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Testing For Abuse Liability Of Drugs In Humans
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Book Synopsis Testing for Abuse Liability of Drugs in Humans by : Marian W. Fischman
Download or read book Testing for Abuse Liability of Drugs in Humans written by Marian W. Fischman and published by . This book was released on 1989 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Representatives from industry, academia and government discuss issues related to testing for drug abuse liability and dependence potential. Contributors critically assess current methods for evaluating drugs in human subjects and describe both the advantages and limitations of each approach. This information permits identification of areas in which further research and development are needed.
Book Synopsis Testing for Abuse Liability of Drugs in Humans by : Mariam W. Fischman
Download or read book Testing for Abuse Liability of Drugs in Humans written by Mariam W. Fischman and published by . This book was released on 1989 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Testing Drugs for Physical Dependence Potential and Abuse Liability by :
Download or read book Testing Drugs for Physical Dependence Potential and Abuse Liability written by and published by . This book was released on 1984 with total page 170 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Nonclinical Assessment of Abuse Potential for New Pharmaceuticals by : Carrie Markgraf
Download or read book Nonclinical Assessment of Abuse Potential for New Pharmaceuticals written by Carrie Markgraf and published by Academic Press. This book was released on 2015-07-14 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy
Book Synopsis Testing for Abuse Liability of Drugs in Humans by : Mariam W. Fischman
Download or read book Testing for Abuse Liability of Drugs in Humans written by Mariam W. Fischman and published by . This book was released on 1989 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Pathways of Addiction by : Institute of Medicine
Download or read book Pathways of Addiction written by Institute of Medicine and published by National Academies Press. This book was released on 1996-11-01 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug abuse persists as one of the most costly and contentious problems on the nation's agenda. Pathways of Addiction meets the need for a clear and thoughtful national research agenda that will yield the greatest benefit from today's limited resources. The committee makes its recommendations within the public health framework and incorporates diverse fields of inquiry and a range of policy positions. It examines both the demand and supply aspects of drug abuse. Pathways of Addiction offers a fact-filled, highly readable examination of drug abuse issues in the United States, describing findings and outlining research needs in the areas of behavioral and neurobiological foundations of drug abuse. The book covers the epidemiology and etiology of drug abuse and discusses several of its most troubling health and social consequences, including HIV, violence, and harm to children. Pathways of Addiction looks at the efficacy of different prevention interventions and the many advances that have been made in treatment research in the past 20 years. The book also examines drug treatment in the criminal justice setting and the effectiveness of drug treatment under managed care. The committee advocates systematic study of the laws by which the nation attempts to control drug use and identifies the research questions most germane to public policy. Pathways of Addiction provides a strategic outline for wise investment of the nation's research resources in drug abuse. This comprehensive and accessible volume will have widespread relevanceâ€"to policymakers, researchers, research administrators, foundation decisionmakers, healthcare professionals, faculty and students, and concerned individuals.
Book Synopsis Prediction and prevention of prescription drug abuse by : Julie A. Marusich
Download or read book Prediction and prevention of prescription drug abuse written by Julie A. Marusich and published by RTI Press. This book was released on 2013-07-22 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 2011, the prevalence of prescription drug abuse exceeded that of any other illicit drug except marijuana. Consequently, efforts to curtail abuse of new medications should begin during the drug development process, where abuse liability can be identified and addressed before a candidate medication has widespread use. The first step in this process is scheduling with the Drug Enforcement Agency so that legal access is appropriately restricted, dependent upon levels of abuse risk and medical benefit. To facilitate scheduling, the Food and Drug Administration (FDA) has published guidance for industry that describes assessment of abuse liability. The purpose of this paper is to review methods that may be used to satisfy the FDA's regulatory requirements for animal behavioral and dependence pharmacology. Methods include psychomotor activity, self-administration (an animal model of the rewarding effects of a drug), drug discrimination (an animal model of the subjective effects of a drug), and evaluation of tolerance and dependence. Data from tests with known drugs of abuse illustrate typical results. While the use of preclinical data to predict abuse liability is an imperfect process, these methods have substantial predictive validity. The ultimate goal is to increase consumer safety through appropriate scheduling of new medications.
Book Synopsis Mechanisms of Tolerance and Dependence by : Charles William Sharp
Download or read book Mechanisms of Tolerance and Dependence written by Charles William Sharp and published by . This book was released on 1984 with total page 396 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book NIDA Research Monograph written by and published by . This book was released on 1976 with total page 432 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Drug Discrimination by : Richard A. Glennon
Download or read book Drug Discrimination written by Richard A. Glennon and published by John Wiley & Sons. This book was released on 2011-08-23 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug discrimination: a practical guide to its contributions to the invention of new chemical entities and evaluations of new or known pharmacological agents Drug discrimination can be described as a "drug detection" procedure that uses a pharmacologically active agent as the subjective stimulus. Although the procedure does require some effort to implement, it can be an extremely important tool for understanding drug action. Whereas medicinal chemists should come to learn the types of information that drug discrimination studies can offer, pharmacologists and psychologists might come to realize how medicinal chemists can apply the types of information that the paradigm routinely provides. Drug Discrimination: Applications to Medicinal Chemistry and Drug Studies provides in-depth analyses of the nature and use of drugs as discriminative stimuli and bridges some of the numerous gaps between medicinal chemistry, pharmacology, and psychology. Stressing the practical aspects of drug discrimination, including types of procedures, study design, data, and interpretation, the book details the advantages and limitations of drug discrimination studies versus other pharmacologic evaluations. Practical information from leading researchers in the field addresses specific topics and techniques that are of interest in drug discovery, evaluation, and development. A groundbreaking new guide to the applications of drug discrimination studies for medicinal chemistry and neuroscience, Drug Discrimination is essential for any scientist, researcher, or student whose interests involve the design, development, and/or action of drugs acting at the level of the central nervous system.
Book Synopsis Ethics and Regulation of Clinical Research by : Robert J. Levine
Download or read book Ethics and Regulation of Clinical Research written by Robert J. Levine and published by Yale University Press. This book was released on 1988-01-01 with total page 484 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of human subjects in medical and scientific research has given rise to troubling ethical questions. How should human subjects be selected for experiments? What should they be told about the research in which they are involved? How can their privacy be protected? When is it permissible to deceive them? How do we deal with subjects such as children, fetuses, and the mentally infirm, for whom informed consent is impossible? In this book, Dr. Robert J. Levine reviews federal regulations, ethical analysis, and case studies in an attempt to answer these questions. His book is an essential reference for everyone--members of institutional review boards, scientists, philosophers, lawyers--addressing the ethical issues involved. "[Levine's] experience as a clinician, IRB chairman, writer and editor of a journal devoted exclusively to issues faced by IRBS makes him uniquely qualified to bring together the legal, ethical, and practical dimensions. . . [The book] is sophisticated but readable. . . [and] should be on every IRB administrator's desk and in every medical ethics library."--Norman Fost, M.D., The New England Journal of Medicine "Levine. . . is one of the foremost historians of contemporary clinical science. . . . His book is at once a guide to primary sources for the history of clinical research in the late twentieth century and a pioneering secondary source about that history."--Daniel M. Fox, Bulletin of the History of Medicine "You will be charmed by the [book's] elegance and lucidity and. . . persuaded of its relevance to doctors in any country."--Alex Paton, British Medical Journal "Should be of wide interest to those keen to see advances in medical research brought into general medical practice."--Gilbert Omenn, Issues in Science and Technology
Book Synopsis WHO Study Group on Tobacco Product Regulation by : World Health Organization
Download or read book WHO Study Group on Tobacco Product Regulation written by World Health Organization and published by World Health Organization. This book was released on 2009 with total page 50 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report makes available the findings of an international group of experts that provide WHO with the latest scientific and technical advice in the area of product regulation. The third report presents the conclusions reached and recommendations made by the members of the WHO Study Group on Tobacco Product Regulation at its fifth meeting, during which it reviewed two background papers specially commissioned for the meeting and which dealt, respectively, with the following two themes: devices designed for the purpose of nicotine delivery to the respiratory system in which tobacco is not necessary for their operation and setting regulatory limits for carcinogens in smokeless tobacco. The Study Group's recommendations in relation to each theme are set out at the end of the section dealing with that theme. Its overall recommendations are summarized in section 4. The Study Group intends this new set of recommendations to be useful to WHO Member States and national policymakers and regulators in shaping tobacco control policy.
Download or read book Drugs, Brains, and Behavior written by and published by . This book was released on 2007 with total page 76 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Urine Testing for Drugs of Abuse by :
Download or read book Urine Testing for Drugs of Abuse written by and published by . This book was released on 1986 with total page 134 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drugs of Abuse written by Raphael C. Wong and published by Springer Science & Business Media. This book was released on 2007-11-05 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive review of the science of drug testing in all its aspects, placing emphasis on technologies that use body fluids other than urine for determining the presence of drugs of abuse. The authors discuss the various body fluid specimens suitable for testing for illicit drugs-particularly saliva, sweat, and hair-describe the structural and manufacturing aspects of on-site testing devices based on lateral flow immunoassay, and detail the pitfalls of using these specimens. They also discuss in detail the problem of sample adulteration and its detection. Since oral fluid has the best potential of succeeding urine as the next matrix of choice for drug detection, four popular saliva testing devices are examined: Intercept®, the Drager Drug Test®, Oratect®, and Drugwipe. Political, social, and legal issues are also considered in articles on privacy, the use of drug testing in courts, and the problem of sample adulteration.
Book Synopsis Critical Issues in Alcohol and Drugs of Abuse Testing by : Amitava Dasgupta
Download or read book Critical Issues in Alcohol and Drugs of Abuse Testing written by Amitava Dasgupta and published by Academic Press. This book was released on 2019-01-10 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Critical Issues in Alcohol and Drugs of Abuse Testing, Second Edition, addresses the general principles and technological advances for measuring drugs and alcohol, along with the pitfalls of drugs of abuse testing. Many designer drugs, for example, are not routinely tested in drugs of abuse panels and may go undetected in a drug test. This updated edition is a must-have for clinical pathologists, toxicologists, clinicians, and medical review officers and regulators, bridging the gap between technical and clinical information. Topics of note include the monitoring of pain management drugs, bath salts, spices (synthetic marijuana), designer drugs and date rape drugs, and more. Serves as a ready resource of information for alcohol and drug testing Ideal resource for making decisions related to the monitoring and interpretation of results Includes concise content for clinical laboratory scientists, toxicologists and clinicians
Book Synopsis Testing and Evaluation of Drugs of Abuse by : Martin W. Adler
Download or read book Testing and Evaluation of Drugs of Abuse written by Martin W. Adler and published by Wiley. This book was released on 1990 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: This work describes how critical biological information on today's abused drugs is obtained in both laboratory and clinical settings. Recent methodological advances, both great and small, are presented in a concise manner by experienced researchers and scholars. The text covers wholesale innovations in methodology, in addition to simple modifications of existing methods that often yield great advances, and the strengths and weaknesses of all methods are assessed. The survey is comprehensive and uncovers key characteristics of abused drugs at the receptor level, on animal behavior, and in humans.
