Synthetic Biology A Primer Revised Edition

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Synthetic Biology - a Primer (revised Edition)

Author : Paul S. FREEMONT
Publisher : World Scientific
ISBN 13 : 1783268808
Total Pages : 194 pages
Book Rating : 4.7/5 (832 download)

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Book Synopsis Synthetic Biology - a Primer (revised Edition) by : Paul S. FREEMONT

Download or read book Synthetic Biology - a Primer (revised Edition) written by Paul S. FREEMONT and published by World Scientific. This book was released on 2015-08-24 with total page 194 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic Biology -- A Primer (Revised Edition) presents an updated overview of the field of synthetic biology and the foundational concepts on which it is built. This revised edition includes new literature references, working and updated URL links, plus some new figures and text where progress in the field has been made.The book introduces readers to fundamental concepts in molecular biology and engineering and then explores the two major themes for synthetic biology, namely 'bottom-up' and 'top-down' engineering approaches. 'Top-down' engineering uses a conceptual framework of systematic design and engineering principles focused around the Design-Build-Test cycle and mathematical modelling. The 'bottom-up' approach involves the design and building of synthetic protocells using basic chemical and biochemical building blocks from scratch exploring the fundamental basis of living systems.Examples of cutting-edge applications designed using synthetic biology principles are presented, including: The book also describes the Internationally Genetically Engineered Machine (iGEM) competition, which brings together students and young researchers from around the world to carry out summer projects in synthetic biology. Finally, the primer includes a chapter on the ethical, legal and societal issues surrounding synthetic biology, illustrating the integration of social sciences into synthetic biology research.Final year undergraduates, postgraduates and established researchers interested in learning about the interdisciplinary field of synthetic biology will benefit from this up-to-date primer on synthetic biology.

Regenesis

Author : George M Church
Publisher : Basic Books
ISBN 13 : 0465038654
Total Pages : 305 pages
Book Rating : 4.4/5 (65 download)

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Book Synopsis Regenesis by : George M Church

Download or read book Regenesis written by George M Church and published by Basic Books. This book was released on 2014-04-08 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: A Harvard biologist and master inventor explores how new biotechnologies will enable us to bring species back from the dead, unlock vast supplies of renewable energy, and extend human life. In Regenesis, George Church and science writer Ed Regis explore the possibilities of the emerging field of synthetic biology. Synthetic biology, in which living organisms are selectively altered by modifying substantial portions of their genomes, allows for the creation of entirely new species of organisms. These technologies-far from the out-of-control nightmare depicted in science fiction-have the power to improve human and animal health, increase our intelligence, enhance our memory, and even extend our life span. A breathtaking look at the potential of this world-changing technology, Regenesis is nothing less than a guide to the future of life.

Synthetic Biology

Author : Gigi Gronvall
Publisher : Createspace Independent Publishing Platform
ISBN 13 : 9781539336839
Total Pages : 198 pages
Book Rating : 4.3/5 (368 download)

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Book Synopsis Synthetic Biology by : Gigi Gronvall

Download or read book Synthetic Biology written by Gigi Gronvall and published by Createspace Independent Publishing Platform. This book was released on 2016-10-08 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology aims to make biology easier to engineer and to program. Thanks to advances in computing power, the ability to make long tracts of DNA, new tools like CRISPR that can be used to edit genomes, and the enthusiasm of young scientists and even amateurs who want to enter the field, synthetic biology is poised to change the future of medicine, agriculture, and manufacturing. Yet, while this new field promises vast opportunities and benefits, there are also risks. There are biosecurity risks that these technologies will be deliberately used for harm; safety risks to people and the environment; ethical and social considerations for how to apply these technologies; and there are risks to the competitiveness of nations that do not invest in these technologies that are likely to spur economic growth. This volume is dedicated to a discussion of what can be done to minimize risks and maximize the benefits of synthetic biology. Praise for Synthetic Biology: Safety, Security, and Promise "There can be no doubt that advances in the life sciences, including new insights and tools provided by synthetic biology, place us in a position to create exciting and novel products and approaches for patients in need. Gigi Gronvall describes that promise but also lays forth critical policy concerns that need to be addressed so that we don't risk safety, security, or the competitiveness of US science." - Margaret Hamburg, MD, Former FDA Commissioner and Foreign Secretary, National Academy of Medicine "Synthetic biology gives us tools that can help tackle global problems that affect humanity-but for that to happen, the risks of bioterror or bio-error need to be dealt with and managed, as well. Gronvall clearly describes the policy challenges that must be addressed and concludes with steps to enhance US leadership and competitiveness in the global bio-economy." - J. Craig Venter, PhD, founder, chairman, and CEO of the J. Craig Venter Institute and co-founder, executive chairman and co-chief scientist of Synthetic Genomics, Inc. "For those of us working in the lab, it is important to embrace conversations with those who aren't - including strategies for biological security, to create new synthetic biology products - with respect for facts about GMO risk/benefit balances, creating a culture of safe lab practices and norms worldwide. Gigi Gronvall dissects such issues at stake in synthetic biology and presents a pragmatic and scientifically responsive path forward for anyone in a position to influence, regulate, decide upon, or benefit from the science to follow." - George Church, PhD, Professor of Genetics Harvard Medical School and Director of PersonalGenomes.org "Synthetic biology presents some of the greatest challenges and opportunities of the 21st Century. Gigi Gronvall navigates a path to follow, to make sure risks are addressed and opportunities are not squandered. It should be read by all concerned about national security." - The Honorable Andrew Weber, head of global partnerships for Metabiota and former Assistant Secretary of Defense for Nuclear, Chemical, and Biological Defense Programs

BioBuilder

Author : Natalie Kuldell PhD.
Publisher : "O'Reilly Media, Inc."
ISBN 13 : 1491907533
Total Pages : 238 pages
Book Rating : 4.4/5 (919 download)

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Book Synopsis BioBuilder by : Natalie Kuldell PhD.

Download or read book BioBuilder written by Natalie Kuldell PhD. and published by "O'Reilly Media, Inc.". This book was released on 2015-06-22 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Today’s synthetic biologists are in the early stages of engineering living cells to help treat diseases, sense toxic compounds in the environment, and produce valuable drugs. With this manual, you can be part of it. Based on the BioBuilder curriculum, this valuable book provides open-access, modular, hands-on lessons in synthetic biology for secondary and post-secondary classrooms and laboratories. It also serves as an introduction to the field for science and engineering enthusiasts. Developed at MIT in collaboration with award-winning high school teachers, BioBuilder teaches the foundational ideas of the emerging synthetic biology field, as well as key aspects of biological engineering that researchers are exploring in labs throughout the world. These lessons will empower teachers and students to explore and be part of solving persistent real-world challenges. Learn the fundamentals of biodesign and DNA engineering Explore important ethical issues raised by examples of synthetic biology Investigate the BioBuilder labs that probe the design-build-test cycle Test synthetic living systems designed and built by engineers Measure several variants of an enzyme-generating genetic circuit Model "bacterial photography" that changes a strain’s light sensitivity Build living systems to produce purple or green pigment Optimize baker’s yeast to produce ?-carotene

Synthetic Biology

Author : R. I. Kitney
Publisher :
ISBN 13 : 9781848168640
Total Pages : 179 pages
Book Rating : 4.1/5 (686 download)

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Book Synopsis Synthetic Biology by : R. I. Kitney

Download or read book Synthetic Biology written by R. I. Kitney and published by . This book was released on 2012 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'Synthetic Biology' provides a broad overview of the emerging field of synthetic biology and the foundational concepts on which it is built. It will be of interest to final year undergraduates, postgraduates and established researchers who are interested in learning about this new field.

An Introduction to Systems Biology

Author : Uri Alon
Publisher : CRC Press
ISBN 13 : 1584886420
Total Pages : 324 pages
Book Rating : 4.5/5 (848 download)

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Book Synopsis An Introduction to Systems Biology by : Uri Alon

Download or read book An Introduction to Systems Biology written by Uri Alon and published by CRC Press. This book was released on 2006-07-07 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Thorough and accessible, this book presents the design principles of biological systems, and highlights the recurring circuit elements that make up biological networks. It provides a simple mathematical framework which can be used to understand and even design biological circuits. The textavoids specialist terms, focusing instead on several well-studied biological systems that concisely demonstrate key principles. An Introduction to Systems Biology: Design Principles of Biological Circuits builds a solid foundation for the intuitive understanding of general principles. It encourages the reader to ask why a system is designed in a particular way and then proceeds to answer with simplified models.

Biology Is Technology

Author : Robert H. Carlson
Publisher : Harvard University Press
ISBN 13 : 0674053621
Total Pages : 290 pages
Book Rating : 4.6/5 (74 download)

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Book Synopsis Biology Is Technology by : Robert H. Carlson

Download or read book Biology Is Technology written by Robert H. Carlson and published by Harvard University Press. This book was released on 2011-04-15 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Essential reading for anyone who wishes to understand the current state of biotechnology and the opportunities and dangers it may create.” —American Scientist Technology is a process and a body of knowledge as much as a collection of artifacts. Biology is no different—and we are just beginning to comprehend the challenges inherent in the next stage of biology as a human technology. It is this critical moment, with its wide-ranging implications, that Robert Carlson considers in Biology Is Technology. He offers a uniquely informed perspective on the endeavors that contribute to current progress in this area—the science of biological systems and the technology used to manipulate them. In a number of case studies, Carlson demonstrates that the development of new mathematical, computational, and laboratory tools will facilitate the engineering of biological artifacts—up to and including organisms and ecosystems. Exploring how this will happen, with reference to past technological advances, he explains how objects are constructed virtually, tested using sophisticated mathematical models, and finally constructed in the real world. Such rapid increases in the power, availability, and application of biotechnology raise obvious questions about who gets to use it, and to what end. Carlson’s thoughtful analysis offers rare insight into our choices about how to develop biological technologies and how these choices will determine the pace and effectiveness of innovation as a public good.

Bioinformatics and Computational Biology

Author : Basant K. Tiwary
Publisher : Springer Nature
ISBN 13 : 9811642419
Total Pages : 239 pages
Book Rating : 4.8/5 (116 download)

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Book Synopsis Bioinformatics and Computational Biology by : Basant K. Tiwary

Download or read book Bioinformatics and Computational Biology written by Basant K. Tiwary and published by Springer Nature. This book was released on 2021-11-23 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook introduces fundamental concepts of bioinformatics and computational biology to the students and researchers in biology, medicine, veterinary science, agriculture, and bioengineering . The respective chapters provide detailed information on biological databases, sequence alignment, molecular evolution, next-generation sequencing, systems biology, and statistical computing using R. The book also presents a case-based discussion on clinical, veterinary, agricultural bioinformatics, and computational bioengineering for application-based learning in the respective fields. Further, it offers readers guidance on reconstructing and analysing biological networks and highlights computational methods used in systems medicine and genome-wide association mapping of diseases. Given its scope, this textbook offers an essential introductory book on bioinformatics and computational biology for undergraduate and graduate students in the life sciences, botany, zoology, physiology, biotechnology, bioinformatics, and genomic science as well as systems biology, bioengineering and the agricultural, and veterinary sciences.

Strange Natures

Author : Kent H. Redford
Publisher : Yale University Press
ISBN 13 : 0300230974
Total Pages : 296 pages
Book Rating : 4.3/5 (2 download)

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Book Synopsis Strange Natures by : Kent H. Redford

Download or read book Strange Natures written by Kent H. Redford and published by Yale University Press. This book was released on 2021-06-22 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: A groundbreaking examination of the implications of synthetic biology for biodiversity conservation Nature almost everywhere survives on human terms. The distinction between what is natural and what is human-made, which has informed conservation for centuries, has become blurred. When scientists can reshape genes more or less at will, what does it mean to conserve nature? The tools of synthetic biology are changing the way we answer that question. Gene editing technology is already transforming the agriculture and biotechnology industries. What happens if synthetic biology is also used in conservation to control invasive species, fight wildlife disease, or even bring extinct species back from the dead? Conservation scientist Kent Redford and geographer Bill Adams turn to synthetic biology, ecological restoration, political ecology, and de-extinction studies and propose a thoroughly innovative vision for protecting nature.

Systems Biology

Author : Edda Klipp
Publisher : John Wiley & Sons
ISBN 13 : 3527675663
Total Pages : 504 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Systems Biology by : Edda Klipp

Download or read book Systems Biology written by Edda Klipp and published by John Wiley & Sons. This book was released on 2016-03-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: This advanced textbook is tailored for an introductory course in Systems Biology and is well-suited for biologists as well as engineers and computer scientists. It comes with student-friendly reading lists and a companion website featuring a short exam prep version of the book and educational modeling programs. The text is written in an easily accessible style and includes numerous worked examples and study questions in each chapter. For this edition, a section on medical systems biology has been included.

Synthetic Biology

Author : Madan L. Nagpal
Publisher : BoD – Books on Demand
ISBN 13 : 1789840899
Total Pages : 208 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Synthetic Biology by : Madan L. Nagpal

Download or read book Synthetic Biology written by Madan L. Nagpal and published by BoD – Books on Demand. This book was released on 2020-02-12 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthetic biology gives us a new hope because it combines various disciplines, such as genetics, chemistry, biology, molecular sciences, and other disciplines, and gives rise to a novel interdisciplinary science. We can foresee the creation of the new world of vegetation, animals, and humans with the interdisciplinary system of biological sciences. These articles are contributed by renowned experts in their fields. The field of synthetic biology is growing exponentially and opening up new avenues in multidisciplinary approaches by bringing together theoretical and applied aspects of science.

Biopunk

Author : Marcus Wohlsen
Publisher : Penguin
ISBN 13 : 1617230073
Total Pages : 274 pages
Book Rating : 4.6/5 (172 download)

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Book Synopsis Biopunk by : Marcus Wohlsen

Download or read book Biopunk written by Marcus Wohlsen and published by Penguin. This book was released on 2012-07-31 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bill Gates recently told Wired that if he were a teenager today, he would be hacking biology. "If you want to change the world in some big way," he says, "that's where you should start-biological molecules." The most disruptive force on the planet resides in DNA. Biotech companies and academic researchers are just beginning to unlock the potential of piecing together life from scratch. Champions of synthetic biology believe that turning genetic code into Lego-like blocks to build never-before-seen organisms could solve the thorniest challenges in medicine, energy, and environmental protection. But as the hackers who cracked open the potential of the personal computer and the Internet proved, the most revolutionary discoveries often emerge from out-of-the-way places, forged by brilliant outsiders with few resources besides boundless energy and great ideas. In Biopunk, Marcus Wohlsen chronicles a growing community of DIY scientists working outside the walls of corporations and universities who are committed to democratizing DNA the way the Internet did information. The "biohacking" movement, now in its early, heady days, aims to unleash an outbreak of genetically modified innovation by making the tools and techniques of biotechnology accessible to everyone. Borrowing their idealism from the worlds of open-source software, artisinal food, Internet startups, and the Peace Corps, biopunks are devoted advocates for open-sourcing the basic code of life. They believe in the power of individuals with access to DNA to solve the world's biggest problems. You'll meet a new breed of hackers who aren't afraid to get their hands wet, from entrepreneurs who aim to bring DNA-based medical tools to the poorest of the poor to a curious tinkerer who believes a tub of yogurt and a jellyfish gene could protect the world's food supply. These biohackers include: -A duo who started a cancer drug company in their kitchen -A team who built an open-source DNA copy machine -A woman who developed a genetic test in her apartment for a deadly disease that had stricken her family Along with the potential of citizen science to bring about disruptive change, Wohlsen explores the risks of DIY bioterrorism, the possibility of genetic engineering experiments gone awry, and whether the ability to design life from scratch on a laptop might come sooner than we think.

Fundamentals of Systems Biology

Author : Markus W. Covert
Publisher : CRC Press
ISBN 13 : 1498728472
Total Pages : 367 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Fundamentals of Systems Biology by : Markus W. Covert

Download or read book Fundamentals of Systems Biology written by Markus W. Covert and published by CRC Press. This book was released on 2017-10-19 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: For decades biology has focused on decoding cellular processes one gene at a time, but many of the most pressing biological questions, as well as diseases such as cancer and heart disease, are related to complex systems involving the interaction of hundreds, or even thousands, of gene products and other factors. How do we begin to understand this complexity? Fundamentals of Systems Biology: From Synthetic Circuits to Whole-cell Models introduces students to methods they can use to tackle complex systems head-on, carefully walking them through studies that comprise the foundation and frontier of systems biology. The first section of the book focuses on bringing students quickly up to speed with a variety of modeling methods in the context of a synthetic biological circuit. This innovative approach builds intuition about the strengths and weaknesses of each method and becomes critical in the book’s second half, where much more complicated network models are addressed—including transcriptional, signaling, metabolic, and even integrated multi-network models. The approach makes the work much more accessible to novices (undergraduates, medical students, and biologists new to mathematical modeling) while still having much to offer experienced modelers--whether their interests are microbes, organs, whole organisms, diseases, synthetic biology, or just about any field that investigates living systems.

Calculations for Molecular Biology and Biotechnology

Author : Frank H. Stephenson
Publisher : Academic Press
ISBN 13 : 9780123756916
Total Pages : 460 pages
Book Rating : 4.7/5 (569 download)

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Book Synopsis Calculations for Molecular Biology and Biotechnology by : Frank H. Stephenson

Download or read book Calculations for Molecular Biology and Biotechnology written by Frank H. Stephenson and published by Academic Press. This book was released on 2010-07-30 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: Calculations for Molecular Biology and Biotechnology: A Guide to Mathematics in the Laboratory, Second Edition, provides an introduction to the myriad of laboratory calculations used in molecular biology and biotechnology. The book begins by discussing the use of scientific notation and metric prefixes, which require the use of exponents and an understanding of significant digits. It explains the mathematics involved in making solutions; the characteristics of cell growth; the multiplicity of infection; and the quantification of nucleic acids. It includes chapters that deal with the mathematics involved in the use of radioisotopes in nucleic acid research; the synthesis of oligonucleotides; the polymerase chain reaction (PCR) method; and the development of recombinant DNA technology. Protein quantification and the assessment of protein activity are also discussed, along with the centrifugation method and applications of PCR in forensics and paternity testing. Topics range from basic scientific notations to complex subjects like nucleic acid chemistry and recombinant DNA technology Each chapter includes a brief explanation of the concept and covers necessary definitions, theory and rationale for each type of calculation Recent applications of the procedures and computations in clinical, academic, industrial and basic research laboratories are cited throughout the text New to this Edition: Updated and increased coverage of real time PCR and the mathematics used to measure gene expression More sample problems in every chapter for readers to practice concepts

Zero to Genetic Engineering Hero

Author : Justin Pahara
Publisher : Maker Media, Inc.
ISBN 13 : 1680457675
Total Pages : 336 pages
Book Rating : 4.6/5 (84 download)

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Book Synopsis Zero to Genetic Engineering Hero by : Justin Pahara

Download or read book Zero to Genetic Engineering Hero written by Justin Pahara and published by Maker Media, Inc.. This book was released on 2021-08-19 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: Zero to Genetic Engineering Hero is made to provide you with a first glimpse of the inner-workings of a cell. It further focuses on skill-building for genetic engineering and the Biology-as-a-Technology mindset (BAAT). This book is designed and written for hands-on learners who have little knowledge of biology or genetic engineering. This book focuses on the reader mastering the necessary skills of genetic engineering while learning about cells and how they function. The goal of this book is to take you from no prior biology and genetic engineering knowledge toward a basic understanding of how a cell functions, and how they are engineered, all while building the skills needed to do so.

Synthetic Biology

Author : Jim Haseloff
Publisher :
ISBN 13 : 9780854037636
Total Pages : 176 pages
Book Rating : 4.0/5 (376 download)

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Book Synopsis Synthetic Biology by : Jim Haseloff

Download or read book Synthetic Biology written by Jim Haseloff and published by . This book was released on 2009 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Quantitative Fundamentals of Molecular and Cellular Bioengineering

Author : K. Dane Wittrup
Publisher : MIT Press
ISBN 13 : 0262042657
Total Pages : 593 pages
Book Rating : 4.2/5 (62 download)

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Book Synopsis Quantitative Fundamentals of Molecular and Cellular Bioengineering by : K. Dane Wittrup

Download or read book Quantitative Fundamentals of Molecular and Cellular Bioengineering written by K. Dane Wittrup and published by MIT Press. This book was released on 2020-01-07 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive presentation of essential topics for biological engineers, focusing on the development and application of dynamic models of biomolecular and cellular phenomena. This book describes the fundamental molecular and cellular events responsible for biological function, develops models to study biomolecular and cellular phenomena, and shows, with examples, how models are applied in the design and interpretation of experiments on biological systems. Integrating molecular cell biology with quantitative engineering analysis and design, it is the first textbook to offer a comprehensive presentation of these essential topics for chemical and biological engineering. The book systematically develops the concepts necessary to understand and study complex biological phenomena, moving from the simplest elements at the smallest scale and progressively adding complexity at the cellular organizational level, focusing on experimental testing of mechanistic hypotheses. After introducing the motivations for formulation of mathematical rate process models in biology, the text goes on to cover such topics as noncovalent binding interactions; quantitative descriptions of the transient, steady state, and equilibrium interactions of proteins and their ligands; enzyme kinetics; gene expression and protein trafficking; network dynamics; quantitative descriptions of growth dynamics; coupled transport and reaction; and discrete stochastic processes. The textbook is intended for advanced undergraduate and graduate courses in chemical engineering and bioengineering, and has been developed by the authors for classes they teach at MIT and the University of Minnesota.