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Author : Hardip Brar Passananti
Publisher :
ISBN 13 :
Total Pages : 392 pages
Book Rating : 4.:/5 (47 download)
Download or read book Studies of Postponed Aging in Drosophila Melanogaster written by Hardip Brar Passananti and published by . This book was released on 2000 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Michael Robertson Rose
Publisher : World Scientific
ISBN 13 : 9814483354
Total Pages : 495 pages
Book Rating : 4.8/5 (144 download)
Download or read book Methuselah Flies: A Case Study In The Evolution Of Aging written by Michael Robertson Rose and published by World Scientific. This book was released on 2004-06-14 with total page 495 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methuselah Flies presents a trailblazing project on the biology of aging. It describes research on the first organisms to have their lifespan increased, and their aging slowed, by hereditary manipulation. These organisms are fruit flies from the species Drosophila melanogaster, the great workhorse of genetics. Michael Rose and his colleagues have been able to double the lifespan of these insects, and improved their health in numerous respects as well. The study of these flies with postponed aging is one of the best means we have of understanding, and ultimately achieving, the postponement of aging in humans. As such, the carefully presented detail of this book will be of value to research devoted to the understanding and control of aging.Methuselah Flies:• is a tightly edited distillation of twenty years of work by many scientists• contains the original publications regarding the longer-lived fruit flies• offers commentaries on each of the topics covered — new, short essays that put the individual research papers in a wider context• gives full access to the original data • captures the scientific significance of postponed aging for a wide academic audience
Author : Alexander M. Vaiserman
Publisher : Springer
ISBN 13 : 3319183265
Total Pages : 351 pages
Book Rating : 4.3/5 (191 download)
Download or read book Life Extension written by Alexander M. Vaiserman and published by Springer. This book was released on 2015-06-09 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book looks at aging through research on Drosophila, the fruit fly that is one of the most widely used model organisms in bio gerontology. Work in model organisms can expand the theoretical knowledge of aging: it yields valuable insight into the molecular and cellular processes that underlie aging process, and it can perhaps provide new therapeutic targets for the treatment of age-related disorders in humans. Drosophila models have been developed for a large variety of aging-related processes and diseases, and this book provides readers with an overview of current research on the use of the Drosophila model to understand the genetic, molecular and physiological mechanisms that underlie the aging process. Themes of health span, life extension and longevity-associated genes emerge in this collation of international research on Drosophila that is of relevance to geriatrics and gerontology, animal genetics and genomics, and biomedicine. This fascinating, illustrated book will be of interest to a wide audience, ranging from academic researchers to the general reader.
Author : Michael R. Rose
Publisher : Oxford University Press
ISBN 13 : 0198039867
Total Pages : 189 pages
Book Rating : 4.1/5 (98 download)
Download or read book The Long Tomorrow written by Michael R. Rose and published by Oxford University Press. This book was released on 2005-09-15 with total page 189 pages. Available in PDF, EPUB and Kindle. Book excerpt: The conquest of aging is now within our grasp. It hasn't arrived yet, writes Michael R. Rose, but a scientific juggernaut has started rolling and is picking up speed. A long tomorrow is coming. In The Long Tomorrow, Rose offers us a delightfully written account of the modern science of aging, spiced with intriguing stories of his own career and leavened with the author's engaging sense of humor and rare ability to make contemporary research understandable to nonscientists. The book ranges from Rose's first experiments while a graduate student--counting a million fruit fly eggs, which took 3,000 hours over the course of a year--to some of his key scientific discoveries. We see how some of his earliest experiments helped demonstrate that "the force of natural selection" was key to understanding the aging process--a major breakthrough. Rose describes how he created the well-known Methuselah Flies, fruit flies that live far longer than average. Equally important, Rose surveys the entire field, offering colorful portraits of many leading scientists and shedding light on research findings from around the world. We learn that rodents given fifteen to forty percent fewer calories live about that much longer, and that volunteers in Biosphere II, who lived on reduced caloric intake for two years, all had improved vital signs. Perhaps most interesting, we discover that aging hits a plateau and stops. Popular accounts of Rose's work have appeared in The New Yorker, Time magazine, and Scientific American, but The Long Tomorrow is the first full account of this exciting new science written for the general reader. "Among his peers, Rose is considered a brilliantly innovative scientist, who has almost single-handedly brought the evolutionary theory of aging from an abstract notion to one of the most exciting topics in science."--Malcolm Gladwell, The New Yorker
Author : Michael R. Rose
Publisher : Springer Science & Business Media
ISBN 13 : 9401716714
Total Pages : 320 pages
Book Rating : 4.4/5 (17 download)
Download or read book Genetics and Evolution of Aging written by Michael R. Rose and published by Springer Science & Business Media. This book was released on 2013-03-09 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aging is one of those subjects that many biologists feel is largely unknown. Therefore, they often feel comfortable offering extremely facile generalizations that are either unsupported or directly refuted in the experimental literature. Despite this unfortunate precedent, aging is a very broad phenomenon that calls out for integration beyond the mere collecting together of results from disparate laboratory organisms. With this in mind, Part One offers several different synthetic perspectives. The editors, Rose and Finch, provide a verbal synthesis of the field that deliberately attempts to look at aging from both sides, the evolutionary and the molecular. The articles by Charlesworth and Clark both provide population genetic perspectives on aging, the former more mathematical, the latter more experimental. Bell takes a completely different approach, arguing that aging may not be the result of evolutionary forces. Bell's model instead proposes that aging could arise from the progressive deterioration of chronic host pathogen interactions. This is the first detailed publication of this model. It marks something of a return to the type of aging theories that predominated in the 1950's and 1960's, theories like the somatic mutation and error catastrophe theories. We hope that the reader will be interested by the contrast in views between the articles based on evolutionary theory and that of Bell. MR. Rose and C. E. Finch (eds. ), Genetics and Evolution of Aging, 5-12, 1994. © 1994 Kluwer Academic Publishers. The J aniform genetics of aging 2 Michael R. Rosel & Caleb E.
Author :
Publisher :
ISBN 13 :
Total Pages : 94 pages
Book Rating : 4.:/5 (734 download)
Download or read book Aging Studies in Drosophila Melanogaster written by and published by . This book was released on 2011 with total page 94 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Siegfried Hekimi
Publisher : Springer Science & Business Media
ISBN 13 : 354048003X
Total Pages : 254 pages
Book Rating : 4.5/5 (44 download)
Download or read book The Molecular Genetics of Aging written by Siegfried Hekimi and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 254 pages. Available in PDF, EPUB and Kindle. Book excerpt: The molecular genetics of aging or life-span determination is an expanding field. One reason is because many people would consider it desirable if hu man life span could be extended. Indeed, it is difficult not to be fascinated by tales of the life and death of people who have succeeded in living a very long life. Because of this, we have placed at the head of this book the chapter by Perls et al. on Centenerians and the Genetics of Longevity. Perls and his coauthors convincingly argue that, while the average life expectancy might be mostly determined by environmental factors because the average person has an average genotype, extremely long life spans are genetically determined. Of course, studying humans to uncover the genetics of aging is not ideal, not so much because one cannot easily perform experiments as because they live such a long time. This is why most of this book describes the current state of research with model organisms such as yeast, worms, flies, and mice. J aswinski focuses on yeast and how metabolic activity and stress resistance affect the longevity of Saccharomyces cerevisiae. In the process, he discusses the concept of aging as applied to a unicellular organism such as yeast and the importance of metabolism and stress resistance for aging in all organisms.
Author : Leslie P. Gartner
Publisher :
ISBN 13 :
Total Pages : 268 pages
Book Rating : 4.:/5 (319 download)
Download or read book Aging in Drosophila written by Leslie P. Gartner and published by . This book was released on 1986 with total page 268 pages. Available in PDF, EPUB and Kindle. Book excerpt: Listing of 763 entries to literature published through 1985. Also includes foreign-language materials. Topical arrangement. Entries are partially annotated. No index.
Author : Michael R. Rose
Publisher : Oxford University Press
ISBN 13 : 0190282576
Total Pages : 240 pages
Book Rating : 4.1/5 (92 download)
Download or read book Evolutionary Biology of Aging written by Michael R. Rose and published by Oxford University Press. This book was released on 1994-10-27 with total page 240 pages. Available in PDF, EPUB and Kindle. Book excerpt: This unique book looks at the biology of aging from a fundamentally new perspective, one based on evolutionary theory rather than traditional concepts which emphasize molecular and cellular processes. The basis for this approach lies in the fact that natural selection, as a powerful determining force, tends to decline in importance with age. Many of the characteristics we associate with aging, the author argues, are more the result of this decline than any mechanical imperative contained within organic structures. This theory in turn yields the most fruitful avenues for seeking answers to the problem of aging, and should be recognized as the intellectual core of gerontology and the foundation for future research. The author ably surveys the vast literature on aging, presenting mathematical, experimental, and comparative findings to illustrate and support the central thesis. The result is the first complete synthesis of this vital field. Evolutionary biologists, gerontologists, and all those concerned with the science of aging will find it a stimulating, strongly argued account.
Author : Mary Christine Falvey
Publisher :
ISBN 13 :
Total Pages : 116 pages
Book Rating : 4.3/5 (129 download)
Download or read book Effect of Light-dark Cycles on Longevity in Drosophila Melanogaster written by Mary Christine Falvey and published by . This book was released on 1971 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Tyson Gary Bross
Publisher :
ISBN 13 :
Total Pages : 356 pages
Book Rating : 4.:/5 (72 download)
Download or read book Diet and the Determination of Longevity in Drosophila Melanogaster written by Tyson Gary Bross and published by . This book was released on 2006 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Trygve O. Tollefsbol
Publisher : Springer Science & Business Media
ISBN 13 : 1597453617
Total Pages : 844 pages
Book Rating : 4.5/5 (974 download)
Download or read book Biological Aging written by Trygve O. Tollefsbol and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 844 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book investigates the various processes that are affected by the age of an organism. Several new tools for the analysis of biological aging have been introduced recently, and this volume provides methods and protocols for these new techniques in addition to its coverage of established procedures. Researchers seeking new technology and techniques will find this volume of tremendous benefit as they move towards new directions.
Author : Catherine Ann Ramsay
Publisher :
ISBN 13 :
Total Pages : 112 pages
Book Rating : 4.:/5 (459 download)
Download or read book The Effects of Laboratory Culture on Aging in Drosophila Melanogaster written by Catherine Ann Ramsay and published by . This book was released on 2000 with total page 112 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Pramod C. Rath
Publisher : Springer
ISBN 13 : 9811021554
Total Pages : 358 pages
Book Rating : 4.8/5 (11 download)
Download or read book Topics in Biomedical Gerontology written by Pramod C. Rath and published by Springer. This book was released on 2016-10-20 with total page 358 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a collection of articles on various aspects of current research on aging. These include model systems, cellular, biochemical and molecular aspects of experimental aging research, as well as selected intervention studies on age-related diseases. Aging is a global challenge to human society. Children are always in a hurry to become adults, while adults produce offspring and add to the gene pool. However, after adulthood or the attainment of reproductive maturity, all physiological parameters of the living organism start to undergo the aging process. Old age sets in slowly but surely, and usually continues for a prolonged period. If vigor and vitality are the main advantages of adulthood, old age offers the rewards of experience and maturity. Biologists ask questions such as: Why do we age? How do we become old? Is it possible to slow down, postpone or even prevent aging? In turn, medical experts ask: What are the diseases associated with old age? Are there medicines that can help affected elderly patients? In fact both groups are asking themselves how can we add more health to old age. Healthy aging is the dream of every individual. But to achieve this, it is fundamental that we first understand the cellular, biochemical and molecular basis of the aging process in mammalian cells, tissues and intact living organisms, which can serve as experimental model systems in Biomedical Gerontology. Once the biology of aging is understood at the genetic and molecular levels, interventional approaches to aging and its associated diseases may be easier to plan and implement at the preclinical level.
Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309171431
Total Pages : 388 pages
Book Rating : 4.3/5 (91 download)
Download or read book Cells and Surveys written by National Research Council and published by National Academies Press. This book was released on 2001-01-19 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: What can social science, and demography in particular, reasonably expect to learn from biological information? There is increasing pressure for multipurpose household surveys to collect biological data along with the more familiar interviewer-respondent information. Given that recent technical developments have made it more feasible to collect biological information in non-clinical settings, those who fund, design, and analyze survey data need to think through the rationale and potential consequences. This is a concern that transcends national boundaries. Cells and Surveys addresses issues such as which biologic/genetic data should be collected in order to be most useful to a range of social scientists and whether amassing biological data has unintended side effects. The book also takes a look at the various ethical and legal concerns that such data collection entails.
Author : David R. Riddle
Publisher : CRC Press
ISBN 13 : 9781420005523
Total Pages : 408 pages
Book Rating : 4.0/5 (55 download)
Download or read book Brain Aging written by David R. Riddle and published by CRC Press. This book was released on 2007-04-19 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recognition that aging is not the accumulation of disease, but rather comprises fundamental biological processes that are amenable to experimental study, is the basis for the recent growth of experimental biogerontology. As increasingly sophisticated studies provide greater understanding of what occurs in the aging brain and how these changes occur
Author : Raymond Pearl
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Rate of Living written by Raymond Pearl and published by . This book was released on 1928 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
