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Author :
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of the Cell written by and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Isabelle Mus-Veteau
Publisher : Springer
ISBN 13 : 1493906623
Total Pages : 441 pages
Book Rating : 4.4/5 (939 download)
Download or read book Membrane Proteins Production for Structural Analysis written by Isabelle Mus-Veteau and published by Springer. This book was released on 2014-06-20 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book updates the latest development in production, stabilization and structural analysis techniques of membrane proteins. This field has made significant advances since the elucidation of the first 3-D structure of a recombinant G Protein Coupled Receptor (GPCR), rhodopsin, with the structure of several more GPCRs having been solved in the past five years. In fact, the 2012 Nobel Prize in Chemistry was awarded for groundbreaking discoveries on the inner workings of GPCRs. This book is essential reading for all researchers, biochemists and crystallographers working with membrane proteins, who are interested by the structural characterization of their favorite protein and who wish to follow the expression, migration, modifications and recycling of a membrane protein.
Author : Sepehr Eskandari
Publisher :
ISBN 13 :
Total Pages : 446 pages
Book Rating : 4.:/5 ( download)
Download or read book Structural Analysis of Integral Membrane Proteins by Freeze-fracture Electron Microscopy written by Sepehr Eskandari and published by . This book was released on 1999 with total page 446 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Barry S. Selinsky
Publisher : Springer Science & Business Media
ISBN 13 : 159259400X
Total Pages : 330 pages
Book Rating : 4.5/5 (925 download)
Download or read book Membrane Protein Protocols written by Barry S. Selinsky and published by Springer Science & Business Media. This book was released on 2008-02-03 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Knowledge of the three-dimensional structure of a protein is absolutely required for the complete understanding of its function. The spatial orientation of amino acids in the active site of an enzyme demonstrates how substrate specificity is defined, and assists the medicinal chemist in the design of s- cific, tight-binding inhibitors. The shape and contour of a protein surface hints at its interaction with other proteins and with its environment. Structural ana- sis of multiprotein complexes helps to define the role and interaction of each individual component, and can predict the consequences of protein mutation or conditions that promote dissociation and rearrangement of the complex. Determining the three-dimensional structure of a protein requires milligram quantities of pure material. Such quantities are required to refine crystallization conditions for X-ray analysis, or to overcome the sensitivity limitations of NMR spectroscopy. Historically, structural determination of proteins was limited to those expressed naturally in large amounts, or derived from a tissue or cell source inexpensive enough to warrant the use of large quantities of cells. H- ever, with the advent of the techniques of modern gene expression, many p- teins that are constitutively expressed in minute amounts can become accessible to large-scale purification and structural analysis.
Author : Hartmut Michel
Publisher : CRC Press
ISBN 13 : 1351088173
Total Pages : 343 pages
Book Rating : 4.3/5 (51 download)
Download or read book Crystallization of Membrane Proteins written by Hartmut Michel and published by CRC Press. This book was released on 2018-01-18 with total page 343 pages. Available in PDF, EPUB and Kindle. Book excerpt: The precise knowledge of the structure of biological macromolecules forms the basis of understanding their function and their mechanism of action. It also lays the foundation for rational protein and drug design. The only method to obtain this knowledge is still crystallography. At present, the structures of about 400 proteins are known at or nearly at atomic proteins. However, only two of them are membrane proteins or complexes of the membrane proteins. The reasons for the difference is not the crystals of membrane proteins resists forming special problems when being analysed. The reason is that the membrane proteins resist into forming into well-ordered crystals. The intention of this book is to help to produce well-ordered crystals proteins and to provide guidelines, it is aimed at both biochemists and protein crystallographer‘s.
Author :
Publisher : Elsevier
ISBN 13 : 0080860591
Total Pages : 284 pages
Book Rating : 4.0/5 (88 download)
Download or read book Membrane Structure written by and published by Elsevier. This book was released on 1981-01-01 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: Membrane Structure
Author :
Publisher : Academic Press
ISBN 13 : 0080961592
Total Pages : 334 pages
Book Rating : 4.0/5 (89 download)
Download or read book Membrane Protein Crystallization written by and published by Academic Press. This book was released on 2009-05-29 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Membranes focuses on Membrane Protein Crystallization, beginning with a review of past successes and general trends, then further discussing challenges of mebranes protein crystallization, cell free production of membrane proteins and novel lipids for membrane protein crystallization. This publication also includes tools to enchance membrane protein crystallization, technique advancements, and crystallization strategies used for photosystem I and its complexes, establishing Membrane Protein Crystallization as a needed, practical reference for researchers.
Author : Raz Jelinek
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 311045369X
Total Pages : 316 pages
Book Rating : 4.1/5 (14 download)
Download or read book Membranes written by Raz Jelinek and published by Walter de Gruyter GmbH & Co KG. This book was released on 2018-05-07 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Describes the properties of cellular membranes and their relationship with fundamental biological processes. This book provides insight on the chemistry, structures, model systems, and techniques employed for studying membrane properties and processes. A major focus is on the prominence of membranes in diverse physiological processes and disease, as well as applications of membranes and biomimetic membrane systems in varied disciplines. The book aims to illuminate the significance and beauty of membrane science, and serve both as an entry point for scholars wishing to embark on membrane research, as well as scientists already working in the field.
Author : Kenneth H. Lundstrom
Publisher : CRC Press
ISBN 13 : 1420016083
Total Pages : 401 pages
Book Rating : 4.4/5 (2 download)
Download or read book Structural Genomics on Membrane Proteins written by Kenneth H. Lundstrom and published by CRC Press. This book was released on 2006-02-23 with total page 401 pages. Available in PDF, EPUB and Kindle. Book excerpt: While the genomic revolution has quickly led to the deposit of more than 30,000 structures in the protein data bank (PDB), less than one percent of those contributions represent membrane proteins despite the fact that membrane proteins constitute some 20 percent of all proteins. This discrepancy becomes significantly troublesome when it is coupled
Author : Jacek Wojcik
Publisher : Royal Society of Chemistry
ISBN 13 : 1849737673
Total Pages : 593 pages
Book Rating : 4.8/5 (497 download)
Download or read book Nuclear Magnetic Resonance written by Jacek Wojcik and published by Royal Society of Chemistry. This book was released on 2013-05-24 with total page 593 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over 17,000 articles concerning NMR published per year, keeping up to date with the latest developments and applications of this technique can prove time-consuming. Now in its 42nd volume, the Specialist Periodical Report on NMR provides a digest of the current literature, compiled by experts in the field. The current volume devotes several chapters to the aspects and applications of spin-spin couplings, and biochemists will find seperate chapters dedicated to proteins, lipids and carbohydrates. Further chapters discuss the latest developments in nuclear sheilding, imaging and NMR in living systems. For a comprehensive account of the latest developments and research using NMR, look no further than Specialist Periodical Reports - Nuclear Magnetic Resonance. An essential book for NMR lab and university shelf.
Author : Reinhard Grisshammer
Publisher : Royal Society of Chemistry
ISBN 13 : 1847552560
Total Pages : 417 pages
Book Rating : 4.8/5 (475 download)
Download or read book Structural Biology of Membrane Proteins written by Reinhard Grisshammer and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 417 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the last few years there have been many exciting and innovative developments in the field of membrane protein structure and this trend is set to continue. Structural Biology of Membrane Proteins is a new monograph covering a wide range of topics with contributions from leading experts in the field. The book is split into three sections: the first discusses topics such as expression, purification and crystallisation; the second covers characterisation techniques and the final section looks at new protein structures. The book will hence have wide appeal to researchers working in and around the field and provide an up-to-date reference source. Introductory sections to each topic are accompanied by more detailed discussions for the more experienced biochemist. Detailed descriptions of experimental methods are included to demonstrate practical approaches to membrane protein structure projects. The book also offers an up-to-date reference source in addition to descriptions of new and emerging developments, including state-of-the-art techniques for solving membrane protein structures. Structural Biology of Membrane Proteins encompasses both basic introductions and detailed descriptions of themes and should appeal to a wide range of biochemical scientists, both experienced and beginner.
Author : Kwang W. Jeon
Publisher : Gulf Professional Publishing
ISBN 13 : 9780123646507
Total Pages : 332 pages
Book Rating : 4.6/5 (465 download)
Download or read book International Review of Cytology written by Kwang W. Jeon and published by Gulf Professional Publishing. This book was released on 2005-08-24 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: International Review of Cytology presents current advances and comprehensive reviews in cell biology - both plant and animal. Authored by some of the foremost scientists in the field, each volume provides up-to-date information and directions for future research. Articles in this volume address Redundancy of biological regulation as the basis for emergence of multidrug resistancedrug resistance; The palladin-myotilin-myopalladin family: Potent modulators of the actin cytoskeleton; Patch-clamp studies of the new permeability pathways in Plasmodium falciparum; Cellular mechanisms of bacterial internalization; Microinsemination and Transfer Using Male Germ Cells; Nuclear envelope, nuclear lamina in inherited diseases.
Author : Hanudatta S. Atreya
Publisher : Springer Science & Business Media
ISBN 13 : 9400749538
Total Pages : 219 pages
Book Rating : 4.4/5 (7 download)
Download or read book Isotope labeling in Biomolecular NMR written by Hanudatta S. Atreya and published by Springer Science & Business Media. This book was released on 2012-10-18 with total page 219 pages. Available in PDF, EPUB and Kindle. Book excerpt: NMR spectroscopy has undergone a revolution in recent years with the advent of several new methods overcoming the problems of sensitivity and resolution. Recent developments in biotechnology have made it easier and economical to introduce 13C, 15N and 2H into proteins and nucleic acids. At the same time, there has been an explosion in the number of NMR experiments that utilize such isotope labeled samples. Thus, a combination of isotopic labeling and multidimensional, multinuclear NMR has opened up new avenues for structural studies of proteins, nucleic acids and their complexes. This book will focus on recent developments in isotope labeling methods for structural studies of small molecules, peptides, proteins and nucleic acids. The aim of the book is to serve as a compendium of isotope labeling for the biomolecular NMR community providing comprehensive coverage of the existing methods and latest developments along with protocols and practical hints on the various experimental aspects. The book will cover a wide range of topics in isotope labeling under one title including emerging areas of metabolonomics and solid state NMR.
Author : G A Webb
Publisher : Royal Society of Chemistry
ISBN 13 : 1847553877
Total Pages : 517 pages
Book Rating : 4.8/5 (475 download)
Download or read book Nuclear Magnetic Resonance written by G A Webb and published by Royal Society of Chemistry. This book was released on 2007-10-31 with total page 517 pages. Available in PDF, EPUB and Kindle. Book excerpt: As a spectroscopic method, Nuclear Magnetic Resonance (NMR) has seen spectacular growth over the past two decades, both as a technique and in its applications. Today the applications of NMR span a wide range of scientific disciplines, from physics to biology to medicine. Each volume of Nuclear Magnetic Resonance comprises a combination of annual and biennial reports which together provide comprehensive of the literature on this topic. This Specialist Periodical Report reflects the growing volume of published work involving NMR techniques and applications, in particular NMR of natural macromolecules which is covered in two reports: "NMR of Proteins and Acids" and "NMR of Carbohydrates, Lipids and Membranes". For those wanting to become rapidly acquainted with specific areas of NMR, this title provides unrivalled scope of coverage. Seasoned practitioners of NMR will find this an in valuable source of current methods and applications. Specialist Periodical Reports provide systematic and detailed review coverage in major areas of chemical research. Compiled by teams of leading authorities in the relevant subject areas, the series creates a unique service for the active research chemist, with regular, in-depth accounts of progress in particular fields of chemistry. Subject coverage within different volumes of a given title is similar and publication is on an annual or biennial basis.
Author : Stephen H White
Publisher : Springer
ISBN 13 : 1461475155
Total Pages : 403 pages
Book Rating : 4.4/5 (614 download)
Download or read book Membrane Protein Structure written by Stephen H White and published by Springer. This book was released on 2013-05-27 with total page 403 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of receptors, ion channels, and other membrane proteins require a solid understanding of the structural principles of these important biomolecules. Membrane protein structure is, however, a very challenging field. The structures of only three types of transmembrane proteins have been determined to moderate or high resolution during the last two decades, a period during which the amino acid sequences of hundreds, if not thousands, of membrane proteins have been reported. As a result, the creation of structural models to serve as guides for studies of receptors, channels, and other membrane proteins has become crucially important. This book has been assembled in order to share the experiences and findings of expert researchers in protein structure and structure-prediction methods as well as membrane biophysics and lipid physical chemistry, whose work establishes the basis for the development of suitable model structures. The reviews presented here emphasize fundamental ideas and provide an entry to the diverse and complex literature. The four major sections deal with the general nature of the membrane protein structure problem, biochemical and molecular biological approaches to protein topology, direct structural methods, and model and physicochemical approaches. The work will be of interest to physiologists, cellular and molecular biologists, biophysicists, and biochemists working on the function of membrane proteins such as receptors, ion channels, and transporters, as well as senior graduate students and independent investigators.
Author : C. Ragan
Publisher : Springer Science & Business Media
ISBN 13 : 9400940858
Total Pages : 447 pages
Book Rating : 4.4/5 (9 download)
Download or read book Techniques for the Analysis of Membrane Proteins written by C. Ragan and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 447 pages. Available in PDF, EPUB and Kindle. Book excerpt: A preface should justify the existence of the book it precedes and this is invariably done in scientific texts by reference to the explosive growth of the field since the last such volume appeared. In molecular biology, most fields can be justifiably described as growing explosively, as should be the case for a young and vigorous science, but the study of membrane proteins stands out as one which has taken giant strides in the last few years. Ignorance of the structure and function of membrane proteins at the molecular level was certainly not due to lack of interest but rather was a result of lack of appropriate techniques. It has above all been the development of new experimental methods which has wrenched membrane biochemistry out of what Anthony Martonosi fetchingly called its 'romantic phase' (Le. lots of ideas and few facts), into an era when the determination of membrane protein structure and mechanism is a reasonable goal. Membrane proteins are generally classified as peripheral or integral. Peripheral proteins are relatively easily dissociated from membranes by mild treatments whence their study is essentially no different to that of soluble proteins. This book therefore concentrates on integral proteins which are strongly bound to the membrane by hydrophobic interactions with lipids. A crucial step in their study is of necessity the d~velopment of methods of solubilization and purification under non-denaturing conditions.
Author : S.S. Rothman
Publisher : Elsevier
ISBN 13 : 008053614X
Total Pages : 281 pages
Book Rating : 4.0/5 (85 download)
Download or read book Membrane Protein Transport written by S.S. Rothman and published by Elsevier. This book was released on 1996-04-16 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: This is the second volume in a series on membrane protein transfer. Membrane protein transport underlies the topological disposition of many proteins within cells and it is this disposition that allows for the co-ordination of the central cellular processes, such as metabolism.
