Spinal Cord Plasticity

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Spinal Interneurons

Author : Lyandysha Viktorovna Zholudeva
Publisher : Academic Press
ISBN 13 : 0128192615
Total Pages : 476 pages
Book Rating : 4.1/5 (281 download)

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Book Synopsis Spinal Interneurons by : Lyandysha Viktorovna Zholudeva

Download or read book Spinal Interneurons written by Lyandysha Viktorovna Zholudeva and published by Academic Press. This book was released on 2022-11-29 with total page 476 pages. Available in PDF, EPUB and Kindle. Book excerpt: The spinal cord is comprised of four types of neurons: motor neurons, pre-ganglionic neurons, ascending projection neurons, and spinal interneurons. Interneurons are neurons that process information within local circuits, and have an incredible ability for neuroplasticity, whether due to persistent activity, neural injury, or in response to disease. Although, by definition, their axons are restricted to the same structure as the soma (in this case the spinal cord), spinal interneurons are capable of sprouting and rewiring entire neural circuits, and contribute to some restoration of disrupted neural communication after injury to the spinal cord (i.e., "bypassing the lesion site). Spinal Interneurons provides a focused overview of how scientists classify interneurons in general, the techniques used to identify subsets of interneurons, their roles in specific neural circuits, and the scientific evidence for their neuroplasticity. Understanding the capacity for neuroplasticity and identity of specific spinal interneurons that are optimal for recovery, may help determine cellular candidates for developing therapies. Spinal Interneurons provides neuroscientists, clinicians, and trainees a reference book exclusively concentrating on spinal interneurons, the techniques and experiments employed to identify and study these cells as part of normal and compromised neural circuits, and highlights the therapeutic potential of these cells by presenting the relevant pre-clinical and clinical work to date. People in industry will also benefit from this book, which compiles the latest in therapeutic strategies for targeting spinal interneurons, what considerations there are for the development and use of treatments, and how such treatments can not only be translated to the clinic, but how existing treatments should be appropriately reverse-translated to the bench. - Comprehensive overview of techniques used to identify, characterize, and classify spinal interneurons and their role in neural circuits - Description of the role that spinal interneurons play in mediating plasticity after compromise to spinal neural networks - In-depth discussion of therapeutic potential of spinal interneurons for spinal cord injury and/or disease

Neurological Rehabilitation

Author : Audrey N. Kusiak
Publisher : Elsevier Inc. Chapters
ISBN 13 : 0128077921
Total Pages : 79 pages
Book Rating : 4.1/5 (28 download)

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Book Synopsis Neurological Rehabilitation by : Audrey N. Kusiak

Download or read book Neurological Rehabilitation written by Audrey N. Kusiak and published by Elsevier Inc. Chapters. This book was released on 2013-01-10 with total page 79 pages. Available in PDF, EPUB and Kindle. Book excerpt: Once thought to be rigidly wired, the spinal cord now is understood to display significant plastic properties, which are manifest as both physiological and structural alterations in response to changes in patterns of use, disuse, and damage. Activity-dependent increases in responsiveness of spinal cord circuits are now thought to underlie or contribute importantly to the hyperalgesia that often follows neurological injuries, the physical therapy-induced improvement in walking and running seen in patients with stroke and spinal cord injury, skill acquisition in normal children, and several other phenomena. Physiological mechanisms underlying spinal cord plasticity include denervation supersensitivity, long-term potentiation, long-term depression, and habituation. Anatomical plasticity seen in the spinal cord after partial injuries includes collateral sprouting of spared axons in response to injury of neighboring axons, and dendritic remodeling in response to loss of regionally segregated synaptic inputs. A form of neuroplasticity that is seen in the peripheral nerves and in the spinal cord of some cold-blooded animals, but not in the central nervous system of birds or mammals, is axon regeneration. It is often difficult to distinguish between regeneration of injured axons and collateral sprouting of neighboring uninjured axons, but the distinction could be very important, especially in the case of complete spinal cord injuries. Several instances of treatment-induced axonal changes that were originally thought to indicate regeneration have turned out to be collateral sprouting. There is reason to suspect that the molecular mechanisms that underlie these two phenomena are different, and, if so, therapeutic approaches to enhancing them may also prove to be very different.

Spinal Cord Plasticity

Author : Michael M. Patterson
Publisher : Springer
ISBN 13 : 9781461355533
Total Pages : 0 pages
Book Rating : 4.3/5 (555 download)

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Book Synopsis Spinal Cord Plasticity by : Michael M. Patterson

Download or read book Spinal Cord Plasticity written by Michael M. Patterson and published by Springer. This book was released on 2012-10-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The area of spinal cord plasticity has become a very actively researched field. The spinal cord has long been known to organize reflex patterns and serve as the major transmission pathway for sensory and motor nerve impulses. However, the role of the spinal cord in information processing and in experience driven alterations is generally not recognized. With recent advances in neural recording techniques, behavioral technologies and neural tracing and imaging methods has come the ability to better assess the role of the spinal cord in behavioral control and alteration. The discoveries in recent years have been revolutionary. Alterations due to nociceptive inputs, simple learning paradigms and repetitive inputs have now been documented and their mechanisms are being elucidated. These findings have important clinical implications. The development of pathological pain after a spinal cord injury likely depends on the sensitization of neurons within the spinal cord. The capacity of the spinal cord to change as a function of experience, and adapt to new environmental relations, also affects the recovery locomotive function after a spinal cord injury. Mechanisms within the spinal cord can support stepping and the capacity for this behavior depends on behavioral training. By taking advantage of the plasticity inherent within the spinal cord, rehabilitative procedures may foster the recovery of function.

Translational Research in Traumatic Brain Injury

Author : Daniel Laskowitz
Publisher : CRC Press
ISBN 13 : 1498766579
Total Pages : 388 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Translational Research in Traumatic Brain Injury by : Daniel Laskowitz

Download or read book Translational Research in Traumatic Brain Injury written by Daniel Laskowitz and published by CRC Press. This book was released on 2016-04-21 with total page 388 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traumatic brain injury (TBI) remains a significant source of death and permanent disability, contributing to nearly one-third of all injury related deaths in the United States and exacting a profound personal and economic toll. Despite the increased resources that have recently been brought to bear to improve our understanding of TBI, the developme

Locomotor Training

Author : Susan J. Harkema
Publisher :
ISBN 13 : 0195342089
Total Pages : 200 pages
Book Rating : 4.1/5 (953 download)

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Book Synopsis Locomotor Training by : Susan J. Harkema

Download or read book Locomotor Training written by Susan J. Harkema and published by . This book was released on 2011 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Physical rehabilitation for walking recovery after spinal cord injury is undergoing a paradigm shift. Therapy historically has focused on compensation for sensorimotor deficits after SCI using wheelchairs and bracing to achieve mobility. With locomotor training, the aim is to promote recovery via activation of the neuromuscular system below the level of the lesion. What basic scientists have shown us as the potential of the nervous system for plasticity, to learn, even after injury is being translated into a rehabilitation strategy by taking advantage of the intrinsic biology of the central nervous system. While spinal cord injury from basic and clinical perspectives was the gateway for developing locomotor training, its application has been extended to other populations with neurologic dysfunction resulting in loss of walking or walking disability.

Neuroanatomy: Text and Atlas

Author : John Harry Martin
Publisher : McGraw Hill Professional
ISBN 13 : 9780071381833
Total Pages : 566 pages
Book Rating : 4.3/5 (818 download)

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Book Synopsis Neuroanatomy: Text and Atlas by : John Harry Martin

Download or read book Neuroanatomy: Text and Atlas written by John Harry Martin and published by McGraw Hill Professional. This book was released on 2003-03-27 with total page 566 pages. Available in PDF, EPUB and Kindle. Book excerpt: With over 400 illustrations, this thoroughly updated edition examines how parts of the nervous system work together to regulate body systems and produce behavior.

The Circuitry of the Human Spinal Cord

Author : Emmanuel Pierrot-Deseilligny
Publisher : Cambridge University Press
ISBN 13 : 9781139445641
Total Pages : 676 pages
Book Rating : 4.4/5 (456 download)

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Book Synopsis The Circuitry of the Human Spinal Cord by : Emmanuel Pierrot-Deseilligny

Download or read book The Circuitry of the Human Spinal Cord written by Emmanuel Pierrot-Deseilligny and published by Cambridge University Press. This book was released on 2005-06-08 with total page 676 pages. Available in PDF, EPUB and Kindle. Book excerpt: Studies of human movement have proliferated in recent years, and there have been many studies of spinal pathways in humans, their role in movement, and their dysfunction in neurological disorders. This comprehensive reference surveys the literature related to the control of spinal cord circuits in human subjects, showing how they can be studied, their role in normal movement, and how they malfunction in disease states. Chapters are highly illustrated and consistently organised, reviewing, for each pathway, the experimental background, methodology, organisation and control, role during motor tasks, and changes in patients with CNS lesions. Each chapter concludes with a helpful resume that can be used independently of the main text to provide practical guidance for clinical studies. This will be essential reading for research workers and clinicians involved in the study, treatment and rehabilitation of movement disorders.

Synaptic Plasticity in Pain

Author : Marzia Malcangio
Publisher : Springer
ISBN 13 : 9781441902252
Total Pages : 504 pages
Book Rating : 4.9/5 (22 download)

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Book Synopsis Synaptic Plasticity in Pain by : Marzia Malcangio

Download or read book Synaptic Plasticity in Pain written by Marzia Malcangio and published by Springer. This book was released on 2009-07-10 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: Primary sensory neurons respond to peripheral stimulation and project to the spinal cord. Specifically, the population of neurons which respond to damaging stimuli terminate in the superficial layers of the dorsal horn. Therefore, the dorsal horns constitute the first relay site for nociceptive fibre terminals which make synaptic contacts with second order neurons. It has recently become clear that the strength of this first pain synapse is plastic and modifiable by several modulators, including neuronal and non-neuronal regulators, and studies on the fundamental processes regulating the plasticity of the first pain synapse have resulted in the identification of new targets for the treatment of chronic pain. This book will be of interest to a wide readership in the pain field.

Cajal's Degeneration and Regeneration of the Nervous System

Author : Santiago Ramón y Cajal
Publisher : History of Neuroscience
ISBN 13 : 0195065166
Total Pages : 977 pages
Book Rating : 4.1/5 (95 download)

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Book Synopsis Cajal's Degeneration and Regeneration of the Nervous System by : Santiago Ramón y Cajal

Download or read book Cajal's Degeneration and Regeneration of the Nervous System written by Santiago Ramón y Cajal and published by History of Neuroscience. This book was released on 1991 with total page 977 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is a reprint of an English translation of Cajal's original work, with abundant notes and commentaries by the editor. This text describes Cajal's fundamental contributions to neuroscience, which continue to be important today. It accurately details Cajal's ideas and data, and providesreaders with the opportunity to learn what Cajal thought about his research career and the significance of his observations. Excerpts from Tello's memorial lectures also provide a contemporary view of Cajal's work.

Neural Plasticity and Disorders of the Nervous System

Author : Aage R. Møller
Publisher : Cambridge University Press
ISBN 13 : 9780521846677
Total Pages : 414 pages
Book Rating : 4.8/5 (466 download)

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Book Synopsis Neural Plasticity and Disorders of the Nervous System by : Aage R. Møller

Download or read book Neural Plasticity and Disorders of the Nervous System written by Aage R. Møller and published by Cambridge University Press. This book was released on 2006-02-23 with total page 414 pages. Available in PDF, EPUB and Kindle. Book excerpt: This 2006 book describes how expression of neural plasticity can cause symptoms of disorder and disease instead of being beneficial.

Spinal Cord Injury

Author : Institute of Medicine
Publisher : National Academies Press
ISBN 13 : 0309095859
Total Pages : 361 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis Spinal Cord Injury by : Institute of Medicine

Download or read book Spinal Cord Injury written by Institute of Medicine and published by National Academies Press. This book was released on 2005-08-27 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: An estimated 11,000 spinal cord injuries occur each year in the United States and more than 200,000 Americans suffer from maladies associated with spinal cord injury. This includes paralysis, bowel and bladder dysfunction, sexual dysfunction, respiratory impairment, temperature regulation problems, and chronic pain. During the last two decades, longstanding beliefs about the inability of the adult central nervous system to heal itself have been eroded by the flood of new information from research in the neurosciences and related fields. However, there are still no cures and the challenge of restoring function in the wake of spinal cord injuries remains extremely complex. Spinal Cord Injury examines the future directions for research with the goal to accelerate the development of cures for spinal cord injuries. While many of the recommendations are framed within the context of the specific needs articulated by the New York Spinal Cord Injury Research Board, the Institute of Medicine's panel of experts looked very broadly at research priorities relating to future directions for the field in general and make recommendations to strengthen and coordinate the existing infrastructure. Funders at federal and state agencies, academic organizations, pharmaceutical and device companies, and non-profit organizations will all find this book to be an essential resource as they examine their opportunities.

Neural Plasticity and Memory

Author : Federico Bermudez-Rattoni
Publisher : CRC Press
ISBN 13 : 1420008412
Total Pages : 368 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Neural Plasticity and Memory by : Federico Bermudez-Rattoni

Download or read book Neural Plasticity and Memory written by Federico Bermudez-Rattoni and published by CRC Press. This book was released on 2007-04-17 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive, multidisciplinary review, Neural Plasticity and Memory: From Genes to Brain Imaging provides an in-depth, up-to-date analysis of the study of the neurobiology of memory. Leading specialists share their scientific experience in the field, covering a wide range of topics where molecular, genetic, behavioral, and brain imaging techniq

Form and Function in the Brain and Spinal Cord

Author : Stephen G. Waxman
Publisher : MIT Press
ISBN 13 : 9780262731553
Total Pages : 546 pages
Book Rating : 4.7/5 (315 download)

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Book Synopsis Form and Function in the Brain and Spinal Cord by : Stephen G. Waxman

Download or read book Form and Function in the Brain and Spinal Cord written by Stephen G. Waxman and published by MIT Press. This book was released on 2003-01-24 with total page 546 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reflects Stephen Waxman's three decades of research on the form and functions of the brain and spinal cord. Building on his experience as a neuroscientist studying model systems as primitive as eels and as a neurologist studying humans, Waxman discusses a wide variety of topics, including the design principles that optimize neural function; molecular and cellular substrates of behavior; the role of glial cells in the brain; the molecular basis for pain; plasticity in the brain and spinal cord; strategies for promoting functional recovery in disorders such as multiple sclerosis, spinal cord injury, and stroke; and prospects for rebuilding the brain and spinal cord. The pieces provide example after example of the elegance of design of the nervous system, of the intricate interplay between structure and function in health and disease, and of the rich borderland between neuroscience and neurology.

The Spinal Cord

Author : Charles Watson
Publisher : Academic Press
ISBN 13 : 0080921388
Total Pages : 408 pages
Book Rating : 4.0/5 (89 download)

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Book Synopsis The Spinal Cord by : Charles Watson

Download or read book The Spinal Cord written by Charles Watson and published by Academic Press. This book was released on 2009-11-27 with total page 408 pages. Available in PDF, EPUB and Kindle. Book excerpt: Many hundreds of thousands suffer spinal cord injuries leading to loss of sensation and motor function in the body below the point of injury. Spinal cord research has made some significant strides towards new treatment methods, and is a focus of many laboratories worldwide. In addition, research on the involvement of the spinal cord in pain and the abilities of nervous tissue in the spine to regenerate has increasingly been on the forefront of biomedical research in the past years. The Spinal Cord, a collaboration with the Christopher and Dana Reeve Foundation, is the first comprehensive book on the anatomy of the mammalian spinal cord. Tens of thousands of articles and dozens of books are published on this subject each year, and a great deal of experimental work has been carried out on the rat spinal cord. Despite this, there is no comprehensive and authoritative atlas of the mammalian spinal cord. Almost all of the fine details of spinal cord anatomy must be searched for in journal articles on particular subjects. This book addresses this need by providing both a comprehensive reference on the mammalian spinal cord and a comparative atlas of both rat and mouse spinal cords in one convenient source. The book provides a descriptive survey of the details of mammalian spinal cord anatomy, focusing on the rat with many illustrations from the leading experts in the field and atlases of the rat and the mouse spinal cord. The rat and mouse spinal cord atlas chapters include photographs of Nissl stained transverse sections from each of the spinal cord segments (obtained from a single unfixed spinal cord), detailed diagrams of each of the spinal cord segments pictured, delineating the laminae of Rexed and all other significant neuronal groupings at each level and photographs of additional sections displaying markers such as acetylcholinesterase (AChE), calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), enkephalin, calcitonin gene-related peptide (CGRP), and neuronal nuclear protein (NeuN). - The text provides a detailed account of the anatomy of the mammalian spinal cord and surrounding musculoskeletal elements - The major topics addressed are: development of the spinal cord; the gross anatomy of the spinal cord and its meninges; spinal nerves, nerve roots, and dorsal root ganglia; the vertebral column, vertebral joints, and vertebral muscles; blood supply of the spinal cord; cytoarchitecture and chemoarchitecture of the spinal gray matter; musculotopic anatomy of motoneuron groups; tracts connecting the brain and spinal cord; spinospinal pathways; sympathetic and parasympathetic elements in the spinal cord; neuronal groups and pathways that control micturition; the anatomy of spinal cord injury in experimental animals - The atlas of the rat and mouse spinal cord has the following features: Photographs of Nissl stained transverse sections from each of 34 spinal segments for the rat and mouse; Detailed diagrams of each of the 34 spinal segments for rat and mouse, delineating the laminae of Rexed and all other significant neuronal groupings at each level. ; Alongside each of the 34 Nissl stained segments, there are additional sections displaying markers such as acetylcholinesterase, calbindin, calretinin, choline acetlytransferase, neurofilament protein (SMI 32), and neuronal nuclear protein (NeuN) - All the major motoneuron clusters are identified in relation to the individual muscles or muscle groups they supply

From Neurons to Neighborhoods

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 0309069882
Total Pages : 610 pages
Book Rating : 4.3/5 (9 download)

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Book Synopsis From Neurons to Neighborhoods by : National Research Council

Download or read book From Neurons to Neighborhoods written by National Research Council and published by National Academies Press. This book was released on 2000-11-13 with total page 610 pages. Available in PDF, EPUB and Kindle. Book excerpt: How we raise young children is one of today's most highly personalized and sharply politicized issues, in part because each of us can claim some level of "expertise." The debate has intensified as discoveries about our development-in the womb and in the first months and years-have reached the popular media. How can we use our burgeoning knowledge to assure the well-being of all young children, for their own sake as well as for the sake of our nation? Drawing from new findings, this book presents important conclusions about nature-versus-nurture, the impact of being born into a working family, the effect of politics on programs for children, the costs and benefits of intervention, and other issues. The committee issues a series of challenges to decision makers regarding the quality of child care, issues of racial and ethnic diversity, the integration of children's cognitive and emotional development, and more. Authoritative yet accessible, From Neurons to Neighborhoods presents the evidence about "brain wiring" and how kids learn to speak, think, and regulate their behavior. It examines the effect of the climate-family, child care, community-within which the child grows.

Spinal Cord Injury (SCI) Repair Strategies

Author : Giuseppe Perale
Publisher : Woodhead Publishing
ISBN 13 : 0081028083
Total Pages : 348 pages
Book Rating : 4.0/5 (81 download)

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Book Synopsis Spinal Cord Injury (SCI) Repair Strategies by : Giuseppe Perale

Download or read book Spinal Cord Injury (SCI) Repair Strategies written by Giuseppe Perale and published by Woodhead Publishing. This book was released on 2019-10-30 with total page 348 pages. Available in PDF, EPUB and Kindle. Book excerpt: Spinal Cord Injury (SCI) Repair Strategies provides researchers the latest information on potential regenerative approaches to spinal cord injury, specifically focusing on therapeutic approaches that target regeneration, including cell therapies, controlled drug delivery systems, and biomaterials. Dr. Giuseppe Perale and Dr. Filippo Rossi lead a team of authoritative authors in academia and industry in this innovative reference on the field of regenerative medicine and tissue engineering. This book presents all the information readers need to understand the current and potential array of techniques, materials, applications and their benefits for spinal cord repair. - Covers current and future repair strategies for spinal cord injury repair - Focuses on key research trends, clinics, biology and engineering - Provides fundamentals on regenerative engineering and tissue engineering

Cortical Connectivity

Author : Robert Chen
Publisher : Springer Science & Business Media
ISBN 13 : 3642327664
Total Pages : 361 pages
Book Rating : 4.6/5 (423 download)

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Book Synopsis Cortical Connectivity by : Robert Chen

Download or read book Cortical Connectivity written by Robert Chen and published by Springer Science & Business Media. This book was released on 2012-10-18 with total page 361 pages. Available in PDF, EPUB and Kindle. Book excerpt: The study and modulation of cortical connections is a rapidly growing area in neuroscience. This unique book by prominent researchers in the field covers recent advances in this area. The first section of the book describes studies of cortical connections, modulation of cortical connectivity and changes in cortical connections with activities such as motor learning and grasping in primates. The second section covers the use of non-invasive brain stimulation to study and modulate cortical connectivity in humans. The last section describes changes in brain connectivity in neurological and psychiatric diseases, and potential new treatments that manipulate brain connectivity. This book provides an up-to-date view of the study of cortical connectivity, and covers its role in both fundamental neuroscience and potential clinical applications.