Stochastic Modelling of Reaction-Diffusion Processes

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Publisher : Cambridge University Press
ISBN 13 : 1108498124
Total Pages : 321 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis Stochastic Modelling of Reaction-Diffusion Processes by : Radek Erban

Download or read book Stochastic Modelling of Reaction-Diffusion Processes written by Radek Erban and published by Cambridge University Press. This book was released on 2020-01-30 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Practical introduction for advanced undergraduate or beginning graduate students of applied mathematics, developed at the University of Oxford.

Stochastic Modelling of Reaction–Diffusion Processes

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Publisher : Cambridge University Press
ISBN 13 : 1108572995
Total Pages : 322 pages
Book Rating : 4.1/5 (85 download)

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Book Synopsis Stochastic Modelling of Reaction–Diffusion Processes by : Radek Erban

Download or read book Stochastic Modelling of Reaction–Diffusion Processes written by Radek Erban and published by Cambridge University Press. This book was released on 2020-01-30 with total page 322 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical introduction to stochastic reaction-diffusion modelling is based on courses taught at the University of Oxford. The authors discuss the essence of mathematical methods which appear (under different names) in a number of interdisciplinary scientific fields bridging mathematics and computations with biology and chemistry. The book can be used both for self-study and as a supporting text for advanced undergraduate or beginning graduate-level courses in applied mathematics. New mathematical approaches are explained using simple examples of biological models, which range in size from simulations of small biomolecules to groups of animals. The book starts with stochastic modelling of chemical reactions, introducing stochastic simulation algorithms and mathematical methods for analysis of stochastic models. Different stochastic spatio-temporal models are then studied, including models of diffusion and stochastic reaction-diffusion modelling. The methods covered include molecular dynamics, Brownian dynamics, velocity jump processes and compartment-based (lattice-based) models.

Stochastic Processes for Physicists

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Publisher : Cambridge University Press
ISBN 13 : 1139486799
Total Pages : 203 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Stochastic Processes for Physicists by : Kurt Jacobs

Download or read book Stochastic Processes for Physicists written by Kurt Jacobs and published by Cambridge University Press. This book was released on 2010-02-18 with total page 203 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stochastic processes are an essential part of numerous branches of physics, as well as in biology, chemistry, and finance. This textbook provides a solid understanding of stochastic processes and stochastic calculus in physics, without the need for measure theory. In avoiding measure theory, this textbook gives readers the tools necessary to use stochastic methods in research with a minimum of mathematical background. Coverage of the more exotic Levy processes is included, as is a concise account of numerical methods for simulating stochastic systems driven by Gaussian noise. The book concludes with a non-technical introduction to the concepts and jargon of measure-theoretic probability theory. With over 70 exercises, this textbook is an easily accessible introduction to stochastic processes and their applications, as well as methods for numerical simulation, for graduate students and researchers in physics.

Stochastic Dynamics in Computational Biology

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Publisher : Springer Nature
ISBN 13 : 3030623874
Total Pages : 284 pages
Book Rating : 4.0/5 (36 download)

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Book Synopsis Stochastic Dynamics in Computational Biology by : Stefanie Winkelmann

Download or read book Stochastic Dynamics in Computational Biology written by Stefanie Winkelmann and published by Springer Nature. This book was released on 2021-01-04 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The aim of this book is to provide a well-structured and coherent overview of existing mathematical modeling approaches for biochemical reaction systems, investigating relations between both the conventional models and several types of deterministic-stochastic hybrid model recombinations. Another main objective is to illustrate and compare diverse numerical simulation schemes and their computational effort. Unlike related works, this book presents a broad scope in its applications, from offering a detailed introduction to hybrid approaches for the case of multiple population scales to discussing the setting of time-scale separation resulting from widely varying firing rates of reaction channels. Additionally, it also addresses modeling approaches for non well-mixed reaction-diffusion dynamics, including deterministic and stochastic PDEs and spatiotemporal master equations. Finally, by translating and incorporating complex theory to a level accessible to non-mathematicians, this book effectively bridges the gap between mathematical research in computational biology and its practical use in biological, biochemical, and biomedical systems.

An Introduction to Stochastic Modeling

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Publisher : Academic Press
ISBN 13 : 1483269272
Total Pages : 410 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis An Introduction to Stochastic Modeling by : Howard M. Taylor

Download or read book An Introduction to Stochastic Modeling written by Howard M. Taylor and published by Academic Press. This book was released on 2014-05-10 with total page 410 pages. Available in PDF, EPUB and Kindle. Book excerpt: An Introduction to Stochastic Modeling provides information pertinent to the standard concepts and methods of stochastic modeling. This book presents the rich diversity of applications of stochastic processes in the sciences. Organized into nine chapters, this book begins with an overview of diverse types of stochastic models, which predicts a set of possible outcomes weighed by their likelihoods or probabilities. This text then provides exercises in the applications of simple stochastic analysis to appropriate problems. Other chapters consider the study of general functions of independent, identically distributed, nonnegative random variables representing the successive intervals between renewals. This book discusses as well the numerous examples of Markov branching processes that arise naturally in various scientific disciplines. The final chapter deals with queueing models, which aid the design process by predicting system performance. This book is a valuable resource for students of engineering and management science. Engineers will also find this book useful.

Nonlinear Reaction-Diffusion Processes for Nanocomposites

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Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3110647516
Total Pages : 178 pages
Book Rating : 4.1/5 (16 download)

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Book Synopsis Nonlinear Reaction-Diffusion Processes for Nanocomposites by : Jesús Ildefonso Díaz

Download or read book Nonlinear Reaction-Diffusion Processes for Nanocomposites written by Jesús Ildefonso Díaz and published by Walter de Gruyter GmbH & Co KG. This book was released on 2021-06-21 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: The series is devoted to the publication of high-level monographs which cover the whole spectrum of current nonlinear analysis and applications in various fields, such as optimization, control theory, systems theory, mechanics, engineering, and other sciences. One of its main objectives is to make available to the professional community expositions of results and foundations of methods that play an important role in both the theory and applications of nonlinear analysis. Contributions which are on the borderline of nonlinear analysis and related fields and which stimulate further research at the crossroads of these areas are particularly welcome. Editor-in-Chief J rgen Appell, W rzburg, Germany Honorary and Advisory Editors Catherine Bandle, Basel, Switzerland Alain Bensoussan, Richardson, Texas, USA Avner Friedman, Columbus, Ohio, USA Umberto Mosco, Worcester, Massachusetts, USA Louis Nirenberg, New York, USA Alfonso Vignoli, Rome, Italy Editorial Board Manuel del Pino, Bath, UK, and Santiago, Chile Mikio Kato, Nagano, Japan Wojciech Kryszewski, Toruń, Poland Vicenţiu D. Rădulescu, Krak w, Poland Simeon Reich, Haifa, Israel Please submit book proposals to J rgen Appell. Titles in planning include Lucio Damascelli and Filomena Pacella, Morse Index of Solutions of Nonlinear Elliptic Equations (2019) Tomasz W. Dlotko and Yejuan Wang, Critical Parabolic-Type Problems (2019) Rafael Ortega, Periodic Differential Equations in the Plane: A Topological Perspective (2019) Ireneo Peral Alonso and Fernando Soria, Elliptic and Parabolic Equations Involving the Hardy-Leray Potential (2020) Cyril Tintarev, Profile Decompositions and Cocompactness: Functional-Analytic Theory of Concentration Compactness (2020) Takashi Suzuki, Semilinear Elliptic Equations: Classical and Modern Theories (2021)

Stochastic Modelling in Process Technology

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Publisher : Elsevier
ISBN 13 : 9780080548975
Total Pages : 290 pages
Book Rating : 4.5/5 (489 download)

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Book Synopsis Stochastic Modelling in Process Technology by : Herold G. Dehling

Download or read book Stochastic Modelling in Process Technology written by Herold G. Dehling and published by Elsevier. This book was released on 2007-07-03 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: There is an ever increasing need for modelling complex processes reliably. Computational modelling techniques, such as CFD and MD may be used as tools to study specific systems, but their emergence has not decreased the need for generic, analytical process models. Multiphase and multicomponent systems, and high-intensity processes displaying a highly complex behaviour are becoming omnipresent in the processing industry. This book discusses an elegant, but little-known technique for formulating process models in process technology: stochastic process modelling. The technique is based on computing the probability distribution for a single particle's position in the process vessel, and/or the particle's properties, as a function of time, rather than - as is traditionally done - basing the model on the formulation and solution of differential conservation equations. Using this technique can greatly simplify the formulation of a model, and even make modelling possible for processes so complex that the traditional method is impracticable. Stochastic modelling has sporadically been used in various branches of process technology under various names and guises. This book gives, as the first, an overview of this work, and shows how these techniques are similar in nature, and make use of the same basic mathematical tools and techniques. The book also demonstrates how stochastic modelling may be implemented by describing example cases, and shows how a stochastic model may be formulated for a case, which cannot be described by formulating and solving differential balance equations. Introduction to stochastic process modelling as an alternative modelling technique Shows how stochastic modelling may be succesful where the traditional technique fails Overview of stochastic modelling in process technology in the research literature Illustration of the principle by a wide range of practical examples In-depth and self-contained discussions Points the way to both mathematical and technological research in a new, rewarding field

Stochastic Processes in Cell Biology

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Author :
Publisher : Springer Nature
ISBN 13 : 3030725154
Total Pages : 773 pages
Book Rating : 4.0/5 (37 download)

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Book Synopsis Stochastic Processes in Cell Biology by : Paul C. Bressloff

Download or read book Stochastic Processes in Cell Biology written by Paul C. Bressloff and published by Springer Nature. This book was released on 2022-01-04 with total page 773 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops the theory of continuous and discrete stochastic processes within the context of cell biology. In the second edition the material has been significantly expanded, particularly within the context of nonequilibrium and self-organizing systems. Given the amount of additional material, the book has been divided into two volumes, with volume I mainly covering molecular processes and volume II focusing on cellular processes. A wide range of biological topics are covered in the new edition, including stochastic ion channels and excitable systems, molecular motors, stochastic gene networks, genetic switches and oscillators, epigenetics, normal and anomalous diffusion in complex cellular environments, stochastically-gated diffusion, active intracellular transport, signal transduction, cell sensing, bacterial chemotaxis, intracellular pattern formation, cell polarization, cell mechanics, biological polymers and membranes, nuclear structure and dynamics, biological condensates, molecular aggregation and nucleation, cellular length control, cell mitosis, cell motility, cell adhesion, cytoneme-based morphogenesis, bacterial growth, and quorum sensing. The book also provides a pedagogical introduction to the theory of stochastic and nonequilibrium processes – Fokker Planck equations, stochastic differential equations, stochastic calculus, master equations and jump Markov processes, birth-death processes, Poisson processes, first passage time problems, stochastic hybrid systems, queuing and renewal theory, narrow capture and escape, extreme statistics, search processes and stochastic resetting, exclusion processes, WKB methods, large deviation theory, path integrals, martingales and branching processes, numerical methods, linear response theory, phase separation, fluctuation-dissipation theorems, age-structured models, and statistical field theory. This text is primarily aimed at graduate students and researchers working in mathematical biology, statistical and biological physicists, and applied mathematicians interested in stochastic modeling. Applied probabilists should also find it of interest. It provides significant background material in applied mathematics and statistical physics, and introduces concepts in stochastic and nonequilibrium processes via motivating biological applications. The book is highly illustrated and contains a large number of examples and exercises that further develop the models and ideas in the body of the text. It is based on a course that the author has taught at the University of Utah for many years.

Inference for Diffusion Processes

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Publisher : Springer Science & Business Media
ISBN 13 : 3642259693
Total Pages : 439 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Inference for Diffusion Processes by : Christiane Fuchs

Download or read book Inference for Diffusion Processes written by Christiane Fuchs and published by Springer Science & Business Media. This book was released on 2013-01-18 with total page 439 pages. Available in PDF, EPUB and Kindle. Book excerpt: Diffusion processes are a promising instrument for realistically modelling the time-continuous evolution of phenomena not only in the natural sciences but also in finance and economics. Their mathematical theory, however, is challenging, and hence diffusion modelling is often carried out incorrectly, and the according statistical inference is considered almost exclusively by theoreticians. This book explains both topics in an illustrative way which also addresses practitioners. It provides a complete overview of the current state of research and presents important, novel insights. The theory is demonstrated using real data applications.

Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology

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Publisher : Springer
ISBN 13 : 3319626272
Total Pages : 377 pages
Book Rating : 4.3/5 (196 download)

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Book Synopsis Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology by : David Holcman

Download or read book Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology written by David Holcman and published by Springer. This book was released on 2017-10-04 with total page 377 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the modeling and mathematical analysis of stochastic dynamical systems along with their simulations. The collected chapters will review fundamental and current topics and approaches to dynamical systems in cellular biology. This text aims to develop improved mathematical and computational methods with which to study biological processes. At the scale of a single cell, stochasticity becomes important due to low copy numbers of biological molecules, such as mRNA and proteins that take part in biochemical reactions driving cellular processes. When trying to describe such biological processes, the traditional deterministic models are often inadequate, precisely because of these low copy numbers. This book presents stochastic models, which are necessary to account for small particle numbers and extrinsic noise sources. The complexity of these models depend upon whether the biochemical reactions are diffusion-limited or reaction-limited. In the former case, one needs to adopt the framework of stochastic reaction-diffusion models, while in the latter, one can describe the processes by adopting the framework of Markov jump processes and stochastic differential equations. Stochastic Processes, Multiscale Modeling, and Numerical Methods for Computational Cellular Biology will appeal to graduate students and researchers in the fields of applied mathematics, biophysics, and cellular biology.

Controlled Diffusion Processes

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Publisher : Springer
ISBN 13 : 9781461260530
Total Pages : 308 pages
Book Rating : 4.2/5 (65 download)

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Book Synopsis Controlled Diffusion Processes by : N.V. Krylov

Download or read book Controlled Diffusion Processes written by N.V. Krylov and published by Springer. This book was released on 2011-10-12 with total page 308 pages. Available in PDF, EPUB and Kindle. Book excerpt: Stochastic control theory is a relatively young branch of mathematics. The beginning of its intensive development falls in the late 1950s and early 1960s. During that period an extensive literature appeared on optimal stochastic control using the quadratic performance criterion (see references in W onham [76J). At the same time, Girsanov [25J and Howard [26J made the first steps in constructing a general theory, based on Bellman's technique of dynamic programming, developed by him somewhat earlier [4J. Two types of engineering problems engendered two different parts of stochastic control theory. Problems of the first type are associated with multistep decision making in discrete time, and are treated in the theory of discrete stochastic dynamic programming. For more on this theory, we note in addition to the work of Howard and Bellman, mentioned above, the books by Derman [8J, Mine and Osaki [55J, and Dynkin and Yushkevich [12]. Another class of engineering problems which encouraged the development of the theory of stochastic control involves time continuous control of a dynamic system in the presence of random noise. The case where the system is described by a differential equation and the noise is modeled as a time continuous random process is the core of the optimal control theory of diffusion processes. This book deals with this latter theory.

Mathematical Models of Chemical Reactions

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Publisher : Manchester University Press
ISBN 13 : 9780719022081
Total Pages : 296 pages
Book Rating : 4.0/5 (22 download)

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Book Synopsis Mathematical Models of Chemical Reactions by : Péter Érdi

Download or read book Mathematical Models of Chemical Reactions written by Péter Érdi and published by Manchester University Press. This book was released on 1989 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Stochastic Dynamics and Irreversibility

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Publisher : Springer
ISBN 13 : 331911770X
Total Pages : 394 pages
Book Rating : 4.3/5 (191 download)

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Book Synopsis Stochastic Dynamics and Irreversibility by : Tânia Tomé

Download or read book Stochastic Dynamics and Irreversibility written by Tânia Tomé and published by Springer. This book was released on 2014-11-26 with total page 394 pages. Available in PDF, EPUB and Kindle. Book excerpt: This textbook presents an exposition of stochastic dynamics and irreversibility. It comprises the principles of probability theory and the stochastic dynamics in continuous spaces, described by Langevin and Fokker-Planck equations, and in discrete spaces, described by Markov chains and master equations. Special concern is given to the study of irreversibility, both in systems that evolve to equilibrium and in nonequilibrium stationary states. Attention is also given to the study of models displaying phase transitions and critical phenomena both in thermodynamic equilibrium and out of equilibrium. These models include the linear Glauber model, the Glauber-Ising model, lattice models with absorbing states such as the contact process and those used in population dynamic and spreading of epidemic, probabilistic cellular automata, reaction-diffusion processes, random sequential adsorption and dynamic percolation. A stochastic approach to chemical reaction is also presented.The textbook is intended for students of physics and chemistry and for those interested in stochastic dynamics. It provides, by means of examples and problems, a comprehensive and detailed explanation of the theory and its applications.

Stochastic Foundations in Movement Ecology

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Publisher : Springer Science & Business Media
ISBN 13 : 3642390102
Total Pages : 310 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Stochastic Foundations in Movement Ecology by : Vicenç Méndez

Download or read book Stochastic Foundations in Movement Ecology written by Vicenç Méndez and published by Springer Science & Business Media. This book was released on 2013-09-18 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the fundamental theory for non-standard diffusion problems in movement ecology. Lévy processes and anomalous diffusion have shown to be both powerful and useful tools for qualitatively and quantitatively describing a wide variety of spatial population ecological phenomena and dynamics, such as invasion fronts and search strategies. Adopting a self-contained, textbook-style approach, the authors provide the elements of statistical physics and stochastic processes on which the modeling of movement ecology is based and systematically introduce the physical characterization of ecological processes at the microscopic, mesoscopic and macroscopic levels. The explicit definition of these levels and their interrelations is particularly suitable to coping with the broad spectrum of space and time scales involved in bio-ecological problems. Including numerous exercises (with solutions), this text is aimed at graduate students and newcomers in this field at the interface of theoretical ecology, mathematical biology and physics.

Stochastic Processes in Cell Biology

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Author :
Publisher : Springer
ISBN 13 : 9783030725211
Total Pages : 0 pages
Book Rating : 4.7/5 (252 download)

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Book Synopsis Stochastic Processes in Cell Biology by : Paul C. Bressloff

Download or read book Stochastic Processes in Cell Biology written by Paul C. Bressloff and published by Springer. This book was released on 2023-01-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book develops the theory of continuous and discrete stochastic processes within the context of cell biology. In the second edition the material has been significantly expanded, particularly within the context of nonequilibrium and self-organizing systems. Given the amount of additional material, the book has been divided into two volumes, with volume I mainly covering molecular processes and volume II focusing on cellular processes. A wide range of biological topics are covered in the new edition, including stochastic ion channels and excitable systems, molecular motors, stochastic gene networks, genetic switches and oscillators, epigenetics, normal and anomalous diffusion in complex cellular environments, stochastically-gated diffusion, active intracellular transport, signal transduction, cell sensing, bacterial chemotaxis, intracellular pattern formation, cell polarization, cell mechanics, biological polymers and membranes, nuclear structure and dynamics, biological condensates, molecular aggregation and nucleation, cellular length control, cell mitosis, cell motility, cell adhesion, cytoneme-based morphogenesis, bacterial growth, and quorum sensing. The book also provides a pedagogical introduction to the theory of stochastic and nonequilibrium processes – Fokker Planck equations, stochastic differential equations, stochastic calculus, master equations and jump Markov processes, birth-death processes, Poisson processes, first passage time problems, stochastic hybrid systems, queuing and renewal theory, narrow capture and escape, extreme statistics, search processes and stochastic resetting, exclusion processes, WKB methods, large deviation theory, path integrals, martingales and branching processes, numerical methods, linear response theory, phase separation, fluctuation-dissipation theorems, age-structured models, and statistical field theory. This text is primarily aimed at graduate students and researchers working in mathematical biology, statistical and biological physicists, and applied mathematicians interested in stochastic modeling. Applied probabilists should also find it of interest. It provides significant background material in applied mathematics and statistical physics, and introduces concepts in stochastic and nonequilibrium processes via motivating biological applications. The book is highly illustrated and contains a large number of examples and exercises that further develop the models and ideas in the body of the text. It is based on a course that the author has taught at the University of Utah for many years.

Stochastic Modelling for Systems Biology

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Author :
Publisher : CRC Press
ISBN 13 : 9781584885405
Total Pages : 296 pages
Book Rating : 4.8/5 (854 download)

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Book Synopsis Stochastic Modelling for Systems Biology by : Darren J. Wilkinson

Download or read book Stochastic Modelling for Systems Biology written by Darren J. Wilkinson and published by CRC Press. This book was released on 2006-04-18 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although stochastic kinetic models are increasingly accepted as the best way to represent and simulate genetic and biochemical networks, most researchers in the field have limited knowledge of stochastic process theory. The stochastic processes formalism provides a beautiful, elegant, and coherent foundation for chemical kinetics and there is a wealth of associated theory every bit as powerful and elegant as that for conventional continuous deterministic models. The time is right for an introductory text written from this perspective. Stochastic Modelling for Systems Biology presents an accessible introduction to stochastic modelling using examples that are familiar to systems biology researchers. Focusing on computer simulation, the author examines the use of stochastic processes for modelling biological systems. He provides a comprehensive understanding of stochastic kinetic modelling of biological networks in the systems biology context. The text covers the latest simulation techniques and research material, such as parameter inference, and includes many examples and figures as well as software code in R for various applications. While emphasizing the necessary probabilistic and stochastic methods, the author takes a practical approach, rooting his theoretical development in discussions of the intended application. Written with self-study in mind, the book includes technical chapters that deal with the difficult problems of inference for stochastic kinetic models from experimental data. Providing enough background information to make the subject accessible to the non-specialist, the book integrates a fairly diverse literature into a single convenient and notationally consistent source.

Stochastic Processes in Physics, Chemistry, and Biology

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Author :
Publisher : Springer
ISBN 13 : 3540453962
Total Pages : 512 pages
Book Rating : 4.5/5 (44 download)

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Book Synopsis Stochastic Processes in Physics, Chemistry, and Biology by : Jan A. Freund

Download or read book Stochastic Processes in Physics, Chemistry, and Biology written by Jan A. Freund and published by Springer. This book was released on 2008-01-11 with total page 512 pages. Available in PDF, EPUB and Kindle. Book excerpt: The theory of stochastic processes originally grew out of efforts to describe Brownian motion quantitatively. Today it provides a huge arsenal of methods suitable for analyzing the influence of noise on a wide range of systems. The credit for acquiring all the deep insights and powerful methods is due ma- ly to a handful of physicists and mathematicians: Einstein, Smoluchowski, Langevin, Wiener, Stratonovich, etc. Hence it is no surprise that until - cently the bulk of basic and applied stochastic research was devoted to purely mathematical and physical questions. However, in the last decade we have witnessed an enormous growth of results achieved in other sciences - especially chemistry and biology - based on applying methods of stochastic processes. One reason for this stochastics boom may be that the realization that noise plays a constructive rather than the expected deteriorating role has spread to communities beyond physics. Besides their aesthetic appeal these noise-induced, noise-supported or noise-enhanced effects sometimes offer an explanation for so far open pr- lems (information transmission in the nervous system and information p- cessing in the brain, processes at the cell level, enzymatic reactions, etc.). They may also pave the way to novel technological applications (noise-- hanced reaction rates, noise-induced transport and separation on the na- scale, etc.). Key words to be mentioned in this context are stochastic r- onance, Brownian motors or ratchets, and noise-supported phenomena in excitable systems.