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Synthesis Spectroscopic And Theoretical Studies Of Ruthenium Complexes Containing Nitrosoarene Pyridine Hybrid Ligands
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Book Synopsis Synthesis, Spectroscopic and Theoretical Studies of Ruthenium Complexes Containing Nitrosoarene-pyridine Hybrid Ligands by :
Download or read book Synthesis, Spectroscopic and Theoretical Studies of Ruthenium Complexes Containing Nitrosoarene-pyridine Hybrid Ligands written by and published by . This book was released on 2013 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds by : Michał Pawel Łomzik
Download or read book Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds written by Michał Pawel Łomzik and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main goal of this thesis was synthesis and preliminary characterization of novel ruthenium(II) polypyridyl complexes bearing biologically active molecules as potential theranostic agents. Luminescence for the diagnostic applications, and cytotoxicity for the anticancer, therapeutic applications are considered as the theranostic properties. Four new ligands containing biologically active moieties - 5-(4-4'-methyl-[2,2'-bipyridine]-4-ylbut-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (L1), 3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L2), 5,5-dimethyl-3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L3) and [1-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)-2,5-dioxoimidazolidin-4-yl]urea (L4) were synthesized and characterized. The ligands were used to obtain nine novel ruthenium(II) polypyridyl complexes. Six complexes were synthesized with ligand L1 ([Ru(bpy)2(L1)]2+, [Ru(Mebpy)2(L1)]2+, [Ru(tBubpy)2(L1)]2+, [Ru(Phbpy)2(L1)]2+, [Ru(dip)2(L1)]2+, [Ru(SO3dip)2(L1)]2-) and three with ligands L2, L3 and L4 ([Ru(bpy)2(L2)]2+, [Ru(bpy)2(L3)]2+, [Ru(bpy)2(L4)]2+) (bpy = 2,2'-bipyridine, Mebpy = 4,4'-dimethyl-2,2-bipyridine, tBubpy = 4,4'-tert-butyl-2,2'-bipyridine, Phbpy = 4,4'-diphenyl-2,2-bipyridine, dip = 4,7-diphenyl-1,10-phenantroline and SO3dip = 4,7-di-(4-sulfonatophenyl)-1,10-phenantroline). The spectroscopic and photophysical properties of those complexes were determined. The presence of ligands L1-L4 in the structure of the complex decreased luminescence quantum yield and luminescence lifetime in comparison with unmodified [Ru(bpy)3]2+ complex. The theoretical calculations have shown that ligands L1-L4 do not have influence on ruthenium core geometry. However, they increased the energy of the HOMO that resulted in a shorter band gap. The simulated electronic absorption spectra were in a good agreement with the experimental data. The interactions between the studied ruthenium complexes and human serum albumin (HSA) were investigated. All studied Ru(II) complexes exhibited strong affinity to HSA with the association constant 105 M-1s-1, which suggests formation of Ru complex-HSA adducts. It was also determined that ruthenium complexes most likely bind to the hydrophobic pocket of protein, located in Sudlow's site I in the subdomain II A. Preliminary cytotoxicity evaluation for the studied ruthenium complexes showed their cytotoxic activity towards cancer cell lines. Those results, together with good luminescence properties of the studied ruthenium complexes (luminescence lifetimes and luminescence quantum yield) make them interesting candidates for potential theranostic applications.
Book Synopsis Ruthenium Chemistry by : Ajay Kumar Mishra
Download or read book Ruthenium Chemistry written by Ajay Kumar Mishra and published by CRC Press. This book was released on 2018-01-17 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.
Book Synopsis The Synthesis, Spectroscopic and Electrochemical Characterisation of Ruthenium(II) and Osmium(II) Polypyridyl Complexes Containing Aryl-bridged 1,2,4-traizole Ligands by : Frances Weldon
Download or read book The Synthesis, Spectroscopic and Electrochemical Characterisation of Ruthenium(II) and Osmium(II) Polypyridyl Complexes Containing Aryl-bridged 1,2,4-traizole Ligands written by Frances Weldon and published by . This book was released on 1998 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Characterization of Some New Polypyridine Ruthenium (II) Complexes Containing S-bonded Thioether Ligands by : Rudi Kroener
Download or read book Synthesis and Characterization of Some New Polypyridine Ruthenium (II) Complexes Containing S-bonded Thioether Ligands written by Rudi Kroener and published by . This book was released on 1984 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Photophysical Studies of Ruthenium (II) Complexes Containing the Ligand 1,2-BIS (2,2'-bipyridyl-6-yl) Ethane by : Ariel V. Macatangay
Download or read book Synthesis and Photophysical Studies of Ruthenium (II) Complexes Containing the Ligand 1,2-BIS (2,2'-bipyridyl-6-yl) Ethane written by Ariel V. Macatangay and published by . This book was released on 1994 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Chiral Iron Pyridine Complexes and Ruthenium Complexes with N-Heterocyclic Carbene and Macrocyclic (N, O) Donor Atom Ligands by : Kar-Yee Lam
Download or read book Chiral Iron Pyridine Complexes and Ruthenium Complexes with N-Heterocyclic Carbene and Macrocyclic (N, O) Donor Atom Ligands written by Kar-Yee Lam and published by . This book was released on 2017-01-26 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Reactivity of Compounds Containing Ruthenium-carbon, -nitrogen, and -oxygen Bonds by :
Download or read book Synthesis and Reactivity of Compounds Containing Ruthenium-carbon, -nitrogen, and -oxygen Bonds written by and published by . This book was released on 1990 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: The products and mechanisms of the thermal reactions of several complexes of the general structure (PMe3)4Ru(X)(Y) and (DMPM)2Ru(X)(Y) where X and Y are hydride, aryl, and benzyl groups, have been investigated. The mechanism of decomposition depends critically on the structure of the complex and the medium in which the thermolysis is carried out. The alkyl hydride complexes are do not react with alkane solvent, but undergo C-H activation processes with aromatic solvents by several different mechanisms. Thermolysis of (PMe3)4Ru(Ph)(Me) or (PMe3)4Ru(Ph)2 leads to the ruthenium benzyne complex (PMe3)4Ru([eta]2-C6H4) (1) by a mechanism which involves reversible dissociation of phosphine. In many ways its chemistry is analogous to that of early rather than late organo transition metal complexes. The synthesis, structure, variable temperature NMR spectroscopy and reactivity of ruthenium complexes containing aryloxide or arylamide ligands are reported. These complexes undergo cleavage of a P-C bond in coordinated trimethylphosphine, insertion of CO and CO2 and hydrogenolysis. Mechanistic studies on these reactions are described. The generation of a series of reactive ruthenium complexes of the general formula (PMe3)4Ru(R)(enolate) is reported. Most of these enolates have been shown to bind to the ruthenium center through the oxygen atom. Two of the enolate complexes 8 and 9 exist in equilibrium between the O- and C-bound forms. The reactions of these compounds are reported, including reactions to form oxygen-containing metallacycles. The structure and reactivity of these ruthenium metallacycles is reported, including their thermal chemistry and reactivity toward protic acids, electrophiles, carbon monoxide, hydrogen and trimethylsilane. 243 refs., 10 tabs.
Book Synopsis The Synthesis, Spectroscopic and Electrochemical Characterisation of Ruthenium (II) Polypyridyl Complexes Containing a Catechol Moiety by : Luke O'Brien
Download or read book The Synthesis, Spectroscopic and Electrochemical Characterisation of Ruthenium (II) Polypyridyl Complexes Containing a Catechol Moiety written by Luke O'Brien and published by . This book was released on 2001 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Ruthenium Complexes Of Chiral And Achiral Phosphorus Ligands Based On The P-N-P Motif by :
Download or read book Ruthenium Complexes Of Chiral And Achiral Phosphorus Ligands Based On The P-N-P Motif written by and published by . This book was released on 2004 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: In recent years there is an increasing awareness of the importance of chiral phosphorus ligands in transition metal organometallic chemistry because of the utility of such complexes in homogeneous catalytic reactions. This thesis deals with synthetic, spectroscopic and X-ray crystallographic studies on ruthenium complexes of chiral and achiral P-N-P type ligands, known as "diphosphazanes", with emphasis on ruthenium carbonyl clusters. Several ruthenium carbonyl clusters have been synthesized and characterized by elemental analyses, ER and NMR (lH, nC and 3lP) spectroscopic data. In several instances, the molecular structures of the clusters have been confirmed by single crystal X-ray diffraction studies. Chapter 1 provides a brief overview of various types of chiral phosphorus ligands and general synthetic routes to diphosphazanes. A brief review of the transition metal chemistry of diphosphazanes and diphosphazane chalcogenides (published since 1994) is presented A review of the literature on the carbonyl clusters of the group-8 transition metals (Fe, Ru, Os) bearing mono- and diphosphines is also included in this chapter The scope and aim of the present investigation is outlined at the end of this chapter. Chapter 2 provides the results obtained in the present investigation and a detailed discussion of the spectroscopic and crystallographic data. The essential feature of the work is summarized at the end of the chapter. Chapter 3 gives a detailed account of the experimental procedure for the synthesis of the compounds and spectroscopic and analytical measurements. The experimental details of X-ray structure determination are also given in this chapter. To save space, the coordinates of the H-atoms and the calculated and observed structure factor tables are not included. In some cases, reference to CCDC deposition number is included. The references of the literature are compiled at the end of the thesis and are indicated in the text by appropriate numbers appearing.
Book Synopsis Synthesis, Reactivity, and Characterization of Ruthenium Complexes Containing a Single Bipyridine Ligand by : Simon I. Barsoum
Download or read book Synthesis, Reactivity, and Characterization of Ruthenium Complexes Containing a Single Bipyridine Ligand written by Simon I. Barsoum and published by . This book was released on 1989 with total page 142 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis of Ligands for Ruthenium and Spectroscopic and Electrochemical Analysis of Ru(1-(2'-(1'-methyl-pyridinium))-2-(2"-pyridine)-aminomethane)3 and Ru(bipyridine)2(1-(2'-(1'-methyl-pyridinium))-2-(2"-pyridine)-aminomethane) by : Brian Tenney
Download or read book Synthesis of Ligands for Ruthenium and Spectroscopic and Electrochemical Analysis of Ru(1-(2'-(1'-methyl-pyridinium))-2-(2"-pyridine)-aminomethane)3 and Ru(bipyridine)2(1-(2'-(1'-methyl-pyridinium))-2-(2"-pyridine)-aminomethane) written by Brian Tenney and published by . This book was released on 1998 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Metal Nitrosyls by : George B. Richter-Addo
Download or read book Metal Nitrosyls written by George B. Richter-Addo and published by Oxford University Press, USA. This book was released on 1992 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers all aspects of metal-nitric oxide chemistry. Topics range from descriptions of the metal-NO bond to their chemical reactions and environmental significance. Treated in detail are coordination and organometallic nitrosyl complexes, interactions of nitric oxide with surfaces, metal nitrosyl clusters and the biosynthesis, biotransformation, and bioinorganic chemistry of nitric oxide. The book includes an examination of all known classes of reactions of metal nitrosyls. The roles of nitric and nitrous oxides in environmental chemistry are outlined in the closing chapter. This book will be of interest to students and researchers in the fields of inorganic, organometallic, and bioinorganic chemistry.
Download or read book Iron Catalysis written by Bernd Plietker and published by Springer Science & Business Media. This book was released on 2011-01-05 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: Juan I. Padrón and Víctor S. Martín: Catalysis by means of Fe-based Lewis acids; Hiroshi Nakazawa*, Masumi Itazaki: Fe–H Complexes in Catalysis; Kristin Schröder, Kathrin Junge, Bianca Bitterlich, and Matthias Beller: Fe-catalyzed Oxidation Reactions of Olefins, Alkanes and Alcohols: Involvement of Oxo- and Peroxo Complexes; Chi-Ming Che, Cong-Ying Zhou, Ella Lai-Ming Wong: Catalysis by Fe=X Complexes (X=NR, CR2); René Peters, Daniel F. Fischer and Sascha Jautze: Ferrocene and Half Sandwich Complexes as Catalysts with Iron Participation; Markus Jegelka, Bernd Plietker: Catalysis by Means of Complex Ferrates.
Download or read book Nitroarenes written by Paul C. Howard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Prior to 1979, consideration of the problem of the carcinogenicity of the aromatic amine class of chemicals took place primarily in poster sessions and symposia of annual meetings of the American Association for Cancer Research and analogous international associations. In November 1979 the first meeting concerned with the aromatic amines was held in Rockville, Haryland under primary sponsorship of the National Cancer Institute. The proceedings from this meeting were published as Monograph 58 of the Journal of the National Cancel' Institute in 1981. The second meeting in this series, the Second International Conference on N-Substituted Aryl Compounds, was held in March/April of 1982 in Hot Springs, Arkansas. The National Cancer Institute and The National Center for Toxicological Research were the primary sponsors of this meeting. The proceedings were published as Volume 49 of the journal En-vil'onmental Health Perspectives in 1983. The third meeting in this series was held in April of 1987 at the Dearborn Hyatt in Dearborn, Michigan. The principal sponsor of this meeting was the Heyer L. Pre ntis Comprehensive Cancer Center of Metropolitan Detroit. The proceedings, Carcinogenic and Mutagenic Responses to Aromatic Amines and Nitroal'enes, were published in 1987 by Elsevier Press. The fourth meeting was held in Cleveland, Ohio, on July 15-19, 1989.
Book Synopsis Iron Catalysis in Organic Chemistry by : Bernd Plietker
Download or read book Iron Catalysis in Organic Chemistry written by Bernd Plietker and published by John Wiley & Sons. This book was released on 2008-09-08 with total page 295 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first comprehensive book to cover this exciting field also deals with the biological aspects, such as enzymes with iron. Following an introduction, this handy reference and handbook goes on to deal with reductions, oxidations of C, H- and C=C bonds, oxidative allylic oxygenation and amination, the oxidation of heteroatoms, cross coupling reactions, aromatic and nucleophilic substitutions, addition to carbonyl compounds, and cyclisations as well as ring opening reactions. The chapters are clearly classified according to the reaction type, allowing readers to quickly locate the desired information.
Book Synopsis Aromatic C-nitroso Compounds by : Hrvoj Vančik
Download or read book Aromatic C-nitroso Compounds written by Hrvoj Vančik and published by Springer Science & Business Media. This book was released on 2013-03-12 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is designed to collect and review the research covering main directions in investigations of aromatic nitroso compounds in last decades, and to present both, the academic aspects of this chemistry, as well as the open field of its applicability. The book is divided in five chapters. The basic structural properties of the nitroso aromatic molecules are described in the first chapter. The second chapter is an overview of the methods of preparations of aromatic nitroso and polynitroso compounds, including classical synthetic methods and some new preparative approaches. The third part deals with the physico-chemical properties of nitroso aromates and azodioxides, its structure, crystallography, quantum chemical calculations, spectroscopy, typical reactions, and especially it is focused on the dimerizations in the solid-state. In the fourth chapter is represented organometallic chemistry of nitroso aromatic molecules and its applications in catalysis. The last part of the book deals with the behavior of this class of compounds in the biological systems, reactions with biomolecules and the use in toxicology.
