Targeted Interference With Signal Transduction Events

Download Targeted Interference With Signal Transduction Events full books in PDF, epub, and Kindle. Read online Targeted Interference With Signal Transduction Events ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!

Targeted Interference with Signal Transduction Events

Author : B. Groner
Publisher : Springer Science & Business Media
ISBN 13 : 3540312099
Total Pages : 192 pages
Book Rating : 4.5/5 (43 download)

DOWNLOAD NOW!

Book Synopsis Targeted Interference with Signal Transduction Events by : B. Groner

Download or read book Targeted Interference with Signal Transduction Events written by B. Groner and published by Springer Science & Business Media. This book was released on 2007-08-09 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book does nothing less than lay out the state of development of tomorrow’s cancer drugs, directed against growth factors, growth factor receptors and intracellular signaling molecules with kinase activities. The sequencing of the human genome and insights into signaling pathways have contributed to the understanding of cancer etiology and the development of new, improved cancer drugs such as Herceptin and Glivec. The deregulation of pathways due to mutated cancer genes provides the conceptual basis for future progress. Will it be possible to derive more efficient cancer drugs?

Primary Liver Cancer

Author : Jianren Gu
Publisher : Springer Science & Business Media
ISBN 13 : 3642287026
Total Pages : 479 pages
Book Rating : 4.6/5 (422 download)

DOWNLOAD NOW!

Book Synopsis Primary Liver Cancer by : Jianren Gu

Download or read book Primary Liver Cancer written by Jianren Gu and published by Springer Science & Business Media. This book was released on 2012-12-02 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Primary Liver Cancer: Challenges and Perspectives" presents the recent progress in basic and clinical research in Primary Liver Cancer (PLC) in China and around the world. PLC patients in China make up more than 50% of the total patients worldwide. By contributing to the book, the leading experts in the field of liver cancer in China as well as in the US share with readers their new concepts, practices, and experiences from bench to bed, from population study to individual survey, from molecular search to clinical practice, and from early diagnosis to treatment. The book is intended for researchers in the fields of epidemiology, molecular genetics, cell biology, immunology of HCC and other cancers, and clinical oncology in primary liver cancer. Jianren Gu is a Professor of molecular oncology at the Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine and Academician of Chinese Academy of Engineering.

Molecular Exploitation of Apoptosis Pathways in Prostate Cancer

Author : Natasha Kyprianou
Publisher : World Scientific
ISBN 13 : 1848164491
Total Pages : 230 pages
Book Rating : 4.8/5 (481 download)

DOWNLOAD NOW!

Book Synopsis Molecular Exploitation of Apoptosis Pathways in Prostate Cancer by : Natasha Kyprianou

Download or read book Molecular Exploitation of Apoptosis Pathways in Prostate Cancer written by Natasha Kyprianou and published by World Scientific. This book was released on 2012 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the functional significance of targeting apoptosis for the treatment of prostate cancer. New concepts on the challenges relating to the development of resistance by androgen-independent tumors are introduced, in terms of the contribution of anoikis and cross-talk of androgens with key growth factor signaling pathways. This volume also provides insightful discussion on the exploitation of the apoptotic and angiogenic synergism towards complete eradication of prostate tumors. Last but not least, it includes reflections on the drug development challenge based on the analysis of data from existing clinical trials.

OECD Series on Testing and Assessment Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors

Download OECD Series on Testing and Assessment Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors PDF Online Free

Author : OECD
Publisher : OECD Publishing
ISBN 13 : 9264221352
Total Pages : 213 pages
Book Rating : 4.2/5 (642 download)

DOWNLOAD NOW!

Book Synopsis OECD Series on Testing and Assessment Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors by : OECD

Download or read book OECD Series on Testing and Assessment Detailed Review Paper on the State of the Science on Novel In Vitro and In Vivo Screening and Testing Methods and Endpoints for Evaluating Endocrine Disruptors written by OECD and published by OECD Publishing. This book was released on 2012-08-21 with total page 213 pages. Available in PDF, EPUB and Kindle. Book excerpt: This paper provides methods for both the mechanistic evaluation of the action of Endocrine Disrupter Chemicals (EDCs).

Clinical Applications of Cytokines

Author : Joost J. Oppenheim
Publisher : Oxford University Press, USA
ISBN 13 : 9780195071290
Total Pages : 406 pages
Book Rating : 4.0/5 (712 download)

DOWNLOAD NOW!

Book Synopsis Clinical Applications of Cytokines by : Joost J. Oppenheim

Download or read book Clinical Applications of Cytokines written by Joost J. Oppenheim and published by Oxford University Press, USA. This book was released on 1993 with total page 406 pages. Available in PDF, EPUB and Kindle. Book excerpt: The driving force for research on cytokines has always been their clinical promise. Their biological properties suggested a key role in hematopoiesis, immunity, tumor genesis, hemostasis, vascularization, repair of connective tissues and integration of the immune system with the neuroendocrine system. Animal studies have shown that cytokines could be used as effective biotherapeutics with easily manageable and reversible toxicities. Clinical trials have confirmed these findings, culminating in the licensing of a number of the cytokines such as interferon alpha, interferon gamma, interleukin 2, erythropoietin, granulocyte colony stimulating factor, and granulocyte-macrophage colony stimulating factor. Many other cytokines are in clinical trials. This is the first comprehensive volume on the cytokines written primarily from a medical perspective. After presenting background information about the structure, production, assays and systemic effects of cytokines and their receptors, it is organized around diseases and organ systems. Infectious diseases, autoimmunity, immunodeficiency states, defective hematopoiesis, allergies, injury repair, cancer, vascular and skin diseases, and neurological disorders are all covered. This work reviews the role that cytokines play in the pathogenesis, diagnosis and therapy of each disease. The authors assess both the current state of the art and the potential for future applications.

Contraceptive Research and Development

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309175658
Total Pages : 534 pages
Book Rating : 4.3/5 (91 download)

DOWNLOAD NOW!

Book Synopsis Contraceptive Research and Development by : Institute of Medicine

Download or read book Contraceptive Research and Development written by Institute of Medicine and published by National Academies Press. This book was released on 1996-11-04 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: The "contraceptive revolution" of the 1960s and 1970s introduced totally new contraceptive options and launched an era of research and product development. Yet by the late 1980s, conditions had changed and improvements in contraceptive products, while very important in relation to improved oral contraceptives, IUDs, implants, and injectables, had become primarily incremental. Is it time for a second contraceptive revolution and how might it happen? Contraceptive Research and Development explores the frontiers of science where the contraceptives of the future are likely to be found and lays out criteria for deciding where to make the next R&D investments. The book comprehensively examines today's contraceptive needs, identifies "niches" in those needs that seem most readily translatable into market terms, and scrutinizes issues that shape the market: method side effects and contraceptive failure, the challenge of HIV/AIDS and other sexually transmitted diseases, and the implications of the "women's agenda." Contraceptive Research and Development analyzes the response of the pharmaceutical industry to current dynamics in regulation, liability, public opinion, and the economics of the health sector and offers an integrated set of recommendations for public- and private-sector action to meet a whole new generation of demand.

Signaling in the Heart

Author : José Marín-García
Publisher : Springer Science & Business Media
ISBN 13 : 1441994610
Total Pages : 511 pages
Book Rating : 4.4/5 (419 download)

DOWNLOAD NOW!

Book Synopsis Signaling in the Heart by : José Marín-García

Download or read book Signaling in the Heart written by José Marín-García and published by Springer Science & Business Media. This book was released on 2011-06-21 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of diverse signaling mechanisms. Alterations in signaling pathways are contributing factors in the development and progression of a broad spectrum of diseases, ranging from dysrhythmias and atherosclerosis to hypertension and the metabolic syndrome. Targeting specific components of these signaling pathways has been shown to be effective in preclinical studies with significant therapeutic impact. This book brings together current knowledge in cardiovascular cell signal transduction mechanisms, advances in novel therapeutic approaches to improve cardiac function, and discussion of future directions. Presented from a post-genomic perspective, this exciting book introduces important new ideas in cardiovascular systems biology. It is an invaluable reference for cardiology researchers and practitioners.

Holland-Frei Cancer Medicine 8

Author : James F. Holland
Publisher : PMPH-USA
ISBN 13 : 9781607950141
Total Pages : 2052 pages
Book Rating : 4.9/5 (51 download)

DOWNLOAD NOW!

Book Synopsis Holland-Frei Cancer Medicine 8 by : James F. Holland

Download or read book Holland-Frei Cancer Medicine 8 written by James F. Holland and published by PMPH-USA. This book was released on 2010 with total page 2052 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland Frei Cancer Medicine serves as a quick reference to current information on an extensive list of cancers, including breast, lung, thyroid, colorectal, ovarian, prostate, and gastric cancer, to name but a few. Presented as an accessible pocket-sized handbook, the chapters are organized in an outline format, offering only the most essential information on the etiology, staging (including TNM staging) and treatment for each cancer type. Individual chapters are devoted to the molecular biology of cancer, cancer prevention, cancer screening, the mechanisms of chemotherapy, and diagnostic imaging in cancer. Additionally, each chapter lists all the major phase III clinical trials, and therefore, serves as an excellent reference of the major randomized controlled trials for each cancer reported to date. Specific chapters are also dedicated to the discussion of oncologic emergencies, pain and palliation, and prescription complications. At the conclusion of the book, a glossary of oncologic terms and chemotherapeutic drug programs, a table of common cancer incidences, and an overview of the mechanisms, common uses, and related toxicities of various anti-cancer agents are featured. In addition, performance status tables, mathematical formulas and a listing of common biomedical / cancer web sites are highlighted.

Encyclopedia of Molecular Pharmacology

Author : Stefan Offermanns
Publisher : Springer Science & Business Media
ISBN 13 : 3540389164
Total Pages : 1515 pages
Book Rating : 4.5/5 (43 download)

DOWNLOAD NOW!

Book Synopsis Encyclopedia of Molecular Pharmacology by : Stefan Offermanns

Download or read book Encyclopedia of Molecular Pharmacology written by Stefan Offermanns and published by Springer Science & Business Media. This book was released on 2008-08-14 with total page 1515 pages. Available in PDF, EPUB and Kindle. Book excerpt: An essential text, this is a fully updated second edition of a classic, now in two volumes. It provides rapid access to information on molecular pharmacology for research scientists, clinicians and advanced students. With the A-Z format of over 2,000 entries, around 350 authors provide a complete reference to the area of molecular pharmacology. The book combines the knowledge of classic pharmacology with the more recent approach of the precise analysis of the molecular mechanisms by which drugs exert their effects. Short keyword entries define common acronyms, terms and phrases. In addition, detailed essays provide in-depth information on drugs, cellular processes, molecular targets, techniques, molecular mechanisms, and general principles.

Cumulated Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 1160 pages
Book Rating : 4.:/5 (31 download)

DOWNLOAD NOW!

Book Synopsis Cumulated Index Medicus by :

Download or read book Cumulated Index Medicus written by and published by . This book was released on 2000 with total page 1160 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Molecular Targeting and Signal Transduction

Author : Rakesh Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1402078471
Total Pages : 331 pages
Book Rating : 4.4/5 (2 download)

DOWNLOAD NOW!

Book Synopsis Molecular Targeting and Signal Transduction by : Rakesh Kumar

Download or read book Molecular Targeting and Signal Transduction written by Rakesh Kumar and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.

Bioorganic Chemistry of Biological Signal Transduction

Author : Herbert Waldmann
Publisher : Springer
ISBN 13 : 3540450351
Total Pages : 230 pages
Book Rating : 4.5/5 (44 download)

DOWNLOAD NOW!

Book Synopsis Bioorganic Chemistry of Biological Signal Transduction by : Herbert Waldmann

Download or read book Bioorganic Chemistry of Biological Signal Transduction written by Herbert Waldmann and published by Springer. This book was released on 2003-07-01 with total page 230 pages. Available in PDF, EPUB and Kindle. Book excerpt: The transduction of signals from the extracellular space across the plasma membrane into the interior of cells and ultimately to the nucleus, where in - sponse to such external signals the transcription of the genetic code is inf- enced, belongs to the most fundamental and important events in the regulation of the life cycle of cells. During recent years several signal transduction cascades have been elucidated which regulate, for instance, the growth and the prolife- tion of organisms as diverse as mammals, flies, worms and yeast. The general picture which emerged from these investigations is that nature employs a c- bination of non-covalent ligand/protein and protein/protein interactions together with a set of covalent protein modifications to generate the signals and transduce them to their destinations. The ligands which are recognized may be low molecular weight compounds like lipids, inositol derivatives, steroids or microbial products like cyclosporin. They may be proteins like, for instance, growth factors or intracellular adaptor proteins which carry SH2 or SH3 domains, and they may be specific DNA stretches which are selectively rec- nized by transcription factors. These and other aspects of biological signal transduction provide an open and rewarding field for investigations by scientists from various different dis- plines of biology, medical research and chemistry working in academic research institutions or in industry.

High Density Lipoproteins

Author : Arnold von Eckardstein
Publisher : Springer
ISBN 13 : 9783319096643
Total Pages : 0 pages
Book Rating : 4.0/5 (966 download)

DOWNLOAD NOW!

Book Synopsis High Density Lipoproteins by : Arnold von Eckardstein

Download or read book High Density Lipoproteins written by Arnold von Eckardstein and published by Springer. This book was released on 2015-01-13 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this Handbook of Experimental Pharmacology on “High Density Lipoproteins – from biological understanding to clinical exploitation” contributing authors (members of COST Action BM0904/HDLnet) summarize in more than 20 chapters our current knowledge on the structure, function, metabolism and regulation of HDL in health and several diseases as well as the status of past and ongoing attempts of therapeutic exploitation. The book is of interest to researchers in academia and industry focusing on lipoprotein metabolism, cardiovascular diseases and immunology as well as clinical pharmacologists, cardiologists, diabetologists, nephrologists and other clinicians interested in metabolic or inflammatory diseases.

Molecular Targeting in Oncology

Author : Howard L. Kaufman
Publisher : Springer Science & Business Media
ISBN 13 : 1597453374
Total Pages : 728 pages
Book Rating : 4.5/5 (974 download)

DOWNLOAD NOW!

Book Synopsis Molecular Targeting in Oncology by : Howard L. Kaufman

Download or read book Molecular Targeting in Oncology written by Howard L. Kaufman and published by Springer Science & Business Media. This book was released on 2007-12-26 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents an overview of the development of targeted therapies for the treatment of cancer with an emphasis on clinical application. The volume covers the complexity of the rapidly developing area of targeted therapies for the treatment of patients with cancer. It is structured in a way so readers may begin with chapters that most interest them and work through the rest of the chapters in the order of their choice.

Index Medicus

Author :
Publisher :
ISBN 13 :
Total Pages : 2036 pages
Book Rating : 4.:/5 (319 download)

DOWNLOAD NOW!

Book Synopsis Index Medicus by :

Download or read book Index Medicus written by and published by . This book was released on 2004 with total page 2036 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vols. for 1963- include as pt. 2 of the Jan. issue: Medical subject headings.

Systems Pharmacology and Pharmacodynamics

Author : Donald E. Mager
Publisher : Springer
ISBN 13 : 3319445340
Total Pages : 511 pages
Book Rating : 4.3/5 (194 download)

DOWNLOAD NOW!

Book Synopsis Systems Pharmacology and Pharmacodynamics by : Donald E. Mager

Download or read book Systems Pharmacology and Pharmacodynamics written by Donald E. Mager and published by Springer. This book was released on 2016-11-29 with total page 511 pages. Available in PDF, EPUB and Kindle. Book excerpt: While systems biology and pharmacodynamics have evolved in parallel, there are significant interrelationships that can enhance drug discovery and enable optimized therapy for each patient. Systems pharmacology is the relatively new discipline that is the interface between these two methods. This book is the first to cover the expertise from systems biology and pharmacodynamics researchers, describing how systems pharmacology may be developed and refined further to show practical applications in drug development. There is a growing awareness that pharmaceutical companies should reduce the high attrition in the pipeline due to insufficient efficacy or toxicity found in proof-of-concept and/or Phase II studies. Systems Pharmacology and Pharmacodynamics discusses the framework for integrating information obtained from understanding physiological/pathological pathways (normal body function system vs. perturbed system due to disease) and pharmacological targets in order to predict clinical efficacy and adverse events through iterations between mathematical modeling and experimentation.

Ibogaine

Author : Geoffrey A. Cordell
Publisher : Gulf Professional Publishing
ISBN 13 : 9780120532063
Total Pages : 364 pages
Book Rating : 4.5/5 (32 download)

DOWNLOAD NOW!

Book Synopsis Ibogaine by : Geoffrey A. Cordell

Download or read book Ibogaine written by Geoffrey A. Cordell and published by Gulf Professional Publishing. This book was released on 2001-09-28 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the Proceedings from the First International Conference on Ibogaines, held in November of 1999 at New York University's School of Medicine. In essence, it presents significant new data on neurobiological, clinical, sociocultural, and policy aspects of ibogaine. Ibogaine is a natural product derived from the bark of the root of the African shrub Tabernathe iboga. It has a history of use as a medicinal and ceremonial agent in West Central Africa, and has been alleged to be effective as a treatment for substance dependence. The study of Ibogaine may shed light on the neurobiology of addiction and lead to the development of new medication for the treatment of addiction. Currently, there is lack of formal approval for the use of ibogaine, and the demand of the addicts themselves has led to a distinctive unofficial network which has provided ibogaine treatment in non-medical settings. If critical safety concerns can be adequately addressed, ibogaine may provide an inexpensive and practical treatment approach, well adapted to environments where resources are severely limited and there is pressing need for clinical services for heroin addicts, such as Eastern Europe. This is a paperback edition of Volume 56 of The Alkaloids (ISBN: 0-12-469556-6) edited by Geoffrey A. Cordell, University of Illinois at Chicago, U.S.A.