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Test No 473 In Vitro Mammalian Chromosome Aberration Test
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Book Synopsis Test No. 473: In Vitro Mammalian Chromosomal Aberration Test by : OECD
Download or read book Test No. 473: In Vitro Mammalian Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2014-09-26 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Book Synopsis Test No. 473: In vitro Mammalian Chromosome Aberration Test by : OECD
Download or read book Test No. 473: In vitro Mammalian Chromosome Aberration Test written by OECD and published by OECD Publishing. This book was released on 1997-07-21 with total page 10 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian somatic cells. Structural aberrations may be of two types: chromosome or chromatid. The in vitro ...
Book Synopsis Test No. 473: In Vitro Mammalian Chromosomal Aberration Test by : Organisation for Economic Co-operation and Development
Download or read book Test No. 473: In Vitro Mammalian Chromosomal Aberration Test written by Organisation for Economic Co-operation and Development and published by . This book was released on 2014 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of the in vitro chromosome aberration test is to identify agents that cause structural chromosome aberrations in cultured mammalian somatic cells. Structural aberrations may be of two types: chromosome or chromatid. The in vitro chromosome aberration test may employ cultures of established cell lines, cell strains or primary cell cultures. Cell cultures are exposed to the test substance (liquid or solid) both with and without metabolic activation during about 1.5 normal cell cycle lengths. At least three analysable concentrations of the test substance should be used. At each concentration duplicate cultures should normally be used. At predetermined intervals after exposure of cell cultures to the test substance, the cells are treated with a metaphase-arresting substance, harvested, stained. Metaphase cells are analysed microscopically for the presence of chromosome aberrations.
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 473: In Vitro Mammalian Chromosomal Aberration Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 473: In Vitro Mammalian Chromosomal Aberration Test written by OECD and published by OECD Publishing. This book was released on 2016-07-29 with total page 22 pages. Available in PDF, EPUB and Kindle. Book excerpt: This test identifies agents that cause structural chromosome aberrations in cultured mammalian somatic cells.
Book Synopsis Genetic Toxicology Testing by : Ray Proudlock
Download or read book Genetic Toxicology Testing written by Ray Proudlock and published by Academic Press. This book was released on 2016-05-28 with total page 458 pages. Available in PDF, EPUB and Kindle. Book excerpt: Genetic Toxicology Testing: A Laboratory Manual presents a practical guide to genetic toxicology testing of chemicals in a GLP environment. The most commonly used assays are described, from laboratory and test design to results analysis. In a methodical manner, individual test methods are described step-by-step, along with equipment, suggested suppliers, recipes for reagents, and evaluation criteria. An invaluable resource in the lab, this book will help to troubleshoot any assay problems you may encounter to optimise quality and efficiency in your genetic toxicology tests. Genetic Toxicology Testing: A Laboratory Manual is an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own. - Offers practical and consistent guidance on the most commonly-performed tests and procedures in a genetic toxicology lab - Describes standard genetic toxicology assays, their methodology, reagents, suppliers, and analysis of their results - Includes guidance on general approaches: formulation for in vitro assays, study monitoring, and Good Laboratory Practice (GLP) - Serves as an essential reference for those new to the genetic toxicology laboratory, or anyone involved in setting up their own lab
Book Synopsis OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 487: In Vitro Mammalian Cell Micronucleus Test by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals, Section 4 Test No. 487: In Vitro Mammalian Cell Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2023-07-04 with total page 30 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells.
Book Synopsis Test No. 487: In Vitro Mammalian Cell Micronucleus Test by : OECD
Download or read book Test No. 487: In Vitro Mammalian Cell Micronucleus Test written by OECD and published by OECD Publishing. This book was released on 2010-07-23 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: The in vitro micronucleus test is a genotoxicity test for the detection of micronuclei in the cytoplasm of interphase cells. Micronuclei may originate from acentric chromosome fragments (i.e. lacking a centromere), or whole chromosomes that are ...
Book Synopsis Genetic Toxicology by : James M. Parry
Download or read book Genetic Toxicology written by James M. Parry and published by Humana Press. This book was released on 2011-12-07 with total page 433 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evaluation of potential mutagenic activity is a critical step in the assessment of the safety of both new and pre-existing chemical types. In Genetic Toxicology: Principles and Methods, expert contributors help to satisfy the demand for education in this tremendously important area of study. The volume covers three basic areas: the scientific basis of the discipline, the methodologies of the main test assays, and the application of the methods, all aimed primarily at scientists in the safety departments of the industries working with both natural and synthetic chemicals. Written in the highly successful Methods in Molecular BiologyTM series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Intuitive and cutting-edge, Genetic Toxicology: Principles and Methods provides crucial support to both laboratory workers in providing quality information on the appropriate application of techniques and to study directors in their assay selection and protocol design in this vital field.
Book Synopsis Critical Pathways to Success in CNS Drug Development by : Neal R. Cutler
Download or read book Critical Pathways to Success in CNS Drug Development written by Neal R. Cutler and published by John Wiley & Sons. This book was released on 2010-01-22 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering the latest advances in CNS drug development, this bookwill guide all those involved in pre-clinical to early clinicaltrials. The authors describe how recent innovations can acceleratethe development of novel CNS compounds, improve early detection ofefficacy and toxicity signals, and increase the safety oflater-stage clinical trials. The current crisis in the drug development industry iscritically reviewed, as well as the steps needed to correct theproblems, including new government-backed regulations andindustry-based innovations designed to accelerate CNS drugdevelopment in the future. Animal-based models of major CNS disorders are described indetail, and the ability of the latest in vitro and computer-basedmodels to simulate CNS disease states and predict drug efficacy andside-effects are examined. Particular attention is given tothe growing use of biomarkers and how they can be used effectivelyin early human trials as signals of potential drug efficacy, aswell as the increasingly important role of imaging studies to guidedose selection. Cognitive assessments that can be useful indicatorsof effect in patient populations are also discussed. Written by a team of clinical scientists involved in CNS drugtrials for over 20 years, and based on a wealth of drug developmentand clinical trial experience, Critical Pathways to Success inCNS Drug Developmentis full of practical advice forsuccessfully designing and executing CNS drug trials, avoidingpotential pitfalls, and complying with government regulations
Author :Joint FAO/WHO Expert Committee on Food Additives. Meeting Publisher :World Health Organization ISBN 13 :9241660627 Total Pages :292 pages Book Rating :4.2/5 (416 download)
Book Synopsis Safety Evaluation of Certain Food Additives by : Joint FAO/WHO Expert Committee on Food Additives. Meeting
Download or read book Safety Evaluation of Certain Food Additives written by Joint FAO/WHO Expert Committee on Food Additives. Meeting and published by World Health Organization. This book was released on 2010 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: The toxicological monographs in this volume summarize the safety data on a number of food additives: branching glycosyltransferase from Rhodothermus obamensis expressed in Bacillus subtilis, cassia gum, ferrous ammonium phosphate, glycerol ester of gum rosin, glycerol ester of tall oil rosin, lycopene from all sources, octenyl succinic acid modified gum arabic, sodium hydrogen sulfate and sucrose oligoesters type I and type II. A monograph on the assessment of dietary exposure to cyclamic acid and its salts is also included. This volume and others in the WHO Food Additives Seriescontain information that is useful to those who produce and use food additives and veterinary drugs and those involved with controlling contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
Book Synopsis Safety evaluation of certain food additives by : World Health Organization
Download or read book Safety evaluation of certain food additives written by World Health Organization and published by World Health Organization. This book was released on 2023-10-02 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Safety evaluation of certain food additives: Prepared by the ninety-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) by : World Health Organization
Download or read book Safety evaluation of certain food additives: Prepared by the ninety-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA) written by World Health Organization and published by Food & Agriculture Org.. This book was released on 2023-10-04 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains monographs prepared at the ninety-fifth meeting of the Joint FAO/WHO Expert Committee on Food Additives (JECFA), which met virtually during 6–17 and 22 June 2022. The toxicological and dietary exposure monographs in this volume summarize the safety and dietary exposure data on eight specific food additives: α-amlyase (JECFA95-1 and JECFA95-2) from Geobacillus stearothermophilus expressed in Bacillus licheniformis; α-amlyase (JECFA95-3) from Rhizomucor pusillus expressed in Aspergillus niger; amyloglucosidase (JECFA95-4) from Rasamsonia emersonii expressed in Aspergillus niger; asparaginase (JECFA95-5) from Pyrococcus furiosus expressed in Bacillus subtilis; β-amylase (JECFA95-6) from Bacillus flexus expressed in Bacillus licheniformis; lipase (JECFA95-7) from Thermomyces lanuginosus and Fusarium oxysporum expressed in Aspergillus oryzaei; and xylanase (JECFA95-9) from Bacillus licheniformis expressed in Bacillus licheniformis. An addendum summarizes the safety and dietary exposure data on a group of related flavouring agents (alicyclic ketones, secondary alcohols and related esters). This volume and others in the WHO Food Additives series contain information that is useful to those who produce and use food additives and veterinary drugs, those involved in the control of contaminants in food, government and food regulatory officers, industrial testing laboratories, toxicological laboratories and universities.
Book Synopsis Principles of Tumors by : Leon P. Bignold
Download or read book Principles of Tumors written by Leon P. Bignold and published by Academic Press. This book was released on 2019-11-01 with total page 688 pages. Available in PDF, EPUB and Kindle. Book excerpt: Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology. This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine. - Presents content that has been totally updated with the most recent developments of the field, including new chapters on tumor imaging exams, new surgical techniques, immunotherapy, gene therapy, and several novel therapies using natural and synthetic compounds - Presents translational approaches for every topic to improve conceptual insights for new research projects - Covers a broad range of subjects, making it easier for the reader to understand related fields - Includes diagrams for complex topics to aid in understanding for non-specialists
Book Synopsis Genotoxic Impurities by : Andrew Teasdale
Download or read book Genotoxic Impurities written by Andrew Teasdale and published by John Wiley & Sons. This book was released on 2011-03-29 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines genotoxic impurities and their impact on the pharmaceutical industry. Specific sections examine this from both a toxicological and analytical perspective. Within these sections, the book defines appropriate strategies to both assess and ultimately control genotoxic impurities, thus aiding the reader to develop effective control measures. An opening section covers the development of guidelines and the threshold of toxicological concern (TTC) and is followed by a section on safety aspects, including safety tests in vivo and vitro, and data interpretation. The second section addresses the risk posed by genotoxic impurities from outside sources and from mutagens within DNA. In the final section, the book deals with the quality perspective of genotoxic impurities focused on two critical aspects, the first being the analysis and the second how to practically evaluate the impurities.
Book Synopsis Ullmann's Industrial Toxicology by : Wiley-VCH
Download or read book Ullmann's Industrial Toxicology written by Wiley-VCH and published by John Wiley & Sons. This book was released on 2005-10-28 with total page 1193 pages. Available in PDF, EPUB and Kindle. Book excerpt: The one-stop resource for health protection professionals, environmental scientists and safety engineers. Since the entire 40-volume Ullmann's Encyclopedia is inaccessible to many readers - particularly individuals, smaller companies or institutes - all the information on industrial toxicology, ecotoxicology, process safety as well as occupational health and safety has been condensed into this convenient 2-volume set. Based on the latest online edition of Ullmann's containing articles never been before in print, this ready reference provides practical information on applying the science of toxicology in both the occupational and environmental setting, and explains the fundamentals necessary for an understanding of the effects of chemical hazards on humans and ecosystems. The detailed and meticulously edited articles have been written by renowned experts from industry and academia, and much of the information has been thoroughly revised. Alongside explanations of safety regulations and legal aspects, this set covers food additives, toxic agents as well as medical and therapeutical issues. Top-quality illustrations, clear diagrams and charts combined with an extensive use of tables enhance the presentation and provide a unique level of detail. Deeper insights into any given area of interest is offered by referenced contributions, while rapid access to a particular subject is enhanced by both a keyword and author index.
Book Synopsis Principles of Toxicology Testing by : Frank A. Barile
Download or read book Principles of Toxicology Testing written by Frank A. Barile and published by CRC Press. This book was released on 2007-07-23 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: The evolution of toxicology testing finds its impetus in the continuing growth of the chemical and pharmaceutical industries, as well as the awareness of public health initiatives, needs, and responses that demand faster, more accurate, more economical methods for screening potential toxicity. Concurrent advances in biotechnology enable viable in v
Book Synopsis OECD Guidelines for the Testing of Chemicals OECD Guidelines for the Testing of Chemicals Fifteenth Addendum - 2004 by : OECD
Download or read book OECD Guidelines for the Testing of Chemicals OECD Guidelines for the Testing of Chemicals Fifteenth Addendum - 2004 written by OECD and published by OECD Publishing. This book was released on 2004-10-07 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The OECD Guidelines for the Testing of Chemicals are a collection of internationally agreed methods for testing the safety of chemicals and chemical preparations, including pesticides and industrial chemicals. This 2005 update contains 11 new and 3 revised guidelines.
