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The Bile Acids Physiology And Metabolism
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Book Synopsis The Bile Acids, Chemistry, Physiology, and Metabolism by : P. Nair
Download or read book The Bile Acids, Chemistry, Physiology, and Metabolism written by P. Nair and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: 1 Mechanisms of Bile Acid Biosynthesis.- I. Introduction.- II. Formation of Cholic Acid.- A. Changes in Steroid Nucleus.- B. Oxidation of Side Chain.- III. Formation of Chenodeoxycholic Acid.- IV. Formation of Other Primary Bile Acids.- V. Conjugation of Bile Acids.- VI. Regulation of Bile Acid Formation.- VII. Formation of Bile Salts in "Primitive" Animals.- A. Changes in Steroid Nucleus.- B. Oxidation of Side Chain.- References.- 2 Bile Salt Transport Systems.- I. Introduction.- II. Active Transport in the Intestine.- III. Passive Proximal Intestinal Absorption of Bile Salts.- IV. Passive Ab.
Book Synopsis The Bile Acids: Chemistry, Physiology, and Metabolism by : K.D.R. Setchell
Download or read book The Bile Acids: Chemistry, Physiology, and Metabolism written by K.D.R. Setchell and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 598 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over a decade has elapsed since the last volume in this series was published. At that time we considered that we had comprehensively covered all aspects relating to bile acid chemistry and physiology. However, major strides have been made in our understanding of the physiology and pathophysiology of bile acids, due largely to the great advances which have taken place in analytical technology. As a result, the need to document these advances was felt acutely, and therefore this volume is devoted to methodologies in bile acid analysis and their applications. This volume includes twelve chapters written by prominent scientists in the field of bile acid research. The initial chapter discusses techniques of extraction and isolation of bile acids from biological fluids. It is followed by descriptions of physical methods of analysis and discussions of the way these techniques have been applied in the field of bile acid research. Of practical value is the inclusion of a comprehensive list of spectra obtained for refer ences by nuclear magnetic resonance spectroscopy and mass spectrometry . These chapters are followed by reviews of biological methods of immuno assay and bioluminescence. Specific applications of these techniques are then addressed in contributions relating to bile acid analysis of tissue, serum, urine, and feces. With this integrated approach we have attempted to provide a volume which represents a comprehensive review of the analytical field of bile acids, while also serving as a useful reference book for those workers involved in bile acid analysis.
Download or read book The Bile Acids written by and published by . This book was released on 1973 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Bile Acids: Chemistry, Physiology, and Metabolism by : P. Nair
Download or read book The Bile Acids: Chemistry, Physiology, and Metabolism written by P. Nair and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two volumes of this series addressed themselves to the chemistry, physiology, and metabolism of the bile acids. The present volume is devoted to the pathophysiology of bile acids. As the role of bile acids in health and disease is being increasingly recognized, we have chosen for discussion a wide range of topics of current importance. The presence of bile acids in brain tissue and their possible role in demyelinating diseases form the subject of a provocative discussion. As an extension of this theme, the presence and quantification of bile acids in extrahepatic tissues is the subject of one chapter. The pathophysiological implications of bile acids at the macromolecular level is highlighted by a chapter on the influence of bile salts on the activity of various enzymes. The general area of hepatobiliary diseases is discussed in two chapters: one describes changes in bile salt metabolism in liver diseases and the other focuses on cholesterol gallstones and their formation and dissolution. Cerebrotendinous xanthomatosis has been shown to entail a defect in bile acid and sterol metabolism, and this metabolic error is the subject of an illuminating exposition. There is presently a concerted research effort being brought to bear on the causes of colon cancer, and one important aspect of this work centers on bile acid metabolism. Aspects of bile acid metabolism and cancer are the subject of two chapters. And finally, the role of dietary fiber in bile acid metabolism is updated.
Book Synopsis The Bile Acids Chemistry, Physiology, and Metabolism by : P. Nair
Download or read book The Bile Acids Chemistry, Physiology, and Metabolism written by P. Nair and published by Springer Science & Business Media. This book was released on 2013-12-11 with total page 381 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bile acids as principal end products of cholesterol metabolism occupy a focal position in our understanding of the role of steroids in bio logical systems. The biogenesis of bile acids from cholesterol in higher ani mals, and their functions in regulating sterol metabolism and in gastrointestinal physiology have been elucidated by the development of elegant methodo logical approaches during the last two decades. The molecular pleomorphism exhibited by the bile acids and bile alcohols in the animal kingdom is a classic example of their role in biochemical evolution. The total story of the bile acids, their chemistry, their role in normal and abnormal physiological processes, and their significance in biochemical evolution has never been available in the form of a comprehensive treatise written in the words of those who have contributed to the development of our knowledge in this area. The Bile Acids, in two volumes, will serve to fill this void, and will also bring together information which will prove in valuable to both the biochemist and the medical scientist. We wish to thank Mrs. Sally Wiseman and Mrs. Lillian Haas for their invaluable assistance with the editing of the manuscripts. This work was supported in part by grants AM-02131, General Research Support SS0-1- FR-05479 (P.P.N.), HE-03299, HE-05209, and a National Heart Institute Research Career Award (D.K. ), K6-HE-734, from the National Institutes of Health, United States Public Health Service. P.P.N. Baltimore, Maryland D.K.
Book Synopsis The Bile Acids: Physiology and metabolism by : David Kritchevsky
Download or read book The Bile Acids: Physiology and metabolism written by David Kritchevsky and published by . This book was released on 1971 with total page 354 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Bile Acids by : David Kritchevsky
Download or read book The Bile Acids written by David Kritchevsky and published by . This book was released on 1973 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Bile Acids by : David Kritchevsky
Download or read book The Bile Acids written by David Kritchevsky and published by . This book was released on 1971 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Bile Acids Chemistry, Physiology, and Metabolism by : P. Nair
Download or read book The Bile Acids Chemistry, Physiology, and Metabolism written by P. Nair and published by Springer. This book was released on 2013-12-17 with total page 372 pages. Available in PDF, EPUB and Kindle. Book excerpt: The bile acids as principal end products of cholesterol metabolism occupy a focal position in our understanding of the role of steroids in bio logical systems. The biogenesis of bile acids from cholesterol in higher ani mals, and their functions in regulating sterol metabolism and in gastrointestinal physiology have been elucidated by the development of elegant methodo logical approaches during the last two decades. The molecular pleomorphism exhibited by the bile acids and bile alcohols in the animal kingdom is a classic example of their role in biochemical evolution. The total story of the bile acids, their chemistry, their role in normal and abnormal physiological processes, and their significance in biochemical evolution has never been available in the form of a comprehensive treatise written in the words of those who have contributed to the development of our knowledge in this area. The Bile Acids, in two volumes, will serve to fill this void, and will also bring together information which will prove in valuable to both the biochemist and the medical scientist. We wish to thank Mrs. Sally Wiseman and Mrs. Lillian Haas for their invaluable assistance with the editing of the manuscripts. This work was supported in part by grants AM-02131, General Research Support SS0-1- FR-05479 (P.P.N.), HE-03299, HE-05209, and a National Heart Institute Research Career Award (D.K. ), K6-HE-734, from the National Institutes of Health, United States Public Health Service. P.P.N. Baltimore, Maryland D.K.
Book Synopsis The Bile Acids: Chemistry, Physiology, and Metabolism by : K.D.R. Setchell
Download or read book The Bile Acids: Chemistry, Physiology, and Metabolism written by K.D.R. Setchell and published by Springer. This book was released on 1988-06-30 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Over a decade has elapsed since the last volume in this series was published. At that time we considered that we had comprehensively covered all aspects relating to bile acid chemistry and physiology. However, major strides have been made in our understanding of the physiology and pathophysiology of bile acids, due largely to the great advances which have taken place in analytical technology. As a result, the need to document these advances was felt acutely, and therefore this volume is devoted to methodologies in bile acid analysis and their applications. This volume includes twelve chapters written by prominent scientists in the field of bile acid research. The initial chapter discusses techniques of extraction and isolation of bile acids from biological fluids. It is followed by descriptions of physical methods of analysis and discussions of the way these techniques have been applied in the field of bile acid research. Of practical value is the inclusion of a comprehensive list of spectra obtained for refer ences by nuclear magnetic resonance spectroscopy and mass spectrometry . These chapters are followed by reviews of biological methods of immuno assay and bioluminescence. Specific applications of these techniques are then addressed in contributions relating to bile acid analysis of tissue, serum, urine, and feces. With this integrated approach we have attempted to provide a volume which represents a comprehensive review of the analytical field of bile acids, while also serving as a useful reference book for those workers involved in bile acid analysis.
Book Synopsis The Bile Acids by : David Kritchevsky
Download or read book The Bile Acids written by David Kritchevsky and published by . This book was released on 1973 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Biliary System by : David Q.-H. Wang
Download or read book The Biliary System written by David Q.-H. Wang and published by Morgan & Claypool Publishers. This book was released on 2012 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The exponential expansion of knowledge in the field of hepatobiliary diseases makes systematic revisions of current concepts almost mandatory nowadays. This eBook summarizes the progress in understanding the molecular mechanism of cholesterol and bile acid metabolism and the physical-chemistry of biliary lipids, with emphasis on biliary lipid metabolism that is regulated by nuclear receptors in the hepatobiliary system. By guiding the readers through the various aspects of anatomy, physiology, and biochemistry of all "players" involved in bile formation, this eBook is intended to be a compendium of recent progresses in understanding the molecular mechanisms of cholesterol and bile acid metabolism. Table of Contents: Introduction / Anatomy of the Liver, Biliary Tract, and Gallbladder / Physical Chemistry of Bile / Hepatic Cholesterol Metabolism / Physical Chemistry and Hepatic Metabolism of Bile Acids / The Enterohepatic Circulation of Bile Acids / Hepatic Secretion of Biliary Lipids and Bile Formation / Summary / Acknowledgments / References / Author Biographies
Book Synopsis Bile Acids and Their Receptors by : Stefano Fiorucci
Download or read book Bile Acids and Their Receptors written by Stefano Fiorucci and published by Springer Nature. This book was released on 2019-09-03 with total page 378 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focusses on the latest results related to the field of bile acids as signaling molecules and describes how these receptors have become a major pharmacological target. It covers all major areas of research in this field, from genetics, chemistry, in silico modeling, molecular biology to clinical applications, offering a cross-country view of the functional role of bile acids as signaling molecules, virtually acting on all major areas of metabolism. While FXR and GPBAR1 are essential bile acid sensors that integrate the de novo bile acid synthesis with intestinal microbiota and liver metabolism, in a broader sense, BARs play a pathogenic role in the development of common human alignments including liver, intestinal and metabolic disorders, such as steatosis (NAFLD) and steato-hepatitis (NASH), diabetes, obesity and atherosclerosis.
Book Synopsis Liver Disease in Children by : Frederick J. Suchy
Download or read book Liver Disease in Children written by Frederick J. Suchy and published by Cambridge University Press. This book was released on 2021-03-18 with total page 875 pages. Available in PDF, EPUB and Kindle. Book excerpt: Liver disease in children is increasing in prevalence, placing a huge burden on healthcare systems and often requiring long-term management. Offering an integrative approach to the science and clinical practice of pediatric hepatology, this is the definitive reference text for improved diagnosis and treatment strategies. In the new edition of this authoritative text, chapters have been thoroughly revised in line with major advances in the field, such as recognizing the increased frequency of fatty liver disease, and how genetic testing has the potential to establish earlier diagnoses for a variety of diseases. Disorders covered include cholestasis, metabolic disorders and hepatitis, with their presentation across the spectrum of infancy, childhood and adolescence discussed. The indications and surgical aspects of liver transplant are explained and post-transplant care is described in detail. This is a valuable resource for pediatricians, hepatologists, gastroenterologists and all clinicians involved in the care of children with liver diseases.
Download or read book The Liver written by Irwin M. Arias and published by John Wiley & Sons. This book was released on 2020-03-09 with total page 1156 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bridging the gap between basic scientific advances and the understanding of liver disease — the extensively revised new edition of the premier text in the field. The latest edition of The Liver: Biology and Pathobiology remains a definitive volume in the field of hepatology, relating advances in biomedical sciences and engineering to understanding of liver structure, function, and disease pathology and treatment. Contributions from leading researchers examine the cell biology of the liver, the pathobiology of liver disease, the liver’s growth, regeneration, metabolic functions, and more. Now in its sixth edition, this classic text has been exhaustively revised to reflect new discoveries in biology and their influence on diagnosing, managing, and preventing liver disease. Seventy new chapters — including substantial original sections on liver cancer and groundbreaking advances that will have significant impact on hepatology — provide comprehensive, fully up-to-date coverage of both the current state and future direction of hepatology. Topics include liver RNA structure and function, gene editing, single-cell and single-molecule genomic analyses, the molecular biology of hepatitis, drug interactions and engineered drug design, and liver disease mechanisms and therapies. Edited by globally-recognized experts in the field, this authoritative volume: Relates molecular physiology to understanding disease pathology and treatment Links the science and pathology of the liver to practical clinical applications Features 16 new “Horizons” chapters that explore new and emerging science and technology Includes plentiful full-color illustrations and figures The Liver: Biology and Pathobiology, Sixth Edition is an indispensable resource for practicing and trainee hepatologists, gastroenterologists, hepatobiliary and liver transplant surgeons, and researchers and scientists in areas including hepatology, cell and molecular biology, virology, and drug metabolism.
Book Synopsis The Bile Acids: Chemistry, Physiology, and Metabolism by : P. Nair
Download or read book The Bile Acids: Chemistry, Physiology, and Metabolism written by P. Nair and published by Springer. This book was released on 1976-12-01 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first two volumes of this series addressed themselves to the chemistry, physiology, and metabolism of the bile acids. The present volume is devoted to the pathophysiology of bile acids. As the role of bile acids in health and disease is being increasingly recognized, we have chosen for discussion a wide range of topics of current importance. The presence of bile acids in brain tissue and their possible role in demyelinating diseases form the subject of a provocative discussion. As an extension of this theme, the presence and quantification of bile acids in extrahepatic tissues is the subject of one chapter. The pathophysiological implications of bile acids at the macromolecular level is highlighted by a chapter on the influence of bile salts on the activity of various enzymes. The general area of hepatobiliary diseases is discussed in two chapters: one describes changes in bile salt metabolism in liver diseases and the other focuses on cholesterol gallstones and their formation and dissolution. Cerebrotendinous xanthomatosis has been shown to entail a defect in bile acid and sterol metabolism, and this metabolic error is the subject of an illuminating exposition. There is presently a concerted research effort being brought to bear on the causes of colon cancer, and one important aspect of this work centers on bile acid metabolism. Aspects of bile acid metabolism and cancer are the subject of two chapters. And finally, the role of dietary fiber in bile acid metabolism is updated.
Book Synopsis Bile Acids in Gastroenterology: Basic and Clinical Advances by : A.F. Hofmann
Download or read book Bile Acids in Gastroenterology: Basic and Clinical Advances written by A.F. Hofmann and published by Springer Science & Business Media. This book was released on 1995-06-30 with total page 428 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book contains the proceedings of the XIIIth International Bile Acid Meeting (Falk Symposium 80), an official satellite meeting of the World Congress of Gastroenterology, held in San Diego, California, U.S.A., September 30--October 2, 1994. It begins with presentations of major advances in bile acid chemistry, biology and pharmacology. The new structure proposed for the mixed micelles present in bile is reviewed, as are the properties of new synthetic analogues of bile acids. The mechanisms by which bile acids interact with cell membranes are discussed in order to provide insight into the hepatotoxic effects of bile acids in cholestatic liver disease. The book further shows the exciting progress in the molecular biology of bile acid transport by the hepatocyte and enterocyte, and concludes with a consensus on the use of ursodeoxycholic acid in cholestatic liver disease and as an adjunct to immunosuppressive therapy after liver transplantation, and to interferon therapy in chronic viral hepatitis.
