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Studies Of Vascular Endothelial Growth Factor Vegf Signaling In Breast Cancer Cells
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Book Synopsis Studies of Vascular Endothelial Growth Factor (VEGF) Signaling in Breast Cancer Cells by :
Download or read book Studies of Vascular Endothelial Growth Factor (VEGF) Signaling in Breast Cancer Cells written by and published by . This book was released on 2000 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our Proposal aims to investigate the function of VEGF in breast cancer cell growth and signaling. Our data suggest that breast cancer cells secrete various levels of VEGF and express in addition to the Flt-1 and Flk-1/KDR receptors, a novel VEGF receptor type which needs to be identified and characterized. These data lead us to hypothesize that VEGF, secreted by breast cancer cells, is a multi-functional protein which acts in an autocrine fashion and can simultaneously activate specific VEGF receptor signaling pathways in breast cancer cells, thereby regulating breast cancer cell growth, tumor angiogenesis and subsequently tumor growth. In order to test this hypothesis, we propose to focus on two basic aims: (a) To identify and characterize the VEGF receptors expressed in breast cancer cell, and to analyze their expression in primary breast tissues. We will elucidate the signaling events upon VEGF stimulation in breast cancer cells and identify which activated signaling molecules are essential for the VEGF-mediated efforts on breast cancer cell growth; and (b) To study the effects of VEGF and VEGF receptor expression on the regulation of tumor angiogenesis and signal transduction pathways in breast cancer cells.
Book Synopsis Vegf and Cancer by : Judith H. Harmey
Download or read book Vegf and Cancer written by Judith H. Harmey and published by Springer Science & Business Media. This book was released on 2004 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: VEGF and Canceris a comprehensive and up to date review of current knowledge on the role of vascular endothelial growth factor (VEGF) in cancer. Key Features: -Discussion of VEGF as potent angiogenic factor and its role in tumor angiogenesis, -Review of the biology, molecular properties and regulation of VEGF, -Discussion of the role of VEGF in a range of different tumor types, both solid tumors and haematological cancers, -Review of the therapeutic potential of different approaches to block VEGF, -Review of recent evidence that in addition to its role as an endothelial cell mitogen, VEGF may also be an autocrine growth factor for tumor cells, regulating survival and invasion. This book is aimed at scientists new to angiogenesis and VEGF biology and provides new information for established researchers and scientists. It will also be a useful text for clinicians interested in anti-angiogenic therapy for treatment of human cancers.
Book Synopsis Killing Breast Cancer Cells With a VEGF-Triggered Cell Death Receptor by :
Download or read book Killing Breast Cancer Cells With a VEGF-Triggered Cell Death Receptor written by and published by . This book was released on 2006 with total page 16 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many breast cancers overexpress the tumor angiogenesis factor VEGF (vascular endothelial growth factor). Consequently numerous VEGF inhibitors are being studied. Some such as bevacizumab extend progression-free survival but have not yet been shown to extend overall survival in breast cancer patients. We are pursuing a totally different approach to targeting VEGF: rather than inhibit VEGF our goal is to convert VEGF to act as a cell death factor. Toward this aim we created a chimeric receptor (R2Fas) composed of domains from VEGF receptor 2 fused to the intracellular domain of the Fas cell death receptor. As controls we generated two inactive versions of R2Fas with mutations in the VEGF receptor 2 domain or the Fas domain. Replication-defective adenoviruses expressing each of the receptors were generated and used to direct expression of the receptors in human breast cancer cell lines. We found that expression of the R2Fas chimeric receptor but not the inactive control receptors could induce apoptosis in several human breast cancer cell lines in vitro. These studies suggest that a receptor such as R2Fas which converts VEGF to act as a cell death factor could yield a new and more aggressive approach to targeting overexpressed VEGF in breast cancer.
Book Synopsis Vascular Endothelial Growth Factor (VEGF) by : Marcellus L. Parker
Download or read book Vascular Endothelial Growth Factor (VEGF) written by Marcellus L. Parker and published by . This book was released on 2013 with total page 239 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular endothelial growth factor (VEGF) is one of the most potent and specific angiogenic factors. The physiologic roles of VEGF in humans include neovascularization and endometrium implantation, and in pathological processes VEGF has been involved in the initation, growth, and metastasis of tumors. In this book, the authors discuss the biology, regulation and clinical significance of VEGF. Topics include VEGF signaling and multi-drug resistance transporter (ABCB1); clinical imaging of tumor vascularity as a biomarker during anti-VEGF therapy; VEGF and kidney cancer; the effect of VEGF on oocyte maturation and embryo development of bovine and ovine in vitro and its mechanisms; physiological functions of VEGF in the retina; VEGF in the regulation of gingival venule diameter under physiological and pathological circumstances; regulation of VEGF expression by progesterone and estradiol in normal and cancer cells; ethanol stimulated angiogenesis via VEGF and protection from ischemia and reperfusion injury; and the role of VEGF in major depression.
Book Synopsis Vascular Endothelial Growth Factor Receptors—Advances in Research and Application: 2012 Edition by :
Download or read book Vascular Endothelial Growth Factor Receptors—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular Endothelial Growth Factor Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyBrief™ that delivers timely, authoritative, comprehensive, and specialized information about Vascular Endothelial Growth Factor Rece in a concise format. The editors have built Vascular Endothelial Growth Factor Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Vascular Endothelial Growth Factor Rece in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Vascular Endothelial Growth Factor Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Vascular Endothelial Growth Factor (VEGF) by : Marcellus L. Parker
Download or read book Vascular Endothelial Growth Factor (VEGF) written by Marcellus L. Parker and published by Nova Science Publishers. This book was released on 2013 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vascular endothelial growth factor (VEGF) is one of the most potent and specific angiogenic factors. The physiologic roles of VEGF in humans include neovascularisation and endometrium implantation, and in pathological processes VEGF has been involved in the initiation, growth, and metastasis of tumors. In this book, the authors discuss the biology, regulation and clinical significance of VEGF. Topics include VEGF signalling and multi-drug resistance transporter (ABCB1); clinical imaging of tumour vascularity as a biomarker during anti-VEGF therapy; VEGF and kidney cancer; the effect of VEGF on oocyte maturation and embryo development of bovine and ovine in vitro and its mechanisms; physiological functions of VEGF in the retina; VEGF in the regulation of gingival venule diameter under physiological and pathological circumstances; regulation of VEGF expression by progesterone and estradiol in normal and cancer cells; ethanol stimulated angiogenesis via VEGF and protection from ischemia and reperfusion injury; and the role of VEGF in major depression.
Book Synopsis Tumor Angiogenesis Regulators by : Ruben R. Gonzalez-Perez
Download or read book Tumor Angiogenesis Regulators written by Ruben R. Gonzalez-Perez and published by CRC Press. This book was released on 2013-05-09 with total page 457 pages. Available in PDF, EPUB and Kindle. Book excerpt: The emphasis of this book is on mechanisms and pathways regulating the expression and actions of classical and novel tumor angiogenesis regulators. The contributors discuss their underlying biology as well as anti-angiogenic drugs currently in use to fight different cancers. The book provides an insight on how factors such as obesity, diabetes, and
Book Synopsis The Development of the Vascular System by : Richard N. Feinberg
Download or read book The Development of the Vascular System written by Richard N. Feinberg and published by S. Karger AG (Switzerland). This book was released on 1991 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Hypoxia, Vascular Endothelial Growth Factor, and Endothelin in Human Breast Cancer by : Andrew Stephen Cox
Download or read book Hypoxia, Vascular Endothelial Growth Factor, and Endothelin in Human Breast Cancer written by Andrew Stephen Cox and published by . This book was released on 2008 with total page 90 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mortality of breast cancer is associated with the consequences of metastases most commonly to bones. Tumor development and metastasis depends not only on the intrinsic properties of the tumor cells, but also on the microenvironment. Key parameters within the microenvironment include the extra-cellular matrix and the levels of oxygen present. Both collagen-coating and hypoxia have been found to significantly modulate both cancer cell growth and apoptosis. Furthermore, in vivo, blocking of the endothelin (ET) pathway, including ET-1, a pleiotropic molecule with angiogenic, anti-apoptotic, and mitogenic properties, was associated with limited tumor growth and metastasis. Similarly, blocking the vascular endothelial growth factor (VEGF) pathway also affected tumor growth, mostly through the abrogation of angiogenesis. It is unclear however how these two pathways within tumor cells are affected by the presence of exogenous ET-1 or VEGF. Using in vitro 2D culture conditions, the effects of ET-1 and VEGF on cobalt chloride (CoCI[subscript]2) chemically-generated hypoxia cultures, in both MCF7 and MDA-MB-231 human breast cancer cells were investigated. The potential role of the extra-cellular matrix is addressed using non-coated or collagen-coated vessels. The results indicate that in response to hypoxia, MCF7 breast cancer cells had overall reduced expression of ET-1 and VEGF pathway genes. Additionally, the metastatic MDA-MB-231 cell line had increased expression of the genes associated with the ET pathways including ET-1 and endothelin receptor A (ET[subscript]AR), regardless of the coating conditions. The hypoxic conditions led to drastic decreases in cell proliferation of both MCF-7 and MDA-MB-231 cells in positively-charged vessels but to a much lesser extent in collagen-coated vessels. Also, the hypoxic conditions were associated with reduced apoptosis in both breast cancer cell lines tested but especially in MDA-MB-231 cells. This study provides new insights into the complex interactions between breast cancer cells and both their physical and chemical microenvironment.
Book Synopsis Growth Factor Receptors—Advances in Research and Application: 2012 Edition by :
Download or read book Growth Factor Receptors—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth Factor Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Growth Factor Receptors. The editors have built Growth Factor Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Growth Factor Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Growth Factor Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Book Synopsis Vascular Growth Factor Receptors as a Target for Auger Electron Radiotherapy of Breast Cancer by :
Download or read book Vascular Growth Factor Receptors as a Target for Auger Electron Radiotherapy of Breast Cancer written by and published by . This book was released on 2001 with total page 11 pages. Available in PDF, EPUB and Kindle. Book excerpt: Breast tumor is a aggressive and highly vascularized tumor in which angiogenesis is necessary to support growth.. Vascular endothelial growth factor (VEGF) is secreted by breast cancer cells(2) to stimulate angiogenesis through the over-expression of its receptors (VEGFR1 & 2) and proliferation of the vascular endothelial cells (VEC) of the surrounding tissue. In contrast, normal VECs express low level of VEGFRs. Strategies for targeting VEGFR to inhibit growth of breast cancer(3-5) have been tested, but had limited success. On binding to its receptors, VEGF is internalized via the receptor mediated endocytosis pathway way to the endosomal compartment of the endothelial cells. Our preliminary data using fluorescein-conjugated VEGF(165) showed that it was internalized into cytoplasmic vesicles inside human umbilical vein endothelial cells (HUVEC) (left panel A) and translocated to near the nucleus which formed a ring of fluorescence surrounding the nucleus (left panel B). Therefore, the aim of the present project is to target the overexpressed VEGFRs on the endothelial cells of the breast tumor, to deliver lethal levels of Auger electron emitting radionuclide Indium-(111) (In111) into breast cancer associated VECs which could be an effective radiotherapy for breast cancer.
Book Synopsis The regulation of angiogenesis by tissue cell-macrophage interactions by : Michal Amit Rahat
Download or read book The regulation of angiogenesis by tissue cell-macrophage interactions written by Michal Amit Rahat and published by Frontiers E-books. This book was released on 2014-11-03 with total page 114 pages. Available in PDF, EPUB and Kindle. Book excerpt: Angiogenesis is the physiological process where new blood vessels grow from existing ones, in order to replenish tissues suffering from inadequate blood supply. Perhaps the most studied angiogenic process occurs in solid tumors whose growing mass and expanding cells create a constant demand for additional supply of oxygen and nutrients for survival. However, other physiological and clinical conditions, such as wound healing, ischemic events, autoimmune and age-related diseases also involve angiogenesis. Angiogenesis is a well-structured process that begins when oxygen and nutrients are depleted, leading to the release of chemokines and growth factors that attract immune cells, particularly macrophages and endothelial cells to the site. Macrophages that are recruited to the site, as well as tissue cells and endothelial cells, secrete pro-angiogenic mediators that affect endothelial cells and promote angiogenesis. These mediators include growth factors such as vascular endothelial cell growth factor (VEGF), matrix metalloproteinases (MMPs), as well as low levels of mediators that are usually seen as pro-inflammatory but are pro-angiogenic when secreted in low levels (e.g. nitric oxide (NO) and TNFa). Thus, macrophages play a major role in angiogenesis. Macrophages exhibit high plasticity and are capable of shifting between different activation modes and functions according to their changing microenvironment. Small differences in the composition of activating factors (e.g. TLR ligands such as LPS, anti-inflammatory cytokines, ECM molecules) in the microenvironment may differently activate macrophages to yield classically activated macrophages (or M1 macrophages) that can kill pathogen and tumor cells, alternatively activated macrophages (or M2 macrophages) that secrete antiinflammatory cytokines, resolution macrophages (rM?) that are involved in the resolution of inflammation, or regulatory macrophages (e.g. Myeloid-Derived Suppressor Cells - MDSCs) that control the function of other immune cells. In fact, macrophages may be activated in a spectrum of subsets that may differently contribute to angiogenesis, and in particular non-classically activated macrophages such as tumor-associated macrophages (TAMs) and Tie2-expressing monocytes (TEMs) can secrete high amounts of pro-angiogenic factors (e.g. VEGF, MMPs) or low levels of pro-inflammatory mediators (e.g. NO or TNFa) resulting in pro-angiogenic effects. Although the importance of macrophages as major contributors and regulators of the angiogenic process is well documented, less is known about the interactions between macrophages and other cell types (e.g. tumor cells, normal epithelial cells, endothelial cells) that regulate angiogenesis. We still have only limited understanding which proteins or complexes mediate these interactions and whether they require cell-cell contact (e.g. through integrins) or soluble factors (e.g. the EGF-CSF-1 loop), which signaling pathways are triggered in each of the two corresponding cell types, and how this leads to secretion of pro- or antiangiogenic factors in the microenvironment. The regulation of such interactions and through them of angiogenesis, whether through post-translational modifications of proteins or via the involvement of microRNA, is still unclear. The goal of this Research Topic is to highlight these interactions and their regulation in the context of both physiological and pathological conditions.
Book Synopsis Vascular Development by : Derek J. Chadwick
Download or read book Vascular Development written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Book Synopsis Tumor Vascularization by : Domenico Ribatti
Download or read book Tumor Vascularization written by Domenico Ribatti and published by Academic Press. This book was released on 2020-01-21 with total page 198 pages. Available in PDF, EPUB and Kindle. Book excerpt: Tumor Vascularization discusses the different types of growth of tumor blood vessels and their implications on research and healthcare. The book is divided into three parts: the first one, General Mechanisms, discusses different vessel growth mechanisms, such as sprouting angiogenesis, non-angiogenesis dependent growth, intussusceptive microvascular growth, vascular co-option and vasculogenic mimicry. The second and third parts, entitled Clinical Implications and Therapeutic Implications are dedicated to translating recent findings in this field to patient treatment and healthcare. This book is a valuable source for cancer researchers, oncologists, graduate students and members of the biomedical field who are interested in tumor progression and blood vessels. Explains new, non-orthodox concepts recently developed and related to the modality of growth of tumor blood vessels Provides information on the types of angiogenesis, non-angiogenesis dependent growth and vascular co-option, discussing both their similarities and differences Encompasses a discussion on clinical implications of tumor vascularization to translate research findings into treatment
Book Synopsis VEGF in Development by : Christiana Ruhrberg
Download or read book VEGF in Development written by Christiana Ruhrberg and published by Springer Science & Business Media. This book was released on 2008-12-11 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book covers vascular endothelial growth factor A (VEGF or VEGFA), a secreted signaling protein. It highlights the central importance of this growth factor for vertebrate development.
Book Synopsis Physiologic and Pathologic Angiogenesis by : Dan Simionescu
Download or read book Physiologic and Pathologic Angiogenesis written by Dan Simionescu and published by BoD – Books on Demand. This book was released on 2017-04-05 with total page 466 pages. Available in PDF, EPUB and Kindle. Book excerpt: The purpose of this book is to highlight novel advances in the field and to incentivize scientists from a variety of fields to pursue angiogenesis as a research avenue. Blood vessel formation and maturation to capillaries, arteries, or veins is a fascinating area which can appeal to multiple scientists, students, and professors alike. Angiogenesis is relevant to medicine, engineering, pharmacology, and pathology and to the many patients suffering from blood vessel diseases and cancer, among others. We are hoping that this book will become a source of inspiration and novel ideas for all.
Book Synopsis Neovascularization, Angiogenesis and Vasculogenic Mimicry in Cancer by : César López-Camarillo
Download or read book Neovascularization, Angiogenesis and Vasculogenic Mimicry in Cancer written by César López-Camarillo and published by Frontiers Media SA. This book was released on 2020-08-21 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
