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Author : G. A. D. Haslewood
Publisher : North-Holland
ISBN 13 :
Total Pages : 232 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Biological Importance of Bile Salts written by G. A. D. Haslewood and published by North-Holland. This book was released on 1978 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : P. Nair
Publisher : Springer Science & Business Media
ISBN 13 : 146157563X
Total Pages : 238 pages
Book Rating : 4.4/5 (615 download)
Download or read book The Bile Acids: Chemistry, Physiology, and Metabolism written by P. Nair and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two volumes of this series addressed themselves to the chemistry, physiology, and metabolism of the bile acids. The present volume is devoted to the pathophysiology of bile acids. As the role of bile acids in health and disease is being increasingly recognized, we have chosen for discussion a wide range of topics of current importance. The presence of bile acids in brain tissue and their possible role in demyelinating diseases form the subject of a provocative discussion. As an extension of this theme, the presence and quantification of bile acids in extrahepatic tissues is the subject of one chapter. The pathophysiological implications of bile acids at the macromolecular level is highlighted by a chapter on the influence of bile salts on the activity of various enzymes. The general area of hepatobiliary diseases is discussed in two chapters: one describes changes in bile salt metabolism in liver diseases and the other focuses on cholesterol gallstones and their formation and dissolution. Cerebrotendinous xanthomatosis has been shown to entail a defect in bile acid and sterol metabolism, and this metabolic error is the subject of an illuminating exposition. There is presently a concerted research effort being brought to bear on the causes of colon cancer, and one important aspect of this work centers on bile acid metabolism. Aspects of bile acid metabolism and cancer are the subject of two chapters. And finally, the role of dietary fiber in bile acid metabolism is updated.
Author : Kozo Shinoda
Publisher : Elsevier
ISBN 13 : 1483263444
Total Pages : 321 pages
Book Rating : 4.4/5 (832 download)
Download or read book Colloidal Surfactants written by Kozo Shinoda and published by Elsevier. This book was released on 2013-10-22 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colloidal Surfactants: Some Physicochemical Properties focuses on the study of surface active agents. This book elaborates the importance of surface active agents in detergency, textile industry, and biological research. The four distinctive features of the substance—moderate maximum concentration of molecularly dispersed species; surface and interfacial depression in very dilute solution; micelle formation above a certain concentration; and solubilization of water-insoluble substances by micelles, are also described. Other topics include the effect of molecular type on the critical micelle concentration, critical micelle concentration, interaction of paraffin chain electrolytes with colloids, and monolayer studies of surface active agents. This publication is suitable for chemists and specialists researching on colloidal surfactants.
Author : Gareth J Jenkins
Publisher : Royal Society of Chemistry
ISBN 13 : 184755833X
Total Pages : 176 pages
Book Rating : 4.8/5 (475 download)
Download or read book Bile Acids written by Gareth J Jenkins and published by Royal Society of Chemistry. This book was released on 2008-07-29 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bile acids are increasingly being seen as extremely important carcinogenic agents in cancers of the bile duct, liver, colon, rectum, and oesophagus. They are essential agents involved in lipid digestion and absorption in mammals, however, they also play wide-ranging roles in a variety of disease states ranging from diabetes to cancer. They have evolved exquisite mechanisms for controlling their own synthesis and to ensure that they are produced at correct concentrations and also kept in the correct anatomical environment. It is only when these fine levels of controls are breached that Bile acids become associated with disease. This breaching of control mechanisms can occur through dietary means (e.g. in obesity) whereby excessive levels of Bile acids are produced and converted (via the bacterial flora) to damaging secondary Bile acids. Furthermore, lack of re-absorption of Bile acids can lead to liver pathologies. The atypical movement of Bile acids into the oesophagus, stimulated by episodes of reflux, is linked to oesophageal cancer. In recent years there have been tremendous advances in the understanding of the mechanisms behind the toxicity and bioactivity of different Bile acids and these are covered at length in this book. Prior to the publication of this book there was no single source of information on the toxicology and bioactivity properties of Bile acids. The book also uniquely collects all the relevant information together regarding the role of Bile acids in human disease and the mechanisms underlying Bile acid induced pathology. Additionally, as Bile acids are synthesised from cholesterol, there is wide recognition of the role for Bile acids in obesity linked diseases and this is also covered in this new publication. The book is edited by two experts in the field who have been involved in Bile acid research for several years and who are closely involved with major research groups in the UK, Europe and the US actively engaged in Bile acid research. The Editors have brought together world experts in their own fields to discuss the contribution of Bile acids to various disease pathologies, as well as discussing the mechanisms behind their activity. The book details the plethora of biological activities of this fascinating group of naturally occurring chemicals and provides a one-stop reference for scientists wishing to gain a fuller understanding of Bile acid activity and function.
Author : P. Nair
Publisher : Springer Science & Business Media
ISBN 13 : 1475706472
Total Pages : 381 pages
Book Rating : 4.4/5 (757 download)
Download or read book The Bile Acids Chemistry, Physiology, and Metabolism written by P. Nair and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bile acids as principal end products of cholesterol metabolism occupy a focal position in our understanding of the role of steroids in bio logical systems. The biogenesis of bile acids from cholesterol in higher ani mals, and their functions in regulating sterol metabolism and in gastrointestinal physiology have been elucidated by the development of elegant methodo logical approaches during the last two decades. The molecular pleomorphism exhibited by the bile acids and bile alcohols in the animal kingdom is a classic example of their role in biochemical evolution. The total story of the bile acids, their chemistry, their role in normal and abnormal physiological processes, and their significance in biochemical evolution has never been available in the form of a comprehensive treatise written in the words of those who have contributed to the development of our knowledge in this area. The Bile Acids, in two volumes, will serve to fill this void, and will also bring together information which will prove in valuable to both the biochemist and the medical scientist. We wish to thank Mrs. Sally Wiseman and Mrs. Lillian Haas for their invaluable assistance with the editing of the manuscripts. This work was supported in part by grants AM-02131, General Research Support SS0-1- FR-05479 (P.P.N.), HE-03299, HE-05209, and a National Heart Institute Research Career Award (D.K. ), K6-HE-734, from the National Institutes of Health, United States Public Health Service. P.P.N. Baltimore, Maryland D.K.
Author : G.P. van Berge Henegouwen
Publisher : Springer Science & Business Media
ISBN 13 : 9780792387688
Total Pages : 364 pages
Book Rating : 4.3/5 (876 download)
Download or read book Biology of Bile Acids in Health and Disease written by G.P. van Berge Henegouwen and published by Springer Science & Business Media. This book was released on 2001-05-31 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Beginning in 1970, the International Bile Acid Meeting has taken place every two years and each time new progress in our understanding of the complex role of bile acids in many metabolic processes of the liver and the intestine has been revealed by a selected group of leading scientists from all over the world. Although originally mainly physiological data on bile acid synthesis and transport were emphasized, and later on also the therapeutic benefit of bile acids in gallstone disease and cholestasis was discovered, we have come now to the molecular biology and genetic era with major discoveries in transport defects and related diseases. This book is the proceedings of Falk Symposium No. 120, held in The Hague, The Netherlands, on October 12-13, 2000 - the 16th International Bile Acid Meeting. One of the main discoveries recently has been the identification of nuclear receptors for bile acids, which gives them a much broader perspective than previously anticipated. It even suggests that bile acids can regulate their biosynthesis and enterohepatic circulation transcriptionally. It will therefore not be surprising that this topic, together with the molecular regulation of cholesterol 7alpha-hydroxylase and cholesterol homeostasis, has a dominant place in these proceedings. Another important topic is the progress in our molecular understanding of hepatic (both at the basolateral and canalicular sites), cholangiocytic and intestinal bile acid transport processes. Further insights into genetic defects causing cholestasis or intestinal malabsorption in animal models and in human diseases are also discussed by a number of well-known authors. Finally the last section deals with new findings on the role of bile acid therapy in cholestatic syndromes or chemoprevention and with the potential benefit of bile acid inhibitors. All contributors provide an update on the most recent developments in their field.
Author : P. Nair
Publisher : Springer Science & Business Media
ISBN 13 : 1468408984
Total Pages : 337 pages
Book Rating : 4.4/5 (684 download)
Download or read book The Bile Acids, Chemistry, Physiology, and Metabolism written by P. Nair and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Mechanisms of Bile Acid Biosynthesis.- I. Introduction.- II. Formation of Cholic Acid.- A. Changes in Steroid Nucleus.- B. Oxidation of Side Chain.- III. Formation of Chenodeoxycholic Acid.- IV. Formation of Other Primary Bile Acids.- V. Conjugation of Bile Acids.- VI. Regulation of Bile Acid Formation.- VII. Formation of Bile Salts in "Primitive" Animals.- A. Changes in Steroid Nucleus.- B. Oxidation of Side Chain.- References.- 2 Bile Salt Transport Systems.- I. Introduction.- II. Active Transport in the Intestine.- III. Passive Proximal Intestinal Absorption of Bile Salts.- IV. Passive Ab.
Author : G. Paumgartner
Publisher : Springer Science & Business Media
ISBN 13 : 9781402028939
Total Pages : 298 pages
Book Rating : 4.0/5 (289 download)
Download or read book Bile Acid Biology and its Therapeutic Implications written by G. Paumgartner and published by Springer Science & Business Media. This book was released on 2005-03-02 with total page 298 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the proceedings of the 18th International Bile Acid Meeting, held as the Falk Symposium 141 in Stockholm, Sweden, on June 18–19, 2004. The International Bile Acid Meetings have become some of the most important meetings in the bile acid field worldwide since Herbert Falk decided to sponsor these Symposia in biannual sequence in 1970. The 17 International Bile Acid Meetings in the past have been a great stimulus for new ideas and methods as well as the development of therapeutic applications of bile acids. They have always been a forum where basic scientists and clinicians interact. Many novel results of bile acid research were first presented at these meetings. The meeting in Stockholm again attracted a large number of basic and clinical scientists interested in bile acid and biliary research from all over the world. Knowledge about the regulation of bile acid synthesis, bile acid transport and enterohepatic circulation in health and in disease has increased considerably during recent years. Accordingly, bile acid research is alive as ever. A new chapter of bile acid research was opened by the finding that bile acids are ligands of nuclear receptors which regulate synthesis, metabolism and transport of bile acids and steroids. A large part of the book is devoted to these topics. The 18th International Bile Acid Meeting was again a truly interdisciplinary symposium at the highest scientific level. Its participants enjoyed hearing the latest reports on bile acid research in the city where so many seminal studies on bile acids were performed. It is hoped that the readers of this book will share the enjoyment.
Author : Frederick J. Suchy
Publisher : Cambridge University Press
ISBN 13 : 1108911374
Total Pages : 875 pages
Book Rating : 4.1/5 (89 download)
Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
Author :
Publisher : Elsevier
ISBN 13 : 0080468845
Total Pages : 6448 pages
Book Rating : 4.0/5 (84 download)
Download or read book Comprehensive Toxicology written by and published by Elsevier. This book was released on 2010-06-01 with total page 6448 pages. Available in PDF, EPUB and Kindle. Book excerpt: An explosive increase in the knowledge of the effects of chemical and physical agents on biological systems has led to an increased understanding of normal cellular functions and the consequences of their perturbations. The 14-volume Second Edition of Comprehensive Toxicology has been revised and updated to reflect new advances in toxicology research, including content by some of the leading researchers in the field. It remains the premier resource for toxicologists in academia, medicine, and corporations. Comprehensive Toxicology Second Edition provides a unique organ-systems structure that allows the user to explore the toxic effects of various substances on each human system, aiding in providing diagnoses and proving essential in situations where the toxic substance is unknown but its effects on a system are obvious. Comprehensive Toxicology Second Edition is the most complete and valuable toxicology work available to researchers today. Contents updated and revised to reflect developments in toxicology research Organized with a unique organ-system approach Features full color throughout Available electronically on sciencedirect.com, as well as in a limited-edition print version
Author : Julianne Zedalis
Publisher :
ISBN 13 : 9781947172401
Total Pages : 1923 pages
Book Rating : 4.1/5 (724 download)
Download or read book Biology for AP ® Courses written by Julianne Zedalis and published by . This book was released on 2017-10-16 with total page 1923 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biology for AP® courses covers the scope and sequence requirements of a typical two-semester Advanced Placement® biology course. The text provides comprehensive coverage of foundational research and core biology concepts through an evolutionary lens. Biology for AP® Courses was designed to meet and exceed the requirements of the College Board’s AP® Biology framework while allowing significant flexibility for instructors. Each section of the book includes an introduction based on the AP® curriculum and includes rich features that engage students in scientific practice and AP® test preparation; it also highlights careers and research opportunities in biological sciences.
Author : Irwin M. Arias
Publisher : John Wiley & Sons
ISBN 13 : 1119436826
Total Pages : 1156 pages
Book Rating : 4.1/5 (194 download)
Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Author : Ryan J. Huxtable
Publisher : Springer Science & Business Media
ISBN 13 : 1489904050
Total Pages : 397 pages
Book Rating : 4.4/5 (899 download)
Download or read book The Biology of Taurine written by Ryan J. Huxtable and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 397 pages. Available in PDF, EPUB and Kindle. Book excerpt: I was pleased and at the same time filled with some misgivings when Professors Alberto Giotti end Ryan Huxtable asked me to introduce this book. The book is the outcome of the Symposium held in Firenze-San Miniato (PI), October 6-9, 1986. The symposium was entitled "Sulfur Amino Acids, Peptides and Related Compounds" and was the 7th international symposium on taurine ßnd assooiated substances. It is always difficult to introduce, with the right brevity end emphasis, a topic which has been studied in depth by numerous experte. Nevertheless, I shall do my best to give a historical perspeotive of the subjects of the meeting which I consider to be very important for the frontiers of researoh on taurine. ~he following topios have also beoome coherent areas of study during the development of researoh on taurine: metabolism, nutrition, neurochemistry, cardiovasoular regulation. Although taurine was isolated in 1821 by ~iedman and Gmel1n, its only biochemioal role known at the time was the synthesis of bile saIte in mammalian tissue. There has been an inoreasing interest in the biologioal action of taurine from metabolio aspects to other biologioal aspects (nutrition, development, eto.). In 1975 it was first demonstrated that taurine deprivation produoed retinal degeneration in cats; more reoent studies showed that a taurine-free diet or the administration of taurine transport inhibitors caused retinal degeneration in other mammlas. More reoent studies have pointed out the role of taurine in development, and the first part of this book is dedicated to these topios
Author : Damjana Rozman
Publisher : Springer Nature
ISBN 13 : 3030396843
Total Pages : 174 pages
Book Rating : 4.0/5 (33 download)
Download or read book Mammalian Sterols written by Damjana Rozman and published by Springer Nature. This book was released on 2020-08-10 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive description of sterols and their novel biological roles in mammalian signaling, the book covers their biosynthesis and structure, describes sterol receptor -mediated actions, their tissue distribution and their role in disease. It offers insight into new research findings, focusing specifically on novel discoveries in bile acid and oxysterol signaling, including the lanosterol-to-cholesterol intermediates. Special attention is paid on the sex distribution of these sterols (male or female) and their sexually dimorphic roles in mammalian species, such as human, rat and mouse. Since sterols and drugs (xenobiotics) use many identical receptor-mediated signaling pathways, the book will be interesting for researchers working on the cross-road of endogenous and xenobiotic metabolism, it is intended for advanced students and scientists in molecular biology and biochemistry as well as for medical doctors in hepatology.
Author : Stefano Fiorucci
Publisher : Springer Nature
ISBN 13 : 3030220052
Total Pages : 378 pages
Book Rating : 4.0/5 (32 download)
Download or read book Bile Acids and Their Receptors written by Stefano Fiorucci and published by Springer Nature. This book was released on 2019-09-03 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.
Author : Leon Schiff
Publisher :
ISBN 13 :
Total Pages : 328 pages
Book Rating : 4.3/5 (91 download)
Download or read book Bile Salt Metabolism written by Leon Schiff and published by . This book was released on 1969 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Robert Weinberger
Publisher : Academic Press
ISBN 13 :
Total Pages : 488 pages
Book Rating : 4.3/5 (91 download)
Download or read book Practical Capillary Electrophoresis written by Robert Weinberger and published by Academic Press. This book was released on 2000-02-16 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: Capillary zone electrophoresis : basic concepts -- Capillary zone electrophoresis : methods development -- Capillary zone electrophoresis : secondary equilibrium, micelles, cyclodextrins, and related reagents -- Capillary isoelectric focusing -- Size separations in capillary gels and polymer networks -- Capillary electrochromatography -- Injection -- Detection -- Putting it all together.
