Statistical and Evolutionary Analysis of Biological Networks

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Publisher : World Scientific
ISBN 13 : 1848164335
Total Pages : 179 pages
Book Rating : 4.8/5 (481 download)

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Book Synopsis Statistical and Evolutionary Analysis of Biological Networks by : Michael P. H. Stumpf

Download or read book Statistical and Evolutionary Analysis of Biological Networks written by Michael P. H. Stumpf and published by World Scientific. This book was released on 2010 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Networks provide a very useful way to describe a wide range of different data types in biology, physics and elsewhere. Apart from providing a convenient tool to visualize highly dependent data, networks allow stringent mathematical and statistical analysis. In recent years, much progress has been achieved to interpret various types of biological network data such as transcriptomic, metabolomic and protein interaction data as well as epidemiological data. Of particular interest is to understand the organization, complexity and dynamics of biological networks and how these are influenced by network evolution and functionality. This book reviews and explores statistical, mathematical and evolutionary theory and tools in the understanding of biological networks. The book is divided into comprehensive and self-contained chapters, each of which focuses on an important biological network type, explains concepts and theory and illustrates how these can be used to obtain insight into biologically relevant processes and questions. There are chapters covering metabolic, transcriptomic, protein interaction and epidemiological networks as well as chapters that deal with theoretical and conceptual material. The authors, who contribute to the book, are active, highly regarded and well-known in the network community.

Statistical and Evolutionary Analysis of Biological Networks

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Author :
Publisher : World Scientific
ISBN 13 : 1848164343
Total Pages : 179 pages
Book Rating : 4.8/5 (481 download)

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Book Synopsis Statistical and Evolutionary Analysis of Biological Networks by : Michael P. H. Stumpf

Download or read book Statistical and Evolutionary Analysis of Biological Networks written by Michael P. H. Stumpf and published by World Scientific. This book was released on 2010 with total page 179 pages. Available in PDF, EPUB and Kindle. Book excerpt: Networks provide a very useful way to describe a wide range of different data types in biology, physics and elsewhere. Apart from providing a convenient tool to visualize highly dependent data, networks allow stringent mathematical and statistical analysis. In recent years, much progress has been achieved to interpret various types of biological network data such as transcriptomic, metabolomic and protein interaction data as well as epidemiological data. Of particular interest is to understand the organization, complexity and dynamics of biological networks and how these are influenced by network evolution and functionality. This book reviews and explores statistical, mathematical and evolutionary theory and tools in the understanding of biological networks. The book is divided into comprehensive and self-contained chapters, each of which focuses on an important biological network type, explains concepts and theory and illustrates how these can be used to obtain insight into biologically relevant processes and questions. There are chapters covering metabolic, transcriptomic, protein interaction and epidemiological networks as well as chapters that deal with theoretical and conceptual material. The authors, who contribute to the book, are active, highly regarded and well-known in the network community. Sample Chapter(s). Chapter 1: A Network Analysis Primer (350 KB). Contents: A Network Analysis Primer (M P H Stumpf & C Wiuf); Evolutionary Analysis of Protein Interaction Networks (C Wiuf & O Ratmann); Motifs in Biological Networks (F Schreiber & H SchwAbbermeyer); Bayesian Analysis of Biological Networks: Clusters, Motifs, Cross-Species Correlations (J Berg & M Lnssig); Network Concepts and Epidemiological Models (R R Kao & I Z Kiss); Evolutionary Origin and Consequences of Design Properties of Metabolic Networks (T Pfeiffer & S Bonhoeffer); Protein Interactions from an Evolutionary Perspective (F Pazos & A Valencia); Statistical Null Models for Biological Network Analysis (W P Kelly et al.). Readership: Academics, researchers, postgraduates and advanced undergraduates in bioinformatics. Biologists, mathematicians/statisticians, physicists and computer scientists.

Analysis of Biological Networks

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Publisher : Wiley-Interscience
ISBN 13 : 0470253460
Total Pages : 392 pages
Book Rating : 4.4/5 (72 download)

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Book Synopsis Analysis of Biological Networks by : Björn H. Junker

Download or read book Analysis of Biological Networks written by Björn H. Junker and published by Wiley-Interscience. This book was released on 2008-03-14 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to biological networks and methods for their analysis Analysis of Biological Networks is the first book of its kind to provide readers with a comprehensive introduction to the structural analysis of biological networks at the interface of biology and computer science. The book begins with a brief overview of biological networks and graph theory/graph algorithms and goes on to explore: global network properties, network centralities, network motifs, network clustering, Petri nets, signal transduction and gene regulation networks, protein interaction networks, metabolic networks, phylogenetic networks, ecological networks, and correlation networks. Analysis of Biological Networks is a self-contained introduction to this important research topic, assumes no expert knowledge in computer science or biology, and is accessible to professionals and students alike. Each chapter concludes with a summary of main points and with exercises for readers to test their understanding of the material presented. Additionally, an FTP site with links to author-provided data for the book is available for deeper study. This book is suitable as a resource for researchers in computer science, biology, bioinformatics, advanced biochemistry, and the life sciences, and also serves as an ideal reference text for graduate-level courses in bioinformatics and biological research.

Applied Statistics for Network Biology

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Publisher : John Wiley & Sons
ISBN 13 : 3527638083
Total Pages : 441 pages
Book Rating : 4.5/5 (276 download)

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Book Synopsis Applied Statistics for Network Biology by : Matthias Dehmer

Download or read book Applied Statistics for Network Biology written by Matthias Dehmer and published by John Wiley & Sons. This book was released on 2011-04-08 with total page 441 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book introduces to the reader a number of cutting edge statistical methods which can e used for the analysis of genomic, proteomic and metabolomic data sets. In particular in the field of systems biology, researchers are trying to analyze as many data as possible in a given biological system (such as a cell or an organ). The appropriate statistical evaluation of these large scale data is critical for the correct interpretation and different experimental approaches require different approaches for the statistical analysis of these data. This book is written by biostatisticians and mathematicians but aimed as a valuable guide for the experimental researcher as well computational biologists who often lack an appropriate background in statistical analysis.

Statistical Methods in Molecular Evolution

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Publisher : Springer Science & Business Media
ISBN 13 : 0387277331
Total Pages : 503 pages
Book Rating : 4.3/5 (872 download)

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Book Synopsis Statistical Methods in Molecular Evolution by : Rasmus Nielsen

Download or read book Statistical Methods in Molecular Evolution written by Rasmus Nielsen and published by Springer Science & Business Media. This book was released on 2006-05-06 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the field of molecular evolution, inferences about past evolutionary events are made using molecular data from currently living species. With the availability of genomic data from multiple related species, molecular evolution has become one of the most active and fastest growing fields of study in genomics and bioinformatics. Most studies in molecular evolution rely heavily on statistical procedures based on stochastic process modelling and advanced computational methods including high-dimensional numerical optimization and Markov Chain Monte Carlo. This book provides an overview of the statistical theory and methods used in studies of molecular evolution. It includes an introductory section suitable for readers that are new to the field, a section discussing practical methods for data analysis, and more specialized sections discussing specific models and addressing statistical issues relating to estimation and model choice. The chapters are written by the leaders of field and they will take the reader from basic introductory material to the state-of-the-art statistical methods. This book is suitable for statisticians seeking to learn more about applications in molecular evolution and molecular evolutionary biologists with an interest in learning more about the theory behind the statistical methods applied in the field. The chapters of the book assume no advanced mathematical skills beyond basic calculus, although familiarity with basic probability theory will help the reader. Most relevant statistical concepts are introduced in the book in the context of their application in molecular evolution, and the book should be accessible for most biology graduate students with an interest in quantitative methods and theory. Rasmus Nielsen received his Ph.D. form the University of California at Berkeley in 1998 and after a postdoc at Harvard University, he assumed a faculty position in Statistical Genomics at Cornell University. He is currently an Ole Rømer Fellow at the University of Copenhagen and holds a Sloan Research Fellowship. His is an associate editor of the Journal of Molecular Evolution and has published more than fifty original papers in peer-reviewed journals on the topic of this book. From the reviews: "...Overall this is a very useful book in an area of increasing importance." Journal of the Royal Statistical Society "I find Statistical Methods in Molecular Evolution very interesting and useful. It delves into problems that were considered very difficult just several years ago...the book is likely to stimulate the interest of statisticians that are unaware of this exciting field of applications. It is my hope that it will also help the 'wet lab' molecular evolutionist to better understand mathematical and statistical methods." Marek Kimmel for the Journal of the American Statistical Association, September 2006 "Who should read this book? We suggest that anyone who deals with molecular data (who does not?) and anyone who asks evolutionary questions (who should not?) ought to consult the relevant chapters in this book." Dan Graur and Dror Berel for Biometrics, September 2006 "Coalescence theory facilitates the merger of population genetics theory with phylogenetic approaches, but still, there are mostly two camps: phylogeneticists and population geneticists. Only a few people are moving freely between them. Rasmus Nielsen is certainly one of these researchers, and his work so far has merged many population genetic and phylogenetic aspects of biological research under the umbrella of molecular evolution. Although Nielsen did not contribute a chapter to his book, his work permeates all its chapters. This book gives an overview of his interests and current achievements in molecular evolution. In short, this book should be on your bookshelf." Peter Beerli for Evolution, 60(2), 2006

Evolution of Networks

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Publisher : OUP Oxford
ISBN 13 : 0191004405
Total Pages : 281 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Evolution of Networks by : S. N. Dorogovtsev

Download or read book Evolution of Networks written by S. N. Dorogovtsev and published by OUP Oxford. This book was released on 2013-11-14 with total page 281 pages. Available in PDF, EPUB and Kindle. Book excerpt: We live in a world of networks, where everything is amazingly close to everything else. The notion of 'network' turns out to be central to our times: the Internet and WWW are changing our lives; our physical existence is based on various biological networks; we are involved in all-enveloping networks of economic and social relations. Only in the 1990s did physicists begin to explore real networks, both natural and artificial, as evolving systems with intriguingly complex and effective architectures. Progress has been so immediate and astounding that we actually face a new science based on a new set of concepts, and, one may even say, on a new philosophy: the natural philosophy of a small world. Old ideas from mathematics, statistical physics, biology, computer science, and so on take on quite new forms in applications to real evolving networks. - What is common to all networks? - What are the general principles of the organization and evolution of networks? - How do the laws of nature work in communication, biological, and social networks? - What are networks? This book, written by physicists, answers these questions and presents a general insight into the world of networks.

Biological Network Analysis

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Publisher : Elsevier
ISBN 13 : 0128193514
Total Pages : 212 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Biological Network Analysis by : Pietro Hiram Guzzi

Download or read book Biological Network Analysis written by Pietro Hiram Guzzi and published by Elsevier. This book was released on 2020-05-11 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Biological Network Analysis: Trends, Approaches, Graph Theory, and Algorithms considers three major biological networks, including Gene Regulatory Networks (GRN), Protein-Protein Interaction Networks (PPIN), and Human Brain Connectomes. The book's authors discuss various graph theoretic and data analytics approaches used to analyze these networks with respect to available tools, technologies, standards, algorithms and databases for generating, representing and analyzing graphical data. As a wide variety of algorithms have been developed to analyze and compare networks, this book is a timely resource. Presents recent advances in biological network analysis, combining Graph Theory, Graph Analysis, and various network models Discusses three major biological networks, including Gene Regulatory Networks (GRN), Protein-Protein Interaction Networks (PPIN) and Human Brain Connectomes Includes a discussion of various graph theoretic and data analytics approaches

Biological Networks

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Publisher : World Scientific
ISBN 13 : 981270695X
Total Pages : 531 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Biological Networks by : Fran‡ois K‚pŠs

Download or read book Biological Networks written by Fran‡ois K‚pŠs and published by World Scientific. This book was released on 2007 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a timely and comprehensive overview of biological networks at all organization levels in the spirit of the complex system approach. It discusses the transversal issues and fundamental principles as well as the overall structure, dynamics, and modeling of a wide array of biological networks at the molecular, cellular, and population levels. Anchored in both empirical data and a strong theoretical background, the book therefore lends valuable credence to the complex systems approach.

Quantitative Analysis of Ecological Networks

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Publisher : Cambridge University Press
ISBN 13 : 1108632971
Total Pages : 250 pages
Book Rating : 4.1/5 (86 download)

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Book Synopsis Quantitative Analysis of Ecological Networks by : Mark R. T. Dale

Download or read book Quantitative Analysis of Ecological Networks written by Mark R. T. Dale and published by Cambridge University Press. This book was released on 2021-04-15 with total page 250 pages. Available in PDF, EPUB and Kindle. Book excerpt: Network thinking and network analysis are rapidly expanding features of ecological research. Network analysis of ecological systems include representations and modelling of the interactions in an ecosystem, in which species or factors are joined by pairwise connections. This book provides an overview of ecological network analysis including generating processes, the relationship between structure and dynamic function, and statistics and models for these networks. Starting with a general introduction to the composition of networks and their characteristics, it includes details on such topics as measures of network complexity, applications of spectral graph theory, how best to include indirect species interactions, and multilayer, multiplex and multilevel networks. Graduate students and researchers who want to develop and understand ecological networks in their research will find this volume inspiring and helpful. Detailed guidance to those already working in network ecology but looking for advice is also included.

Complex Systems

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Publisher : Elsevier
ISBN 13 : 9780080550596
Total Pages : 526 pages
Book Rating : 4.5/5 (55 download)

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Book Synopsis Complex Systems by :

Download or read book Complex Systems written by and published by Elsevier. This book was released on 2011-09-22 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: There has been recently some interdisciplinary convergence on a number of precise topics which can be considered as prototypes of complex systems. This convergence is best appreciated at the level of the techniques needed to deal with these systems, which include: 1) A domain of research around a multiple point where statistical physics, information theory, algorithmic computer science, and more theoretical (probabilistic) computer science meet: this covers some aspects of error correcting codes, stochastic optimization algorithms, typical case complexity and phase transitions, constraint satisfaction problems. 2) The study of collective behavior of interacting agents, its impact on understanding some types of economical and financial problems, their link to population and epidemics dynamics, game theory, social, biological and computer networks and evolution. The present book is the written version of the lectures given during the Les Houches summer school session on "Complex Systems", devoted to these emerging interdisciplinary fields. The lectures consist both in a number of long methodological courses (probability theory, statistical physics of disordered systems, information theory, network structure and evolution, agent-based economics and numerical methods) and more specific, 'problem oriented' courses. Lecturers are all leading experts in their field; they have summarized recent results in a clear and authoritative manner. The "Les Houches lecture notes" have a long tradition of excellence and are often found to be useful for a number of years after they were written. The book is of interest to students and researchers with various backgrounds: probability theory, computer science, information theory, physics, finance, biology, etc. · Topical and comprehensive survey of the emerging, interdisciplinary field of "Complex Systems", covered by recognized world experts · "Les Houches lectures notes": a long tradition of excellence and long-lasting impact · Of interest to a broad audience (mathematics, physics, biology, informatics, finance, geology, etc.) · Some applications may have concrete impact · Selected topics in complex systems: forefront of research in the field

Modeling and Analysis of Bio-molecular Networks

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Publisher : Springer Nature
ISBN 13 : 981159144X
Total Pages : 464 pages
Book Rating : 4.8/5 (115 download)

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Book Synopsis Modeling and Analysis of Bio-molecular Networks by : Jinhu Lü

Download or read book Modeling and Analysis of Bio-molecular Networks written by Jinhu Lü and published by Springer Nature. This book was released on 2020-12-06 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book addresses a number of questions from the perspective of complex systems: How can we quantitatively understand the life phenomena? How can we model life systems as complex bio-molecular networks? Are there any methods to clarify the relationships among the structures, dynamics and functions of bio-molecular networks? How can we statistically analyse large-scale bio-molecular networks? Focusing on the modeling and analysis of bio-molecular networks, the book presents various sophisticated mathematical and statistical approaches. The life system can be described using various levels of bio-molecular networks, including gene regulatory networks, and protein-protein interaction networks. It first provides an overview of approaches to reconstruct various bio-molecular networks, and then discusses the modeling and dynamical analysis of simple genetic circuits, coupled genetic circuits, middle-sized and large-scale biological networks, clarifying the relationships between the structures, dynamics and functions of the networks covered. In the context of large-scale bio-molecular networks, it introduces a number of statistical methods for exploring important bioinformatics applications, including the identification of significant bio-molecules for network medicine and genetic engineering. Lastly, the book describes various state-of-art statistical methods for analysing omics data generated by high-throughput sequencing. This book is a valuable resource for readers interested in applying systems biology, dynamical systems or complex networks to explore the truth of nature.

Biological Networks

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Publisher : World Scientific
ISBN 13 : 9812772367
Total Pages : 531 pages
Book Rating : 4.8/5 (127 download)

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Book Synopsis Biological Networks by : Francois Kepes

Download or read book Biological Networks written by Francois Kepes and published by World Scientific. This book was released on 2007 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume presents a timely and comprehensive overview of biological networks at all organization levels in the spirit of the complex systems approach. It discusses the transversal issues and fundamental principles as well as the overall structure, dynamics, and modeling of a wide array of biological networks at the molecular, cellular, and population levels. Anchored in both empirical data and a strong theoretical background, the book therefore lends valuable credence to the complex systems approach. Sample Chapter(s). Chapter 1: Scale-Free Networks in Biology (821 KB). Contents: Scale-Free Networks in Biology (E Almaas et al.); Modularity in Biological Networks (R V Sol(r) et al.); Inference of Biological Regulatory Networks: Machine Learning Approaches (F d''Alch(r)-Buc); Transcriptional Networks (F K(r)p s); Protein Interaction Networks (K Tan & T Ideker); Metabolic Networks (D A Fell); Heterogeneous Molecular Networks (V Schnchter); Evolution of Regulatory Networks (A Veron et al.); Complexity in Neuronal Networks (Y Fr(r)gnac et al.); Networks of the Immune System (R E Callard & J Stark); A History of the Study of Ecological Networks (L-F Bersier); Dynamic Network Models of Ecological Diversity, Complexity, and Nonlinear Persistence (R J Williams & N D Martinez); Infection Transmission through Networks (J S Koopman). Readership: Graduate students and industry experts in systems biology and complex systems; biologists; chemists; physicists; mathematicians; computer scientists

Complex Networks

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Publisher : Springer Science & Business Media
ISBN 13 : 9783540223542
Total Pages : 548 pages
Book Rating : 4.2/5 (235 download)

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Book Synopsis Complex Networks by : Eli Ben-Naim

Download or read book Complex Networks written by Eli Ben-Naim and published by Springer Science & Business Media. This book was released on 2004-09-01 with total page 548 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume is devoted to the applications of techniques from statistical physics to the characterization and modeling of complex networks. The first two parts of the book concern theory and modeling of networks, the last two parts survey applications to a wide variety of natural and artificial networks. The tutorial reviews that form this book are aimed at students and newcomers to the field, and will also constitute a modern and comprehensive reference for experts. To this aim, all contributions have been carefully peer-reviewed not only for scientific content but also for self-consistency and readability.

Bayesian Evolutionary Analysis with BEAST

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Publisher : Cambridge University Press
ISBN 13 : 1316298345
Total Pages : 263 pages
Book Rating : 4.3/5 (162 download)

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Book Synopsis Bayesian Evolutionary Analysis with BEAST by : Alexei J. Drummond

Download or read book Bayesian Evolutionary Analysis with BEAST written by Alexei J. Drummond and published by Cambridge University Press. This book was released on 2015-08-06 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: What are the models used in phylogenetic analysis and what exactly is involved in Bayesian evolutionary analysis using Markov chain Monte Carlo (MCMC) methods? How can you choose and apply these models, which parameterisations and priors make sense, and how can you diagnose Bayesian MCMC when things go wrong? These are just a few of the questions answered in this comprehensive overview of Bayesian approaches to phylogenetics. This practical guide: • Addresses the theoretical aspects of the field • Advises on how to prepare and perform phylogenetic analysis • Helps with interpreting analyses and visualisation of phylogenies • Describes the software architecture • Helps developing BEAST 2.2 extensions to allow these models to be extended further. With an accompanying website providing example files and tutorials (http://beast2.org/), this one-stop reference to applying the latest phylogenetic models in BEAST 2 will provide essential guidance for all users – from those using phylogenetic tools, to computational biologists and Bayesian statisticians.

Analysis of Biological Networks

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Author :
Publisher : John Wiley & Sons
ISBN 13 : 1118209915
Total Pages : 278 pages
Book Rating : 4.1/5 (182 download)

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Book Synopsis Analysis of Biological Networks by : Björn H. Junker

Download or read book Analysis of Biological Networks written by Björn H. Junker and published by John Wiley & Sons. This book was released on 2011-09-20 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: An introduction to biological networks and methods for their analysis Analysis of Biological Networks is the first book of its kind to provide readers with a comprehensive introduction to the structural analysis of biological networks at the interface of biology and computer science. The book begins with a brief overview of biological networks and graph theory/graph algorithms and goes on to explore: global network properties, network centralities, network motifs, network clustering, Petri nets, signal transduction and gene regulation networks, protein interaction networks, metabolic networks, phylogenetic networks, ecological networks, and correlation networks. Analysis of Biological Networks is a self-contained introduction to this important research topic, assumes no expert knowledge in computer science or biology, and is accessible to professionals and students alike. Each chapter concludes with a summary of main points and with exercises for readers to test their understanding of the material presented. Additionally, an FTP site with links to author-provided data for the book is available for deeper study. This book is suitable as a resource for researchers in computer science, biology, bioinformatics, advanced biochemistry, and the life sciences, and also serves as an ideal reference text for graduate-level courses in bioinformatics and biological research.

Biological Networks

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Author :
Publisher :
ISBN 13 : 9814475394
Total Pages : pages
Book Rating : 4.8/5 (144 download)

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Book Synopsis Biological Networks by :

Download or read book Biological Networks written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Analysis of Phylogenetics and Evolution with R

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Author :
Publisher : Springer Science & Business Media
ISBN 13 : 0387351000
Total Pages : 221 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Analysis of Phylogenetics and Evolution with R by : Emmanuel Paradis

Download or read book Analysis of Phylogenetics and Evolution with R written by Emmanuel Paradis and published by Springer Science & Business Media. This book was released on 2006-11-25 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book integrates a wide variety of data analysis methods into a single and flexible interface: the R language. The book starts with a presentation of different R packages and gives a short introduction to R for phylogeneticists unfamiliar with this language. The basic phylogenetic topics are covered. The chapter on tree drawing uses R's powerful graphical environment. A section deals with the analysis of diversification with phylogenies, one of the author's favorite research topics. The last chapter is devoted to the development of phylogenetic methods with R and interfaces with other languages (C and C++). Some exercises conclude these chapters.