Sustainable Routes To Porous Silicon Nanostructures As Drug And Gene Delivery Vehicles

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Sustainable Routes to Porous Silicon Nanostructures as Drug and Gene Delivery Vehicles

Author : Jhansi Rani Kalluri
Publisher :
ISBN 13 :
Total Pages : 124 pages
Book Rating : 4.:/5 (17 download)

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Book Synopsis Sustainable Routes to Porous Silicon Nanostructures as Drug and Gene Delivery Vehicles by : Jhansi Rani Kalluri

Download or read book Sustainable Routes to Porous Silicon Nanostructures as Drug and Gene Delivery Vehicles written by Jhansi Rani Kalluri and published by . This book was released on 2018 with total page 124 pages. Available in PDF, EPUB and Kindle. Book excerpt: Porous silicon (pSi), with its nanoscale architecture, acts as a promising resorbable biomaterial for a broad variety of applications: biosensors, orthopedic tissue engineering, and controlled drug delivery. The most conventional methods for preparing porous silicon particles are anodization of silicon wafers and metal-assisted chemical etching (MACE). These established techniques require elemental crystalline silicon feedstocks, and the use of corrosive hydrofluoric acid (HF) and organic solvents. Rather than employing these methods, we have developed an eco-friendly alternative of producing pSi from silicon accumulator plants/agriculture waste. Two different silicon accumulator plants Bambuseae (tabasheer) and Equisetum telmateia (great horsetail)have been investigated for this purpose, and high surface area porous silicon nanostructures prepared using a magnesiothermic reduction of silica isolated from these plants. This fabrication process of pSi includes extraction of biogenic silica from the ground plant by calcination, followed by reduction with magnesium, and purification of reduced Si product. Details of fabrication process and characterization of pSi powders by a combination of scanning electron microscopy (SEM), energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD), transmission electron microscopy (TEM), and low temperature nitrogen gas adsorption measurements will be outlined in this presentation. As pointed out above, Bambuseae serves as a viable eco-friendly starting materials for fabricating porous silicon (pSi).At the same time, if the selected plant leaf components contain medicinally-active species (antibacterial) as well, then the single substance can provide not only the nanoscale high surface area drug delivery carrier, but the drug itself. With this idea in mind using a single plant source (Bambuseae) we have developed porous silicon based drug delivery carrier matrix for the sustained release of antibacterials. Nanoentrapment of vitamins, nutrients, and plant based therapeutics is another attractive area in food and pharmaceutical industries to address the challenges of stability and bioavailability of entrapped agents. One way to increase the bioavailability of the drugs is by enhancing their solubility. We have evaluated the ability of nanostructured plant-derived porous silicon particles (pSi) as potential candidates to increase the solubility of plant extracts rich in therapeutic polyphenolic compounds (Equisetum arvense) and a poorly water soluble vitamin (vitamin d3). We have also evaluated the ability of plant derived porous silicon nanoparticles (pSiNPs) as gene delivery vehicles. Following necessary reduction of pSiNP particle size and functionalization with primary amine moieties at the nanoparticle surface, the binding of a reporter plasmid DNA, pEF1-eGFP (endothelial factor 1 enhanced green fluorescent protein, 6429 bp) to the pSiNPs was investigated, followed by attempted transfection of HEK293 cells.

Modification of Porous Silicon for DNA Synthesis and Drug Delivery Systems

Author : Steven James Peter McInnes
Publisher :
ISBN 13 :
Total Pages : 110 pages
Book Rating : 4.:/5 (226 download)

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Book Synopsis Modification of Porous Silicon for DNA Synthesis and Drug Delivery Systems by : Steven James Peter McInnes

Download or read book Modification of Porous Silicon for DNA Synthesis and Drug Delivery Systems written by Steven James Peter McInnes and published by . This book was released on 2005 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery

Author : M Karimi
Publisher : Myprint
ISBN 13 : 9781681748467
Total Pages : 114 pages
Book Rating : 4.7/5 (484 download)

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Book Synopsis Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery by : M Karimi

Download or read book Smart Internal Stimulus-Responsive Nanocarriers for Drug and Gene Delivery written by M Karimi and published by Myprint. This book was released on 2015-11-19 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Fusogenic Porous Silicon Nanoparticles as a Platform Technology for Gene Therapy

Author : Byungji Kim
Publisher :
ISBN 13 :
Total Pages : 259 pages
Book Rating : 4.:/5 (11 download)

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Book Synopsis Fusogenic Porous Silicon Nanoparticles as a Platform Technology for Gene Therapy by : Byungji Kim

Download or read book Fusogenic Porous Silicon Nanoparticles as a Platform Technology for Gene Therapy written by Byungji Kim and published by . This book was released on 2019 with total page 259 pages. Available in PDF, EPUB and Kindle. Book excerpt: With increasing discoveries in genetic and biological pathways with respect to disease treatment, the potential for gene therapy is growing exponentially. In parallel, gene modulating tools have also expanded; catalyzed by the discovery of the RNA interference and zinc finger proteins in the 1990s, the 21st century has seen a variety of mechanisms for editing genetic expression (e.g. double-stranded oligonucleotides, zinc finger nucleases (ZFNs), transcription activator-like effector nuclease (TALENS), clustered regularly interspaced short palindromic repeats (CRISPR/Cas), etc.). However, a primary roadblock in enabling these gene editing tools for clinical translation is the biological clearance and degradation mechanisms that prevent the tools from reaching the target cells. The fusogenic porous silicon nanoparticles (FNPs) present an effective solution to this delivery challenge. Chapter one provides introductory overview of gene therapy, their limitations, as well as the current state-of-the-art technologies with the aim of delineating materials design criteria of RNAi therapeutics. Furthermore, a brief analysis and discussion on trends of publications and clinical translations of RNAi therapy formulations are provided. Chapter two details the synthesis protocol of fusogenic porous silicon nanoparticles. As the FNPs comprise of multi-layer structure (ie. payload-loaded pSiNPs, calcium silicate sealing, lipid bilayer encapsulation, targeting peptide decoration), the protocol requires delicate and precise handling for formation of stable nanoparticles. Examples of successful versus unsuccessful syntheses are presented, and critical steps to positive outcome are highlighted. The potential for variations and alternative optimizations to the protocol are discussed. Chapter three delves into the material properties that enable FNP function, and the biological pathways that FNPs depend on for its unique cellular uptake and processing. The intracellular fate and metabolism of individual components of the FNP system (e.g. oligonucleotide payload, pSiNP core, and lipid bilayer shell) are also presented. The fundamental information gained from studying the material interaction at a single-cell level is used to inform the following chapters that deal with application of FNPs in disease models. Chapters 4-6 demonstrate the FNPs as a platform technology that can be developed into a wide range of therapeutic formulations. By simple exchange of targeting peptides and the siRNA payload, the FNPs demonstrate successful therapeutic outcomes in mouse models of cancer (Chapter 4) and bacterial infections (Chapters 5 and 6).

Smart External Stimulus-responsive Nanocarriers for Drug and Gene Delivery

Author : Mahdi Karimi (Scientist)
Publisher :
ISBN 13 : 9781681740744
Total Pages : pages
Book Rating : 4.7/5 (47 download)

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Book Synopsis Smart External Stimulus-responsive Nanocarriers for Drug and Gene Delivery by : Mahdi Karimi (Scientist)

Download or read book Smart External Stimulus-responsive Nanocarriers for Drug and Gene Delivery written by Mahdi Karimi (Scientist) and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of smart drug delivery vehicles involves designing and preparing a nanostructure (or microstructure) that can be loaded with a cargo, this can be a therapeutic drug, a contrast agent for imaging, or a nucleic acid for gene therapy. The nanocarrier serves to protect the cargo from degradation by enzymes in the body, to enhance the solubility of insoluble drugs, to extend the circulation half-life, and to enhance its penetration and accumulation at the target site. Importantly, smart nanocarriers can be designed to be responsive to a specific stimulus, so that the cargo is only released or activated when desired. In this volume we cover smart nanocarriers that respond to externally applied stimuli that usually involve application of physical energy. This physical energy can be applied from outside the body and can either cause cargo release, or can activate the nanostructure to be cytotoxic, or both. The stimuli covered include light of various wavelengths (ultraviolet, visible or infrared), temperature (increased or decreased), magnetic fields (used to externally manipulate nanostructures and to activate them), ultrasound, and electrical and mechanical forces. Finally we discuss the issue of nanotoxicology and the future scope of the field.

Tuning Surface Chemistry and Nanostructure in Porous Silicon for Molecular Separation, Detection and Delivery

Author : Chia-Chen Wu
Publisher :
ISBN 13 : 9781303527197
Total Pages : 21 pages
Book Rating : 4.5/5 (271 download)

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Book Synopsis Tuning Surface Chemistry and Nanostructure in Porous Silicon for Molecular Separation, Detection and Delivery by : Chia-Chen Wu

Download or read book Tuning Surface Chemistry and Nanostructure in Porous Silicon for Molecular Separation, Detection and Delivery written by Chia-Chen Wu and published by . This book was released on 2013 with total page 21 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mesoporous materials with engineered surface properties are of interest for molecular separations, catalysis, drug delivery, and chemical sensing. One of the longstanding chemical challenges in the engineering of nanomaterials is to control the placement of different chemistries in spatially distinct regions on a nanoscale object. This thesis focuses on discovering and understanding processes to prepare such spatially differentiated chemistries on porous silicon. For the porous silicon system, the ability to prepare pores of average diameter anywhere from 1 to 200 nm allows the harnessing of surface tension and capillary forces to promote or obstruct the infiltration of reagent for selective modification. The first process investigated involves placing different chemistries on the pore walls by means of microdroplet patterning. In this method, a chemical resist is drop-coated on a porous silicon sample to mask distinct regions across the plane of the chip for subsequent chemical modification. Two chemistries, silicon oxide and silicon-methyl, are demonstrated here. The differential partitioning of test molecules on the resulting hydrophilic/hydrophobic film is achieved by simultaneous optical reflectance measurement of both regions, where the reflectance spectrum contains a convolution of the Fabry-Pérot interference spectrum for both types of surface chemistries. A second approach to engineer porous Si nanostructures that is investigated uses a hydrophobic organic liquid as a chemical resist; it is infiltrated into the pores to mask the interior of the porous silicon film, while the exterior surface and the pore mouths of the film are subjected to an aqueous chemical reaction with HF and subsequent chemical modification by thermal hydrosilylation. When chemically modified with a hydrophobic dodecyl species, the resulting film has a hydrophilic interior and a hydrophobic outer surface. The ability of these core-shell porous nanostructures to admit and release small molecules is assessed and exploited. The last portion of the thesis focuses on an evaluation of chemically modified porous silicon particles as oral drug delivery material, with an emphasis on the ability of the interior of the porous silicon nanostructure to protect physiologically unstable drugs. Partially oxidized porous silicon particles show no toxicity to nematodes at particle concentration up to 1 mg/mL in culture media. In vitro experiments show the particles protect anthelmintic protein-based drug Cry5B from hydrolytic degradation in simulated gastric fluid, and the bioactivity against nematodes is maintained. However, much reduced bioactivity of the therapeutic particles is observed In vivo on hookworm-infected hamsters. The lack of effectiveness in treating the disease In vivo is attributed to the short residence time of the particles in the gut of the animals.

Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery

Author : M Karimi
Publisher : Myprint
ISBN 13 : 9781681748450
Total Pages : 94 pages
Book Rating : 4.7/5 (484 download)

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Book Synopsis Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery by : M Karimi

Download or read book Smart External Stimulus-Responsive Nanocarriers for Drug and Gene Delivery written by M Karimi and published by Myprint. This book was released on 2015-11-19 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Porous Silicon Nanoneedles for Intracellular Delivery of Small Interfering RNA

Author : Ciro Chiappini Dottore
Publisher :
ISBN 13 :
Total Pages : 408 pages
Book Rating : 4.:/5 (796 download)

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Book Synopsis Porous Silicon Nanoneedles for Intracellular Delivery of Small Interfering RNA by : Ciro Chiappini Dottore

Download or read book Porous Silicon Nanoneedles for Intracellular Delivery of Small Interfering RNA written by Ciro Chiappini Dottore and published by . This book was released on 2011 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rational and directed delivery of genetic material to the cell is a formidable tool to investigate the phenotypic effects of gene expression regulation and a promising therapeutic strategy for genetic defects. RNA interference constitutes a versatile approach to gene silencing. Despite the development of numerous strategies the transfection of small interfering RNA (siRNA) is highly dependent on cell type and conditions. Direct physical access to the intracellular compartment is a promising path for high efficiency delivery independently of cell type and conditions. Silicon nanowires grant such access with minimal toxic effects, and allow intracellular delivery of DNA when actuated by atomic force microscope. These findings reveal the potential for porous silicon nanostructures to serve as delivery vectors for nucleic acids due to their porous nature, elevated biocompatibility, and biodegradability. This dissertation illustrates the development a novel platform for efficient siRNA transfection based on an array of porous silicon nanoneedles. The synthesis of biodegradable and biocompatible porous nanowires was accomplished by a novel strategy for electroless etch of silicon that allows anisotropic etch simultaneously with porosification. An ordered array of cone shaped porous silicon nanoneedles with tunable tip size, array density and aspect ratio was obtained coupling this strategy with patterned metal deposition and selective reactive ion etch. This process also granted control over porosity, nanopore size and flexural modulus. The combination of these parameters was appropriately optimized to ensure cell penetration, maximize siRNA loading and minimize cytotoxic effects. Loading of the negatively charged siRNA molecules was optimized by applying an external electric field to the nanoneedles under appropriate voltage conditions to obtain a tenfold increase over open circuit loading, and efficient penetration of the siRNA within the porous volume of the needles. Alternative surface chemistry modification provided a means for effective siRNA loading and sustained release. siRNA transfection was achieved by either imprinting the nanoneedles array chip over a culture of MDA-MB-231 cells or allowing the cells to self-impale over the needles. The procedures allowed the needles to penetrate across the cell membrane without influencing cell proliferation. siRNA was successfully transfected and was effective at suppressing gene expression.

Chemically Modified and Nanostructured Porous Silicon as a Drug Delivery Material and Device

Author : Emily Jessica Anglin
Publisher :
ISBN 13 :
Total Pages : 158 pages
Book Rating : 4.:/5 (187 download)

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Book Synopsis Chemically Modified and Nanostructured Porous Silicon as a Drug Delivery Material and Device by : Emily Jessica Anglin

Download or read book Chemically Modified and Nanostructured Porous Silicon as a Drug Delivery Material and Device written by Emily Jessica Anglin and published by . This book was released on 2007 with total page 158 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thesis describes the fabrication, chemical modification, drug release, and toxicity studies of nanostructured porous silicon for the purposes of developing a smart drug delivery device. The first chapter is an introductory chapter, presenting the chemical and physical properties of porous silicon, the concepts and issues of current drug delivery devices and materials, and how porous silicon can address the issues regarding localized and controlled drug therapies. The second chapter discusses chemical modifications of nanostructured porous Si for stabilizing the material in biologically relevant media while providing an extended release of a therapeutic in vitro. This chapter also demonstrates the utility of the porous silicon optical signatures for effectively monitoring drug release from the system and its applications for development of a self-reporting drug delivery device. In chapter three, the concept of providing a triggered release of a therapeutic from porous silicon microparticles through initiation by an external stimulus is demonstrated. The microparticles are chemically modified, and the release is enhanced by a short application of ultrasound to the particulate system. The effect of ultrasound on the drug release and particle size is discussed. Chapter four presents a new method for sustaining the release of a monoclonal antibody from the porous matrix of porous SiO2. The therapeutic is incorporated into the films through electrostatic adsorption and a slow release is observed in vitro. A new method of quantifying the extent of drug loading is monitored with interferometry. The last chapter of the thesis provides a basic in vivo toxicity study of various porous Si microparticles for intraocular applications. Three types of porous Si particles are fabricated and studied in a rabbit eye model. The toxicity studies were conducted by collaborators at the Shiley Eye Center, La Jolla, CA. This work, demonstrates the feasibility of developing a self-reporting, extended release drug delivery system using porous Si microparticles for intraocular applications.

Silicon in a One-dimensional Porous Nanotube Structure and Its Evaluation as Drug Delivery Vector in Vitro

Author : Tan Khanh Le Nguyen
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (136 download)

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Book Synopsis Silicon in a One-dimensional Porous Nanotube Structure and Its Evaluation as Drug Delivery Vector in Vitro by : Tan Khanh Le Nguyen

Download or read book Silicon in a One-dimensional Porous Nanotube Structure and Its Evaluation as Drug Delivery Vector in Vitro written by Tan Khanh Le Nguyen and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug delivery is a promising therapeutic approach to achieve sustainable drug release while minimizing adverse side effects triggered by non-specificity of the free drugs. Among delivery vectors, biodegradable nanomaterials are of utmost interest for minimizing deleterious consequences stemming from long-term carrier accumulation. With regard to inorganic nanomaterials, porous silicon (pSi) is among a few that can degrade and release non-toxic byproducts (i.e. orthosilicic acid), and dissolution kinetics of the materials can readily be controlled via modulating structural morphology as well as surface chemistry. To date, a great number of pSi-based delivery vectors with intricate designs have been presented to address multiple challenges in therapeutic delivery. Since the shape of the nanocarriers have been shown to influence interactions with multiple biological components, pSi with various geometrical shapes (i.e. discoidal, hemisphere and platelet shapes) have been introduced in recent years, and promising therapeutic efficacy has also been demonstrated in various disease models. Recently, via a sacrificial ZnO template method developed by our group, we have shown that one-dimensional (1D) porous nanotube structure of Si (pSiNTs) with well-defined shell thickness, inner diameter and length can readily be achieved. Since the materials can degrade in biological media and exert negligible effects to viability of both normal (e.g. human embryonic kidney, HEK 293) and cancer (e.g. HeLa cervical cancer) human cells, it is of great interest to evaluate pSiNTs as potential therapeutic platforms. Interestingly, we have also demonstrated pSiNTs can also serve as a facile template for facilitating formation of a secondary nanostructure, so called platinum nanocrystals (Pt NCs) with potential anti-cancer properties. Evaluation of in vitro anti-cancer activity of this novel nanohybrid revealed the viability of HeLa cells was reduced in a time-dependent manner as a consequence of a "Trojan horse" mechanism, in which a high concentration of Pt NCs are internalized within cells assisted by pSiNTs and subsequently released via dissolution of the nanotube matrix. In addition, pSiNTs are also evaluated as potential therapeutic delivery vectors for nucleic acids. Preliminary in vitro studies suggest the materials can deliver reporter plasmids DNA (circular DNA) encoding green fluorescent proteins (eGFP) into HEK 293 cells. In another study, downregulations of eGFP (in HeLa) and estrogen receptors (ER) (in MCF-7 breast cancer cells) are also demonstrated via delivery of small interfering RNA (siRNAs) targeting eGFP-mRNA (siGFP) and ER-mRNA (siER) by pSiNTs. All in all, these studies presented herein demonstrate the potential merit of pSiNTs in drug delivery and serve as a foundation for future studies to design pSiNTs-based platforms that can successively address multiple biological barriers encountered upon systemic administration. Such studies expand the library of possible pSi structures in nanomedicine for suitable disease models and associated applications.

Carbohydrate-silica Nanoparticles for Sirna Delivery

Author : Olivia Mariel Chesniak
Publisher :
ISBN 13 : 9780438969421
Total Pages : 156 pages
Book Rating : 4.9/5 (694 download)

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Book Synopsis Carbohydrate-silica Nanoparticles for Sirna Delivery by : Olivia Mariel Chesniak

Download or read book Carbohydrate-silica Nanoparticles for Sirna Delivery written by Olivia Mariel Chesniak and published by . This book was released on 2019 with total page 156 pages. Available in PDF, EPUB and Kindle. Book excerpt: RNA interference (RNAi) has long been pursued for its therapeutic potential. Sequence-specific knockdown of gene expression requires that small interfering RNA (siRNA) gain access to cellular cytoplasm, presenting difficulties for both the transport of nucleic acids to cells and their voyage across cellular membranes. Numerous materials are under development as siRNA delivery vehicles to address this need. The carbohydrate dextran has been incorporated into amine-functionalized sil- ica nanoparticles (Dex-SiO2-NPs), enhancing their biocompatibility and success as siRNA delivery vehicles. Inspired by the work of Stober and others, reagent concentrations in the synthesis of Dex- SiO2-NPs have been adjusted to tune nanoparticle diameter. The size, shape, and morphology of Dex-SiO2-NPs have been characterized using transmission electron microscopy (TEM) and energy dispersive x-ray spectroscopy (EDS). These methods have revealed that Dex-SiO2-NPs decrease in silicon density toward their centers, when compared with SiO2-NPs. Thermal and porosity analysis were used to profile Dex-SiO2-NPs both containing dextran and after its removal by calcination. Having measured an increase in mesopores and decrease in micropores with calcination, it has been concluded that dextran serves as a porogen in Dex-SiO2-NP synthesis. Not only does dextran imbue these materials with unique morphology, it also enhances their function as delivery vehicles. Dex-SiO2-NPs improve enhanced green fluorescent protein (EGFP) supression compared to silica nanoparticles synthesized in the absence of dextran in human lung and kidney cells in vitro.

Nanosilicon

Author : Vijay Kumar
Publisher : Elsevier
ISBN 13 : 0080549519
Total Pages : 385 pages
Book Rating : 4.0/5 (85 download)

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Book Synopsis Nanosilicon by : Vijay Kumar

Download or read book Nanosilicon written by Vijay Kumar and published by Elsevier. This book was released on 2011-07-28 with total page 385 pages. Available in PDF, EPUB and Kindle. Book excerpt: Properties of nanosilicon in the form of nanoparticles, nanowires, nanotubes, and as porous material are of great interest. They can be used in finding suitable components for future miniature devices, and for the more exciting possibilities of novel optoelectronic applications due to bright luminescence from porous silicon, nanoparticles and nanowires. New findings from research into metal encapsulated clusters, silicon fullerenes and nanotubes have opened up a new paradigm in nanosilicon research and this could lead to large scale production of nanoparticles with control on size and shape as well as novel quasi one-dimensional structures. There are possibilities of using silicon as an optical material and in the development of a silicon laser. In Nanosilicon, leading experts cover state-of-the-art experimental and theoretical advances in the different forms of nanosilicon. Furthermore, applications of nanosilicon to single electron transistors, as photonic material, chemical and biological sensors at molecular scale, and silicon nanowire devices are also discussed. Self-assemblies of silicon nanoforms are important for applications. These developments are also related to cage structures of silicon in clathrates. With an interesting focus on the bottlenecks in the advancement of silicon based technology, this book provides a much-needed overview of the current state of understanding of nanosilicon research. Latest developments in nanoparticles, nanowires and nanotubes of silicon Focus on nanosilicon - a very timely subject attracting large interest Novel chapters on metal encapsulated silicon clusters and nanotubes

Oral Lipid-Based Formulations

Author : David J. Hauss
Publisher : CRC Press
ISBN 13 : 1420017268
Total Pages : 370 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Oral Lipid-Based Formulations by : David J. Hauss

Download or read book Oral Lipid-Based Formulations written by David J. Hauss and published by CRC Press. This book was released on 2007-06-08 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oral lipid-based formulations are attracting considerable attention due to their capacity to facilitate gastrointestinal absorption and reduce or eliminate the effect of food on the absorption of poorly water-soluble, lipophilic drugs. Despite the obvious and demonstrated utility of these formulations for addressing a persistent and growing problem

Strategies to Modify the Drug Release from Pharmaceutical Systems

Author : Marcos Luciano Bruschi
Publisher : Woodhead Publishing
ISBN 13 : 0081001126
Total Pages : 208 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Strategies to Modify the Drug Release from Pharmaceutical Systems by : Marcos Luciano Bruschi

Download or read book Strategies to Modify the Drug Release from Pharmaceutical Systems written by Marcos Luciano Bruschi and published by Woodhead Publishing. This book was released on 2015-06-16 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the earliest dosage forms to modern drug delivery systems, came a great development and growth of knowledge with respect to drug delivery. Strategies to Modify the Drug Release from Pharmaceutical Systems will address principles, systems, applications and advances in the field.It will be principally a textbook and a reference source of strategies to modify the drug release. Moreover, the characterization, mathematical and physicochemical models, applications and the systems will be discussed. Addresses the principles, systems, applications and advances in the field of drug delivery Highlights the mathematical and physicochemical principles related to strategies Discusses drug release and its possible modifications

FASTtrack Pharmaceutics

Author : Yvonne Perrie
Publisher : Pharmaceutical Press
ISBN 13 : 0857110594
Total Pages : 257 pages
Book Rating : 4.8/5 (571 download)

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Book Synopsis FASTtrack Pharmaceutics by : Yvonne Perrie

Download or read book FASTtrack Pharmaceutics written by Yvonne Perrie and published by Pharmaceutical Press. This book was released on 2012 with total page 257 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Pharmaceutics - Drug delivery and targeting focuses on what pharmacy students really need to know in order to pass exams, providing concise, bulleted information, key points, tips and an all-important self-assessment section which includes MCQs."--Page 4 of cover.

Nanopharmaceuticals: Principles and Applications Vol. 3

Author : Vinod Kumar Yata
Publisher : Springer Nature
ISBN 13 : 3030471209
Total Pages : 340 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis Nanopharmaceuticals: Principles and Applications Vol. 3 by : Vinod Kumar Yata

Download or read book Nanopharmaceuticals: Principles and Applications Vol. 3 written by Vinod Kumar Yata and published by Springer Nature. This book was released on 2020-08-19 with total page 340 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the third volume on this subject and focuses on the recent advances of nanopharmaceuticals in cancer, dental, dermal and drug delivery applications and presents their safety, toxicity and therapeutic efficacy. The book also includes the transport phenomenon of nanomaterials and important pathways for drug delivery applications. It goes on to explain the toxicity of nanoparticles to different physiological systems and methods used to assess this for different organ systems using examples of in vivo systems.

Comprehensive Nanoscience and Nanotechnology

Author :
Publisher : Academic Press
ISBN 13 : 012812296X
Total Pages : 1881 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Comprehensive Nanoscience and Nanotechnology by :

Download or read book Comprehensive Nanoscience and Nanotechnology written by and published by Academic Press. This book was released on 2019-01-02 with total page 1881 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Nanoscience and Technology, Second Edition, Five Volume Set allows researchers to navigate a very diverse, interdisciplinary and rapidly-changing field with up-to-date, comprehensive and authoritative coverage of every aspect of modern nanoscience and nanotechnology. Presents new chapters on the latest developments in the field Covers topics not discussed to this degree of detail in other works, such as biological devices and applications of nanotechnology Compiled and written by top international authorities in the field