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Author : Jingjing Wang
Publisher :
ISBN 13 :
Total Pages : 0 pages
Book Rating : 4.:/5 (946 download)
Download or read book Studies on the Synthesis of Marine Natural Product ( - )-Zampanolide and Its Analogues written by Jingjing Wang and published by . This book was released on 2016 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Yohan J. G. Boursereau
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (278 download)
Download or read book Synthesis of Analogues of the Marine Natural Product Manzamine A and Biological Studies written by Yohan J. G. Boursereau and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Synthesis of Biologically Active Marine Natural Product Analogues written by and published by . This book was released on 2006 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Natural products have long been a source of inspiration for many drugs in human use. The Andersen lab examines compounds from marine sources that can be used as lead structures for drug discovery. Synthetic studies, structure-activity relationships (SAR) and biological findings of two such compounds are described in this thesis. The first is pelorol, a meroterpene isolated from a tropical sponge Dactylospongia elegans. Pelorol is a small molecule activator of SHIP 1, a phosphatase that is a negative regulator of the P13K pathway in hematopoetic cells. Using a synthetic route from a previous co-worker, Lu Yang, a series of SHIP 1 activating compounds based on pelorol were synthesized. These compounds were evaluated for selectivity, potency, and efficacy in a series of biological studies, leading to the discovery of 2.27 as a preclinical lead compound. Water-soluble prodrugs of the SHIP 1-activating compounds were also synthesized and their properties reported. The second compound examined is ceratamine A, an alkaloid isolated from the sponge Pseudoceratina sp. from Papua New Guinea. Ceratamines A and B are microtubule stabilizing antimitotic agents that may be useful in cancer chemotherapy. The core imidazo[4,5,d]azepine heterocycle of the ceratamines has no precedent among known synthetic or natural compounds. The relatively simple structure of the ceratamines and the novel antimitotic phenotype they generate makes them attractive targets. Desbromo ceratamine A (3.44) was synthesized by an efficient and scaleable route, confirming the structure of ceratamine A and validating the biological activity of the core pharmacophore. Synthetic efforts towards ceratamine A were ultimately thwarted by the inability to install the bromine atoms present in the natural product. A significant finding is that the bromine atoms in ceratamine A contribute significantly to the antimitotic potency of the compound necessitating a bioisosteric approach to more potent antimitotic ceratami.
Author : Matthew B. Nodwell
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book Synthesis of Biologically Active Marine Natural Product Analogues written by Matthew B. Nodwell and published by . This book was released on 2008 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Alban R. Pereira
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (13 download)
Download or read book Marine Natural Products written by Alban R. Pereira and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Lee Wang
Publisher :
ISBN 13 :
Total Pages : 293 pages
Book Rating : 4.:/5 (113 download)
Download or read book Total Synthesis of Marine Natural Products written by Lee Wang and published by . This book was released on 2019 with total page 293 pages. Available in PDF, EPUB and Kindle. Book excerpt: The total syntheses of two peptidic cytotoxins, micromide and lagunamide A was completed employing both solid phase and solution phase methods. Micromide was derived from an unknown species of marine cyanobacterium of the genus Symploca. Its synthesis was accomplished using both solid-phase and solution phase chemistry. Comparison of the synthetic and natural product's NMR spectra reveal that the reported structure of micromide was incorrect. Syntheses of multiple analogs of micromide was completed to resolve the discrepancies in the NMR spectra. The new data suggests that micromide requires a structural revision. Lagunamide A is a cyclic depsipeptide isolated from Moorea procudens. The peptide portion was achieved through solid phase peptide synthesis (SPPS) and the polyketide moiety was achieved using Kobayashi's vinylogous Mukaiyama aldol reaction (VMAR).
Author : K. F. Albizati
Publisher : Springer Verlag
ISBN 13 : 9780387543765
Total Pages : 322 pages
Book Rating : 4.5/5 (437 download)
Download or read book Synthesis of Marine Natural Products written by K. F. Albizati and published by Springer Verlag. This book was released on 1992-01-01 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Atta-ur Rahman
Publisher : Elsevier
ISBN 13 : 0323989241
Total Pages : 440 pages
Book Rating : 4.3/5 (239 download)
Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 2021-07-21 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry, Volume 70 covers the synthesis or testing and recording of the medicinal properties of natural products, providing cutting-edge accounts of fascinating developments in the isolation, structure elucidation, synthesis, biosynthesis and pharmacology of a diverse array of bioactive natural products. With the rapid developments in spectroscopic techniques and accompanying advances in high-throughput screening techniques, this book presents exciting opportunities in the field of new drug development to the pharmaceutical industry. Natural products in the plant and animal kingdom offer a huge diversity of chemical structures that are the result of biosynthetic processes that have been modulated over the millennia through genetic effects. - Focuses on the chemistry of bioactive natural products - Contains contributions by leading authorities in the field - Presents sources of new pharmacophores
Author : David J. Newman
Publisher : CRC Press
ISBN 13 : 1351643282
Total Pages : 650 pages
Book Rating : 4.3/5 (516 download)
Download or read book Chemical Biology of Natural Products written by David J. Newman and published by CRC Press. This book was released on 2017-09-22 with total page 650 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chemical Biology of Natural Products This unique, long-awaited volume is designed to address contemporary aspects of natural product chemistry and its influence on biological systems, not solely on human interactions. The subjects covered include discovery, isolation and characterization, biosynthesis, biosynthetic engineering, pharmaceutical, and other applications of these compounds. Each chapter begins with a brief and simple introduction to the subject matter, and then proceeds to guide the reader towards the more contemporary, cutting-edge research in the field, with the contributing authors presenting current examples from their own work in order to exemplify key themes. Topics covered in the text include genome mining, heterologous expression, natural product synthesis, biosynthesis, glycosylation, chemical ecology, and therapeutic applications of natural products, both current and potential.
Author : Goutam Brahmachari
Publisher : John Wiley & Sons
ISBN 13 : 3527337946
Total Pages : 544 pages
Book Rating : 4.5/5 (273 download)
Download or read book Bioactive Natural Products written by Goutam Brahmachari and published by John Wiley & Sons. This book was released on 2015-03-23 with total page 544 pages. Available in PDF, EPUB and Kindle. Book excerpt: Ein multidisziplinärer Überblick über die aktuellen Themen und Zukunftstrends in der Erforschung von Naturstoffen mit Schwerpunkt auf pharmazeutischen und medizinischen Anwendungen.
Author : Hiromasa Kiyota
Publisher : Springer
ISBN 13 : 9783642070280
Total Pages : 0 pages
Book Rating : 4.0/5 (72 download)
Download or read book Marine Natural Products written by Hiromasa Kiyota and published by Springer. This book was released on 2010-11-11 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author :
Publisher :
ISBN 13 :
Total Pages : 776 pages
Book Rating : 4.3/5 (91 download)
Download or read book American Doctoral Dissertations written by and published by . This book was released on 2002 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ramasamy Santhanam
Publisher : CRC Press
ISBN 13 : 1000707695
Total Pages : 189 pages
Book Rating : 4.0/5 (7 download)
Download or read book Biology and Ecology of Pharmaceutical Marine Tunicates written by Ramasamy Santhanam and published by CRC Press. This book was released on 2019-10-10 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ocean is a source of unique natural products, mainly accumulated in living organisms. The c.4000 species of tunicates or sea squirts (Phylum, Chordata; Subphylum, Urochordata) are a high-potential yet under-studied source of bioactive compounds for pharmaceuticals. The secondary metabolites such as alkaloids isolated from these organisms have led to the discovery of an approved anti-tumor drug, anti-cancer drugs Yondelis® and Aplidin®, as well as many others in clinical trial. There is an urgent need for more research on the bioactive compounds of marine tunicates and better knowledge about the identification and biology of these species. This is the first focused book to meet this need. The taxonomy, common name, global distribution, habitat, diagnostic features and pharmaceutical compounds (along with their activities) of 165 key species of tunicates are given, with high-quality illustrations. Contributed by scientists of both Marine Biology and Pharmacy disciplines, this book will serve as a standard reference for researchers, teachers and students of Fisheries Science, Marine Biology, Life Sciences, Biotechnology, Natural Products, and Pharmacy, and as a valuable guide for pharmaceutical companies involved in the development of new drugs from marine organisms.
Author : Yasushi Nishihara
Publisher : Springer Science & Business Media
ISBN 13 : 3642323685
Total Pages : 247 pages
Book Rating : 4.6/5 (423 download)
Download or read book Applied Cross-Coupling Reactions written by Yasushi Nishihara and published by Springer Science & Business Media. This book was released on 2012-12-14 with total page 247 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Applied Cross-Coupling Reactions” provides students and teachers of advanced organic chemistry with an overview of the history, mechanisms and applications of cross-coupling reactions. Since the discovery of the transition-metal-catalyzed cross-coupling reactions in 1972, numerous synthetic uses and industrial applications have been developed. The mechanistic studies of the cross-coupling reactions have disclosed that three fundamental reactions: oxidative addition, transmetalation, and reductive elimination, are involved in a catalytic cycle. Cross-coupling reactions have allowed us to produce a variety of compounds for industrial purposes, such as natural products, pharmaceuticals, liquid crystals and conjugate polymers for use in electronic devices. Indeed, the Nobel Prize for Chemistry in 2010 was awarded for work on cross-coupling reactions. In this book, the recent trends in cross-coupling reactions are also introduced from the point of view of synthesis design and catalytic activities of transition-metal catalysts.
Author : Clementina M.M. Santos
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128056282
Total Pages : 64 pages
Book Rating : 4.1/5 (28 download)
Download or read book Progress in Heterocyclic Chemistry written by Clementina M.M. Santos and published by Elsevier Inc. Chapters. This book was released on 2013-09-06 with total page 64 pages. Available in PDF, EPUB and Kindle. Book excerpt: This review covers work published in the calendar year 2012. Novel reaction chemistry and new ring synthetic methods for pyrans, [1]benzopyrans, dihydro[1]benzopyrans (chromenes, chromans), [2]benzopyrans, dihydro[2]benzopyrans (isochromenes, isochromans), pyranones, coumarins, chromones, xanthenes, xanthones, thiopyrans, dioxins, dioxanes, trioxanes, tetraoxanes, dithianes, trithianes, and oxathianes are reviewed.
Author :
Publisher :
ISBN 13 :
Total Pages : 854 pages
Book Rating : 4.F/5 ( download)
Download or read book Dissertation Abstracts International written by and published by . This book was released on 2006 with total page 854 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Zhiyong Li
Publisher : Springer
ISBN 13 : 9402416129
Total Pages : 570 pages
Book Rating : 4.4/5 (24 download)
Download or read book Symbiotic Microbiomes of Coral Reefs Sponges and Corals written by Zhiyong Li and published by Springer. This book was released on 2019-06-07 with total page 570 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the symbiotic microbiomes of invertebrates in coral reefs, especially sponges and corals. It provides in-depth and up-to-date reviews on the microbial structure and diversity, metabolism and function, symbiosis and coevolution, environment and adaption, and bioactive potentials. Meanwhile, the future perspectives will be discussed according to the existing problems and the development trend. This book will be of particular interest to the professionals in marine ecology, marine biotechnology, as well as medicinal chemists and molecular biologists.
