The Orchid and the Dandelion

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Publisher : Vintage
ISBN 13 : 1101946571
Total Pages : 305 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis The Orchid and the Dandelion by : W. Thomas Boyce MD

Download or read book The Orchid and the Dandelion written by W. Thomas Boyce MD and published by Vintage. This book was released on 2019-01-29 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Based on groundbreaking research that has the power to change the lives of countless children--and the adults who love them." --Susan Cain, author of Quiet: The Power of Introverts. A book that offers hope and a pathway to success for parents, teachers, psychologists, and child development experts coping with difficult children. In Tom Boyce's extraordinary new book, he explores the "dandelion" child (hardy, resilient, healthy), able to survive and flourish under most circumstances, and the "orchid" child (sensitive, susceptible, fragile), who, given the right support, can thrive as much as, if not more than, other children. Boyce writes of his pathfinding research as a developmental pediatrician working with troubled children in child-development research for almost four decades, and explores his major discovery that reveals how genetic make-up and environment shape behavior. He writes that certain variant genes can increase a person's susceptibility to depression, anxiety, attention deficit hyperactivity disorder, and antisocial, sociopathic, or violent behaviors. But rather than seeing this "risk" gene as a liability, Boyce, through his daring research, has recast the way we think of human frailty, and has shown that while these "bad" genes can create problems, they can also, in the right setting and the right environment, result in producing children who not only do better than before but far exceed their peers. Orchid children, Boyce makes clear, are not failed dandelions; they are a different category of child, with special sensitivities and strengths, and need to be nurtured and taught in special ways. And in The Orchid and the Dandelion, Boyce shows us how to understand these children for their unique sensibilities, their considerable challenges, their remarkable gifts.

Origins of the Social Mind

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Author :
Publisher : Guilford Press
ISBN 13 : 9781593851033
Total Pages : 572 pages
Book Rating : 4.8/5 (51 download)

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Book Synopsis Origins of the Social Mind by : Bruce J. Ellis

Download or read book Origins of the Social Mind written by Bruce J. Ellis and published by Guilford Press. This book was released on 2005-01-01 with total page 572 pages. Available in PDF, EPUB and Kindle. Book excerpt: Applying an evolutionary framework to advance the understanding of child development, this volume brings together leading figures to contribute chapters in their areas of expertise. Researcher- and student-friendly chapters adhere to a common format.

Assessing the Human Health Risks of Trichloroethylene

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Publisher : National Academies Press
ISBN 13 : 9780309102834
Total Pages : 452 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Assessing the Human Health Risks of Trichloroethylene by : National Research Council

Download or read book Assessing the Human Health Risks of Trichloroethylene written by National Research Council and published by National Academies Press. This book was released on 2007-01-08 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: Trichloroethylene is a chlorinated solvent widely used as a degreasing agent in industrial and manufacturing settings. It is also used as a chemical intermediate in making other chemicals and is a component of products such as typewriter correction fluid, paint removers, adhesives, and spot removers. In 2001, EPA issued a draft health risk assessment and proposed exposure standards for trichloroethylene. PA's Scientific Advisory Board (SAB) reviewed the draft and it was issued for public comment. A number of scientific issues were raised during the course of these reviews. Assessing the Human Health Risks of Trichloroethylene identifies and assesses the key scientific issues relevant to analyzing the human health risks of trichloroethylene, considering pertinent toxicologic, epidemiologic, population susceptibility, and other available information, including relevant published scientific literature, EPA's 2001 draft health risk assessment of trichloroethylene, scientific and technical comments received by EPA from public and private sources, and additional relevant information to be provided by the sponsoring agencies. This report highlights issues critical to the development of an objective, realistic, and scientifically balanced trichloroethylene health risk assessment. Guidance for hazard characterization of trichloroethylene is presented in Chapters 2 through 10. Chapter 2 provides guidance for evaluating large sets of epidemiologic data. In Chapter 3, the committee applies this guidance as an example in its evaluation of the epidemiologic data on trichloroethylene and kidney cancer, and this example should help guide evaluations of other cancer risks. Chapter 3 also assesses new information on the kidney toxicity of trichloroethylene and its metabolites and potential modes of action. Chapters 4, 5, 6, 7, and 8 evaluate the key issues regarding liver toxicity and cancer, reproductive and developmental toxicity, neurotoxicity, respiratory tract toxicity and cancer, and immunotoxicity, respectively. However, the committee's review focused on mode-of-action information to understand how trichloroethylene might affect certain processes differently in different species. Chapter 9 discusses susceptibility to trichloroethylene and its metabolites, and Chapter 10 describes important factors in considering trichloroethylene in mixtures. Physiologically based pharmacokinetic models are evaluated in Chapter 11, and guidance is provided on future directions for model development. Finally, Chapter 12 considers issues related to dose-response assessment and quantitative assessment of risk.

Antimicrobial Susceptibility Testing Protocols

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Author :
Publisher : CRC Press
ISBN 13 : 1420014498
Total Pages : 430 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Antimicrobial Susceptibility Testing Protocols by : Richard Schwalbe

Download or read book Antimicrobial Susceptibility Testing Protocols written by Richard Schwalbe and published by CRC Press. This book was released on 2007-05-22 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: The clinical microbiology laboratory is often a sentinel for the detection of drug resistant strains of microorganisms. Standardized protocols require continual scrutiny to detect emerging phenotypic resistance patterns. The timely notification of clinicians with susceptibility results can initiate the alteration of antimicrobial chemotherapy and

The Promise of Adolescence

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Publisher : National Academies Press
ISBN 13 : 0309490111
Total Pages : 493 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis The Promise of Adolescence by : National Academies of Sciences, Engineering, and Medicine

Download or read book The Promise of Adolescence written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2019-07-26 with total page 493 pages. Available in PDF, EPUB and Kindle. Book excerpt: Adolescenceâ€"beginning with the onset of puberty and ending in the mid-20sâ€"is a critical period of development during which key areas of the brain mature and develop. These changes in brain structure, function, and connectivity mark adolescence as a period of opportunity to discover new vistas, to form relationships with peers and adults, and to explore one's developing identity. It is also a period of resilience that can ameliorate childhood setbacks and set the stage for a thriving trajectory over the life course. Because adolescents comprise nearly one-fourth of the entire U.S. population, the nation needs policies and practices that will better leverage these developmental opportunities to harness the promise of adolescenceâ€"rather than focusing myopically on containing its risks. This report examines the neurobiological and socio-behavioral science of adolescent development and outlines how this knowledge can be applied, both to promote adolescent well-being, resilience, and development, and to rectify structural barriers and inequalities in opportunity, enabling all adolescents to flourish.

Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic

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Author :
Publisher : National Academies Press
ISBN 13 : 0309297095
Total Pages : 128 pages
Book Rating : 4.3/5 (92 download)

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Book Synopsis Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic by : National Research Council

Download or read book Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic written by National Research Council and published by National Academies Press. This book was released on 2013-11-20 with total page 128 pages. Available in PDF, EPUB and Kindle. Book excerpt: The US Environmental Protection Agency (EPA) Integrated Risk Information System (IRIS) program develops toxicologic assessments of environmental contaminants. IRIS assessments provide hazard identification and dose-response assessment information. The information is then used in conjunction with exposure information to characterize risks to public health and may be used in risk-based decisionmaking, in regulatory actions, and for other risk-management purposes. Since the middle 1990s, EPA has been in the process of updating the IRIS assessment of inorganic arsenic. In response to a congressional mandate for an independent review of the IRIS assessment of inorganic arsenic, EPA requested that the National Research Council convene a committee to conduct a two-phase study. Critical Aspects of EPA's IRIS Assessment of Inorganic Arsenic is the report of the first phase of that study. This report evaluates critical scientific issues in assessing cancer and noncancer effects of oral exposure to inorganic arsenic and offers recommendations on how the issues could be addressed in EPA's IRIS assessment.

Susceptibility Weighted Imaging in MRI

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 111814807X
Total Pages : 817 pages
Book Rating : 4.1/5 (181 download)

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Book Synopsis Susceptibility Weighted Imaging in MRI by : E. Mark Haacke

Download or read book Susceptibility Weighted Imaging in MRI written by E. Mark Haacke and published by John Wiley & Sons. This book was released on 2014-03-25 with total page 817 pages. Available in PDF, EPUB and Kindle. Book excerpt: MRI Susceptibility Weighted Imaging discusses the promising new MRI technique called Susceptibility Weighted Imaging (SWI), a powerful tool for the diagnosis and treatment of acute stroke, allowing earlier detection of acute stroke hemorrhage and easier detection of microbleeds in acute ischemia. The book is edited by the originators of SWI and features contributions from the top leaders in the science. Presenting an even balance between technical/scientific aspects of the modality and clinical application, this book includes over 100 super high-quality radiographic images and 100 additional graphics and tables.

Holland-Frei Cancer Medicine

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Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2004 pages
Book Rating : 4.1/5 (19 download)

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Book Synopsis Holland-Frei Cancer Medicine by : Robert C. Bast, Jr.

Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2004 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates

Challenging Inequities in Health

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Publisher : Oxford University Press
ISBN 13 : 019513740X
Total Pages : 365 pages
Book Rating : 4.1/5 (951 download)

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Book Synopsis Challenging Inequities in Health by : Timothy Evans

Download or read book Challenging Inequities in Health written by Timothy Evans and published by Oxford University Press. This book was released on 2001 with total page 365 pages. Available in PDF, EPUB and Kindle. Book excerpt: This text provides a unique view of global inequities in health status and health sytems. Emphasizing socioeconomic conditions, it combines chapters on conceptual and measurement issues with case studies from around the world.

Transforming the Workforce for Children Birth Through Age 8

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Author :
Publisher : National Academies Press
ISBN 13 : 0309324882
Total Pages : 587 pages
Book Rating : 4.3/5 (93 download)

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Book Synopsis Transforming the Workforce for Children Birth Through Age 8 by : National Research Council

Download or read book Transforming the Workforce for Children Birth Through Age 8 written by National Research Council and published by National Academies Press. This book was released on 2015-07-23 with total page 587 pages. Available in PDF, EPUB and Kindle. Book excerpt: Children are already learning at birth, and they develop and learn at a rapid pace in their early years. This provides a critical foundation for lifelong progress, and the adults who provide for the care and the education of young children bear a great responsibility for their health, development, and learning. Despite the fact that they share the same objective - to nurture young children and secure their future success - the various practitioners who contribute to the care and the education of children from birth through age 8 are not acknowledged as a workforce unified by the common knowledge and competencies needed to do their jobs well. Transforming the Workforce for Children Birth Through Age 8 explores the science of child development, particularly looking at implications for the professionals who work with children. This report examines the current capacities and practices of the workforce, the settings in which they work, the policies and infrastructure that set qualifications and provide professional learning, and the government agencies and other funders who support and oversee these systems. This book then makes recommendations to improve the quality of professional practice and the practice environment for care and education professionals. These detailed recommendations create a blueprint for action that builds on a unifying foundation of child development and early learning, shared knowledge and competencies for care and education professionals, and principles for effective professional learning. Young children thrive and learn best when they have secure, positive relationships with adults who are knowledgeable about how to support their development and learning and are responsive to their individual progress. Transforming the Workforce for Children Birth Through Age 8 offers guidance on system changes to improve the quality of professional practice, specific actions to improve professional learning systems and workforce development, and research to continue to build the knowledge base in ways that will directly advance and inform future actions. The recommendations of this book provide an opportunity to improve the quality of the care and the education that children receive, and ultimately improve outcomes for children.

Magnetic Susceptibility of Superconductors and Other Spin Systems

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 1489923799
Total Pages : 609 pages
Book Rating : 4.4/5 (899 download)

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Book Synopsis Magnetic Susceptibility of Superconductors and Other Spin Systems by : T.L. Francavilla

Download or read book Magnetic Susceptibility of Superconductors and Other Spin Systems written by T.L. Francavilla and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 609 pages. Available in PDF, EPUB and Kindle. Book excerpt: The workshop entitled Magnetic Susceptibility of Superconductors and other Spin Systems (S4) was held at Coolfont Resort and Health Spa. located near Berkley Springs West Virginia on May 20-23. 1991. There were over sixty attendees. approximately half from the United States. the remainder representing over twelve different countries. The international character of the workshop may be gleaned form the attendee list, included in this volume. The intent of the workshop was to bring together those experimentalists and theoreticians whose efforts have resulted in significant recent contributions to the development and use of the ac susceptibility technique as well as to the interpretation of data obtained from these measurements. Many spirited discussions occurred during and after the presentations. These are reflected in the manuscripts contained in these proceedings. Although camera ready manuscripts were required from all participants at registration, all manuscripts were revised and reflect the lively exchanges that followed each presentation. The small size of the workshop allowed the participants a high degree of flexibility. Consequently when a controversial topic such as "the irreversibility line" emerged, a special session was organized on the spot. At the suggestion of Ron Goldfarb, participants were invited to contribute a one page summary containing their thoughts on the topic. These stand alone contributions were retyped and included as submitted, with only minor editorial changes. These proceedings are intended for those experienced scientists new to the field and graduate students just beginning their research.

Antimicrobial Susceptibility Testing

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Publisher : Springer Science & Business Media
ISBN 13 : 1475792069
Total Pages : 196 pages
Book Rating : 4.4/5 (757 download)

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Book Synopsis Antimicrobial Susceptibility Testing by : James A. Poupard

Download or read book Antimicrobial Susceptibility Testing written by James A. Poupard and published by Springer Science & Business Media. This book was released on 2013-11-21 with total page 196 pages. Available in PDF, EPUB and Kindle. Book excerpt: The papers assembled in this collection comprise a majority of the oral presentations as well as several poster presentations given at the 22nd Annual Symposium arranged by the Bastern Pennsylvania Branch of the American Society for MicrobioloS)'. The symposium would not be possible without the generous support of the many sponsors (see sponsor list) or without the concerted effort of a11 the Committee members. This Symposium series has evolved into an annual Bastern Pennsylvania Branch ASM event that attracts participants from a wide geographie area. It should be noted that one of the hallmarks of these symposia involves interaction between the presenters and those in attendance. Several authors have altered their by the participants. Therefore, the manuscript that manuscripts based on comments fo11ows should be viewed as a group effort of both the participants and presenters. J ames Poupard Lori Walsh Bruee Kleger ix CONTENTS 1 Introduction 1: CURRENT METHODS The Evolution of Antimicrobial Susceptibility Testing Methods . . . . . . . . . . . . . . . 3 James A. Poupard, Stephen F. Rittenhouse, and Lori R. Walsh Antimicrobial Susceptibility Tests: Testing Methods and Interpretive Problems. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 15 Patrick R. Murray Clinician Utilization of Rapid Antibiotic Susceptibility Data: A Prospective Study . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 27 Franklin P. Koontz SESSION 2: CONTEMPORARY ISSUES IN SUSCEPTIBILITY TESTING When We Should Be Testing, How Often and What to Report . . . . . . . . . . . . . . . 35 Raymond C. Bartlett Areas of Recent Emphasis of the National Committee for Clinical Laboratory Standards Subcommittee on Antimicrobial Susceptibility Testing . . . . . . . . . . . . . . . . . . . . . . . 61 James H. Jorgensen Non-Traditional Approaches for Quality Control of Antimicrobial Susceptibility Tests . . . . . . . . . . . . . . . . . . . . . . . . .

Scientific Frontiers in Developmental Toxicology and Risk Assessment

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Author :
Publisher : National Academies Press
ISBN 13 : 0309070864
Total Pages : 348 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Scientific Frontiers in Developmental Toxicology and Risk Assessment by : National Research Council

Download or read book Scientific Frontiers in Developmental Toxicology and Risk Assessment written by National Research Council and published by National Academies Press. This book was released on 2000-12-21 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Scientific Frontiers in Developmental Toxicology and Risk Assessment reviews advances made during the last 10-15 years in fields such as developmental biology, molecular biology, and genetics. It describes a novel approach for how these advances might be used in combination with existing methodologies to further the understanding of mechanisms of developmental toxicity, to improve the assessment of chemicals for their ability to cause developmental toxicity, and to improve risk assessment for developmental defects. For example, based on the recent advances, even the smallest, simplest laboratory animals such as the fruit fly, roundworm, and zebrafish might be able to serve as developmental toxicological models for human biological systems. Use of such organisms might allow for rapid and inexpensive testing of large numbers of chemicals for their potential to cause developmental toxicity; presently, there are little or no developmental toxicity data available for the majority of natural and manufactured chemicals in use. This new approach to developmental toxicology and risk assessment will require simultaneous research on several fronts by experts from multiple scientific disciplines, including developmental toxicologists, developmental biologists, geneticists, epidemiologists, and biostatisticians.

Geoinformatics and Modelling of Landslide Susceptibility and Risk

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Author :
Publisher : Springer
ISBN 13 : 3030104958
Total Pages : 231 pages
Book Rating : 4.0/5 (31 download)

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Book Synopsis Geoinformatics and Modelling of Landslide Susceptibility and Risk by : Sujit Mandal

Download or read book Geoinformatics and Modelling of Landslide Susceptibility and Risk written by Sujit Mandal and published by Springer. This book was released on 2019-05-28 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book discusses various statistical models and their implications for developing landslide susceptibility and risk zonation maps. It also presents a range of statistical techniques, i.e. bivariate and multivariate statistical models and machine learning models, as well as multi-criteria evaluation, pseudo-quantitative and probabilistic approaches. As such, it provides methods and techniques for RS & GIS-based models in spatial distribution for all those engaged in the preparation and development of projects, research, training courses and postgraduate studies. Further, the book offers a valuable resource for students using RS & GIS techniques in their studies.

Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth

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Author :
Publisher : National Academies Press
ISBN 13 : 030948202X
Total Pages : 391 pages
Book Rating : 4.3/5 (94 download)

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Book Synopsis Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth by : National Academies of Sciences, Engineering, and Medicine

Download or read book Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2020-01-18 with total page 391 pages. Available in PDF, EPUB and Kindle. Book excerpt: Healthy mental, emotional, and behavioral (MEB) development is a critical foundation for a productive adulthood. Much is known about strategies to support families and communities in strengthening the MEB development of children and youth, by promoting healthy development and also by preventing and mitigating disorder, so that young people reach adulthood ready to thrive and contribute to society. Over the last decade, a growing body of research has significantly strengthened understanding of healthy MEB development and the factors that influence it, as well as how it can be fostered. Yet, the United States has not taken full advantage of this growing knowledge base. Ten years later, the nation still is not effectively mitigating risks for poor MEB health outcomes; these risks remain prevalent, and available data show no significant reductions in their prevalence. Fostering Healthy Mental, Emotional, and Behavioral Development in Children and Youth: A National Agenda examines the gap between current research and achievable national goals for the next ten years. This report identifies the complexities of childhood influences and highlights the need for a tailored approach when implementing new policies and practices. This report provides a framework for a cohesive, multidisciplinary national approach to improving MEB health.

Development of Psychopathology

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Author :
Publisher : SAGE
ISBN 13 : 1452236577
Total Pages : 521 pages
Book Rating : 4.4/5 (522 download)

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Book Synopsis Development of Psychopathology by : Benjamin L. Hankin

Download or read book Development of Psychopathology written by Benjamin L. Hankin and published by SAGE. This book was released on 2005-03-23 with total page 521 pages. Available in PDF, EPUB and Kindle. Book excerpt: "..a blending of two important approaches to understanding psychopathology- the developmental approach and the vulnerability approach. I think a book like this is timely, is needed, and would be of interest to professors who teach courses in psychopathology at the advanced undergraduate and graduate levels." — Robin Lewis, Old Dominion University "Bringing together developmental psychopathology frameworks and the vulnerability-stress models of psychological disorders is an excellent idea. I am aware of no other book that incorporates these two approaches. Having taught Psychopathology courses for both master′s and doctoral students, I reviewed many books to recommend and use in the courses. It is my belief that a book of this type is needed particularly for graduate students." —Linda Guthrie, Tennessee State University Edited by Benjamin L. Hankin and John R. Z. Abela, Development of Psychopathology: A Vulnerability-Stress Perspective brings together the foremost experts conducting groundbreaking research into the major factors shaping psychopathological disorders across the lifespan in order to review and integrate the theoretical and empirical literature in this field. The volume editors build upon two important and established research and clinical traditions: developmental psychopathology frameworks and vulnerability-stress models of psychological disorders. In the past two decades, each of these separate approaches has blossomed. However, despite the scientific progress each has achieved individually, no forum previously brought these traditions together in the unified way accomplished in this book. Key Features: Consists of three-part text that systematically integrates vulnerability-stress models of psychopathology with a developmental psychopathological approach. Brings together leading experts in the field of vulnerability, stress, specific vulnerabilities to psychological disorders, psychopathological disorders, and clinical interventions. Takes a cross-theoretical, integrative approach presenting cutting-edge theory and research at a sophisticated level. Development of Psychopathology will be a valuable resource for upper-division undergraduate and graduate students in clinical psychology, as well as for researchers, doctoral students, clinicians, and instructors in the areas of developmental psychopathology, clinical psychology, experimental psychopathology, psychiatry, counseling psychology, and school psychology.

Genetic Diversity and Disease Susceptibility

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Author :
Publisher : BoD – Books on Demand
ISBN 13 : 1789842018
Total Pages : 166 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Genetic Diversity and Disease Susceptibility by : Yamin Liu

Download or read book Genetic Diversity and Disease Susceptibility written by Yamin Liu and published by BoD – Books on Demand. This book was released on 2018-10-17 with total page 166 pages. Available in PDF, EPUB and Kindle. Book excerpt: Polymorphism or variation in DNA sequence can affect individual phenotypes such as color of skin or eyes, susceptibility to diseases, and response to drugs, vaccines, chemicals, and pathogens. Especially, the interfaces between genetics, disease susceptibility, and pharmacogenomics have recently been the subject of intense research activity. This book is a self-contained collection of valuable scholarly papers related to genetic diversity and disease susceptibility, pharmacogenomics, ongoing advances in technology, and analytic methods in this field. The book contains nine chapters that cover the three main topics of genetic polymorphism, genetic diversity, and disease susceptibility and pharmacogenomics. Hence, this book is particularly useful to academics, scientists, physicians, pharmacists, practicing researchers, and postgraduate students whose work relates to genetic polymorphisms.