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Author : Sheau Yong Lau
Publisher :
ISBN 13 :
Total Pages : 54 pages
Book Rating : 4.:/5 (96 download)
Download or read book Synthesis and Characterization of Ruthenium (II) Complexes with Polypyridyl Ligands written by Sheau Yong Lau and published by . This book was released on 2007 with total page 54 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Youxiang Wang
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.:/5 (396 download)
Download or read book Synthesis and Characterization of Polypyridyl Ligands and Ruthenium(II) Complexes Based on the Reactivity of 4,5-diazafluorenone in the Presence and Absence of Ruthenium(II) Ion written by Youxiang Wang and published by . This book was released on 1998 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Youxiang Wang
Publisher :
ISBN 13 :
Total Pages : 190 pages
Book Rating : 4.:/5 (326 download)
Download or read book Synthesis and Characterization of Ruthenium (II) Polypyridyl Complexes written by Youxiang Wang and published by . This book was released on 1994 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rudi Kroener
Publisher :
ISBN 13 :
Total Pages : 190 pages
Book Rating : 4.:/5 (12 download)
Download or read book Synthesis and Characterization of Some New Polypyridine Ruthenium (II) Complexes Containing S-bonded Thioether Ligands written by Rudi Kroener and published by . This book was released on 1984 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michele Lorena Folmar
Publisher :
ISBN 13 :
Total Pages : 24 pages
Book Rating : 4.:/5 (976 download)
Download or read book Synthesis and Characterization of a New Ruthenium(ii) Polypyridyl Compound with a Quinolate-type Ligand written by Michele Lorena Folmar and published by . This book was released on 2016 with total page 24 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ajay Kumar Mishra
Publisher : CRC Press
ISBN 13 : 1351616501
Total Pages : 386 pages
Book Rating : 4.3/5 (516 download)
Download or read book Ruthenium Chemistry written by Ajay Kumar Mishra and published by CRC Press. This book was released on 2018-01-17 with total page 386 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book will describe Ruthenium complexes as chemotherapeutic agent specifically at tumor site. It has been the most challenging task in the area of cancer therapy. Nanoparticles are now emerging as the most effective alternative to traditional chemotherapeutic approach. Nanoparticles have been shown to be useful in this respect. However, in view of organ system complicacies, instead of using nanoparticles as a delivery tool, it will be more appropriate to synthesize a drug of nanoparticle size that can use blood transport mechanism to reach the tumor site and regress cancer. Due to less toxicity and effective bio-distribution, ruthenium (Ru) complexes are of much current interest. Additionally, lumiscent Ru-complexes can be synthesized in nanoparticle size and can be directly traced at tissue level. The book will contain the synthesis, characterization, and applications of various Ruthenium complexes as chemotherapeutic agents. The book will also cover the introduction to chemotherapy, classification of Ru- complexes with respect to their oxidation states and geometry, Ruthenium complexes of nano size: shape and binding- selectivity, binding of ruthenium complexes with DNA, DNA cleavage studies and cytotoxicity. The present book will be more beneficial to researchers, scientists and biomedical. Current book will empower specially to younger generation to create a new world of ruthenium chemistry in material science as well as in medicines. This book will be also beneficial to national/international research laboratories, and academia with interest in the area of coordination chemistry more especially to the Ruthenium compounds and its applications.
Author : Colin R. Spencer
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (122 download)
Download or read book Synthesis and Characterization of Ruthenium Polypyridyl Complexes for Application in Photodynamic Therapy written by Colin R. Spencer and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Eighteen polypyridyl ruthenium complexes were synthesized and characterized to test their ability to be new photodynamic compounds (PDCs). Each compound bears oxazo- or imidazo[4,5-f][1,10]phenanthroline ligands with a varying R-group and 2,2-bipyridine and 1,10-phenanthroline ancillary ligands. Biological tests were employed for the complexes to test the potential to be new PDCs, and included DNA photocleavage, DNA binding, and photocytotoxicity. Compounds containing thiophenes as the R-group showed significant DNA damage in the photocleavage assays as well as light toxicity and low dark toxicity in photocytotoxic assays. Compounds with 1,10-phenanthroline ancillary ligands generally showed more DNA photocleavage, unwinding, and binding compared to their 2,2'-bipyridine counterparts. Dinuclear compounds containing the bis(imidazo[4,5-f][1,10]phenanthroline) bridging ligand exhibited the best results for high light toxicity and low dark toxicity, the strongest binding to DNA, and the most potency for DNA photocleavage. As such these compounds are promising candidates for new PDCs and warrant further investigations.
Author : Meijin Li
Publisher : Open Dissertation Press
ISBN 13 : 9781361428276
Total Pages : pages
Book Rating : 4.4/5 (282 download)
Download or read book Design, Synthesis and Characterization of Ruthenium(ii) and Rhenium(i) Complexes with Functionalized Ligands for Photo-And Electrochemi- Luminescence, Solvatochromism, Molecular Recognition and HPLC Separation Studies written by Meijin Li and published by Open Dissertation Press. This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Design, Synthesis and Characterization of Ruthenium(II) and Rhenium(I) Complexes With Functionalized Ligands for Photo-and Electrochemi- Luminescence, Solvatochromism, Molecular Recognition and HPLC Separation Studies" by Meijin, Li, 李梅金, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled DESIGN, SYNTHESIS AND CHARACTERIZATION OF RUTHENIUM(II) AND RHENIUM(I) COMPLEXES WITH FUNCTIONALIZED LIGANDS FOR PHOTO- AND ELECTROCHEMI- LUMINESCENCE, SOLVATOCHROMISM, MOLECULAR RECOGNITION AND HPLC SEPARATION STUDIES Submitted by LI MEIJIN for the degree of Doctor of Philosophy at The University of Hong Kong in July 2006 A series of ruthenium(II) and rhenium(I) diimine complexes containing thia-, selena- and aza-crowns derived from 1,10-phenanthroline, [Ru(bpy) (phen-3S)](ClO ) 2 4 2 (phen-3S = 1,13-dioxa-4,7,10-trithiacyclopentadecano[2,3-f][1,10]phenanthroline), [Ru(bpy) (phen-2S)](ClO ) (phen-2S = 1,7,10,16-tetraoxa-4,13-dithiacyclohexa- 2 4 2 dodecano[2,3-f][1,10]phenanthroline), [Ru(bpy) (phen-S)](ClO ) (phen-S = 1,4,10,13- 2 4 2 tetraoxa-7-thiacyclopentadecano[2,3-f][1,10]phenanthroline), [Ru(bpy) (phen-Se)](ClO ) 2 4 2 (phen-Se = 1,4,10,13-tetraoxa-7-selenacyclopentadecano[2,3-f][1,10]phenanthroline), [Ru(bpy) (phen-OEt](ClO ) (phen-OEt = 5,6-diethoxy-[1,10]phenanthroline), 2 4 2 [Ru(bpy) (phen-2NH)](ClO ) (phen-2NH = 1,13-diaxa-4,7,10-trioxacyclopenta- 2 4 2 decano[2,3-f][1,10]phenanthroline), [Re(CO) (py)(phen-3S)]PF, [Re(CO) (py)(phen-S)]OTf 3 6 3 and [Re(CO) (py)(phen-Se)]OTf have been synthesized and characterized, and their photophysics, electrogenerated chemiluminescence (ECL) and electrochemistry were studied. Their interaction with metal ions was investigated by UV-vis, luminescence, NMR spectroscopy and ECL. [Ru(bpy) (phen-3S)](ClO ) and [Re(CO) (py)(phen-3S)]
Author : Mathew Stein
Publisher :
ISBN 13 :
Total Pages : 58 pages
Book Rating : 4.:/5 (861 download)
Download or read book Synthesis and Characterization of a Series of Ruthenium Polypyridyl Metal Complexes written by Mathew Stein and published by . This book was released on 1999 with total page 58 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michał Pawel Łomzik
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (11 download)
Download or read book Synthesis and Characterization of Hybrid Drugs Based on Ruthenium Complex Moiety and Biologically Active Organic Compounds written by Michał Pawel Łomzik and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The main goal of this thesis was synthesis and preliminary characterization of novel ruthenium(II) polypyridyl complexes bearing biologically active molecules as potential theranostic agents. Luminescence for the diagnostic applications, and cytotoxicity for the anticancer, therapeutic applications are considered as the theranostic properties. Four new ligands containing biologically active moieties - 5-(4-4'-methyl-[2,2'-bipyridine]-4-ylbut-1-yn-1-yl)pyridine-2-carbaldehyde semicarbazone (L1), 3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L2), 5,5-dimethyl-3-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)imidazolidine-2,4-dione (L3) and [1-(5-4'-methyl-[2,2'-bipyridine]-4-ylpentyl)-2,5-dioxoimidazolidin-4-yl]urea (L4) were synthesized and characterized. The ligands were used to obtain nine novel ruthenium(II) polypyridyl complexes. Six complexes were synthesized with ligand L1 ([Ru(bpy)2(L1)]2+, [Ru(Mebpy)2(L1)]2+, [Ru(tBubpy)2(L1)]2+, [Ru(Phbpy)2(L1)]2+, [Ru(dip)2(L1)]2+, [Ru(SO3dip)2(L1)]2-) and three with ligands L2, L3 and L4 ([Ru(bpy)2(L2)]2+, [Ru(bpy)2(L3)]2+, [Ru(bpy)2(L4)]2+) (bpy = 2,2'-bipyridine, Mebpy = 4,4'-dimethyl-2,2-bipyridine, tBubpy = 4,4'-tert-butyl-2,2'-bipyridine, Phbpy = 4,4'-diphenyl-2,2-bipyridine, dip = 4,7-diphenyl-1,10-phenantroline and SO3dip = 4,7-di-(4-sulfonatophenyl)-1,10-phenantroline). The spectroscopic and photophysical properties of those complexes were determined. The presence of ligands L1-L4 in the structure of the complex decreased luminescence quantum yield and luminescence lifetime in comparison with unmodified [Ru(bpy)3]2+ complex. The theoretical calculations have shown that ligands L1-L4 do not have influence on ruthenium core geometry. However, they increased the energy of the HOMO that resulted in a shorter band gap. The simulated electronic absorption spectra were in a good agreement with the experimental data. The interactions between the studied ruthenium complexes and human serum albumin (HSA) were investigated. All studied Ru(II) complexes exhibited strong affinity to HSA with the association constant 105 M-1s-1, which suggests formation of Ru complex-HSA adducts. It was also determined that ruthenium complexes most likely bind to the hydrophobic pocket of protein, located in Sudlow's site I in the subdomain II A. Preliminary cytotoxicity evaluation for the studied ruthenium complexes showed their cytotoxic activity towards cancer cell lines. Those results, together with good luminescence properties of the studied ruthenium complexes (luminescence lifetimes and luminescence quantum yield) make them interesting candidates for potential theranostic applications.
Author : Carmen Kloer
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (143 download)
Download or read book Synthesis and Characterization of Ruthenium(II)-hispolon Complexes written by Carmen Kloer and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Brian W. Arbuckle
Publisher :
ISBN 13 :
Total Pages : 454 pages
Book Rating : 4.:/5 (42 download)
Download or read book Part I. Preparation and Characterization of Ruthenium (II) Chloride and Palladium Chloride Complexes of the Mesocyclic Ligands, 1,5-dithiacyclooctane, 1,5-dithiacyclooctane 1-oxide, and 3-hydroxy-1,5-dithiacyclooctane. Part II. Structure of Trans-1,5-diphenyl-1,5-diphosphacyclooctane (3a); Preparation and Characterization of Palladium (II) Chloride and Nickel (II) Chloride Complexes of the Mesocyclic Ligand Cis-1,5-diphenyl-1,5-diphosphacyclooctane (3b). written by Brian W. Arbuckle and published by . This book was released on 1990 with total page 454 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Eugenia Soyo Narh
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.:/5 (945 download)
Download or read book Structure-activity Relationships of Ruthenium(II) Polypyridyl Complexes with Redox-active Intercalating Ligands written by Eugenia Soyo Narh and published by . This book was released on 2016 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: The investigation and development of transition metal complexes as cancer chemotherapeutics has gained a lot of interest in the past few decades and has become a promising area of research. Metal complexes of platinum and ruthenium in particular that have demonstrated success as anticancer drugs or are under exploration currently for clinical use are highlighted in Chapter 1. Chapter 2 describes studies undertaken to understand the neurotoxicity of ruthenium(II) polypyridyl complexes (RPCs), including toxicity in mice and inhibition of the enzyme acetylcholinesterase (AChE), as previous work by Dwyer demonstrated that RPCs could be acutely toxic in mice, presumably due to their inhibition of AChE. Several ruthenium complexes were screened for their enzyme inhibitory potency which was correlated to their structural properties including size, charge, and lipophilicity. In addition, the inhibitory activity of the compounds was correlated to their animal toxicity data so as to understand the potential mode of action of the RPCs in vivo. Chapter 3 describes the synthesis of a series of novel ruthenium(II) polypyridyl complexes and their characterization. These complexes were prepared in an effort to tune the reduction potential of the redox-active intercalating ligand (RAIL) to potentials slightly above and below those observed for the Ru-tatpp complexes. The redox activity of ruthenium-tatpp complexes appears to be responsible for their DNA cleavage activity and these analogues, with slightly different reduction potentials, should give us additional insight into the activity of this class of RPCs. In Chapter 4, the electrochemical properties of the RPCs were measured and correlated with their ability to cause DNA cleavage under reducing conditions with GSH. Complexes with reduction potentials less (more positive) than the redox couple of GSH/GSSG were shown to efficiently cleave DNA. However complexes with higher reduction potentials than the biological reducing agent were not observed to cleave DNA under the same conditions. Cytotoxicity screening of these complexes in human non-small cell lung carcinoma cell lines (NSCLC -- H358 and HOP-62) and breast adenocarcinoma cell line (MCF-7), as well as the non-malignant cell line (MCF-10) was performed and described in Chapter 4.
Author : Pelokazi Nkombi
Publisher :
ISBN 13 :
Total Pages : 236 pages
Book Rating : 4.:/5 (112 download)
Download or read book Ruthenium (II) Complexes of Mixed Bipyridyl and Dithiolate/thiourea Ligands written by Pelokazi Nkombi and published by . This book was released on 2018 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alvin A. Holder
Publisher : John Wiley & Sons
ISBN 13 : 3527695249
Total Pages : 395 pages
Book Rating : 4.5/5 (276 download)
Download or read book Ruthenium Complexes written by Alvin A. Holder and published by John Wiley & Sons. This book was released on 2017-11-01 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Edited by a team of highly respected researchers combining their expertise in chemistry, physics, and medicine, this book focuses on the use of rutheniumcontaining complexes in artificial photosynthesis and medicine. Following a brief introduction to the basic coordination chemistry of ruthenium complexes and their synthesis in section one, as well as their photophysical and photochemical properties, the authors discuss in detail the major concepts of artificial photosynthesis and mechanisms of hydrogen production and water oxidation with ruthenium in section two. The third section of the text covers biological properties and important medical applications of ruthenium complexes as therapeutic agents or in diagnostic imaging. Aimed at stimulating research in this active field, this is an invaluable information source for researchers in academia, health research institutes and governmental departments working in the field of organometallic chemistry, green and sustainable chemistry as well as medicine/drug discovery, while equally serving as a useful reference also for scientists in industry.
Author : Qiaoqin Zhao
Publisher :
ISBN 13 :
Total Pages : 192 pages
Book Rating : 4.:/5 (451 download)
Download or read book The Synthesis, Characterization and Photophysical Properties of Ruthenium Polypyridyl Complexes Containing 3,3' Substituted Bipyridyl and Crown Ether Derivatized Diazafluorene Ligands written by Qiaoqin Zhao and published by . This book was released on 2000 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Matthew Thomas Mongelli
Publisher :
ISBN 13 :
Total Pages : 149 pages
Book Rating : 4.:/5 (861 download)
Download or read book Synthesis, Characterization and Physical Studies of Ligand Bridged Bimetallic Aqua Ruthenium (II) Polypyridyl Complexes written by Matthew Thomas Mongelli and published by . This book was released on 2004 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt:
