key genes, these scientists were able to lengthen worms’ lifespans up to tenfold, while also controlling the onset of many of the physical problems that beset old age. As the global population ages, the potential impact of this discovery on society is vast—as is the potential for profit. With The Longevity Seekers, science writer Ted Anton takes readers inside this tale that began with worms and branched out to snare innovative minds from California to Crete, investments from big biotech, and endorsements from TV personalities like Oprah and Dr. Oz. Some of the research was remarkable, such as the discovery of an enzyme in humans that stops cells from aging. And some, like an oft-cited study touting the compound resveratrol, found in red wine—proved highly controversial, igniting a science war over truth, credit, and potential profit. As the pace of discovery accelerated, so too did powerful personal rivalries and public fascination, driven by the hope that a longer, healthier life was right around the corner. Anton has spent years interviewing and working with the scientists at the frontier of longevity science, and this book offers a behind-the-scenes look at the state-of-the-art research and the impact it might have on global public health, society, and even our friends and family. With spectacular science and an unforgettable cast of characters, The Longevity Seekers has all the elements of a great story and sheds light on discoveriesthat could fundamentally reshape human life.

Biology of Longevity and Aging

Author : Robert Arking
Publisher : Oxford University Press, USA
ISBN 13 : 0199387966
Total Pages : 721 pages
Book Rating : 4.1/5 (993 download)

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Book Synopsis Biology of Longevity and Aging by : Robert Arking

Download or read book Biology of Longevity and Aging written by Robert Arking and published by Oxford University Press, USA. This book was released on 2019 with total page 721 pages. Available in PDF, EPUB and Kindle. Book excerpt: Revised edition of: Biology of aging: observations and principles. 2006.