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Author : Xuelei Qian
Publisher :
ISBN 13 :
Total Pages : 526 pages
Book Rating : 4.3/5 (121 download)
Download or read book Stereoselective Synthesis of Substituted Tetrahydrofurans and Studies of Myrmicarin Alkaloids written by Xuelei Qian and published by . This book was released on 2006 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Atta-ur-Rahman
Publisher : Elsevier
ISBN 13 : 1483163539
Total Pages : 939 pages
Book Rating : 4.4/5 (831 download)
Download or read book Studies in Natural Products Chemistry written by Atta-ur-Rahman and published by Elsevier. This book was released on 2013-10-22 with total page 939 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry, Volume 14: Stereoselective Synthesis, Part I is a collection of discourses on the stereoselective synthesis of the anticancer anthrucycline antibiotics; tetramic acid antibiotics; 3-and 4-deoxyhexoses; polysaccharides; levoglucosenone as precursor to natural products; synthesis of oligoribonucleotides; and oxidation of guaiazulene. This volume deals with a broad range of natural products focusing on the synthesis of antibiotics and anticancer agents — anthracyclines, tetramic acid, taxodione, vinblastine, and vincristine. These aforementioned drugs are used for the treatment of cancer (anthracyclines) and Hodgkin's disease and childhood acute leukemia (vinblastine and vincristine). The importance of the latest developments in the stereocontrolled synthesis of polysaccharides is discussed as polysaccharides play a fundamental role in cell life and have many technical applications. The synthesis of bioactive carbohydrates 3- and 4-deoxy-hexoses is compared with the more occurring deoxyhexoses in nature such as the 2-deoxy, 6-deoxy, and 2,6-dideoxy-hexoses, because the former are rare compounds and useful tools in the study of biological and biochemical properties of mono- and oligosaccharides, glycoproteins, and antibiotics. Alkaloids derived from Apocynaceae are known for their medicinal properties; hence the synthetic approaches to vinblastine and vincristine are discussed. Because of the minute amounts available from herbal sources, efforts toward their chemical synthesis are given more reference. This book can be a useful reference for the organic chemists. Chemical researchers, pharmaceutical scientists, and professionals of bioorganic chemistry will likewise gain a lot from this collection.
Author : Atta-ur Rahman
Publisher : Elsevier
ISBN 13 : 008054178X
Total Pages : 772 pages
Book Rating : 4.0/5 (85 download)
Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 1995-08-10 with total page 772 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry
Author : Alison Evelynn Ondrus
Publisher :
ISBN 13 :
Total Pages : 416 pages
Book Rating : 4.:/5 (456 download)
Download or read book Total Synthesis and Study of Myrmicarin Alkaloids written by Alison Evelynn Ondrus and published by . This book was released on 2009 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: (Cont.) Efficient and Stereoselective Dimerization of Pyrroloindolizine Derivatives Inspired by a Hypothesis for the Biosynthesis of Complex Myrmicarin Alkaloids Pyrroloindolizine derivatives participate in efficient and stereoselective homo- and heterodimerization reactions upon treatment with Bronsted or Lewis acids. The distinctive ability of pyrroloindolizines to act as azafulvenium ion precursors provides direct access to both heptacyclic and hexacyclic dimeric products. The inherent reactivity of these structures suggests a concise synthesis of complex myrmicarin alkaloids via dimerization of pyrroloindolizines, and may have implications for the biosynthesis of these intriguing alkaloids. V. Reversible Dimerization of (+)-Myrmicarin 215B Bronsted acid-promoted reversible dimerization of myrmicarin 215B leads to formation of a new heptacyclic product, isomyrmicarin 430B, that possesses a C1,C2-trans, C2,C3-trans substituted cyclopentane ring. Mechanistic studies illustrate that isomyrmicarin 430B arises by isomerization of isomyrmicarin 430A via fragmentation to tricyclic azafulvenium ions. Factors influencing the structure of heptacyclic isomyrmicarin products and potential relevance of this reversible vinyl pyrroloindolizine dimerization to the biosynthesis of complex myrmicarins are discussed.
Author : Atta-ur Rahman
Publisher : Elsevier
ISBN 13 : 1483193241
Total Pages : 541 pages
Book Rating : 4.4/5 (831 download)
Download or read book Studies in Natural Products Chemistry written by Atta-ur Rahman and published by Elsevier. This book was released on 2013-10-22 with total page 541 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies in Natural Products Chemistry Volume 12: Stereoselective Synthesis (Part H) reviews the stereoselective synthetic and mechanistic chemistry of bicyclomycin. It discusses chemical studies of the taxane diterpenes; the synthetic methodology for 2-amino alcohols of biological interest; and the synthesis and structure of hydroxylated indolizidines. Some of the topics covered in the book are the synthetic routes to the oxahydrindene subunit of the avermectin-milbemycin family of antiparasitic agents; isolation, structure elucidation, biosynthesis, and biological activity of the avermectins; two-stage coupling process of macrolide antibiotics synthesis; and synthesis of the rifamycin S ansa-chain compound. The complete synthesis of erythromycin A is also covered. The role of isocyanides in the synthesis of beta lactam antibiotics and the characteristics of the beta lactam antibiotics are discussed. The development of an A-Ring annulation strategy for taxane synthesis is also presented. A chapter is devoted to the advances in the synthesis of tumor-promoting diterpenes. The book can provide useful information to chemists, biologists, students, and researchers.
Author : Atta-ur- Rahman
Publisher :
ISBN 13 : 9780444429704
Total Pages : 760 pages
Book Rating : 4.4/5 (297 download)
Download or read book Studies in Natural Products Chemistry written by Atta-ur- Rahman and published by . This book was released on 1988 with total page 760 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Mihály Nógrádi
Publisher : John Wiley & Sons
ISBN 13 : 3527292438
Total Pages : 407 pages
Book Rating : 4.5/5 (272 download)
Download or read book Stereoselective Synthesis written by Mihály Nógrádi and published by John Wiley & Sons. This book was released on 1994-12-05 with total page 407 pages. Available in PDF, EPUB and Kindle. Book excerpt: The state-of-the-art in stereoselective synthesis! Thoroughly revised and updated, this enlarged second edition offers a plethora of valuable information on methods and reagents in stereoselective synthesis. Methods have been selected for high efficiency and selectivity; mechanistic aspects are treated succinctly, with a strong emphasis on practical applications. For this new edition, material has been added on * homogeneous diastereoselective hydrogenations * enantioselective oxidations * novel, efficient chiral auxiliaries Much of the information given is presented in figures and tables, which makes the book a valuable reference work for the practically minded organic chemist. From reviews of the first edition: 'The extensive material in the volume should prove particularly useful to anyone involved in synthetic chemistry or teaching a course in organic chemistry.' Journal of Medicinal Chemistry 'With nearly 1400 references cited, the book contains a wealth of information and should be a useful addition to the chemist's library.' The American Scientist
Author : Eckhard Ottow
Publisher : Springer Science & Business Media
ISBN 13 : 3642784968
Total Pages : 147 pages
Book Rating : 4.6/5 (427 download)
Download or read book Stereoselective Synthesis written by Eckhard Ottow and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 147 pages. Available in PDF, EPUB and Kindle. Book excerpt: Devising methods and reagents for stereoselective synthesis is an intellectually demanding venture. Six experts on diastereo- and enantioselective synthesis contributed their papers to this volume. They were presented at a symposium on stereoselective synthesis to honour Professor Dr. Dr. h.c. Rudolf Wiechert's achievements in medicinal chemistry research. The symposium was organized by the Schering AG on the occasion of Professor Wiechert's 65th birthday.
Author : Erick M. Carreira
Publisher : John Wiley & Sons
ISBN 13 : 9783527324521
Total Pages : 664 pages
Book Rating : 4.3/5 (245 download)
Download or read book Classics in Stereoselective Synthesis written by Erick M. Carreira and published by John Wiley & Sons. This book was released on 2009-02-09 with total page 664 pages. Available in PDF, EPUB and Kindle. Book excerpt: Die wichtigsten und nützlichsten Methoden der modernen stereoselektiven Synthese sind in diesem Band zusammengefasst. Viele anschauliche Beispiele für die Darstellung von Wirkstoffen und Naturstoffen regen zur gezielten Abwandlung und Integration in eigene Synthesewege an. Dabei geht es den Autoren weniger darum, das Gebiet in seiner Gesamtheit darzustellen; vielmehr versuchen sie, die wirklich grundlegenden Ansätze auszuwählen, die jeder organische Synthesechemiker kennen und anwenden sollte.
Author : Atta-ur- Rahman
Publisher : Elsevier Science & Technology
ISBN 13 : 9780444872982
Total Pages : 564 pages
Book Rating : 4.8/5 (729 download)
Download or read book Stereoselective Synthesis written by Atta-ur- Rahman and published by Elsevier Science & Technology. This book was released on 1989 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: Section 1
Author :
Publisher :
ISBN 13 :
Total Pages : 756 pages
Book Rating : 4.:/5 (112 download)
Download or read book Stereoselective Synthesis written by and published by . This book was released on 1989 with total page 756 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Musong Kim
Publisher :
ISBN 13 :
Total Pages : 220 pages
Book Rating : 4.3/5 (121 download)
Download or read book Stereoselective Synthesis of 2,3,4-trisubstituted Tetrahydrofurans and a General Approach to a Total Synthesis of ( - )-indolizidine 195B and Related Indolizidines written by Musong Kim and published by . This book was released on 2002 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Christophe Michoud
Publisher :
ISBN 13 :
Total Pages : 414 pages
Book Rating : 4.:/5 (39 download)
Download or read book Studies Directed Toward the Synthesis of Strychnos Alkaloids written by Christophe Michoud and published by . This book was released on 1993 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Atta-ur Rahman
Publisher : Elsevier Science & Technology
ISBN 13 : 9780444880338
Total Pages : 776 pages
Book Rating : 4.8/5 (83 download)
Download or read book Stereoselective Synthesis written by Atta-ur Rahman and published by Elsevier Science & Technology. This book was released on 1989 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: Section 1
Author : Vasyl Andrushko
Publisher : John Wiley & Sons
ISBN 13 : 1118628330
Total Pages : 1836 pages
Book Rating : 4.1/5 (186 download)
Download or read book Stereoselective Synthesis of Drugs and Natural Products written by Vasyl Andrushko and published by John Wiley & Sons. This book was released on 2013-08-16 with total page 1836 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brings together the best tested and proven stereoselective synthetic methods Both the chemical and pharmaceutical industries are increasingly dependent on stereoselective synthetic methods and strategies for the generation of new chiral drugs and natural products that offer specific 3-D structures. With the publication of Stereoselective Synthesis of Drugs and Natural Products, researchers can turn to this comprehensive two-volume work to guide them through all the core methods for the synthesis of chiral drugs and natural products. Stereoselective Synthesis of Drugs and Natural Products features contributions from an international team of synthetic chemists and pharmaceutical and natural product researchers. These authors have reviewed the tremendous body of literature in the field in order to compile a set of reliable, tested, and proven methods alongside step-by-step guidance. This practical resource not only explores synthetic methodology, but also reaction mechanisms and applications in medicinal chemistry and drug discovery. The publication begins with an introductory chapter covering general principles and methodologies, nomenclature, and strategies of stereoselective synthesis. Next, it is divided into three parts: Part One: General Methods and Strategies Part Two: Stereoselective Synthesis by Bond Formation including C-C bond formation C-H bond formation C-O bond formation C-N bond formation Other C-heteroatom formation and other bond formation Part Three: Methods of Analysis and Chiral Separation References in every chapter serve as a gateway to the literature in the field. With this publication as their guide, chemists involved in the stereoselective synthesis of drugs and natural products now have a single, expertly edited source for all the methods they need.
Author : Keith Raymond Chann
Publisher :
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.3/5 (121 download)
Download or read book The Stereoselective Synthesis of Substituted Tetrahydrofurans written by Keith Raymond Chann and published by . This book was released on 2002 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Stereoselective synthesis written by and published by . This book was released on 1988 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
