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Synthesis And Applications Of Isotopically Labelled Compounds
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Book Synopsis Synthesis and Applications of Isotopically Labelled Compounds by : Ulrich Pleiss
Download or read book Synthesis and Applications of Isotopically Labelled Compounds written by Ulrich Pleiss and published by . This book was released on 2001-03-28 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This outstanding book covers the most recent advances in the production of stable and radioactive isotopes as well as in the synthesis, analysis and applications of isotopically labelled compounds. Written by internationally renowned contributors, it provides authoritative and wide-ranging coverage of significant growth areas including: * new methodologies in the production of isotopes * novel approaches to compounds labelled with isotopes of hydrogen, carbon and other stable, long-lived and short-lived radioactive isotopes * advances in the analysis of istopically labelled compounds * recent and future applications of isotopes in pharmaceutical research and development, in pharmacological and clinical sutdies and nuclear medicine, as well as in agricultural, nutritional and environmental research * recent applications of isotopes in investigating organic and bioorganic mechanisms and pathways * safety and regulations of handling isotopes This will be an invaluable information and reference source to anyone involved in the production of isotopes, the synthesis and analysis of compounds labelled with stable, long-lived or short-lived radioactive isotopes, in drug research and development, in clinical investigations and nuclear medicine, in agricultural research and development and environmental investigations, in the elucidation of biological and chemical pathways, handling radioisotopes, laboratory design and other areas.
Book Synopsis Synthesis and Applications of Isotopically Labelled Compounds by : Ulrich Pleiss
Download or read book Synthesis and Applications of Isotopically Labelled Compounds written by Ulrich Pleiss and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Synthesis and Applications of Isotopically Labelled Compounds by : Ulrich Pleiss
Download or read book Synthesis and Applications of Isotopically Labelled Compounds written by Ulrich Pleiss and published by Wiley. This book was released on 2001-03-28 with total page 736 pages. Available in PDF, EPUB and Kindle. Book excerpt: This outstanding book covers the most recent advances in the production of stable and radioactive isotopes as well as in the synthesis, analysis and applications of isotopically labelled compounds. Written by internationally renowned contributors, it provides authoritative and wide-ranging coverage of significant growth areas including: * new methodologies in the production of isotopes * novel approaches to compounds labelled with isotopes of hydrogen, carbon and other stable, long-lived and short-lived radioactive isotopes * advances in the analysis of istopically labelled compounds * recent and future applications of isotopes in pharmaceutical research and development, in pharmacological and clinical sutdies and nuclear medicine, as well as in agricultural, nutritional and environmental research * recent applications of isotopes in investigating organic and bioorganic mechanisms and pathways * safety and regulations of handling isotopes This will be an invaluable information and reference source to anyone involved in the production of isotopes, the synthesis and analysis of compounds labelled with stable, long-lived or short-lived radioactive isotopes, in drug research and development, in clinical investigations and nuclear medicine, in agricultural research and development and environmental investigations, in the elucidation of biological and chemical pathways, handling radioisotopes, laboratory design and other areas.
Book Synopsis Synthesis and Applications of Isotopically-Labelled Compounds by : David Hesk
Download or read book Synthesis and Applications of Isotopically-Labelled Compounds written by David Hesk and published by Elsevier. This book was released on 2024-02-04 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis and Applications of Isotopically-Labelled Compounds: Recent Advances and Emerging Topics reviews recent advances in the field of tritium, carbon-14, and stable isotope compound synthesis along with their analysis.The emerging field of the development of deuterated pharmaceuticals is also discussed, along with the application of isotopically labelled compounds in drug metabolism studies.There currently is no authoritative text for this area that presents a comprehensive guide to the field for the community, as well as newcomers, interested parties or collaborators who need to be able to communicate with the labeling groups. This book will fill this gap and provide a "one-stop shop" by having a comprehensive review of recent developments This book will cover details around the analytical chemistry in depth in Chapter 9 which will tie in the with synthesis reviews in the earlier chapters 1 through 4. Chapter 3 will also include a section on a new method of stable isotope analysis. In addition, Chapters 5, 7 and will cover the analytical chemistry aspects of these specific areas.
Book Synopsis Synthesis and Applications of Isotopically Labelled Compounds 1997 by : J. R. Heys
Download or read book Synthesis and Applications of Isotopically Labelled Compounds 1997 written by J. R. Heys and published by . This book was released on 1998-06-11 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Synthesis and Applications of Isotopically Labelled Compounds provides a wide-ranging, authoritative and comprehensive coverage of the most recent advances in the synthesis, production and applications of stable and radioactive isotopes. This volume focuses on significant growth areas including applications of isotopes in clinical research and medicine, advances in the analysis of isotopically labelled compounds, novel approaches to compounds labelled with isotopes of hydrogen, applications of isotopes in organic and bio-organic reaction mechanisms, isotopes in macro-molecules, applications of isotopes in metabolism and toxicology, production of stable isotopes and radioisotopes and applications of isotopes in pharmaceutical and agricultural research. Contributions are drawn from major research groups around the world providing an invaluable information and reference source to anyone involved in the production of isotopes, the synthesis and analysis of stable or radioactive isotopically labelled compounds, the applications of short-lived isotopes, drug metabolism and pharmacokinetics, pharmaceutical research and development, clinical research, biosynthesis, handling radioisotopes, laboratory design and other related areas.
Book Synopsis Synthesis and Applications of Isotopically Labelled Compounds, 1991 by : E. Buncel
Download or read book Synthesis and Applications of Isotopically Labelled Compounds, 1991 written by E. Buncel and published by Elsevier Publishing Company. This book was released on 1992 with total page 820 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Fourth International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds attracted some 400 scientists from over 20 countries. The scientific program consisted of three plenary lectures, 97 invited and contributed talks presented in 15 sessions on diverse topics, and 85 poster presentations. This proceedings volume covers the full texts of all the contributions, providing comprehensive, state-of-the-art information of interest to readers in chemistry, pharmacology, biochemistry and the medical sciences.
Book Synopsis The Organic Chemistry of Isotopic Labelling by : James R Hanson
Download or read book The Organic Chemistry of Isotopic Labelling written by James R Hanson and published by Royal Society of Chemistry. This book was released on 2019-04-05 with total page 201 pages. Available in PDF, EPUB and Kindle. Book excerpt: The chemical synthesis of isotopically labelled compounds is a pre-requisite for many chemical, biochemical and medicinal investigations. The constraints imposed by the requirements for regiospecific labelling and, in some instances, the time-scale of the synthesis often lead to quite different synthetic strategies to those that are used for the unlabelled material. Whilst there are many specialist papers, reviews and long books devoted to particular isotopes, there is no currently available short introductory book devoted to the organic chemistry of isotopic labelling. The aim of this book is to introduce research workers to a variety of methods that have been used to achieve these synthetic labelling objectives before exploring a particular method in detail. It covers a number of different isotopes and the methods that have been used to introduce them into organic compounds. Labelling methods also provide useful undergraduate teaching examples of modern synthetic reactions and their stereochemical consequences using relatively simple substrates. The book will therefore have a wider appeal than just those involved in using isotopes in research such as environmental and pharmaceutical chemists as well as organic chemists.
Book Synopsis Preparation of Compounds Labeled with Tritium and Carbon-14 by : Rolf Voges
Download or read book Preparation of Compounds Labeled with Tritium and Carbon-14 written by Rolf Voges and published by John Wiley & Sons. This book was released on 2009-03-12 with total page 682 pages. Available in PDF, EPUB and Kindle. Book excerpt: Compounds labeled with carbon-14 and tritium are indispensable tools for research in biomedical sciences, discovery and development of pharmaceuticals and agrochemicals. Preparation of Compounds Labeled with Tritium and Carbon-14 is a comprehensive, authoritative and up-to-date discussion of the strategies, synthetic approaches, reactions techniques, and resources for the preparation of compounds labeled with either of these isotopes. A large number of examples are presented for the use of isotopic sources and building blocks in the preparation of labeled target compounds, illustrating the range of possibilities for embedding isotopic labels in selected moieties of complex structures. Topics include: Formulation of synthetic strategies for preparing labeled compounds Isotope exchange methods and synthetic alternatives for preparing tritiated compounds In-depth discussion of carbon-14 building blocks and their utility in synthesis Preparation of enantiomerically pure isotopically labeled compounds Applications of biotransformations Preparation of Compounds Labeled with Tritium and Carbon-14 is an essential guide to the specialist strategies and tactics used by chemists to prepare compounds tagged with theradioactive atoms carbon-14 and tritium.
Book Synopsis Drug Discovery and Evaluation: Methods in Clinical Pharmacology by : H.Gerhard Vogel
Download or read book Drug Discovery and Evaluation: Methods in Clinical Pharmacology written by H.Gerhard Vogel and published by Springer Science & Business Media. This book was released on 2010-12-15 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Discovery and Evaluation has become a more and more difficult, expensive and time-consuming process. The effect of a new compound has to be detected by in vitro and in vivo methods of pharmacology. The activity spectrum and the potency compared to existing drugs have to be determined. As these processes can be divided up stepwise we have designed a book series "Drug Discovery and Evaluation" in the form of a recommendation document. The methods to detect drug targets are described in the first volume of this series "Pharmacological Assays" comprising classical methods as well as new technologies. Before going to man, the most suitable compound has to be selected by pharmacokinetic studies and experiments in toxicology. These preclinical methods are described in the second volume „Safety and Pharmacokinetic Assays". Only then are first studies in human beings allowed. Special rules are established for Phase I studies. Clinical pharmacokinetics are performed in parallel with human studies on tolerability and therapeutic effects. Special studies according to various populations and different therapeutic indications are necessary. These items are covered in the third volume: „Methods in Clinical Pharmacology".
Book Synopsis Synthesis and Applications of Isotopically Labeled Compounds, 1985 by : Richard Robert Muccino
Download or read book Synthesis and Applications of Isotopically Labeled Compounds, 1985 written by Richard Robert Muccino and published by Elsevier Publishing Company. This book was released on 1986 with total page 600 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Isotope Dilution Mass Spectrometry by : Jose Alonso
Download or read book Isotope Dilution Mass Spectrometry written by Jose Alonso and published by Royal Society of Chemistry. This book was released on 2019-03-22 with total page 473 pages. Available in PDF, EPUB and Kindle. Book excerpt: Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used in routine analysis labs (including environmental, food safety and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique. The main objective of this book is to cover the theory and applications of Isotope Dilution in Analytical Chemistry. The scope is comprehensive to include elemental analysis, speciation analysis, organic analysis and biochemical and clinical analysis together with applications in metabolism studies and traceability of goods. Until now there have been no books published with the same general scope (only book chapters on particular applications). This is a textbook focused at post-graduate level covering the basic knowledge required for doctoral studies in this field. Isotope Dilution Mass Spectrometry will also outline practical applications of interest for routine testing laboratories where isotope dilution procedures are implemented or can be implemented in the future. This unique book covers all the theoretical and practical aspects of Isotope Dilution Mass Spectrometry (IDMS). Due to the increasing application of IDMS in many research laboratories and the increasing implementation of IDMS methodologies in routine testing laboratories, scientists in industry and working in or affiliated to this area will this an invaluable source of information. Concerning the theoretical aspects, the authors present a uniform theoretical background which grows from previous developments in Organic, Speciation and Elemental analysis both in their own laboratory and in other laboratories around the world. This general approach will be simpler and will also include new emerging fields such as quantitative proteomics and metabolism studies.
Download or read book Isotopes written by John Richards Jones and published by . This book was released on 1980 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Isotopes by : Royal Society of Chemistry (Great Britain)
Download or read book Isotopes written by Royal Society of Chemistry (Great Britain) and published by CRC Press. This book was released on 1988 with total page 276 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is a survey of isotopes with particular reference to the fields of analytical chemistry, organic chemistry, medicinal chemistry and radiochemistry. The work is aimed at graduate and senior undergraduate level.
Book Synopsis Reactive Drug Metabolites by : Amit S. Kalgutkar
Download or read book Reactive Drug Metabolites written by Amit S. Kalgutkar and published by John Wiley & Sons. This book was released on 2012-09-06 with total page 445 pages. Available in PDF, EPUB and Kindle. Book excerpt: Closing a gap in the scientifi c literature, this first comprehensive introduction to the topic is based on current best practice in one of the largest pharmaceutical companies worldwide. The first chapters trace the development of our understanding of drug metabolite toxicity, covering basic concepts and techniques in the process, while the second part details chemical toxicophores that are prone to reactive metabolite formation. This section also reviews the various drug-metabolizing enzymes that can participate in catalyzing reactive metabolite formation, including a discussion of the structure-toxicity relationships for drugs. Two chapters are dedicated to the currently hot topics of herbal constituents and IADRs. The next part covers current strategies and approaches to evaluate the reactive metabolite potential of new drug candidates, both by predictive and by bioanalytical methods. There then follows an in-depth analysis of the toxicological potential of the top 200 prescription drugs, illustrating the power and the limits of the toxicophore concept, backed by numerous case studies. Finally, a risk-benefi t approach to managing the toxicity risk of reactive metabolite-prone drugs is presented. Since the authors carefully develop the knowledge needed, from fundamental considerations to current industry standards, no degree in pharmacology is required to read this book, making it perfect for medicinal chemists without in-depth pharmacology training.
Download or read book Lipidomics written by Xianlin Han and published by John Wiley & Sons. This book was released on 2016-04-06 with total page 496 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covers the area of lipidomics from fundamentals and theory to applications Presents a balanced discussion of the fundamentals, theory, experimental methods and applications of lipidomics Covers different characterizations of lipids including Glycerophospholipids; Sphingolipids; Glycerolipids and Glycolipids; and Fatty Acids and Modified Fatty Acids Includes a section on quantification of Lipids in Lipidomics such as sample preparation; factors affecting accurate quantification; and data processing and interpretation Details applications of Lipidomics Tools including for Health and Disease; Plant Lipidomics; and Lipidomics on Cellular Membranes
Book Synopsis Isotope Production and Applications in the 21st Century by : Nigel R Stevenson
Download or read book Isotope Production and Applications in the 21st Century written by Nigel R Stevenson and published by World Scientific. This book was released on 2000-10-09 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Third International Conference on Isotopes focused on the theme of “Isotope Production and Applications in the 21st Century” and included presentations by several eminent experts in this field. The three central subjects — Isotopes in Medicine, Industry and the Environment — were supplemented by presentations on the latest developments in isotope production and synthesis, research into radiopharmaceuticals, applications in agriculture, analytical applications, radiocarbon dating, AMS and PET. Various views on the future directions for producers and users of isotopes were considered at this multi-disciplinary meeting. Contents:Isotope Facilities and ProgramsRadiochemical Synthesis I–II, Nuclear Analytical Applications of Radioisotopes I–IIRadioisotope ProductionSeparation and Applications of Stable IsotopesIndustrial Applications and Radiation SafetyRadiopharmaceutical Applications and Medical Imaging I–IIProduction and Applications of Isotope Tracers in Industry I–IIUse of Isotopes in Environmental Studies I–IIApplications of Isotopes in Medical Imaging and TherapyRadiation Safety Aspects at Isotope FacilitiesApplications in Agriculture and NutritionAMS and Radiocarbon Dating TechniquesPoster SessionApplications of Isotopes in Environmental StudiesProduction and Applications of Short-Lived RadioisotopesLabeling Compounds and Other Applications of TritiumNovel Applications of Isotopes and Opportunities for Technology TransferClosing Plenary Session: “Isotope Production and Applications in the 21st Century” Readership: Radiochemists, radiopharmacists, environmental scientists, reactor and accelerator physicists, and nuclear medicine researchers. Keywords:
Book Synopsis Handbook of Nuclear Chemistry by : Attila Vértes
Download or read book Handbook of Nuclear Chemistry written by Attila Vértes and published by Springer Science & Business Media. This book was released on 2010-12-10 with total page 3693 pages. Available in PDF, EPUB and Kindle. Book excerpt: This revised and extended 6 volume handbook set is the most comprehensive and voluminous reference work of its kind in the field of nuclear chemistry. The Handbook set covers all of the chemical aspects of nuclear science starting from the physical basics and including such diverse areas as the chemistry of transactinides and exotic atoms as well as radioactive waste management and radiopharmaceutical chemistry relevant to nuclear medicine. The nuclear methods of the investigation of chemical structure also receive ample space and attention. The international team of authors consists of scores of world-renowned experts - nuclear chemists, radiopharmaceutical chemists and physicists - from Europe, USA, and Asia. The Handbook set is an invaluable reference for nuclear scientists, biologists, chemists, physicists, physicians practicing nuclear medicine, graduate students and teachers - virtually all who are involved in the chemical and radiopharmaceutical aspects of nuclear science. The Handbook set also provides further reading via the rich selection of references.
