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Author : M. Charton
Publisher :
ISBN 13 : 9783662152973
Total Pages : 176 pages
Book Rating : 4.1/5 (529 download)
Download or read book Steric Effects in Drug Design written by M. Charton and published by . This book was released on 2014-01-15 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Volkhard Austel
Publisher : Springer
ISBN 13 : 9780387123981
Total Pages : 176 pages
Book Rating : 4.1/5 (239 download)
Download or read book Steric Effects in Drug Design written by Volkhard Austel and published by Springer. This book was released on 1983 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : S. N. Pandeya
Publisher : New Age International
ISBN 13 : 9788122409437
Total Pages : 228 pages
Book Rating : 4.4/5 (94 download)
Download or read book An Introduction to Drug Design written by S. N. Pandeya and published by New Age International. This book was released on 1997 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Book Entitled, An Introduction To Drug Design Aims To Optimize The Discovery Of Drugs At A Low Cost And On Occasions To Change Their Pharmacokinetic And Pharmacodyanamic Properties. The Introductory Chapter Which Forms The Basis Of Drug Discovery Is Followed By The Present-Day Thinking Regarding The Best Approaches To Drug Discovery Are Considered. Similarly, There Have Been Major Advances In The Employment Of Computers In Structure-Activity Analysis, And A Discussion Of The State Of The Art In This Area Is Also Included.The Chapter On Qsar Highlights The Role Of Physico-Chemical Parameters In Predicting The Future Course Of Drug Discovery With Rational Drug Design. The Role Of Enzymes In Drug Action Is Well Established, And A Chapter On Design Of Enzyme Inhibitors Is Well Documented. In Addition, The Increased Understanding Of The Design And Utilisation Of Prodrugs Has Led To A Discussion Of The Relevant Issues In This Text.Thus The Book Will Fill The Need Of A Text For Designing New Drugs And The Principles Of New Drug Discovery.
Author : A.F. Casy
Publisher : Springer Science & Business Media
ISBN 13 : 1489923977
Total Pages : 580 pages
Book Rating : 4.4/5 (899 download)
Download or read book The Steric Factor in Medicinal Chemistry written by A.F. Casy and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt: 'It is indeed the merit of Dr. Alan F. Casy to bring in these pages a clear and comprehensive view of medicinal stereochemistry, a discipline in which he has been active and successful for many years both as a teacher and a researcher. Written for graduate students and research workers in medicinal chemistry and pharmacology, this book will contribute significantly towards a better education of scientists by removing the fear of stereochemistry caused by ignorance, moderating the overconfidence of possible zealots, and outlining a broader context.'-from the foreword by Bernard Testa
Author : H. J. Smith
Publisher : Elsevier
ISBN 13 : 1483183505
Total Pages : 306 pages
Book Rating : 4.4/5 (831 download)
Download or read book Introduction to the Principles of Drug Design written by H. J. Smith and published by Elsevier. This book was released on 2016-06-14 with total page 306 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduction to the Principles of Drug Design provides a framework of fundamental drug design and principles into which drugs following on developments may be fitted. This book presents the rationales behind the design of drugs. Organized into nine chapters, this book begins with an overview of how the body handles a drug in terms of absorption, metabolism, distribution, and excretion. This text then examines the critical drug activity at the receptor site, which is usually related to blood and other distribution fluid levels. Other chapters consider the factors involved in binding a drug, metabolite, or substrate to a receptor. The final chapter deals with the design of chemotherapeutic agent for clinical use in the treatment of human infections. This book is intended for use in undergraduate pharmacy courses in medicinal chemistry and as an aid in similar courses in biochemistry and pharmacology. Graduates in chemistry just entering the pharmaceutical industry will also find this book useful.
Author : Edward B. Roche
Publisher : Pergamon
ISBN 13 :
Total Pages : 312 pages
Book Rating : 4.3/5 (91 download)
Download or read book Bioreversible Carriers in Drug Design written by Edward B. Roche and published by Pergamon. This book was released on 1987 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : E. J. Ariëns
Publisher : Elsevier
ISBN 13 : 1483216101
Total Pages : 441 pages
Book Rating : 4.4/5 (832 download)
Download or read book Drug Design written by E. J. Ariëns and published by Elsevier. This book was released on 2013-10-22 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Design, Volume VIII covers a critical review and new extensions of quantitative methods in drug design, the design of particular types of agents, such as synthetic sweeteners, and selective ion binding compounds. The book discusses the advances in the methodology of quantitative drug design; the application of pattern recognition to drug design; and the design of controlled drug delivery systems. The text also describes the use of receptor binding as a tool in the development of new bioactive steroids; the design of synthetic sweeteners; and the prospective assessment of environmental effects of chemicals. The design of selective ion binding macrocyclic compounds and their biological applications are also encompassed. Chemists, pharmacologists, biochemists, and people involved in drug design and manufacture will find the book invaluable.
Author : Yvonne Connolly Martin
Publisher :
ISBN 13 :
Total Pages : 448 pages
Book Rating : 4.3/5 (91 download)
Download or read book Quantitative Drug Design written by Yvonne Connolly Martin and published by . This book was released on 1978 with total page 448 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rainer Franke
Publisher : Walter de Gruyter GmbH & Co KG
ISBN 13 : 3112706994
Total Pages : 412 pages
Book Rating : 4.1/5 (127 download)
Download or read book Theoretical Drug Design Methods written by Rainer Franke and published by Walter de Gruyter GmbH & Co KG. This book was released on 1984-12-31 with total page 412 pages. Available in PDF, EPUB and Kindle. Book excerpt: No detailed description available for "Theoretical Drug Design Methods".
Author : BAREHAM BAREHAM J
Publisher : Academic Press
ISBN 13 : 1483294838
Total Pages : 376 pages
Book Rating : 4.4/5 (832 download)
Download or read book Drug Design written by BAREHAM BAREHAM J and published by Academic Press. This book was released on 2014-11-26 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Design, Volume IX examines various aspects of drug design and covers topics ranging from the consequences of the Hansch paradigm for the pharmaceutical industry to the Masca model of pharmacochemistry. A physicochemical basis for the design of orally active prodrugs is also considered, along with the use of interactive graphics in medicinal chemistry. Comprised of seven chapters, this volume begins with a discussion on efforts to avoid toxicity, not only of drugs, pesticides, and food additives but also of chemicals in general. The reader is then introduced to various aspects of the development of bioactive agents, including the optimization of existing agents by the design of more efficient prodrugs. Other chapters focus on Hansch's paradigm and its application to industrial practice; the application of multivariate statistics to pharmacochemistry; a logico-structural approach to computer-assisted drug design; and spatial arrangements in bioactive molecules. This book will be of interest to pharmacologists, chemists, and those involved in drug design.
Author : Alfred Burger
Publisher :
ISBN 13 :
Total Pages : 316 pages
Book Rating : 4.:/5 (319 download)
Download or read book A Guide to the Chemical Basis of Drug Design written by Alfred Burger and published by . This book was released on 1983-09-23 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book by a leading author in the field of medicinal chemistry deals with the chemical structure of biologically active compounds. Presents a unique historical overview of drug discovery and design using the historical facts of the pharmacology to reveal the serendipity of discovery and to point toward new structures that may be developed based on what has gone before.
Author : Kristian Stromgaard
Publisher : CRC Press
ISBN 13 : 1315354543
Total Pages : 579 pages
Book Rating : 4.3/5 (153 download)
Download or read book Textbook of Drug Design and Discovery, Fifth Edition written by Kristian Stromgaard and published by CRC Press. This book was released on 2016-08-19 with total page 579 pages. Available in PDF, EPUB and Kindle. Book excerpt: Building on the success of the previous editions, the Textbook of Drug Design and Discovery, Fifth Edition, has been thoroughly revised and updated to provide a complete source of information on all facets of drug design and discovery for students of chemistry, pharmacy, pharmacology, biochemistry, and medicine. The information is presented in an up-to-date review form with an underlying and fundamental focus on the educational aspects. Beginning with an introduction to drug design and discovery, the first eight chapters cover molecular recognition, ligand-based drug design, and biostructure-based drug design. The authors also discuss drug-like properties and decision making in medicinal chemistry, chemical biology, natural products in drug discovery, and in vivo imaging in drug discovery. The middle six chapters provide an overview of peptide and protein drug design, prodrugs in drug design and development, and enzyme inhibitors. The authors also go through receptors (structure, function, and pharmacology), ion channels (structure and function), and neurotransmitter transporters (structure, function, and drug binding). The following chapters address important neurotransmitter systems, GABA and glutamic acid receptors and transporter ligands, acetylcholine, histamine, dopamine and serotonin, and opioid and cannabinoid receptors. The book concludes with an examination of neglected diseases, anticancer agents, tyrosine kinase receptors, and antibiotics.
Author : M. Charton
Publisher : Springer
ISBN 13 : 9783540123989
Total Pages : 186 pages
Book Rating : 4.1/5 (239 download)
Download or read book Steric Effects in Drug Design written by M. Charton and published by Springer. This book was released on 1983-07-01 with total page 186 pages. Available in PDF, EPUB and Kindle. Book excerpt: With contributions by numerous experts
Author : Pandi Veerapandian
Publisher : Routledge
ISBN 13 : 1351413066
Total Pages : 665 pages
Book Rating : 4.3/5 (514 download)
Download or read book Structure-Based Drug Design written by Pandi Veerapandian and published by Routledge. This book was released on 2018-03-29 with total page 665 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introducing the most recent advances in crystallography, nuclear magnetic resonance, molecular modeling techniques, and computational combinatorial chemistry, this unique, interdisciplinary reference explains the application of three-dimensional structural information in the design of pharmaceutical drugs. Furnishing authoritative analyses by world-renowned experts, Structure-Based Drug Design discusses protein structure-based design in optimizing HIV protease inhibitors and details the biochemical, genetic, and clinical data on HIV-1 reverse transcriptase presents recent results on the high-resolution three-dimensional structure of the catalytic core domain of HIV-1 integrase as a foundation for divergent combination therapy focuses on structure-based design strategies for uncovering receptor antagonists to treat inflammatory diseases demonstrates a systematic approach to the design of inhibitory compounds in cancer treatment reviews current knowledge on the Interleukin-1 (IL-1) system and progress in the development of IL-1 modulators describes the influence of structure-based methods in designing capsid-binding inhibitors for relief of the common cold and much more!
Author : E. J. Ariëns
Publisher : Elsevier
ISBN 13 : 1483216098
Total Pages : 312 pages
Book Rating : 4.4/5 (832 download)
Download or read book Drug Design written by E. J. Ariëns and published by Elsevier. This book was released on 2013-10-22 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drug Design, Volume VII covers the design of agents such as blood substitutes, pesticides derived from insect pheromones, and herbicides related to the auxin-type plant hormones. The book discusses the design of artificial blood substitutes and auxin-type herbicides; the use of insect pheromones as a basis for the development of more effective selective pest control agents; and the development and application of new steric substituent parameters in drug design. The text also describes the use of computer technology in drug design. Pharmacologists, chemists, biochemists, and people involved in drug design and manufacture will find the book invaluable.
Author : A. F. Casy
Publisher :
ISBN 13 : 9781489923981
Total Pages : 592 pages
Book Rating : 4.9/5 (239 download)
Download or read book The Steric Factor in Medicinal Chemistry written by A. F. Casy and published by . This book was released on 2014-01-15 with total page 592 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Topliss
Publisher : Elsevier
ISBN 13 : 0323146872
Total Pages : 535 pages
Book Rating : 4.3/5 (231 download)
Download or read book Quantitative Structure-Activity Relationships of Drugs written by John Topliss and published by Elsevier. This book was released on 2012-12-02 with total page 535 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal Chemistry, Volume 19: Quantitative Structure-Activity Relationships of Drugs is a critical review of the applications of various quantitative structure-activity relationship (QSAR) methodologies in different drug therapeutic areas and discusses the results in terms of their contribution to medicinal chemistry. After briefly describing the developments in QSAR research, this 12-chapter volume goes on discussing the contributions of QSAR methodology in elucidating drug action and rational development of drugs against bacterial, fungal, viral, and other parasitic infections of man. Other chapters explore the mode of action and QSAR of antitumor, cardiovascular, antiallergic, antiulcer, antiarthritic, and nonsteroidal antiinflammatory drugs (NSAID) agents. The discussion then shifts to the pharmacologic effects and QSAR analysis of central nervous system agents, steroids, and other hormones. A chapter examines the major chemicals affecting insects and mites, with particular emphasis on the parameters of binding correlation and reactivity for insect and mite enzymes. The concluding chapters cover the limitations of the QSAR approach in the quantitative treatment of drug absorption, distribution, and metabolism. This volume is of great value to medicinal chemists, scientists, and researchers.
