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Synthesis And Conformational Analysis Of Peptidomimetics Containing Unnatural Amino Acids Based On A Piperazinone And Butyrolactone Gamma Butyrolactone Scaffolds
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Book Synopsis Synthesis and Conformational Analysis of Peptidomimetics Containing Unnatural Amino Acids Based on a Piperazinone and Γ-butyrolactone [gamma-butyrolactone] Scaffolds by : Karine Guitot
Download or read book Synthesis and Conformational Analysis of Peptidomimetics Containing Unnatural Amino Acids Based on a Piperazinone and Γ-butyrolactone [gamma-butyrolactone] Scaffolds written by Karine Guitot and published by . This book was released on 2008 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Conformational Analysis of Peptidomimetics Containing Unnatural Amino Acids Based on a Piperazinone and [gamma]-butyrolactone [gamma-butyrolactone] Scaffolds by : Karine Guitot
Download or read book Synthesis and Conformational Analysis of Peptidomimetics Containing Unnatural Amino Acids Based on a Piperazinone and [gamma]-butyrolactone [gamma-butyrolactone] Scaffolds written by Karine Guitot and published by . This book was released on 2008 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Conformational Analysis of Peptidomimetics Containing Unnatural Amino Acids Based on a Piperazinone and Gamma-butyrolactone Scaffolds by : Karine Guitot
Download or read book Synthesis and Conformational Analysis of Peptidomimetics Containing Unnatural Amino Acids Based on a Piperazinone and Gamma-butyrolactone Scaffolds written by Karine Guitot and published by . This book was released on 2008 with total page 229 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The DESIGN AND SYNTHESIS OF NOVEL UNNATURAL AMINO ACIDS AND THE DESIGN AND SYNTHESIS OF PEPTIDES & PEPTIDOMIMETICS CONTAINING UNNATURAL AMINO ACIDS FOR THE STUDY OF G-PROTEIN COUPLED RECEPTORS. by :
Download or read book The DESIGN AND SYNTHESIS OF NOVEL UNNATURAL AMINO ACIDS AND THE DESIGN AND SYNTHESIS OF PEPTIDES & PEPTIDOMIMETICS CONTAINING UNNATURAL AMINO ACIDS FOR THE STUDY OF G-PROTEIN COUPLED RECEPTORS. written by and published by . This book was released on 2010 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nature has gifted peptides as important modulators in the human body, but these types of molecules often have not been favored when we were looking for therapeutic agents. The poor bioavailability, fast degradation and until recent high manufacturing costs of some bioactive peptides lowered their potential usage in the health industry. Under these circumstances, unnatural amino acids were developed as indispensible tools providing enormous support to peptide science. By incorporating proper unnatural amino acids into a peptide or protein, we now can significantly improve peptide's or protein's half-life, cell permeability, bio-distribution, etc. In addition, their potency and receptor/acceptor selectivity could also be enhanced. Site-specific modifications of peptides and proteins under physiological conditions with the use of unnatural amino acids also have been made easier with the advance of biotechnology. Therefore, my research described in this dissertation contributes to the efforts in the development of novel unnatural amino acids. In particular, I have focused on novel methods in the synthesis of anti beta-functionalized gamma, delta-unsaturated amino acids. These amino acids have special interests in peptide chemistry: they can provide conformational constraints to the peptide 3D structures; the beta-functionalization allows the introduction of pharmaceutically interesting side chain groups; and the terminal double bond which is orthogonal to peptide synthesis provides access to further chemical modifications. Two general methodologies for the synthesis of both racemic and optically active anti beta-functionalized gamma, delta--unsaturated amino acids were developed by using the thio-Claisen rearrangement (TCR) reaction. Excellent diastereoselectivies and enantioselectivities were obtained when C2-symmetric chiral auxiliaries were selected to control the stereochemistry outcome. The mechanism and the scope of the TCR reaction were also studied, showing unique advantages in the preparation of these biological interesting amino acids. Another effort of developing angiotensin II type 1 (AT1) receptor biased peptide ligands is also documented in this dissertation. The AT1 receptor is a 7-transmembrane G-protein coupled receptor, which recent researches have shown could be activated through a beta-arrestins only, but G-protein independent, pathway. We synthesized 12 analogs of Sar1,Ile4,Ile8-AngII (SII), and tested them in biological assays, and obtained valuable information for further "perfect" biased ligands design.
Book Synopsis Preparative Carbohydrate Chemistry by : Stephen Hanessian
Download or read book Preparative Carbohydrate Chemistry written by Stephen Hanessian and published by CRC Press. This book was released on 1997-01-02 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Detailing commonly used methods and procedures, this reference discusses the reactions and derivative forms of carbohydrates. Preparative Carbohydrate Chemistry covers the formation, cleavage, and reactions of derivatives and illustrates bond-forming reactions of SN2 types, free radicals, chain extensions, and branching. The contents include: sugar derivatives; selected reactions in carbohydrate chemistry; chemical synthesis of oligosaccharides and O-and N -glycosyl compounds; enzymatic synthesis of sialic acid, KDO, and related deoxyulosonic acids, and of oligosaccharides; synthesis of -glycosyl compounds; carbocycles from carbohydrates; and total synthesis of sugars from non-sugars. This authoritative reference offers relevant chapters on reactions and derivative forms of carbohydrates, including commonly used methods as well as new experimental procedures. It also contains insightful chapter commentaries and succinct topic histories.
Book Synopsis Solid-Phase Organic Synthesis by : Patrick H. Toy
Download or read book Solid-Phase Organic Synthesis written by Patrick H. Toy and published by John Wiley & Sons. This book was released on 2012-01-10 with total page 560 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents both the fundamental concepts and the most recent applications in solid-phase organic synthesis With its emphasis on basic concepts, Solid-Phase Organic Synthesis guides readers through all the steps needed to design and perform successful solid-phase organic syntheses. The authors focus on the fundamentals of heterogeneous supports in the synthesis of organic molecules, explaining the use of a solid material to facilitate organic synthesis. This comprehensive text not only presents the fundamentals, but also reviews the most recent research findings and applications, offering readers everything needed to conduct their own state-of-the-art science experiments. Featuring chapters written by leading researchers in the field, Solid-Phase Organic Synthesis is divided into two parts: Part One, Concepts and Strategies, discusses the linker groups used to attach the synthesis substrate to the solid support, colorimetric tests to identify the presence of functional groups, combinatorial synthesis, and diversity-oriented synthesis. Readers will discover how solid-phase synthesis is currently used to facilitate the discovery of new molecular functionality. The final chapter discusses how using a support can change or increase reaction selectivity. Part Two, Applications, presents examples of the solid-phase synthesis of various classes of organic molecules. Chapters explore general asymmetric synthesis on a support, strategies for heterocyclic synthesis, and synthesis of radioactive organic molecules, dyes, dendrimers, and oligosaccharides. Each chapter ends with a set of conclusions that underscore the key concepts and methods. References in each chapter enable readers to investigate any topic in greater depth. With its presentation of basic concepts as well as recent findings and applications, Solid-Phase Organic Synthesis is the ideal starting point for students and researchers in organic, medicinal, and combinatorial chemistry who want to take full advantage of current solid-phase synthesis techniques.
Book Synopsis Targets in Heterocyclic Systems by :
Download or read book Targets in Heterocyclic Systems written by and published by . This book was released on 1997 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Design and Strategy in Organic Synthesis by : Stephen Hanessian
Download or read book Design and Strategy in Organic Synthesis written by Stephen Hanessian and published by Wiley-VCH. This book was released on 2013-09-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This long-awaited graduate level book, written by one of the world's leading organic chemists in collaboration with two of his former and present coworkers, adopts a refreshingly unique approach to synthesis planning and execution. Following an introductory look at the concept of synthesis, the authors discuss the Why, What, and How of organic synthesis as they apply to natural products. Although emphasis is on the Chiron Approach utilizing amino-acids, carbohydrates, hydroxy acids, terpenes, lactones and other naturally occurring small molecules as starting materials, catalytic asymmetric methods are also included as a corollary whenever relevant. A must-have source of first class information for everyone working in organic synthesis, be it in academia or industry. With a foreword by Larry E. Overman and David W. C. MacMillan
Book Synopsis Plant Secondary Metabolism by : David S. Seigler
Download or read book Plant Secondary Metabolism written by David S. Seigler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 766 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life has evolved as a unified system; no organism exists similar role also has been suggested for fatty acids from alone, but each is in intimate contact with other organisms cyanolipids. Nonprotein amino acids, cyanogenic glyco and its environment. Historically, it was easier for workers sides, and the non-fatty-acid portion of cyanolipids also are in various disciplines to delimit artificially their respective incorporated into primary metabolites during germination. areas of research, rather than attempt to understand the entire Secondary metabolites of these structural types are accumu system of living organisms. This was a pragmatic and neces lated in large quantities in the seeds of several plant groups sary way to develop an understanding for the various parts. where they probably fulfill an additional function as deter We are now at a point, however, where we need to investi rents to general predation. gate those things common to the parts and, specifically, those The second type of relationship involves interaction of things that unify the parts. The fundamental aspects of many plants with other organisms and with their environment. Bio of these interactions are chemical in nature. Plants constitute logical interactions must be viewed in the light of evolution an essential part of all life systems; phytochemistry provides ary change and the coadaptation, or perhaps coevolution, of a medium for linking several fields of study.
Book Synopsis The Claisen Rearrangement by : Martin Hiersemann
Download or read book The Claisen Rearrangement written by Martin Hiersemann and published by John Wiley & Sons. This book was released on 2007-02-27 with total page 591 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first comprehensive coverage of all facets of the Claisen rearrangement and its variants. As such, this book helps synthetic chemists to exploit the vast potential of this elegant C-C linking reaction, discusses a wealth of catalytic options, and gives those more theory-minded chemists a detailed insight into the mechanistic aspects of the Claisen rearrangement. An invaluable source of information and a ready reference for all organic and catalytic chemists, as well as those working with/on organometallics, and in industry.
Book Synopsis Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates by : Al Postigo
Download or read book Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates written by Al Postigo and published by Elsevier. This book was released on 2018-09-10 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Late-Stage Fluorination of Bioactive Molecules and Biologically-Relevant Substrates reviews how the use of these techniques on compounds with already known and relevant biological activity can provide new pharmaceutical leads with improved medicinal properties. The fluorination strategies discussed take into account both conventional and novel reagents, including nucleophilic, electrophilic, those of a radical nature, and diverse families of organic compounds, such as (hetero) aromatic rings and aliphatic substrates. Drawing on the authors' expert knowledge, this book provides researchers with a broad set of applicable methods to use in their work.
Book Synopsis Targets in Heterocyclic Systems by : Orazio A. Attanasi
Download or read book Targets in Heterocyclic Systems written by Orazio A. Attanasi and published by . This book was released on 2009-07-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 11 keeps the international standard of the THS series, covering the synthesis, reactivity, activity (including medicinal) and mass spectrometry of different systems.
Book Synopsis Fundamentals of Oil & Gas Industry for Beginners by : Samir Dalvi
Download or read book Fundamentals of Oil & Gas Industry for Beginners written by Samir Dalvi and published by Notion Press. This book was released on with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: A prominent linchpin in world politics and in security policies world over, oil and gas have tremendous value in both, the political and economical sectors of global relations, business establishments and policy. Regardless of whether one is a novice to a given field, or a well accomplished veteran in the field, there is a need for the continued engagement with the basics that underlie the core subjects. With that in mind, the Fundamentals of Oil and Gas is a perfect primer for the first-timer in the field, while also a copious text to help a seasoned veteran stay abreast with the nuances of the world of Oil and Gas.
Book Synopsis Natural Compounds as Drugs, Volume II by : Frank Petersen
Download or read book Natural Compounds as Drugs, Volume II written by Frank Petersen and published by Springer Science & Business Media. This book was released on 2008-07-29 with total page 425 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of substances derived from plants, fungi, bacteria and marine organisms has a long tradition in medicine. This book highlights the biodiversity-driven approaches which are now of eminent importance in natural products research. It addresses the question why natural products display such a complex chemical information, what makes them often unique and what their characteristics are. A compilation of current applicable technology makes this a brilliant reference work.
Book Synopsis Combinatorial Synthesis of Natural Product-Based Libraries by : Armen M. Boldi
Download or read book Combinatorial Synthesis of Natural Product-Based Libraries written by Armen M. Boldi and published by CRC Press. This book was released on 2006-05-16 with total page 363 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditionally, the search for new compounds from natural products has been a time- and resource-intensive process. The recent application of combinatorial methods and high-throughput synthesis has allowed scientists to generate a range of new molecular structures from natural products and observe how they interact with biological targets. Combinato
Book Synopsis Spectroscopic Methods in Bioinorganic Chemistry by : Edward I. Solomon
Download or read book Spectroscopic Methods in Bioinorganic Chemistry written by Edward I. Solomon and published by . This book was released on 1998 with total page 488 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume contains recent advances in spectrographic methods, including EPR, magnetic Mossbauer, paramagnetic and multi-D NMR, metalloprotein crystallography, EAS, magnetic circular dichroism, resonance Raman, X-ray absorption spectroscopy, and electron structure calculations. The book concentrates on topics where spectrographic methods have had a major impact, such as electron transfer, cluster interactions, intermediates, and definition of active site structure, and it includes a thorough tutorial on basic methods.
Book Synopsis Drug Discovery and Development, Volume 1 by : Mukund S. Chorghade
Download or read book Drug Discovery and Development, Volume 1 written by Mukund S. Chorghade and published by Wiley-Interscience. This book was released on 2006-06-16 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: From first principles to real-world applications -- here is the first comprehensive guide to drug discovery and development Modern drug discovery and development require the collaborative efforts of specialists in a broadarray of scientific, technical, and business disciplines--from biochemistry to molecular biology, organic chemistry to medicinal chemistry, pharmacology to marketing. Yet surprisingly, until now, there were no authoritative references offering a complete, fully integrated picture of the process. The only comprehensive guide of its kind, this groundbreaking two-volume resource provides an overview of the entire sequence of operations involved in drug discovery and development--from initial conceptualization to commercialization to clinicians and medical practitioners. Volume 1: Drug Discovery describes all the steps in the discovery process, including conceptualizing a drug, creating a library of candidates for testing, screening candidates for in vitro and in vivo activity, conducting and analyzing the results of clinical trials, and modifying a drug as necessary. Volume 2: Drug Development delves into the nitty-gritty details of optimizing the synthetic route, drug manufacturing, outsourcing, and marketing--including drug coloring and delivery methods. Featuring contributions from a world-class team of experts, Drug Discovery and Development: * Features fascinating case studies, including the discovery and development of erythromycin analogs, Tagamet, and Ultiva (remifentanil) * Discusses the discovery of medications for bacterial infections, Parkinson's disease, psoriasis, peptic ulcers, atopic dermatitis, asthma, and cancer * Includes chapters on combinatorial chemistry, molecular biology-based drug discovery, genomics, and chemogenomics Drug Discovery and Development is an indispensable working resource for industrialchemists, biologists, biochemists, and executives who work in the pharmaceutical industry.
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