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Story Of Interferon The The Ups And Downs In The Life Of A Scientist
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Book Synopsis The Story of Interferon by : Kari Cantell
Download or read book The Story of Interferon written by Kari Cantell and published by World Scientific. This book was released on 1998 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: "... It is likely to be useful to future historians of science as a primary source. Its factual content is, as far as I can tell, entirely accurate."
Book Synopsis Story Of Interferon, The: The Ups And Downs In The Life Of A Scientist by : Kari Cantell
Download or read book Story Of Interferon, The: The Ups And Downs In The Life Of A Scientist written by Kari Cantell and published by World Scientific. This book was released on 1998-05-21 with total page 267 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Finnish doctor Kari Cantell is one of the scientists to whom the development of the drugs called interferons can be attributed. Interferons have achieved an important place in the treatment of cancer, viral infections and multiple sclerosis. In the 1960s Cantell and his coworkers developed a method for the preparation of interferon in white blood cells. During those years, most of the global production of interferon took place in Finland and the vast majority of the clinical studies in the world employed Finnish interferon.The memoirs of Cantell record interferon's long road from the laboratory to the pharmacy shelf. The journey took more than three decades and involved moments of triumph as well as desperation in the lives of many scientists.The book will give the reader a glimpse of the world of science; how research is carried out in the laboratory and the clinic; how the mind of the scientist operates and how he experiences success and failure; how warm friendships and bitter conflicts develop between investigators; how the involvement of money and politics harms as well as helps research.The Interferon Story is a richly rewarding book written for ordinary people without a basic knowledge of biology or medicine. It can be read as a thriller describing the struggle of scientists against the most feared diseases of mankind.
Book Synopsis Science and American Foreign Relations since World War II by : Greg Whitesides
Download or read book Science and American Foreign Relations since World War II written by Greg Whitesides and published by Cambridge University Press. This book was released on 2020-05-28 with total page 705 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sciences played a critical role in American foreign policy after World War II. From atomic energy and satellites to the green revolution, scientific advances were central to American diplomacy in the early Cold War, as the United States leveraged its scientific and technical pre-eminence to secure alliances and markets. The growth of applied research in the 1970s, exemplified by the biotech industry, led the United States to promote global intellectual property rights. Priorities shifted with the collapse of the Soviet Union, as attention turned to information technology and environmental sciences. Today, international relations take place within a scientific and technical framework, whether in the headlines on global warming and the war on terror or in the fine print of intellectual property rights. Science and American Foreign Relations since World War II provides the historical background necessary to understand the contemporary geopolitics of science.
Book Synopsis Multiple Sclerosis by : T. Jock Murray, MD
Download or read book Multiple Sclerosis written by T. Jock Murray, MD and published by Demos Medical Publishing. This book was released on 2004-12-01 with total page 594 pages. Available in PDF, EPUB and Kindle. Book excerpt: Multiple Sclerosis: The History of a Disease won a 2005 ForeWord Book of the Year Silver Medal! The basic facts about multiple sclerosis are well known: it is the most common neurologic disease of young adults, usually beginning with episodic attacks of neurologic symptoms, then entering a progressive phase some years later. Its onset has an average age of 30, and occurs in about 1 in 500 individuals of European ancestry living primarily in temperate climates. There appears to be a complex interaction between a genetic predisposition and an environmental trigger that initiates the disease. But these facts do not convey the impact of the disease on the people whose lives it affects. In this elegantly written and comprehensive history, we meet individuals who suffered with MS in the centuries before the disease had a name, including blessed Lidwina of Holland, who took joy from her misery, believing that she was sent to accept suffering for the sins of others; Augustus d'Est, grandson of George III and cousin of Queen Victoria, whose case shows how someone with access to the best of medical care of the age was understood and managed; and Heinrich Heine, the great German poet, who also had access to all medical services that were available, but who progressed into his mattress grave in two decades, aware of the loss of physical ability while still able to compose great poetry to the end. From these early cases the author demonstrates how progress in diagnosing and managing multiple sclerosis has paralleled the development of medical science, from the early developments in modern studies of anatomy and pathology, to the framing of the disease in the nineteenth century, and eventually to modern diagnosis and treatment. From beginning to end, Dr. Murray takes us on a fascinating journey of discovery, in the process showing how the evolution of our understanding of multiple sclerosis has been part of the greater history of medical knowledge.
Download or read book Interferon written by Toine Pieters and published by Routledge. This book was released on 2005-03-15 with total page 347 pages. Available in PDF, EPUB and Kindle. Book excerpt: This innovative study charts the beginnings, history and fate of Interferon - one of modern medicine's most famous and infamous drugs. Interferon is part of the medical profession's armoury against viral infection, cancer and MS. The story of its development and use is one of survival in the face of remarkable cycles of promise and disappointment as a miracle drug. By telling this story, Toine Pieters' book provides insight into the research, manufacture, and marketing of new bio-molecules that mark modern medical science. Pieters' closely argued book adopts a multi-disciplinary approach in seeking to trace the extraordinary voyage of interferon. Through the lens of interferon's voyage, the book explores the interaction of the broad range of actors driving medical science: *biological and clinical researchers *the pharmaceutical industry *high-powered government agencies *doctors and patients *the media. The book demonstrates how research on interferon led to new clinical definitions of cancer and a new rationale for therapeutic use of the drug. Interferon provides a marvellous insight into the development of one of the most controversial drugs of our time. It enhances our understanding of how medicine manufacture and marketing all played a part in pushing back the boundaries of research, from the post-penicillin era to the genetics revolution in medicine. This study is of particular interest to undergraduates and postgraduates in the fields of History of Medicine, Pharmacology, Medical Genetics and History of Science.
Download or read book Love and Science written by Jan Vilcek and published by Seven Stories Press. This book was released on 2016-12-20 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt: Long before he became one of the world's most celebrated immunologists, Jan Vilcek began life in Slovakia as the child of Jewish parents at a time when Jews were being exterminated all across Europe. He owes his and his mother’s survival to the courage of brave people and good luck. As a young man growing up in Czechoslovakia in the aftermath of the Second World War, Vilcek went to medical school and chose a career in virology and immunology at a time when these fields were still in their infancy. While still in his twenties he published a paper in the prestigious journal Nature, and he hosted the first international conference on interferon. Fleeing Communist Czechoslovakia with his wife Marica, Vilcek continued his research at NYU School of Medicine, going on to establish a highly successful career in biomedical research, and creating one of the most important and trailblazing medicines of our age. After his arrival in the US in 1965 as a penniless refugee, he soon went on to spearhead some of the key advances in the research of interferon that enabled its therapeutic application, and through his research into tumor necrosis factor (TNF) made advances that led to the discovery of new genes and proteins and signaling pathways, opening up previously uncharted areas of medical innovation that have led to important new treatments for a wide range of autoimmune and inflammatory diseases. Along the way Vilcek acquired material wealth he had never aspired to, catapulting him into the world of philanthropy. Love and Science shows how advances in science sometimes result from the greatest disappointments, and how achievement in medical research is usually a team effort, where ideas are shared, where friendship and love sometimes matter most and serendipity is as important as a will to succeed—and where, over time, the least expected thing sometimes becomes the most important. In Vilcek's case the vaunted cure for cancer that many saw in TNF never materialized. However, out of the ashes of that hope came many related treatments that have changed countless lives and alleviated much suffering.
Book Synopsis Understanding Viruses by : Teri Shors
Download or read book Understanding Viruses written by Teri Shors and published by Jones & Bartlett Publishers. This book was released on 2017 with total page 969 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understanding Viruses continues to set the standard for the fundamentals of virology. This classic textbook combines molecular, clinical, and historical aspects of human viral diseases in a new stunning interior design featuring high quality art that will engage readers. Preparing students for their careers, the Third Edition greatly expands on molecular virology and virus families. This practical text also includes the latest information on influenza, global epidemiology statistics, and the recent outbreaks of Zika and Ebola viruses to keep students on the forefront of cutting-edge virology information. Numerous case studies and feature boxes illuminate fascinating research and historical cases stimulate student interest, making the best-selling Understanding Viruses the clear choice in virology. Each new print copy includes Navigate 2 Advantage Access that unlocks a comprehensive and interactive eBook, student practice activities and assessments, a full suite of instructor resources (available to adopting instructors with course ID), and learning analytics reporting tools (available to adopting instructors with course ID).
Book Synopsis Case for Interferon by : Joseph Cummins
Download or read book Case for Interferon written by Joseph Cummins and published by Simon and Schuster. This book was released on 2021-01-05 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Touted as a potential breakthrough cancer therapy in the 1980s by the scientific community and publications such as TIME and Newsweek magazine, the reputation of interferon has not lived up to its early promise. Interferons are small proteins with anti-viral and anti-cancer effects, which have the power to modulate the functioning of the immune system. But Dr. Joseph Cummins, an early interferon pioneer, holder of sixteen US medical patents, author of more than sixty scientific publications, as well as having taught veterinary medicine at the University of Missouri, University of Illinois, and Texas A & M University, argues that the current thinking on interferon is fundamentally flawed. Interferon is created in small quantities in the body in response to infection, and seems to work best at these low dosages. However, the public health cowboys, working under the assumption that anything good in tiny amounts must be better in massive amounts, pursued exactly the wrong strategy. High-dose interferon does not work in the body and may even cause problems. The first remarkable results for interferon and the flu were reported by the Soviets in the 1970s, but Western medicine discounted these findings because they believed the dosages were so low they couldn’t possibly be effective. In the 1980s, when interferon was expensive to produce and only small quantities could be manufactured, the results were remarkable. Dr. Cummins was an early pioneer of low-dose interferon, and his remarkable findings among animals led to collaborations with medical doctors for human trials, even going so far as Africa at the height of the HIV-AIDS epidemic. Cummins reviews the evidence for this inexpensive, safe treatment and makes an eloquent argument for medical science to take another look at interferon to tackle today’s most challenging health conditions, including COVID-19.
Book Synopsis Interferon: The Dawn of Recombinant Protein Drugs by : J. Lindenmann
Download or read book Interferon: The Dawn of Recombinant Protein Drugs written by J. Lindenmann and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 149 pages. Available in PDF, EPUB and Kindle. Book excerpt: Forty years of Interferon I wish to dedicate this short introduction to the memory of Alick Isaacs (1921-1967), and to that of Sir Christopher Andrewes (1896-1988). Let us go back more than 40 years. In 1956 Isaacs was in charge of the Wodd Influenza Centre. Andrewes was head of the division of bac teriology and virology, and deputy director of the National Institute for Medical Research in London. When researchers are faced with a seemingly new phenomenon, ex planations are easy to come by. These explanations fall into two broad categories: the phenomenon in question is either due to something or to the lack of something. I apologize for the primitive way in which I ex press this, but I am going to give three examples, scattered over 100 years, of what I mean. First example: in 1880 the great French microbiologist Louis Pas teur was involved in work on chicken cholera. He was struck by the following observation: if a suitable chicken broth was inoculated with the bacterium, the organism grew profusely and the liquid became tur bid. If he now freed the fluid, by sedimentation or filtration, from the bulk of the organisms and re-inoculated it with the same bacterium, no growth occurred.
Book Synopsis The Beautiful Cure by : Daniel M. Davis
Download or read book The Beautiful Cure written by Daniel M. Davis and published by University of Chicago Press. This book was released on 2021-03-19 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Visceral.”—Wall Street Journal “Illuminating.”—Publishers Weekly “Heroic.”—Science The immune system holds the key to human health. In The Beautiful Cure, leading immunologist Daniel M. Davis describes how the scientific quest to understand how the immune system works—and how it is affected by stress, sleep, age, and our state of mind—is now unlocking a revolutionary new approach to medicine and well-being. The body’s ability to fight disease and heal itself is one of the great mysteries and marvels of nature. But in recent years, painstaking research has resulted in major advances in our grasp of this breathtakingly beautiful inner world: a vast and intricate network of specialist cells, regulatory proteins, and dedicated genes that are continually protecting our bodies. Far more powerful than any medicine ever invented, the immune system plays a crucial role in our daily lives. We have found ways to harness these natural defenses to create breakthrough drugs and so-called immunotherapies that help us fight cancer, diabetes, arthritis, and many age-related diseases, and we are starting to understand whether activities such as mindfulness might play a role in enhancing our physical resilience. Written by a researcher at the forefront of this adventure, The Beautiful Cure tells a dramatic story of scientific detective work and discovery, of puzzles solved and mysteries that linger, of lives sacrificed and saved. With expertise and eloquence, Davis introduces us to this revelatory new understanding of the human body and what it takes to be healthy.
Book Synopsis Recombinant Protein Drugs by : P. Buckel
Download or read book Recombinant Protein Drugs written by P. Buckel and published by Birkhäuser. This book was released on 2012-12-06 with total page 207 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recombinant protein drugs are intimately associated with the impressive success story of the Biotech Industry during the past thirty years, some of them belonging to the most successful pharmaceutical products. More than thirty different proteins are available for a variety of clinical applications, over 300 proteins are presently being evaluated in clinical trials. In this new volume of the MDT series, historical, technical and clinical aspects of recombinant protein drug discovery and development are presented, covering past, present and future highlights. Leading scientists and co-founders of early Biotech companies describe technical breakthroughs and the fascinating story of pioneering discoveries, as well as the long way of translating them into products and business. Therefore, this book represents an exciting documentation of the beginning of a new era in the pharmaceutical industry. In addition, scientists from basic research, clinic and industry actively involved in new developments discuss...
Book Synopsis Subalternity vs. Hegemony, Cuba's Outstanding Achievements in Science and Biotechnology, 1959-2014 by : Angelo Baracca
Download or read book Subalternity vs. Hegemony, Cuba's Outstanding Achievements in Science and Biotechnology, 1959-2014 written by Angelo Baracca and published by Springer. This book was released on 2016-07-12 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt: The present book introduces an original (new) perspective on Cuba. This book revisits Cuba's choice, after the 1959 revolution, to develop an advanced healthcare and scientific system. It also introduces new aspects of the problem development/underdevelopment. From the start, every effort of the Cuban leadership and scientific community was driven by the primary purpose of meeting the country’s basic economic and social needs. Immediate key measures taken after the revolution included free education up to higher levels and free health services. In only a couple of decades Third World diseases were defeated and a First World health profile was achieved. In the sciences, support and collaboration was sought and welcomed from both Soviet and western countries. Moreover, due to the backward position of the Soviet Union in genetics and molecular biology, in the early 1970s Cuban scientists were trained in these fields mainly by Italian biologists. In the following decade, initially relying on contacts with American and Finnish specialists, Cuban biologists and physicians built a large industrial biotechnology complex to produce and commercialize Cuban-made, and often invented, medicines and vaccines. In the early 1990s the sudden collapse of the Soviet Union and the socialist market created an unprecedented challenge. Yet Cuba’s scientific system substantially resiled, despite unavoidable setbacks. This crisis was faced by confirming and reinforcing government support for biotechnology, with the result that today Cuba excels at a global level in the typical capital-intensive field of biotechnology. While this book is especially devoted to historians of science and technology and to biotechnologists, it is of interest to the general public.
Book Synopsis Several Worlds: Reminiscences And Reflections Of A Chinese-american Physician by : Monto Ho
Download or read book Several Worlds: Reminiscences And Reflections Of A Chinese-american Physician written by Monto Ho and published by World Scientific. This book was released on 2005-10-25 with total page 349 pages. Available in PDF, EPUB and Kindle. Book excerpt: This fascinating book comprises the autobiographical reminiscences and reflections of Monto Ho, M.D., a Chinese-born, American physician and widely recognized infectious disease specialist. It presents a remarkable opportunity to understand his personal history, the development of his scholarly qualities, and the logic of his scientific and cultural passions.A leader in the field over the past half a century, the author was a pioneer investigator of interferon. He made major contributions to the pathogenesis of virus infections in the immunocompromised host, especially of cytomegalovirus and other herpesvirus infections in organ transplant recipients. He built a strong science-based infectious diseases group at the University of Pittsburgh in the US.In his “second career” in Taiwan, Monto Ho changed the direction of his research to address problems that were important to that country. He recognized the threat posed by the emergence of antibiotic-resistant bacteria and the need to enhance the quality of training of infectious diseases physicians. These efforts paid unexpected dividends. The appropriate use of antibiotics has become an important national health priority, and there is now intense research on the devastating outbreaks of enterovirus 71 in children.
Book Synopsis Cold War Triangle by : Renilde Loeckx
Download or read book Cold War Triangle written by Renilde Loeckx and published by Leuven University Press. This book was released on 2021-03-22 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: The extraordinary story of scientists in East and West combatting HIV A small group of scientists were doggedly working in the field of antiviral treatments when the AIDS epidemic struck. Faced with one of the grand challenges of modern biology of the twentieth century, scientists worked across the political divide of the Cold War to produce a new class of antivirals. Their molecules were developed by a Californian start-up together with teams of scientists at the Rega Institute of KU Leuven and the Institute of Organic Chemistry and Biochemistry (IOCB) of the Academy of Sciences in Prague. These molecules became the cornerstone of the blockbuster drugs now used to combat and prevent HIV. Cold War Triangle gives an insight into the human face of science as it recounts the extraordinary story of scientists in East and West who overcame ideological barriers and worked together for the benefit of humanity.
Book Synopsis Protein Therapeutics, 2 Volume Set by : Tristan Vaughan
Download or read book Protein Therapeutics, 2 Volume Set written by Tristan Vaughan and published by John Wiley & Sons. This book was released on 2017-08-02 with total page 480 pages. Available in PDF, EPUB and Kindle. Book excerpt: In this practice-oriented two volume handbook, professionals from some of the largest biopharmaceutical companies and top academic researchers address the key concepts and challenges in the development of protein pharmaceuticals for medicinal chemists and drug developers of all trades. Following an introduction tracing the rapid development of the protein therapeutics market over the last decade, all currently used therapeutic protein scaffolds are surveyed, from human and non-human antibodies to antibody mimetics, bispecific antibodies and antibody-drug conjugates. This ready reference then goes on to review other key aspects such as pharmacokinetics, safety and immunogenicity, manufacture, formulation and delivery. The handbook then takes a look at current key clinical applications for protein therapeutics, from respiratory and inflammation to oncology and immune-oncology, infectious diseases and rescue therapy. Finally, several exciting prospects for the future of protein therapeutics are highlighted and discussed.
Download or read book Gene Jockeys written by Nicolas Rasmussen and published by JHU Press. This book was released on 2014-05-15 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific scramble to discover the first generation of drugs created through genetic engineering. The biotech arena emerged in the 1970s and 1980s, when molecular biology, one of the fastest-moving areas of basic science in the twentieth century, met the business world. Gene Jockeys is a detailed study of the biotech projects that led to five of the first ten recombinant DNA drugs to be approved for medical use in the United States: human insulin, human growth hormone, alpha interferon, erythropoietin, and tissue plasminogen activator. Drawing on corporate documents obtained from patent litigation, as well as interviews with the ambitious biologists who called themselves gene jockeys, historian Nicolas Rasmussen chronicles the remarkable, and often secretive, work of the scientists who built a new domain between academia and the drug industry in the pursuit of intellectual rewards and big payouts. In contrast to some who critique the rise of biotechnology, Rasmussen contends that biotech was not a swindle, even if the public did pay a very high price for the development of what began as public scientific resources. Within the biotech enterprise, the work of corporate scientists went well beyond what biologists had already accomplished within universities, and it accelerated the medical use of the new drugs by several years. In his technically detailed and readable narrative, Rasmussen focuses on the visible and often heavy hands that construct and maintain the markets in public goods like science. He looks closely at how science follows money, and vice versa, as researchers respond to the pressures and potential rewards of commercially viable innovations. In biotechnology, many of those engaged in crafting markets for genetically engineered drugs were biologists themselves who were in fact trying to do science. This book captures that heady, fleeting moment when a biologist could expect to do great science through the private sector and be rewarded with both wealth and scientific acclaim.
Book Synopsis Clinical Handbook for Biotherapy by : Paula Trahan Rieger
Download or read book Clinical Handbook for Biotherapy written by Paula Trahan Rieger and published by Jones & Bartlett Learning. This book was released on 1999 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: A pocket (4x7.5") reference on all major biological agents and their respective nursing management. Individual chapters on all major categories follow a consistent format of overview of biology, mechanisms of action, regulatory approvals, clinical tips, side effects, administration and dosing, bibliography, and useful web sites and addresses. Information is presented in outline format. Includes overview chapters on biotherapy and the immune system, plus a glossary. Annotation copyrighted by Book News, Inc., Portland, OR
