The Aptamer Handbook

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The Aptamer Handbook

Author : Sven Klussmann
Publisher : John Wiley & Sons
ISBN 13 : 3527607919
Total Pages : 518 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis The Aptamer Handbook by : Sven Klussmann

Download or read book The Aptamer Handbook written by Sven Klussmann and published by John Wiley & Sons. This book was released on 2006-08-21 with total page 518 pages. Available in PDF, EPUB and Kindle. Book excerpt: In The Aptamer Handbook, leading scientists from academia as well as biotech and pharma companies introduce the revolutionary concept of designing RNA and DNA oligonucleotides with novel functions by in vitro selection. These functions comprise high affinity binding (aptamers), catalytic activity (ribozymes and deoxyribozymes) or combinations of binding and catalytic properties (aptazymes). Basic concepts and technologies describing in detail how these functional oligonucleotides can be identified are presented. Numerous examples demonstrate the versatility of in vitro selected oligonucleotides. Special emphasis has been put on a section that shows the broad applicability of aptamers, e. g. in target validation, for analytics, or as new therapeutics. This first overview in the field is of prime interest for a broad audience of scientists both in academia and in industry who wish to expand their knowledge on the potential of new oligonucleotide functions and their applications.

Nucleic Acid Aptamers

Author : Günter Mayer
Publisher : Springer Nature
ISBN 13 : 1071626957
Total Pages : 283 pages
Book Rating : 4.0/5 (716 download)

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Book Synopsis Nucleic Acid Aptamers by : Günter Mayer

Download or read book Nucleic Acid Aptamers written by Günter Mayer and published by Springer Nature. This book was released on 2022-09-26 with total page 283 pages. Available in PDF, EPUB and Kindle. Book excerpt: This updated book reflects improvements in a variety of techniques used to study the aptamer field. Beginning with a section on selection procedures, the volume continues with methods to characterize aptamers’ interaction and structural properties by biophysical approaches, as well as a variety of applications that have been adapted to the aptamer compound class. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step and readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Nucleic Acid Aptamers: Selection, Characterization, and Application, Second Edition serves as an ideal guide for researchers aiming to further our understanding of aptamer biology and more.

Handbook of Smart Materials in Analytical Chemistry

Author : Miguel de la Guardia
Publisher : John Wiley & Sons
ISBN 13 : 1119422612
Total Pages : 931 pages
Book Rating : 4.1/5 (194 download)

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Book Synopsis Handbook of Smart Materials in Analytical Chemistry by : Miguel de la Guardia

Download or read book Handbook of Smart Materials in Analytical Chemistry written by Miguel de la Guardia and published by John Wiley & Sons. This book was released on 2019-01-22 with total page 931 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive guide to smart materials and how they are used in sample preparation, analytical processes, and applications This comprehensive, two-volume handbook provides detailed information on the present state of new materials tailored for selective sample preparation and the legal frame and environmental side effects of the use of smart materials for sample preparation in analytical chemistry, as well as their use in the analytical processes and applications. It covers both methodological and applied analytical aspects, relating to the development and application of new materials for solid-phase extraction (SPE) and solid-phase microextraction (SPME), their use in the different steps and techniques of the analytical process, and their application in specific fields such as water, food, air, pharmaceuticals, clinical sciences and forensics. Every chapter in Handbook of Smart Materials in Analytical Chemistry is written by experts in the field to provide a comprehensive picture of the present state of this key area of analytical sciences and to summarize current applications and research literature in a critical way. Volume 1 covers New Materials for Sample Preparation and Analysis. Volume 2 handles Analytical Processes and Applications. Focuses on the development and applications of smart materials in analytical chemistry Covers both, methodological and applied analytical aspects, for the development of new materials and their use in the different steps and techniques of the analytical process and their application in specific fields Features applications in key areas including water, air, environment, pharma, food, forensic, and clinical Presents the available tools for the use of new materials suitable to aid recognition process to the sample preparation and analysis A key resource for analytical chemists, applied laboratories, and instrument companies Handbook of Smart Materials in Analytical Chemistry, 2V Set is an excellent reference book for specialists and advanced students in the areas of analytical chemistry, including both research and application environments.

Handbook of RNA Biochemistry

Author : Roland K. Hartmann
Publisher : John Wiley & Sons
ISBN 13 : 3527650555
Total Pages : 1368 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Handbook of RNA Biochemistry by : Roland K. Hartmann

Download or read book Handbook of RNA Biochemistry written by Roland K. Hartmann and published by John Wiley & Sons. This book was released on 2015-03-31 with total page 1368 pages. Available in PDF, EPUB and Kindle. Book excerpt: The second edition of a highly acclaimed handbook and ready reference. Unmatched in its breadth and quality, around 100 specialists from all over the world share their up-to-date expertise and experiences, including hundreds of protocols, complete with explanations, and hitherto unpublished troubleshooting hints. They cover all modern techniques for the handling, analysis and modification of RNAs and their complexes with proteins. Throughout, they bear the practising bench scientist in mind, providing quick and reliable access to a plethora of solutions for practical questions of RNA research, ranging from simple to highly complex. This broad scope allows the treatment of specialized methods side by side with basic biochemical techniques, making the book a real treasure trove for every researcher experimenting with RNA.

The Nanobiotechnology Handbook

Author : Yubing Xie
Publisher : CRC Press
ISBN 13 : 1439838704
Total Pages : 692 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Nanobiotechnology Handbook by : Yubing Xie

Download or read book The Nanobiotechnology Handbook written by Yubing Xie and published by CRC Press. This book was released on 2012-11-16 with total page 692 pages. Available in PDF, EPUB and Kindle. Book excerpt: A thorough overview of nanobiotechnology and its place in advances in applied science and engineering, The Nanobiotechnology Handbook combines contributions from physics, bioorganic and bioinorganic chemistry, molecular and cellular biology, materials science, and medicine as well as from mechanical, electrical, chemical, and biomedical engineering

The Biomedical Engineering Handbook

Author : Joseph D. Bronzino
Publisher : CRC Press
ISBN 13 : 1439863113
Total Pages : 5430 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis The Biomedical Engineering Handbook by : Joseph D. Bronzino

Download or read book The Biomedical Engineering Handbook written by Joseph D. Bronzino and published by CRC Press. This book was released on 2018-10-03 with total page 5430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The definitive "bible" for the field of biomedical engineering, this collection of volumes is a major reference for all practicing biomedical engineers and students. Now in its fourth edition, this work presents a substantial revision, with all sections updated to offer the latest research findings. New sections address drugs and devices, personali

Aptamers in Biotechnology

Author : Katharina Urmann
Publisher : Springer Nature
ISBN 13 : 3030540618
Total Pages : 217 pages
Book Rating : 4.0/5 (35 download)

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Book Synopsis Aptamers in Biotechnology by : Katharina Urmann

Download or read book Aptamers in Biotechnology written by Katharina Urmann and published by Springer Nature. This book was released on 2020-07-31 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the development, characterization and applications of aptamers in different areas of biotechnology ranging from therapeutics to diagnostics and protein purification. Hailed as chemical antibodies, these single-stranded nucleic acid receptors were predicted to supersede antibodies in traditional assays, such as ELISA, within a short time. While this has yet to happen, readers will find in this book a deep insight into the progress of aptamer technology and a critical discussion about the limitations that need to be overcome in order to find wider acceptance and use outside of the still relatively small aptamer-community. This book covers all aspects of aptamer generation and application for the aptamer-experienced reader and curious novice alike, with the addition of an industry perspective on the future of aptamer-use in biotechnology.

Handbook of Analysis of Oligonucleotides and Related Products

Author : Jose V. Bonilla
Publisher : CRC Press
ISBN 13 : 1439819947
Total Pages : 502 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Handbook of Analysis of Oligonucleotides and Related Products by : Jose V. Bonilla

Download or read book Handbook of Analysis of Oligonucleotides and Related Products written by Jose V. Bonilla and published by CRC Press. This book was released on 2011-02-23 with total page 502 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oligonucleotides represent one of the most significant pharmaceutical breakthroughs in recent years, showing great promise as diagnostic and therapeutic agents for malignant tumors, cardiovascular disease, diabetes, viral infections, and many other degenerative disorders. The Handbook of Analysis of Oligonucleotides and Related Products is an essen

A Comprehensive Guide to Aptamers

Author : Tom Shuster
Publisher :
ISBN 13 : 9781536162936
Total Pages : 149 pages
Book Rating : 4.1/5 (629 download)

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Book Synopsis A Comprehensive Guide to Aptamers by : Tom Shuster

Download or read book A Comprehensive Guide to Aptamers written by Tom Shuster and published by . This book was released on 2019-09-06 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: This collection opens with a focus on recent advancements on the development of nucleic acid aptamers as alternative delivery systems for therapeutic oligonucleotides. Additionally, key examples of targeted delivery of the most common nucleic acid therapeutics, including small interfering RNAs, short hairpin RNAs, microRNAs and antisense oligonucleotides for a number of disorders are discussed. The following chapter deals with in vivo studies that were conducted with radiopharmaceuticals based on aptamers, the radionuclides used, the radiolabeling strategies, the chemical modifications of interest to improve their properties, and the main aptamers advantages and drawbacks for application as radiopharmaceuticals. In conclusion, the authors discuss the perspectives of using aptamers in various detection methods, their advantages and disadvantages, and the results of such work carried out through the present day.

Biosensors for Security and Bioterrorism Applications

Author : Dimitrios P. Nikolelis
Publisher : Springer
ISBN 13 : 3319289268
Total Pages : 508 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Biosensors for Security and Bioterrorism Applications by : Dimitrios P. Nikolelis

Download or read book Biosensors for Security and Bioterrorism Applications written by Dimitrios P. Nikolelis and published by Springer. This book was released on 2016-03-12 with total page 508 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book offers comprehensive coverage of biomarker/biosensor interactions for the rapid detection of weapons of bioterrorism, as well as current research trends and future developments and applications. It will be useful to researchers in this field who are interested in new developments in the early detection of such. The authors have collected very valuable and, in some aspects indispensable experience in the area i.e. in the development and application of portable biosensors for the detection of potential hazards. Most efforts are centered on the development of immunochemical assays including flow-lateral systems and engineered antibodies and their fragments. In addition, new approaches to the detection of enzyme inhibitors, direct enzymatic and microbial detection of metabolites and nutrients are elaborated. Some realized prototypes and concept devices applicable for the further use as a basis for the cooperation programs are also discussed.There is a particular focus on electrochemical and optical detection systems,including those employing carbon nanotubes, quantum dots and metalnanoparticles. The authors are well-known scientists and most of them are editors of respected international scientific journals. Although recently developed biosensors utilize known principles, the biosensing devices described can significantly shorten the time required for successful detection and enhance efforts in more time-consuming directions, e.g. remote sensing systems and validation in real-sample analysis.The authors describe advances in all stages of biosensor development: theselection of biochemical components, their use in biosensor assembly, detection principles and improvements and applications for real sample assays.

Aptamers for Analytical Applications

Author : Yiyang Dong
Publisher : John Wiley & Sons
ISBN 13 : 3527342672
Total Pages : 426 pages
Book Rating : 4.5/5 (273 download)

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Book Synopsis Aptamers for Analytical Applications by : Yiyang Dong

Download or read book Aptamers for Analytical Applications written by Yiyang Dong and published by John Wiley & Sons. This book was released on 2019-02-11 with total page 426 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential guide that puts the focus on method developments and applications in aptamers In recent years, aptamer-based systems have been developed for a wide-range of analytical and medical applications. Aptamers for Analytical Applications offers an introduction to the topic, outlines the common protocols for aptamer synthesis, as well as providing information on the different optimization strategies that can obtain higher affinities to target molecules. The contributors?noted experts on the topic?provide an in-depth review of the characterization of aptamer-target molecule interaction and immobilization strategies and discuss the developments of methods for all the relevant applications. The book outlines different schemes to efficiently immobilize aptamers on substrates as well as summarizing the characterization methods for aptamer-ligand complexes. In addition, aptamer-based colorimetric, enzyme-linked, fluorescent, electrochemical, lateral flow and non-labeling analytical methods are presented. The book also reflects state-of-the-art and emerging applications of aptamer-based methods. This important resource: -Provides a guide to aptamers which provide highly specific and sensitive molecular recognition, with affinities in the range of antibodies and are much cheaper to produce -Offers a discussion of the analytical method developments and improvements with established systems and beyond -Offers a comprehensive guide to all the relevant application areas -Presents an authoritative book from contributors who are noted experts in the field Written for analytical chemists, biochemists, analytical researchers, Aptamers for Analytical Applications is a comprehensive book that adopts a methodological point of view to the important aspects of aptamer generation and modification with a strong emphasis on method developments for relevant applications.

Aptamers

Author : Gulab Singh Yadav
Publisher : Springer Nature
ISBN 13 : 9811388369
Total Pages : 186 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Aptamers by : Gulab Singh Yadav

Download or read book Aptamers written by Gulab Singh Yadav and published by Springer Nature. This book was released on 2019-11-11 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book discusses the basics of aptamers and the advent of aptamer-based technology in recent times. The book covers the diverse applications of aptamers, such as in detection of animal and plant pathogens, disease diagnosis and therapeutics, environmental contamination detection etc. Besides these applications, the book also describes the use of these synthetic or modified DNA, as drug delivery vehicles. The different chapters describe how the binding capacity and specificity of aptamers can be exploited in various ways. The book also discusses how these attributes of aptamers can outdo the antibody technology in biomedical and diagnostic solutions. This crisp and concise book gives the readers an insight into the most recent biotechnological applications of aptamers.

Aptamers

Author : Rakesh N. Veedu
Publisher : CRC Press
ISBN 13 : 1315341123
Total Pages : 209 pages
Book Rating : 4.3/5 (153 download)

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Book Synopsis Aptamers by : Rakesh N. Veedu

Download or read book Aptamers written by Rakesh N. Veedu and published by CRC Press. This book was released on 2017-03-03 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aptamers, often termed as ‘chemical antibodies,’ are an emerging class of synthetic ligands for efficient target-specific molecular recognition. The objective of this book is to highlight recent advances and potential of aptamers in various disease conditions. . This book focuses on the applications of aptamers in targeted nanotherapy, detection, and in molecular imaging in various disease conditions such as cancer, neurological diseases and infectious diseases.

Aptamers in Bioanalysis

Author : M. Mascini
Publisher : John Wiley & Sons
ISBN 13 : 0470380764
Total Pages : 346 pages
Book Rating : 4.4/5 (73 download)

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Book Synopsis Aptamers in Bioanalysis by : M. Mascini

Download or read book Aptamers in Bioanalysis written by M. Mascini and published by John Wiley & Sons. This book was released on 2009-04-27 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the first book to detail bioanalytical technologies and methods that have been developed using aptamers in analytical, medical, environmental, and food science applications. After an introduction to aptamers, aptamer targets, and their general uses, it discusses different applications with particular attention to the comparison between aptamer-based biosensors and methods versus the corresponding immunosensors. Examples of aptamer-based diagnostic techniques include whole-cell protein profiling (proteomics) and medical diagnostics for the distinction of diseased versus healthy states. This is a core reference for analytical chemists, electrochemists, pharmaceutical/medicinal chemists, biotechnologists, and others.

Biosensors Based on Aptamers and Enzymes

Author : Man Bock Gu
Publisher : Springer
ISBN 13 : 3642541437
Total Pages : 338 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Biosensors Based on Aptamers and Enzymes by : Man Bock Gu

Download or read book Biosensors Based on Aptamers and Enzymes written by Man Bock Gu and published by Springer. This book was released on 2014-07-08 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volumes are organized topically and provide a comprehensive discussion of developments in the respective field over the past 3-5 years. The series also discusses new discoveries and applications. Special volumes are dedicated to selected topics which focus on new biotechnological products and new processes for their synthesis and purification. In general, special volumes are edited by well-known guest editors. The series editor and publisher will however always be pleased to receive suggestions and supplementary information. Manuscripts are accepted in English.

Making and Using Antibodies

Author : Gary C. Howard
Publisher : CRC Press
ISBN 13 : 1439869081
Total Pages : 462 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Making and Using Antibodies by : Gary C. Howard

Download or read book Making and Using Antibodies written by Gary C. Howard and published by CRC Press. This book was released on 2013-07-29 with total page 462 pages. Available in PDF, EPUB and Kindle. Book excerpt: Antibodies protect us from a wide range of infectious diseases and cancers and have become an indispensable tool in science—both for conventional immune response research as well as other areas related to protein identification analysis. This second edition of Making and Using Antibodies: A Practical Handbook provides clear guidance on all aspects of how to make and use antibodies for research along with their commercial and industrial applications. Keeping pace with new developments in this area, all chapters in this new edition have been revised, updated, or expanded. Along with discussions of current applications, new material in the book includes chapters on western blotting, aptamers, antibodies as therapeutics, quantitative production, and humanization of antibodies. The authors present clear descriptions of basic methods for making and using antibodies and supply detailed descriptions of basic laboratory techniques. Each chapter begins with introductory material, allowing for a better understanding of each concept, and practical examples are included to help readers grasp the real-world scenarios in which antibodies play a part. From the eradication of smallpox to combating cancer, antibodies present an attractive solution to a range of biomedical problems. They are relatively easy to make and use, have great flexibility in applications, and are cost effective for most labs. This volume will assist biomedical researchers and students and pave the way for future discovery of new methods for making and using antibodies for a host of applications.

Antisense Drug Technology

Author : Stanley T. Crooke
Publisher : CRC Press
ISBN 13 : 0849387957
Total Pages : 858 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Antisense Drug Technology by : Stanley T. Crooke

Download or read book Antisense Drug Technology written by Stanley T. Crooke and published by CRC Press. This book was released on 2007-07-25 with total page 858 pages. Available in PDF, EPUB and Kindle. Book excerpt: Extensively revised and updated, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition reflects the logarithmic progress made in the past four years of oligonucleotide-based therapies, and, in particular, antisense therapeutics and research. Interpreting lessons learned from the clinical trials of first generation drugs, the book evaluates the technology as a whole and offers new directions and avenues of research and development. Divided into five parts, the book begins with a thorough introduction to the mechanism of antisense drug action including the RNase H mechanism, small RNA silencing pathways, and the potential therapeutics of splice switching oligonucleotides. Leading researchers demonstrate the basics of oligonucleotide therapeutics in part two by delineating medicinal chemistry, pharmacokinetics, and delivery routes such as liposomal formulations for nucleic acid delivery. Part three details hybridization based drugs and considers the dramatic advances represented by 2’ methoxyethyl chimeric antisense inhibitors and duplex RNA drugs. Other chemical classes of drugs and mechanisms of action are described in part four with further discussions on improving the second generation antisense drugs. The final part delves deeply into therapeutic applications. Contributing authors examine the potential of antisense drugs for the alleviation of cardiovascular diseases, metabolic diseases, inflammatory diseases, cancer, neurological disorders, and immune modulation. Presenting a highly detailed, lucid discussion of the remarkable advances in the field, Antisense Drug Technology: Principles, Strategies, and Applications, Second Edition provides the platform for researchers to continue to aggressively pursue the great opportunity represented by this exciting technology.