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The Biology And Prevention Of Aerodigestive Tract Cancers
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Book Synopsis The Biology and Prevention of Aerodigestive Tract Cancers by : Guy R. Newell
Download or read book The Biology and Prevention of Aerodigestive Tract Cancers written by Guy R. Newell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers contained in this volume were presented ati the Golden Jubilee Cancer Prevention Conference, "The Biology and Prevention of Aerodigestive Tract Cancers," sponsored by The University of Texas M. D. Anderson Cancer Center in Houston, Texas, February 21-23, 1991. The purpose of the conference was to further the understanding of the biology, epidemiology, and prevention of aerodigestive tract cancers. Advances in under standing the biology of aerodigestive tract cancers have led to successful early chemoprevention trials. Chemopreventive agents in current use are capable 9f reversing premalignant lesions, as well as reducing the number of second primary cancers of the head and neck. These trials hold the promise that effective prevention methods for these cancers will be forthcoming in the foreseeable future. Carcinogenic exposures appear to affect the entiry epithelial lining of the upper aerodigestive tract, a phenomena described as "field cancerization. " This process contributes to the development of both synchronous and metachronous aerodigestive tract cancers. It also provides a sound rationale for the chemoprevention of these cancers. Animal models are important for identifying the critical components of field cancerization and for testing potentially new chemopreventive agents and regimens. The hamster lung carcinogen esis model and the hamster cheek model are discussed. Aerodigestive tract cancers account for about 20% of newly diagnosed invasive cancers. Cigarette smoking and alcohol consumption are the most important risk factors for these cancers.
Book Synopsis How Tobacco Smoke Causes Disease by :
Download or read book How Tobacco Smoke Causes Disease written by and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 1990 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Clinical and Biological Basis of Lung Cancer Prevention by : Yves Martinet
Download or read book Clinical and Biological Basis of Lung Cancer Prevention written by Yves Martinet and published by Birkhäuser. This book was released on 2012-12-06 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung cancer is a disease with pandemic public health implications as it is now the leading cause of cancer mortality throughout the world. This book results from two recent International Association for the Study of Lung Cancer (IASLC) Workshops on lung cancer prevention. It strikes a balance between considering public health approaches to tobacco control and population-based screening, advances in clinical evaluation of chemoprevention approaches, and the biology of lung carcinogenesis. Indeed, while the science of smoking cessation is evolving as new pharmacological tools are moving into clinical evaluation, the current impact of molecular diagnostics is profound. The rapidly-evolving diagnostic technologies are revolutionizing basic scientific investigation of cancer, and this trend is expected to soon spill over into the clinical practice of medicine. The evolution of economical diagnostic platforms to allow for direct bronchial epithelial evaluation in high-risk populations promises to improve the diagnostic lead-time for this disease. The hope is that enough progress will occur to permit lung cancer detection in advance of clinical cancer so that the disease can be addressed early on, while it is still confined to the site of origin. Chemoprevention, which is designed to intervene in the early phase of carcinogenesis prior to any subjective clinical manifestation of a cancer, is also generating greater research interest. Moreover, the benefit of aerosolized administration of chemoprevention agents over conventional oral administration has strong appeal and may result in the reduction of the incidence of cancer when combined with new diagnostic technologies.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1993 with total page 1488 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Oral Cancer written by Peter Thomson and published by Cambridge Scholars Publishing. This book was released on 2018-12-12 with total page 291 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a concise, informed and practical manual detailing the cause, prevention and interventional treatment of oral cancer – the deadliest of oral diseases. In the 21st century, oral cancer remains a lethal and deforming disease exhibiting rising incidence of epidemic proportions, particularly in younger patients, and is of global significance with over 300,000 new cases presenting each year. Despite advances in diagnosis and management, half of all patients die within five years. Even following successful initial treatment, long-term prognosis is compromised by the presentation of advanced tumours and development of widespread, multi-focal disease throughout the mouth and upper aero-digestive tract. The transformation of normal mouth lining into ‘potentially malignant’ and subsequently malignant tissue is a complex, multistep and multifactorial process in which accumulated genetic alterations, often instigated by overuse of tobacco and alcohol, disrupt the normal functioning of oral epithelial cells. Unfortunately, there is considerable public ignorance regarding oral cancer, and it is imperative for disease prevention to raise awareness of the causes and symptoms of the disease, especially in those populations most ‘at-risk’ of cancer. This book provides pragmatic strategies to improve both prevention and treatment intervention. Spanning nearly 40 years of clinical investigation, it reviews the biological basis of oral cancer, outlines primary, secondary and tertiary preventive strategies and describe a pragmatic treatment intervention protocol that specifically utilizes the ‘potentially malignant window’ to identify malignant disease at the earliest possible stage and intervention to ‘stop the oral cancer clock’ and halt the progression of this deadliest of oral diseases.
Book Synopsis Chemoprevention of Cancer by : Daniel W. Nixon
Download or read book Chemoprevention of Cancer written by Daniel W. Nixon and published by CRC Press. This book was released on 1994-11-08 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemoprevention of Cancer guides you through the exciting new field of cancer chemoprevention. It covers epidemiology, known chemopreventive compounds, development of new chemopreventive agents, specific examples of preventive agents and their mechanisms of action, and current prevention clinical trials.
Book Synopsis Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications by : Maria A. Livrea
Download or read book Vitamin A and Retinoids: An Update of Biological Aspects and Clinical Applications written by Maria A. Livrea and published by Birkhäuser. This book was released on 2012-12-06 with total page 301 pages. Available in PDF, EPUB and Kindle. Book excerpt: Rapid progress has been made in our understanding of the molecular mechanisms of cell growth and oncogenesis during the past decade. Special attention has been given to the presentation of the frequently neglected close correlation between changes in signal transduction and metabolic pathways during oncogenesis. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on the clinical efficiency of retinoids in skin disorders and cancer. The book presents recent findings on the regulation of cell growth in normal and neoplastic tissues by growth factors including hormones, and by the activation and inactivation of oncogenes and tumor suppressor genes, respectively. It also offers a survey of the molecular and cell biochemistry of retinoids. Basic researchers in biochemistry, pharmacology and cell biology as well as clinicians will find this book very informative and up-to-date. This book advances the knowledge of mechanisms regulating metabolism and functioning of vitamin A and offers the most recent results of research on clinical efficiency of retinoids in skin disorders and cancer. Basic researchers in biochemistry, pharmacology, cell biology, and clinicians will find this book very informative and up-to-date. The chapters, organized in six sections, are contributed by leading scientists who have been working in the retinoid field for decades. Their experience and competence is aknowledged worldwide.
Book Synopsis Disease Prevention Research at NIH by : Ronald L. Gordner
Download or read book Disease Prevention Research at NIH written by Ronald L. Gordner and published by . This book was released on 1993 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antioxidants in Disease Mechanisms and Therapy by :
Download or read book Antioxidants in Disease Mechanisms and Therapy written by and published by Academic Press. This book was released on 1996-12-10 with total page 734 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antioxidants in Disease Mechanisms and Therapy presents molecular actions of natural and synthetic antioxidants and emphasizes the potential role in disease mechanisms and therapeutic strategies. The modulationof gene expression by the induction of antioxidant enzymes is a novel role beyond the direct antioxidant action. The volume explores the current state of knowledge on oxidants and antioxidants in disease processes, including arteriosclerosis, adult respiratory distress syndrome, cystic fibrosis, Down's syndrome, inflammation, cataract, age-related macular degeneration, afflications of the nervous system, AIDS, liver diseases, diabetes, skin diseases, and cancer. Contains cutting-edge information on focused topics written by expert scientists Provides the first in-depth treatment of novel compounds, such as melatonin and polyamines Attempts molecular pathophysiology which links basic science and the clinic Presents critical assessment of controversial topics
Book Synopsis Current Bibliographies in Medicine by :
Download or read book Current Bibliographies in Medicine written by and published by . This book was released on 1988 with total page 436 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Lung Cancer written by Barbara Driscoll and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work, Lung Cancer, Volume 2: Diagnostic and Therapeutic Methods and Reviews, in the Methods in Molecular Medicine series presents an overview of the current status of those methods useful in the diagnosis and tre- ment of lung cancer—both as it exists in the clinic and as it is being revoluti- ized in the laboratory. The book is intended to serve as a resource for researchers wishing to increase their knowledge of current and cutting edge technologies, in order that their investigations into neoplasms of the lung may benefit from this enriched diversity of techniques and approaches. Owing to the complex nature of the disease and the variety of methods available to analyze and attack it, no volume attempting to define diagnostic and therapeutic approaches to lung cancer can ever be complete. The sheer number of investigators involved in lung cancer research guarantees that some aspect will be inadvertently excluded. However, I hope that the range of techniques included herein will serve to open up new avenues of investigation for both the novice and experienced researcher.
Download or read book Smokeless Tobacco Or Health written by and published by . This book was released on 1992 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Current Catalog by : National Library of Medicine (U.S.)
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1992 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Lung Cancer written by Heine H. Hansen and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primary lung tumors are now a global health problem. The incidence has risen dramatically during the last 5--6 decades, reflecting the popularity of cigarette smoking. In this, the fifth volume dealing with lung cancer in the series KappaCANCER TREATMENT AND RESEARCHkappa, many current research topics are covered by notable authorities, including chemoprevention, growth factors, multidrug resistance, new agents, and haematopoietic growth factors. Altogether, the 17 chapters from twelve countries highlight some of the rapid developments taking place in basic and clinical research of lung cancer. These chapters not only give up-to-date information, they will also stimulate further research into this man-made disease which was almost unheard of a century ago.
Book Synopsis Smokeless Tobacco Or Health by : DIANE Publishing Company
Download or read book Smokeless Tobacco Or Health written by DIANE Publishing Company and published by DIANE Publishing. This book was released on 1995-08 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smokeless tobacco use is increasing throughout the U.S., especially among the most vulnerable of our citizens -- the children. With more than 30,000 new cases of oral cancer reported last year in the U.S. alone, it is time that use of smokeless tobacco take its rightful place next to cigarette smoking as a serious health risk that must be stopped. This report includes the following chapters: Clinical and Pathological Effects; Carcinogenesis; Nicotine Effects and Addiction; Prevention; Cessation: Recommendations for the Control of Smokeless Tobacco. Tables, photos and graphs.
Book Synopsis Journal of the National Cancer Institute by :
Download or read book Journal of the National Cancer Institute written by and published by . This book was released on 2001 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt:
