Systems Biology In Toxicology And Environmental Health

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Systems Biology in Toxicology and Environmental Health

Author : Rebecca Fry
Publisher : Academic Press
ISBN 13 : 0128015683
Total Pages : 284 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Systems Biology in Toxicology and Environmental Health by : Rebecca Fry

Download or read book Systems Biology in Toxicology and Environmental Health written by Rebecca Fry and published by Academic Press. This book was released on 2015-06-11 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems Biology in Toxicology and Environmental Health uses a systems biological perspective to detail the most recent findings that link environmental exposures to human disease, providing an overview of molecular pathways that are essential for cellular survival after exposure to environmental toxicants, recent findings on gene-environment interactions influencing environmental agent-induced diseases, and the development of computational methods to predict susceptibility to environmental agents. Introductory chapters on molecular and cellular biology, toxicology and computational biology are included as well as an assessment of systems-based tools used to evaluate environmental health risks. Further topics include research on environmental toxicants relevant to human health and disease, various high-throughput technologies and computational methods, along with descriptions of the biological pathways associated with disease and the developmental origins of disease as they relate to environmental contaminants. Systems Biology in Toxicology and Environmental Health is an essential reference for undergraduate students, graduate students, and researchers looking for an introduction in the use of systems biology approaches to assess environmental exposures and their impacts on human health. Provides the first reference of its kind, demonstrating the application of systems biology in environmental health and toxicology Includes introductions to the diverse fields of molecular and cellular biology, toxicology, and computational biology Presents a foundation that helps users understand the connections between the environment and health effects, and the biological mechanisms that link them

A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment

Author : Natàlia Garcia-Reyero
Publisher : Springer
ISBN 13 : 3319660845
Total Pages : 422 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment by : Natàlia Garcia-Reyero

Download or read book A Systems Biology Approach to Advancing Adverse Outcome Pathways for Risk Assessment written by Natàlia Garcia-Reyero and published by Springer. This book was released on 2018-02-24 with total page 422 pages. Available in PDF, EPUB and Kindle. Book excerpt: Social pressure to minimize the use of animal testing, the ever-increasing concern on animal welfare, and the need for more human-relevant and more predictive toxicity tests are some of the drivers for new approaches to chemical screening. This book focuses on The Adverse Outcome Pathway, an analytical construct that describes a sequential chain of causally linked events at different levels of biological organization that lead to an adverse health or ecotoxicological effect. While past efforts have focused on toxicological pathway-based vision for human and ecological health assessment relying on in vitro systems and predictive models, The Adverse Outcome Pathway framework provides a simplified and structured way to organize toxicological information. Within the book, a systems biology approach supplies the tools to infer, link, and quantify the molecular initiating events and the key events and key event relationships leading to adverse outcomes. The advancement of these tools is crucial for the successful implementation of AOPs for regulatory purposes.

Statistics for Environmental Biology and Toxicology

Author : A. John Bailer
Publisher : Routledge
ISBN 13 : 1351414143
Total Pages : 596 pages
Book Rating : 4.3/5 (514 download)

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Book Synopsis Statistics for Environmental Biology and Toxicology by : A. John Bailer

Download or read book Statistics for Environmental Biology and Toxicology written by A. John Bailer and published by Routledge. This book was released on 2020-04-03 with total page 596 pages. Available in PDF, EPUB and Kindle. Book excerpt: Statistics for Environmental Biology and Toxicology presents and illustrates statistical methods appropriate for the analysis of environmental data obtained in biological or toxicological experiments. Beginning with basic probability and statistical inferences, this text progresses through non-linear and generalized linear models, trend testing, time-to-event data and analysis of cross-classified tabular and categorical data. For the more complex analyses, extensive examples including SAS and S-PLUS programming code are provided to assist the reader when implementing the methods in practice.

Environmental Health Perspectives

Author :
Publisher :
ISBN 13 :
Total Pages : 102 pages
Book Rating : 4.:/5 (3 download)

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Book Synopsis Environmental Health Perspectives by :

Download or read book Environmental Health Perspectives written by and published by . This book was released on 1993 with total page 102 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Information Resources in Toxicology

Author : P.J. Bert Hakkinen
Publisher : Academic Press
ISBN 13 : 9780080920030
Total Pages : 1552 pages
Book Rating : 4.9/5 (2 download)

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Book Synopsis Information Resources in Toxicology by : P.J. Bert Hakkinen

Download or read book Information Resources in Toxicology written by P.J. Bert Hakkinen and published by Academic Press. This book was released on 2009-08-19 with total page 1552 pages. Available in PDF, EPUB and Kindle. Book excerpt: This latest version of Information Resources in Toxicology (IRT) continues a tradition established in 1982 with the publication of the first edition in presenting an extensive itemization, review, and commentary on the information infrastructure of the field. This book is a unique wide-ranging, international, annotated bibliography and compendium of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. Thoroughly updated, the current edition analyzes technological changes and is rife with online tools and links to Web sites. IRT-IV is highly structured, providing easy access to its information. Among the “hot topics covered are Disaster Preparedness and Management, Nanotechnology, Omics, the Precautionary Principle, Risk Assessment, and Biological, Chemical and Radioactive Terrorism and Warfare are among the designated. • International in scope, with contributions from over 30 countries • Numerous key references and relevant Web links • Concise narratives about toxicologic sub-disciplines • Valuable appendices such as the IUPAC Glossary of Terms in Toxicology • Authored by experts in their respective sub-disciplines within toxicology

Information Resources in Toxicology, Volume 1: Background, Resources, and Tools

Author : Steve Gilbert
Publisher : Academic Press
ISBN 13 : 0128137258
Total Pages : 1055 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Information Resources in Toxicology, Volume 1: Background, Resources, and Tools by : Steve Gilbert

Download or read book Information Resources in Toxicology, Volume 1: Background, Resources, and Tools written by Steve Gilbert and published by Academic Press. This book was released on 2020-05-16 with total page 1055 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new fifth edition of Information Resources in Toxicology offers a consolidated entry portal for the study, research, and practice of toxicology. Both volumes represents a unique, wide-ranging, curated, international, annotated bibliography, and directory of major resources in toxicology and allied fields such as environmental and occupational health, chemical safety, and risk assessment. The editors and authors are among the leaders of the profession sharing their cumulative wisdom in toxicology’s subdisciplines. This edition keeps pace with the digital world in directing and linking readers to relevant websites and other online tools. Due to the increasing size of the hardcopy publication, the current edition has been divided into two volumes to make it easier to handle and consult. Volume 1: Background, Resources, and Tools, arranged in 5 parts, begins with chapters on the science of toxicology, its history, and informatics framework in Part 1. Part 2 continues with chapters organized by more specific subject such as cancer, clinical toxicology, genetic toxicology, etc. The categorization of chapters by resource format, for example, journals and newsletters, technical reports, organizations constitutes Part 3. Part 4 further considers toxicology’s presence via the Internet, databases, and software tools. Among the miscellaneous topics in the concluding Part 5 are laws and regulations, professional education, grants and funding, and patents. Volume 2: The Global Arena offers contributed chapters focusing on the toxicology contributions of over 40 countries, followed by a glossary of toxicological terms and an appendix of popular quotations related to the field. The book, offered in both print and electronic formats, is carefully structured, indexed, and cross-referenced to enable users to easily find answers to their questions or serendipitously locate useful knowledge they were not originally aware they needed. Among the many timely topics receiving increased emphasis are disaster preparedness, nanotechnology, -omics, risk assessment, societal implications such as ethics and the precautionary principle, climate change, and children’s environmental health. Introductory chapters provide a backdrop to the science of toxicology, its history, the origin and status of toxicoinformatics, and starting points for identifying resources Offers an extensive array of chapters organized by subject, each highlighting resources such as journals, databases,organizations, and review articles Includes chapters with an emphasis on format such as government reports, general interest publications, blogs, and audiovisuals Explores recent internet trends, web-based databases, and software tools in a section on the online environment Concludes with a miscellany of special topics such as laws and regulations, chemical hazard communication resources, careers and professional education, K-12 resources, funding, poison control centers, and patents Paired with Volume Two, which focuses on global resources, this set offers the most comprehensive compendium of print, digital, and organizational resources in the toxicological sciences with over 120 chapters contributions by experts and leaders in the field

Computational Toxicology

Author : Sean Ekins
Publisher : Wiley-Interscience
ISBN 13 : 9780470049624
Total Pages : 0 pages
Book Rating : 4.0/5 (496 download)

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Book Synopsis Computational Toxicology by : Sean Ekins

Download or read book Computational Toxicology written by Sean Ekins and published by Wiley-Interscience. This book was released on 2007-06-29 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive analysis of state-of-the-art molecular modeling approaches and strategies applied to risk assessment for pharmaceutical and environmental chemicals This unique volume describes how the interaction of molecules with toxicologically relevant targets can be predicted using computer-based tools utilizing X-ray crystal structures or homology, receptor, pharmacophore, and quantitative structure activity relationship (QSAR) models of human proteins. It covers the in vitro models used, newer technologies, and regulatory aspects. The book offers a complete systems perspective to risk assessment prediction, discussing experimental and computational approaches in detail, with: * An introduction to toxicology methods and an explanation of computational methods * In-depth reviews of QSAR methods applied to enzymes, transporters, nuclear receptors, and ion channels * Sections on applying computers to toxicology assessment in the pharmaceutical industry and in the environmental arena * Chapters written by leading international experts * Figures that illustrate computational models and references for further information This is a key resource for toxicologists and scientists in the pharmaceutical industry and environmental sciences as well as researchers involved in ADMET, drug discovery, and technology and software development.

Understanding Toxicology

Author : Steven Mercurio
Publisher : Jones & Bartlett Learning
ISBN 13 : 9781284126525
Total Pages : 0 pages
Book Rating : 4.1/5 (265 download)

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Book Synopsis Understanding Toxicology by : Steven Mercurio

Download or read book Understanding Toxicology written by Steven Mercurio and published by Jones & Bartlett Learning. This book was released on 2016-08-19 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Toxicology is a comprehensive study of toxicants and their impact on all levels of biology--from cell, to complex organism, to ecosystem. Unlike other texts of its kind, this text is uniquely structured by biological system, making it easy for readers to understand the impact of toxins on each system. Common mechanisms are explored in the cellular and complex organ system chapters to approach a systems biology perspective that is more applicable to modern computational toxicology risk assessment. Understanding Toxicology begins with three research questions that challenge the reader to discover what information is needed to solve controversies at the level of the cell, the complex organism, and the ecosystem. The book continues with a cellular, complex organism, and ecosystem analysis of toxicology principles including risk assessment. The cellular section follows common mechanisms from the outside to the inside of cells and individual organelles. A forensic approach analyzes complex organisms from outside to inside. The ecosystem section starts with a dispersion approach to determine environmental concentration and addresses toxicants in divisions similar to how the EPA determines impacts. Key Features • Uses lively, engaging examples making the text fun and easy to read and understand • Allows the reader to approach the subject from a research perspective as well as a public policy perspective • Covers biological toxicants including venoms, poisons, as well as microbial and fungal toxins, and plant toxins • Thoroughly covers all organisms including fish, plants, and microbes • Includes outlines and review questions in each chapter

Toxicity Testing in the 21st Century

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309151732
Total Pages : 217 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Toxicity Testing in the 21st Century by : National Research Council

Download or read book Toxicity Testing in the 21st Century written by National Research Council and published by National Academies Press. This book was released on 2007-11-05 with total page 217 pages. Available in PDF, EPUB and Kindle. Book excerpt: Advances in molecular biology and toxicology are paving the way for major improvements in the evaluation of the hazards posed by the large number of chemicals found at low levels in the environment. The National Research Council was asked by the U.S. Environmental Protection Agency to review the state of the science and create a far-reaching vision for the future of toxicity testing. The book finds that developing, improving, and validating new laboratory tools based on recent scientific advances could significantly improve our ability to understand the hazards and risks posed by chemicals. This new knowledge would lead to much more informed environmental regulations and dramatically reduce the need for animal testing because the new tests would be based on human cells and cell components. Substantial scientific efforts and resources will be required to leverage these new technologies to realize the vision, but the result will be a more efficient, informative and less costly system for assessing the hazards posed by industrial chemicals and pesticides.

Toxicology and Human Environments

Author : Ernest Hodgson
Publisher : Academic Press
ISBN 13 : 0124158137
Total Pages : 452 pages
Book Rating : 4.1/5 (241 download)

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Book Synopsis Toxicology and Human Environments by : Ernest Hodgson

Download or read book Toxicology and Human Environments written by Ernest Hodgson and published by Academic Press. This book was released on 2012-09-28 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Environmental toxicology is generally held to be the study of the potential of constituents of outdoor environments to impact either human health or the biological structure of the ecosystems involved. This volume is a first attempt to integrate toxicological studies of all of the many human environments, both indoor and outdoor, and their complex interrelationships. Included are considerations of natural environments, the agroecosystem, occupational, urban and domestic environments as well as the environment associated with Superfund sites and military deployments. The primary emphasis is on public health, including the potential health effects of toxicants found in different environments, the bioprocessing of such toxicants in humans and surrogate animals and the principles of risk analysis. Approaches the toxicology of human environments in a new and unique way, stressing the complex interrelationships of all human environments and the implication for human and environmental health Each chapter is written by an acknowledged expert and is addressed to those interested in the broader implications of the environmental modifications that are always associated with the activities of humans living and working in them

Hormesis

Author : Mark P. Mattson
Publisher : Springer Science & Business Media
ISBN 13 : 1607614952
Total Pages : 219 pages
Book Rating : 4.6/5 (76 download)

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Book Synopsis Hormesis by : Mark P. Mattson

Download or read book Hormesis written by Mark P. Mattson and published by Springer Science & Business Media. This book was released on 2009-12-01 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hormesis is a poorly understood phenomenon affecting all forms of life on earth. This groundbreaking book summarizes and analyzes the various positives of hormesis in an attempt to reveal hormesis as a fundamental principle of biomedical sciences as a whole.

Computational Methods for Reproductive and Developmental Toxicology

Author : Donald R. Mattison
Publisher : CRC Press
ISBN 13 : 1439861080
Total Pages : 330 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Computational Methods for Reproductive and Developmental Toxicology by : Donald R. Mattison

Download or read book Computational Methods for Reproductive and Developmental Toxicology written by Donald R. Mattison and published by CRC Press. This book was released on 2015-12-02 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building from the perspective of reproductive and developmental biology, Computational Methods for Reproductive and Developmental Toxicology provides a timely and comprehensive overview of approaches in reproductive and developmental toxicology. The book, which is part of the QSAR in Environmental and Health Sciences series, is divided into three broad sections. The first provides a review of methods and approaches to meet the need for safety assessments in product development and regulatory approaches for environmental chemicals. The next one reviews the biological processes and endpoints involved in reproduction and development. The final and largest section summarizes protocols for evaluating biological processes and endpoints within reproduction and development. It also discusses informatics resources and computational methods. The book takes a cross-disciplinary approach bringing together developmental, reproductive and systems biology, chemistry, toxicology, pharmacology, biostatistics, information sciences, bioinformatics, and computational approaches. This valuable resource provides those in the field with the necessary knowledge to evaluate both classic and recent approaches to characterize toxicity.

Opportunities for Environmental Applications of Marine Biotechnology

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171466
Total Pages : 186 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Opportunities for Environmental Applications of Marine Biotechnology by : National Research Council

Download or read book Opportunities for Environmental Applications of Marine Biotechnology written by National Research Council and published by National Academies Press. This book was released on 2000-10-30 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 2-day workshop is the culmination of a study of the status and future of marine biotechnology. The overall goal of this workshop is to examine what was initially called "Opportunities for Marine Biotechnology in the United States," to consider where we are now in this field of "Environmental Marine Biotechnology," to envision the field in the future, and to discuss any impediments that might be encountered along the way. Opportunities for Environmental Applications of Marine Biotechnology: Proceedings of the October 5-6, 1999, Workshop addresses the question of where the federal government should invest its limited funds and what future initiatives should be planned.

Green Toxicology

Author : Alexandra Maertens
Publisher : Royal Society of Chemistry
ISBN 13 : 1839164409
Total Pages : 307 pages
Book Rating : 4.8/5 (391 download)

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Book Synopsis Green Toxicology by : Alexandra Maertens

Download or read book Green Toxicology written by Alexandra Maertens and published by Royal Society of Chemistry. This book was released on 2022-02-01 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: Green toxicology is an integral part of green chemistry. One of the key goals of green chemistry is to design less toxic chemicals. Therefore, an understanding of toxicology and hazard assessment is important for any chemist working in green chemistry, but toxicology is rarely part of most chemists' education. As a consequence, chemists lack the toxicological lens necessary to view chemicals in order to design safer substitutions. This book seeks to fill that gap and demonstrate how a basic understanding of toxicology, as well as the tools of in silico and in vitro toxicology, can be an integral part of green chemistry. R&D chemists, product stewards, and toxicologists who work in the field of sustainability, can all benefit from integrating green toxicology principles into their work. Topics include in silico tools for hazard assessment, toxicity testing, and lifecycle considerations, this book aims to act as a bridge between green toxicologists and green chemists.

Systems Biology: A Very Short Introduction

Author : Eberhard O. Voit
Publisher : Oxford University Press
ISBN 13 : 0192563459
Total Pages : 161 pages
Book Rating : 4.1/5 (925 download)

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Book Synopsis Systems Biology: A Very Short Introduction by : Eberhard O. Voit

Download or read book Systems Biology: A Very Short Introduction written by Eberhard O. Voit and published by Oxford University Press. This book was released on 2020-03-26 with total page 161 pages. Available in PDF, EPUB and Kindle. Book excerpt: Systems biology came about as growing numbers of engineers and scientists from other fields created algorithms which supported the analysis of biological data in incredible quantities. Whereas biologists of the past had been forced to study one item or aspect at a time, due to technical and biological limitations, it suddenly became possible to study biological phenomena within their natural contexts. This interdisciplinary field offers a holistic approach to interpreting these processes, and has been responsible for some of the most important developments in the science of human health and environmental sustainability. This Very Short Introduction outlines the exciting processes and possibilities in the new field of systems biology. Eberhard O. Voit describes how it enabled us to learn how intricately the expression of every gene is controlled, how signaling systems keep organisms running smoothly, and how complicated even the simplest cells are. He explores what this field is about, why it is needed, and how it will affect our understanding of life, particularly in the areas of personalized medicine, drug development, food and energy production, and sustainable stewardship of our environments. Throughout he considers how new tools are being provided from the fields of mathematics, computer science, engineering, physics, and chemistry to grasp the complexity of the countless interacting processes in cells which would overwhelm the cognitive and analytical capabilities of the human mind. ABOUT THE SERIES: The Very Short Introductions series from Oxford University Press contains hundreds of titles in almost every subject area. These pocket-sized books are the perfect way to get ahead in a new subject quickly. Our expert authors combine facts, analysis, perspective, new ideas, and enthusiasm to make interesting and challenging topics highly readable.

Computational Toxicology

Author : Bruce A. Fowler
Publisher : Academic Press
ISBN 13 : 012396508X
Total Pages : 274 pages
Book Rating : 4.1/5 (239 download)

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Book Synopsis Computational Toxicology by : Bruce A. Fowler

Download or read book Computational Toxicology written by Bruce A. Fowler and published by Academic Press. This book was released on 2013-06-04 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. The examples provided in this book are based on cutting-edge technologies and set out to stimulate the further development of this promising field to offer rapid, better and more cost-effective answers to major public health concerns. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared

Oxford Textbook of Global Public Health

Author : Roger Detels
Publisher : Oxford University Press
ISBN 13 : 019881013X
Total Pages : 1717 pages
Book Rating : 4.1/5 (988 download)

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Book Synopsis Oxford Textbook of Global Public Health by : Roger Detels

Download or read book Oxford Textbook of Global Public Health written by Roger Detels and published by Oxford University Press. This book was released on 2017 with total page 1717 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sixth edition of the hugely successful, internationally recognised textbook on global public health and epidemiology, with 3 volumes comprehensively covering the scope, methods, and practice of the discipline