Spinal Cord Plasticity

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Publisher : Springer Science & Business Media
ISBN 13 : 1461514371
Total Pages : 328 pages
Book Rating : 4.4/5 (615 download)

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Book Synopsis Spinal Cord Plasticity by : Michael M. Patterson

Download or read book Spinal Cord Plasticity written by Michael M. Patterson and published by Springer Science & Business Media. This book was released on 2011-06-28 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of spinal cord plasticity has become a very actively researched field. The spinal cord has long been known to organize reflex patterns and serve as the major transmission pathway for sensory and motor nerve impulses. However, the role of the spinal cord in information processing and in experience driven alterations is generally not recognized. With recent advances in neural recording techniques, behavioral technologies and neural tracing and imaging methods has come the ability to better assess the role of the spinal cord in behavioral control and alteration. The discoveries in recent years have been revolutionary. Alterations due to nociceptive inputs, simple learning paradigms and repetitive inputs have now been documented and their mechanisms are being elucidated. These findings have important clinical implications. The development of pathological pain after a spinal cord injury likely depends on the sensitization of neurons within the spinal cord. The capacity of the spinal cord to change as a function of experience, and adapt to new environmental relations, also affects the recovery locomotive function after a spinal cord injury. Mechanisms within the spinal cord can support stepping and the capacity for this behavior depends on behavioral training. By taking advantage of the plasticity inherent within the spinal cord, rehabilitative procedures may foster the recovery of function.

Spinal Interneurons

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Publisher : Academic Press
ISBN 13 : 0128192615
Total Pages : 476 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Spinal Interneurons by : Lyandysha Viktorovna Zholudeva

Download or read book Spinal Interneurons written by Lyandysha Viktorovna Zholudeva and published by Academic Press. This book was released on 2022-11-29 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spinal cord is comprised of four types of neurons: motor neurons, pre-ganglionic neurons, ascending projection neurons, and spinal interneurons. Interneurons are neurons that process information within local circuits, and have an incredible ability for neuroplasticity, whether due to persistent activity, neural injury, or in response to disease. Although, by definition, their axons are restricted to the same structure as the soma (in this case the spinal cord), spinal interneurons are capable of sprouting and rewiring entire neural circuits, and contribute to some restoration of disrupted neural communication after injury to the spinal cord (i.e., “bypassing the lesion site). Spinal Interneurons provides a focused overview of how scientists classify interneurons in general, the techniques used to identify subsets of interneurons, their roles in specific neural circuits, and the scientific evidence for their neuroplasticity. Understanding the capacity for neuroplasticity and identity of specific spinal interneurons that are optimal for recovery, may help determine cellular candidates for developing therapies. Spinal Interneurons provides neuroscientists, clinicians, and trainees a reference book exclusively concentrating on spinal interneurons, the techniques and experiments employed to identify and study these cells as part of normal and compromised neural circuits, and highlights the therapeutic potential of these cells by presenting the relevant pre-clinical and clinical work to date. People in industry will also benefit from this book, which compiles the latest in therapeutic strategies for targeting spinal interneurons, what considerations there are for the development and use of treatments, and how such treatments can not only be translated to the clinic, but how existing treatments should be appropriately reverse-translated to the bench. Comprehensive overview of techniques used to identify, characterize, and classify spinal interneurons and their role in neural circuits Description of the role that spinal interneurons play in mediating plasticity after compromise to spinal neural networks In-depth discussion of therapeutic potential of spinal interneurons for spinal cord injury and/or disease

Textbook of Neural Repair and Rehabilitation

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Publisher : Cambridge University Press
ISBN 13 : 1107011671
Total Pages : 693 pages
Book Rating : 4.1/5 (7 download)

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Book Synopsis Textbook of Neural Repair and Rehabilitation by : Michael E. Selzer

Download or read book Textbook of Neural Repair and Rehabilitation written by Michael E. Selzer and published by Cambridge University Press. This book was released on 2014 with total page 693 pages. Available in PDF, EPUB and Kindle. Book excerpt: In two freestanding volumes, the Textbook of Neural Repair and Rehabilitation provides comprehensive coverage of the science and practice of neurological rehabilitation. Revised throughout, bringing the book fully up to date, this volume, Neural Repair and Plasticity, covers the basic sciences relevant to recovery of function following injury to the nervous system, reviewing anatomical and physiological plasticity in the normal central nervous system, mechanisms of neuronal death, axonal regeneration, stem cell biology, and research strategies targeted at axon regeneration and neuron replacement. New chapters have been added covering pathophysiology and plasticity in cerebral palsy, stem cell therapies for brain disorders and neurotrophin repair of spinal cord damage, along with numerous others. Edited and written by leading international authorities, it is an essential resource for neuroscientists and provides a foundation for the work of clinical rehabilitation professionals.

Spinal Cord Plasticity

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Author :
Publisher :
ISBN 13 : 9781461514381
Total Pages : 256 pages
Book Rating : 4.5/5 (143 download)

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Book Synopsis Spinal Cord Plasticity by : Michael M Patterson

Download or read book Spinal Cord Plasticity written by Michael M Patterson and published by . This book was released on 2001-07-31 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Brain and Spinal Cord Plasticity

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Author :
Publisher :
ISBN 13 : 9781634849593
Total Pages : 100 pages
Book Rating : 4.8/5 (495 download)

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Book Synopsis Brain and Spinal Cord Plasticity by : Amy Jo Marcano-Reik

Download or read book Brain and Spinal Cord Plasticity written by Amy Jo Marcano-Reik and published by . This book was released on 2016 with total page 100 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Neurological Rehabilitation

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Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128077921
Total Pages : 680 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neurological Rehabilitation by : Audrey N. Kusiak

Download or read book Neurological Rehabilitation written by Audrey N. Kusiak and published by Elsevier Inc. Chapters. This book was released on 2013-01-10 with total page 680 pages. Available in PDF, EPUB and Kindle. Book excerpt: Once thought to be rigidly wired, the spinal cord now is understood to display significant plastic properties, which are manifest as both physiological and structural alterations in response to changes in patterns of use, disuse, and damage. Activity-dependent increases in responsiveness of spinal cord circuits are now thought to underlie or contribute importantly to the hyperalgesia that often follows neurological injuries, the physical therapy-induced improvement in walking and running seen in patients with stroke and spinal cord injury, skill acquisition in normal children, and several other phenomena. Physiological mechanisms underlying spinal cord plasticity include denervation supersensitivity, long-term potentiation, long-term depression, and habituation. Anatomical plasticity seen in the spinal cord after partial injuries includes collateral sprouting of spared axons in response to injury of neighboring axons, and dendritic remodeling in response to loss of regionally segregated synaptic inputs. A form of neuroplasticity that is seen in the peripheral nerves and in the spinal cord of some cold-blooded animals, but not in the central nervous system of birds or mammals, is axon regeneration. It is often difficult to distinguish between regeneration of injured axons and collateral sprouting of neighboring uninjured axons, but the distinction could be very important, especially in the case of complete spinal cord injuries. Several instances of treatment-induced axonal changes that were originally thought to indicate regeneration have turned out to be collateral sprouting. There is reason to suspect that the molecular mechanisms that underlie these two phenomena are different, and, if so, therapeutic approaches to enhancing them may also prove to be very different.

Plasticity of primary afferent neurons and sensory processing after spinal cord injury

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889193969
Total Pages : 222 pages
Book Rating : 4.8/5 (891 download)

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Book Synopsis Plasticity of primary afferent neurons and sensory processing after spinal cord injury by : Alexander Rabchevsky

Download or read book Plasticity of primary afferent neurons and sensory processing after spinal cord injury written by Alexander Rabchevsky and published by Frontiers Media SA. This book was released on 2015-01-05 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic injury of the spinal cord affects the entire organism directly and indirectly. Primary injury destroys neurons and severs axons which participate in neural circuits. Secondary injuries and pathologies arise from numerous sources including systemic inflammation, consequential damage of cutaneous, muscular, and visceral tissues, and dysregulation of autonomic, endocrine and sensory- motor functions. Evidence is mounting that spinal cord injury (SCI) affects regions of the nervous system spatially remote from the injury site, as well as peripheral tissues, and alters some basic characteristics of primary afferent cell biology and physiology (cell number, size/frequency, electrophysiology, other). The degree of afferent input and processing above the lesion is generally intact, while that in the peri-lesion area is highly variable, though pathologies emerge in both regions, including a variety of pain syndromes. Primary afferent input to spinal regions below the injury and the processing of this information becomes even more important in the face of complete or partial loss of descending input because such spared sensory processing can lead to both adaptive and pathological outcomes. This issue hosts review and research articles considering mechanisms of plasticity of primary afferent neurons and sensory processing after SCI, and how such plasticity contributes to sparing and/or recovery of functions, as well as exacerbation of existing and/or emergent pathologies. A critical issue for the majority of the SCI community is chronic above-, peri-, and below-level neuropathic pain, much of which may arise, at least in part, from plasticity of afferent fibers and nociceptive circuitry. For example, autonomic dysreflexia is common hypertensive syndrome that often develops after SCI that is highly reliant on maladaptive nociceptive sensory input and processing below the lesion. Moreover, the loss of descending input leaves the reflexive components of bladder/bowel/sexual function uncoordinated and susceptible to a variety of effects through afferent fiber plasticity. Finally, proper afferent feedback is vital for the effectiveness of activity-dependent rehabilitative therapies, but aberrant nociceptive input may interfere with these approaches since they are often unchecked due to loss of descending modulation.

Plasticity of Primary Afferent Neurons and Sensory Processing After Spinal Cord Injury

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Author :
Publisher :
ISBN 13 :
Total Pages : 221 pages
Book Rating : 4.:/5 (16 download)

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Book Synopsis Plasticity of Primary Afferent Neurons and Sensory Processing After Spinal Cord Injury by :

Download or read book Plasticity of Primary Afferent Neurons and Sensory Processing After Spinal Cord Injury written by and published by . This book was released on 2015 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Autonomic Dysfunction After Spinal Cord Injury

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Publisher : Elsevier
ISBN 13 : 0080460100
Total Pages : 472 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Autonomic Dysfunction After Spinal Cord Injury by : Lynne C. Weaver

Download or read book Autonomic Dysfunction After Spinal Cord Injury written by Lynne C. Weaver and published by Elsevier. This book was released on 2005-10-11 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Autonomic dysfunction is a major and poorly understood consequence of spinal cord injury. It is a cause of very serious disability and requires much more research. It should be a focus of treatment strategies. This book will be of interest to anyone involved in research and treatment of spinal cord injury since it helps to explain the tremendously negative impact on the body caused by cord injury that is not as obvious as paralysis and loss of sensation. It contains a compilation of what is known about bladder, cardiovascular, bowel and sexual dysfunction after spinal cord injury, as it relates to the changes within the autonomic nervous system control of these functions. The book begins with a description of the time course of autonomic dysfunctions and their ramifications from the first hours after a spinal cord injury to the more stable chronic states. The next section contains three chapters that address anatomical findings that may provide some of the foundation for autonomic dysfunctions in many of the systems. The system-specific chapters then follow in four sections. Each section begins with a chapter or two defining the clinical problems experienced by people with cord injury. The following chapters present research, basic and clinical, that address the autonomic dysfunctions.

Propriospinal Neurons: Essential Elements in Locomotion, Autonomic Function and Plasticity after Spinal Cord Injury and Disease

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Author :
Publisher : Frontiers Media SA
ISBN 13 : 2889669165
Total Pages : 177 pages
Book Rating : 4.8/5 (896 download)

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Book Synopsis Propriospinal Neurons: Essential Elements in Locomotion, Autonomic Function and Plasticity after Spinal Cord Injury and Disease by : Katinka Stecina

Download or read book Propriospinal Neurons: Essential Elements in Locomotion, Autonomic Function and Plasticity after Spinal Cord Injury and Disease written by Katinka Stecina and published by Frontiers Media SA. This book was released on 2021-06-28 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Synaptic Plasticity in Pain

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Publisher : Springer Science & Business Media
ISBN 13 : 1441902260
Total Pages : 500 pages
Book Rating : 4.4/5 (419 download)

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Book Synopsis Synaptic Plasticity in Pain by : Marzia Malcangio

Download or read book Synaptic Plasticity in Pain written by Marzia Malcangio and published by Springer Science & Business Media. This book was released on 2009-05-28 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.

The Circuitry of the Human Spinal Cord

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Author :
Publisher :
ISBN 13 : 0511124163
Total Pages : 666 pages
Book Rating : 4.5/5 (111 download)

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Book Synopsis The Circuitry of the Human Spinal Cord by : Emmanuel Pierrot-Deseilligny

Download or read book The Circuitry of the Human Spinal Cord written by Emmanuel Pierrot-Deseilligny and published by . This book was released on 2006-05-23 with total page 666 pages. Available in PDF, EPUB and Kindle. Book excerpt: Surveys the control of human spinal cord circuits, in normal movement and in disease states.

Neuroanatomy

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Publisher : McGraw-Hill Europe
ISBN 13 :
Total Pages : 564 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Neuroanatomy by : John Harry Martin

Download or read book Neuroanatomy written by John Harry Martin and published by McGraw-Hill Europe. This book was released on 2003 with total page 564 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over 400 illustrations, this thoroughly updated edition examines how parts of the nervous system work together to regulate body systems and produce behavior.

Make Life Visible

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Publisher : Springer Nature
ISBN 13 : 9811379084
Total Pages : 292 pages
Book Rating : 4.8/5 (113 download)

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Book Synopsis Make Life Visible by : Yoshiaki Toyama

Download or read book Make Life Visible written by Yoshiaki Toyama and published by Springer Nature. This book was released on 2019-10-02 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This open access book describes marked advances in imaging technology that have enabled the visualization of phenomena in ways formerly believed to be completelyimpossible. These technologies have made major contributions to the elucidation of the pathology of diseases as well as to their diagnosis and therapy. The volume presents various studies from molecular imaging to clinical imaging. It also focuses on innovative, creative, advanced research that gives full play to imaging technology inthe broad sense, while exploring cross-disciplinary areas in which individual research fields interact and pursuing the development of new techniques where they fuse together. The book is separated into three parts, the first of which addresses the topic of visualizing and controlling molecules for life. Th e second part is devoted to imaging of disease mechanisms, while the final part comprises studies on the application of imaging technologies to diagnosis and therapy. Th e book contains the proceedings of the 12th Uehara International Symposium 2017, “Make Life Visible” sponsored by the Uehara Memorial Foundation and held from June 12 to 14, 2017. It is written by leading scientists in the field and is an open access publication under a CC BY 4.0 license.

Spinal Cord Medicine

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Publisher : Lippincott Williams & Wilkins
ISBN 13 : 1451154275
Total Pages : 1899 pages
Book Rating : 4.4/5 (511 download)

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Book Synopsis Spinal Cord Medicine by : Denise I. Campagnolo

Download or read book Spinal Cord Medicine written by Denise I. Campagnolo and published by Lippincott Williams & Wilkins. This book was released on 2011-12-07 with total page 1899 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive and practical reference is the perfect resource for the medical specialist treating persons with spinal cord injuries. The book provides detail about all aspects of spinal cord injury and disease. The initial seven chapters present the history, anatomy, imaging, epidemiology, and general acute management of spinal cord injury. The next eleven chapters deal with medical aspects of spinal cord damage, such as pulmonary management and the neurogenic bladder. Chapters on rehabilitation are followed by nine chapters dealing with diseases that cause non-traumatic spinal cord injury. A comprehensive imaging chapter is included with 30 figures which provide the reader with an excellent resource to understand the complex issues of imaging the spine and spinal cord.

Neural Plasticity and Disorders of the Nervous System

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Publisher : Cambridge University Press
ISBN 13 : 1139447998
Total Pages : 380 pages
Book Rating : 4.1/5 (394 download)

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Book Synopsis Neural Plasticity and Disorders of the Nervous System by : Aage R. Møller

Download or read book Neural Plasticity and Disorders of the Nervous System written by Aage R. Møller and published by Cambridge University Press. This book was released on 2010-12-23 with total page 380 pages. Available in PDF, EPUB and Kindle. Book excerpt: Neural Plasticity and Disorders of the Nervous System provides comprehensive coverage of the pathophysiology of neurological disorders emphasising those disorders where expression of plasticity is evident. Including the basis for the expression of neural plasticity; how reorganisation of the nervous system can cause hyperactivity in sensory systems producing central neuropathic pain, tinnitus and paresthesia; the role of little-known non-classical pathways in pain and sensory disorders and their subcortical connections; hyper- and hypoactivity of motor systems after injury, and the role of spinal reflexes and internal processing in the spinal cord. Phantom symptoms and disorders of nerves and associated disorders are discussed, along with disorders that can be cured by microvascular decompression operations. A detailed and comprehensive description of the organisation of pain circuits and sensory and motor nervous systems is also included. This 2006 text is aimed at students and graduates of neuroscience and medicine.

Locomotor Training

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Publisher : Oxford University Press, USA
ISBN 13 : 0195342089
Total Pages : 200 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Locomotor Training by : Susan J. Harkema

Download or read book Locomotor Training written by Susan J. Harkema and published by Oxford University Press, USA. This book was released on 2011 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Locomotor training is aiming to promote recovery after spinal cord injury via activation of the neuromuscular system below the level of the lesion