Sparse Graphical Modeling For High Dimensional Data

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Sparse Graphical Modeling for High Dimensional Data

Author : Faming Liang
Publisher : CRC Press
ISBN 13 : 0429582900
Total Pages : 150 pages
Book Rating : 4.4/5 (295 download)

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Book Synopsis Sparse Graphical Modeling for High Dimensional Data by : Faming Liang

Download or read book Sparse Graphical Modeling for High Dimensional Data written by Faming Liang and published by CRC Press. This book was released on 2023-08-02 with total page 150 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a general framework for learning sparse graphical models with conditional independence tests. It includes complete treatments for Gaussian, Poisson, multinomial, and mixed data; unified treatments for covariate adjustments, data integration, and network comparison; unified treatments for missing data and heterogeneous data; efficient methods for joint estimation of multiple graphical models; effective methods of high-dimensional variable selection; and effective methods of high-dimensional inference. The methods possess an embarrassingly parallel structure in performing conditional independence tests, and the computation can be significantly accelerated by running in parallel on a multi-core computer or a parallel architecture. This book is intended to serve researchers and scientists interested in high-dimensional statistics, and graduate students in broad data science disciplines. Key Features: A general framework for learning sparse graphical models with conditional independence tests Complete treatments for different types of data, Gaussian, Poisson, multinomial, and mixed data Unified treatments for data integration, network comparison, and covariate adjustment Unified treatments for missing data and heterogeneous data Efficient methods for joint estimation of multiple graphical models Effective methods of high-dimensional variable selection Effective methods of high-dimensional inference

High-Dimensional Statistics

Author : Martin J. Wainwright
Publisher : Cambridge University Press
ISBN 13 : 1108498027
Total Pages : 571 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis High-Dimensional Statistics by : Martin J. Wainwright

Download or read book High-Dimensional Statistics written by Martin J. Wainwright and published by Cambridge University Press. This book was released on 2019-02-21 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: A coherent introductory text from a groundbreaking researcher, focusing on clarity and motivation to build intuition and understanding.

Statistics for High-Dimensional Data

Author : Peter Bühlmann
Publisher : Springer Science & Business Media
ISBN 13 : 364220192X
Total Pages : 568 pages
Book Rating : 4.6/5 (422 download)

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Book Synopsis Statistics for High-Dimensional Data by : Peter Bühlmann

Download or read book Statistics for High-Dimensional Data written by Peter Bühlmann and published by Springer Science & Business Media. This book was released on 2011-06-08 with total page 568 pages. Available in PDF, EPUB and Kindle. Book excerpt: Modern statistics deals with large and complex data sets, and consequently with models containing a large number of parameters. This book presents a detailed account of recently developed approaches, including the Lasso and versions of it for various models, boosting methods, undirected graphical modeling, and procedures controlling false positive selections. A special characteristic of the book is that it contains comprehensive mathematical theory on high-dimensional statistics combined with methodology, algorithms and illustrations with real data examples. This in-depth approach highlights the methods’ great potential and practical applicability in a variety of settings. As such, it is a valuable resource for researchers, graduate students and experts in statistics, applied mathematics and computer science.

Mixture Models

Author : Weixin Yao
Publisher : CRC Press
ISBN 13 : 1040009875
Total Pages : 398 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Mixture Models by : Weixin Yao

Download or read book Mixture Models written by Weixin Yao and published by CRC Press. This book was released on 2024-04-18 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mixture models are a powerful tool for analyzing complex and heterogeneous datasets across many scientific fields, from finance to genomics. Mixture Models: Parametric, Semiparametric, and New Directions provides an up-to-date introduction to these models, their recent developments, and their implementation using R. It fills a gap in the literature by covering not only the basics of finite mixture models, but also recent developments such as semiparametric extensions, robust modeling, label switching, and high-dimensional modeling. Features Comprehensive overview of the methods and applications of mixture models Key topics include hypothesis testing, model selection, estimation methods, and Bayesian approaches Recent developments, such as semiparametric extensions, robust modeling, label switching, and high-dimensional modeling Examples and case studies from such fields as astronomy, biology, genomics, economics, finance, medicine, engineering, and sociology Integrated R code for many of the models, with code and data available in the R Package MixSemiRob Mixture Models: Parametric, Semiparametric, and New Directions is a valuable resource for researchers and postgraduate students from statistics, biostatistics, and other fields. It could be used as a textbook for a course on model-based clustering methods, and as a supplementary text for courses on data mining, semiparametric modeling, and high-dimensional data analysis.

Functional Data Analysis with R

Author : Ciprian M. Crainiceanu
Publisher : CRC Press
ISBN 13 : 1003856306
Total Pages : 338 pages
Book Rating : 4.0/5 (38 download)

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Book Synopsis Functional Data Analysis with R by : Ciprian M. Crainiceanu

Download or read book Functional Data Analysis with R written by Ciprian M. Crainiceanu and published by CRC Press. This book was released on 2024-03-11 with total page 338 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emerging technologies generate data sets of increased size and complexity that require new or updated statistical inferential methods and scalable, reproducible software. These data sets often involve measurements of a continuous underlying process, and benefit from a functional data perspective. Functional Data Analysis with R presents many ideas for handling functional data including dimension reduction techniques, smoothing, functional regression, structured decompositions of curves, and clustering. The idea is for the reader to be able to immediately reproduce the results in the book, implement these methods, and potentially design new methods and software that may be inspired by these approaches. Features: Functional regression models receive a modern treatment that allows extensions to many practical scenarios and development of state-of-the-art software. The connection between functional regression, penalized smoothing, and mixed effects models is used as the cornerstone for inference. Multilevel, longitudinal, and structured functional data are discussed with emphasis on emerging functional data structures. Methods for clustering functional data before and after smoothing are discussed. Multiple new functional data sets with dense and sparse sampling designs from various application areas are presented, including the NHANES linked accelerometry and mortality data, COVID-19 mortality data, CD4 counts data, and the CONTENT child growth study. Step-by-step software implementations are included, along with a supplementary website (www.FunctionalDataAnalysis.com) featuring software, data, and tutorials. More than 100 plots for visualization of functional data are presented. Functional Data Analysis with R is primarily aimed at undergraduate, master's, and PhD students, as well as data scientists and researchers working on functional data analysis. The book can be read at different levels and combines state-of-the-art software, methods, and inference. It can be used for self-learning, teaching, and research, and will particularly appeal to anyone who is interested in practical methods for hands-on, problem-forward functional data analysis. The reader should have some basic coding experience, but expertise in R is not required.

Bayesian Nonparametrics for Causal Inference and Missing Data

Author : Michael J. Daniels
Publisher : CRC Press
ISBN 13 : 1000927717
Total Pages : 263 pages
Book Rating : 4.0/5 (9 download)

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Book Synopsis Bayesian Nonparametrics for Causal Inference and Missing Data by : Michael J. Daniels

Download or read book Bayesian Nonparametrics for Causal Inference and Missing Data written by Michael J. Daniels and published by CRC Press. This book was released on 2023-08-23 with total page 263 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bayesian Nonparametrics for Causal Inference and Missing Data provides an overview of flexible Bayesian nonparametric (BNP) methods for modeling joint or conditional distributions and functional relationships, and their interplay with causal inference and missing data. This book emphasizes the importance of making untestable assumptions to identify estimands of interest, such as missing at random assumption for missing data and unconfoundedness for causal inference in observational studies. Unlike parametric methods, the BNP approach can account for possible violations of assumptions and minimize concerns about model misspecification. The overall strategy is to first specify BNP models for observed data and then to specify additional uncheckable assumptions to identify estimands of interest. The book is divided into three parts. Part I develops the key concepts in causal inference and missing data and reviews relevant concepts in Bayesian inference. Part II introduces the fundamental BNP tools required to address causal inference and missing data problems. Part III shows how the BNP approach can be applied in a variety of case studies. The datasets in the case studies come from electronic health records data, survey data, cohort studies, and randomized clinical trials. Features • Thorough discussion of both BNP and its interplay with causal inference and missing data • How to use BNP and g-computation for causal inference and non-ignorable missingness • How to derive and calibrate sensitivity parameters to assess sensitivity to deviations from uncheckable causal and/or missingness assumptions • Detailed case studies illustrating the application of BNP methods to causal inference and missing data • R code and/or packages to implement BNP in causal inference and missing data problems The book is primarily aimed at researchers and graduate students from statistics and biostatistics. It will also serve as a useful practical reference for mathematically sophisticated epidemiologists and medical researchers.

High-Dimensional Data Analysis with Low-Dimensional Models

Author : John Wright
Publisher : Cambridge University Press
ISBN 13 : 1108805558
Total Pages : 718 pages
Book Rating : 4.1/5 (88 download)

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Book Synopsis High-Dimensional Data Analysis with Low-Dimensional Models by : John Wright

Download or read book High-Dimensional Data Analysis with Low-Dimensional Models written by John Wright and published by Cambridge University Press. This book was released on 2022-01-13 with total page 718 pages. Available in PDF, EPUB and Kindle. Book excerpt: Connecting theory with practice, this systematic and rigorous introduction covers the fundamental principles, algorithms and applications of key mathematical models for high-dimensional data analysis. Comprehensive in its approach, it provides unified coverage of many different low-dimensional models and analytical techniques, including sparse and low-rank models, and both convex and non-convex formulations. Readers will learn how to develop efficient and scalable algorithms for solving real-world problems, supported by numerous examples and exercises throughout, and how to use the computational tools learnt in several application contexts. Applications presented include scientific imaging, communication, face recognition, 3D vision, and deep networks for classification. With code available online, this is an ideal textbook for senior and graduate students in computer science, data science, and electrical engineering, as well as for those taking courses on sparsity, low-dimensional structures, and high-dimensional data. Foreword by Emmanuel Candès.

High-Dimensional Covariance Estimation

Author : Mohsen Pourahmadi
Publisher : John Wiley & Sons
ISBN 13 : 1118573668
Total Pages : 204 pages
Book Rating : 4.1/5 (185 download)

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Book Synopsis High-Dimensional Covariance Estimation by : Mohsen Pourahmadi

Download or read book High-Dimensional Covariance Estimation written by Mohsen Pourahmadi and published by John Wiley & Sons. This book was released on 2013-05-28 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods for estimating sparse and large covariance matrices Covariance and correlation matrices play fundamental roles in every aspect of the analysis of multivariate data collected from a variety of fields including business and economics, health care, engineering, and environmental and physical sciences. High-Dimensional Covariance Estimation provides accessible and comprehensive coverage of the classical and modern approaches for estimating covariance matrices as well as their applications to the rapidly developing areas lying at the intersection of statistics and machine learning. Recently, the classical sample covariance methodologies have been modified and improved upon to meet the needs of statisticians and researchers dealing with large correlated datasets. High-Dimensional Covariance Estimation focuses on the methodologies based on shrinkage, thresholding, and penalized likelihood with applications to Gaussian graphical models, prediction, and mean-variance portfolio management. The book relies heavily on regression-based ideas and interpretations to connect and unify many existing methods and algorithms for the task. High-Dimensional Covariance Estimation features chapters on: Data, Sparsity, and Regularization Regularizing the Eigenstructure Banding, Tapering, and Thresholding Covariance Matrices Sparse Gaussian Graphical Models Multivariate Regression The book is an ideal resource for researchers in statistics, mathematics, business and economics, computer sciences, and engineering, as well as a useful text or supplement for graduate-level courses in multivariate analysis, covariance estimation, statistical learning, and high-dimensional data analysis.

High-Dimensional Probability

Author : Roman Vershynin
Publisher : Cambridge University Press
ISBN 13 : 1108415199
Total Pages : 299 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis High-Dimensional Probability by : Roman Vershynin

Download or read book High-Dimensional Probability written by Roman Vershynin and published by Cambridge University Press. This book was released on 2018-09-27 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: An integrated package of powerful probabilistic tools and key applications in modern mathematical data science.

Statistical Analysis for High-Dimensional Data

Author : Arnoldo Frigessi
Publisher : Springer
ISBN 13 : 3319270990
Total Pages : 313 pages
Book Rating : 4.3/5 (192 download)

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Book Synopsis Statistical Analysis for High-Dimensional Data by : Arnoldo Frigessi

Download or read book Statistical Analysis for High-Dimensional Data written by Arnoldo Frigessi and published by Springer. This book was released on 2016-02-16 with total page 313 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book features research contributions from The Abel Symposium on Statistical Analysis for High Dimensional Data, held in Nyvågar, Lofoten, Norway, in May 2014. The focus of the symposium was on statistical and machine learning methodologies specifically developed for inference in “big data” situations, with particular reference to genomic applications. The contributors, who are among the most prominent researchers on the theory of statistics for high dimensional inference, present new theories and methods, as well as challenging applications and computational solutions. Specific themes include, among others, variable selection and screening, penalised regression, sparsity, thresholding, low dimensional structures, computational challenges, non-convex situations, learning graphical models, sparse covariance and precision matrices, semi- and non-parametric formulations, multiple testing, classification, factor models, clustering, and preselection. Highlighting cutting-edge research and casting light on future research directions, the contributions will benefit graduate students and researchers in computational biology, statistics and the machine learning community.

Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics

Author : Christine Sinoquet
Publisher : OUP Oxford
ISBN 13 : 0191019208
Total Pages : 415 pages
Book Rating : 4.1/5 (91 download)

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Book Synopsis Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics by : Christine Sinoquet

Download or read book Probabilistic Graphical Models for Genetics, Genomics, and Postgenomics written by Christine Sinoquet and published by OUP Oxford. This book was released on 2014-09-18 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nowadays bioinformaticians and geneticists are faced with myriad high-throughput data usually presenting the characteristics of uncertainty, high dimensionality and large complexity. These data will only allow insights into this wealth of so-called 'omics' data if represented by flexible and scalable models, prior to any further analysis. At the interface between statistics and machine learning, probabilistic graphical models (PGMs) represent a powerful formalism to discover complex networks of relations. These models are also amenable to incorporating a priori biological information. Network reconstruction from gene expression data represents perhaps the most emblematic area of research where PGMs have been successfully applied. However these models have also created renewed interest in genetics in the broad sense, in particular regarding association genetics, causality discovery, prediction of outcomes, detection of copy number variations, and epigenetics. This book provides an overview of the applications of PGMs to genetics, genomics and postgenomics to meet this increased interest. A salient feature of bioinformatics, interdisciplinarity, reaches its limit when an intricate cooperation between domain specialists is requested. Currently, few people are specialists in the design of advanced methods using probabilistic graphical models for postgenomics or genetics. This book deciphers such models so that their perceived difficulty no longer hinders their use and focuses on fifteen illustrations showing the mechanisms behind the models. Probabilistic Graphical Models for Genetics, Genomics and Postgenomics covers six main themes: (1) Gene network inference (2) Causality discovery (3) Association genetics (4) Epigenetics (5) Detection of copy number variations (6) Prediction of outcomes from high-dimensional genomic data. Written by leading international experts, this is a collection of the most advanced work at the crossroads of probabilistic graphical models and genetics, genomics, and postgenomics. The self-contained chapters provide an enlightened account of the pros and cons of applying these powerful techniques.

High-Dimensional Statistics

Author : Martin J. Wainwright
Publisher : Cambridge University Press
ISBN 13 : 1108571239
Total Pages : 571 pages
Book Rating : 4.1/5 (85 download)

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Book Synopsis High-Dimensional Statistics by : Martin J. Wainwright

Download or read book High-Dimensional Statistics written by Martin J. Wainwright and published by Cambridge University Press. This book was released on 2019-02-21 with total page 571 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have witnessed an explosion in the volume and variety of data collected in all scientific disciplines and industrial settings. Such massive data sets present a number of challenges to researchers in statistics and machine learning. This book provides a self-contained introduction to the area of high-dimensional statistics, aimed at the first-year graduate level. It includes chapters that are focused on core methodology and theory - including tail bounds, concentration inequalities, uniform laws and empirical process, and random matrices - as well as chapters devoted to in-depth exploration of particular model classes - including sparse linear models, matrix models with rank constraints, graphical models, and various types of non-parametric models. With hundreds of worked examples and exercises, this text is intended both for courses and for self-study by graduate students and researchers in statistics, machine learning, and related fields who must understand, apply, and adapt modern statistical methods suited to large-scale data.

Introduction to High-Dimensional Statistics

Author : Christophe Giraud
Publisher : CRC Press
ISBN 13 : 1000408329
Total Pages : 364 pages
Book Rating : 4.0/5 (4 download)

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Book Synopsis Introduction to High-Dimensional Statistics by : Christophe Giraud

Download or read book Introduction to High-Dimensional Statistics written by Christophe Giraud and published by CRC Press. This book was released on 2021-08-25 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Praise for the first edition: "[This book] succeeds singularly at providing a structured introduction to this active field of research. ... it is arguably the most accessible overview yet published of the mathematical ideas and principles that one needs to master to enter the field of high-dimensional statistics. ... recommended to anyone interested in the main results of current research in high-dimensional statistics as well as anyone interested in acquiring the core mathematical skills to enter this area of research." —Journal of the American Statistical Association Introduction to High-Dimensional Statistics, Second Edition preserves the philosophy of the first edition: to be a concise guide for students and researchers discovering the area and interested in the mathematics involved. The main concepts and ideas are presented in simple settings, avoiding thereby unessential technicalities. High-dimensional statistics is a fast-evolving field, and much progress has been made on a large variety of topics, providing new insights and methods. Offering a succinct presentation of the mathematical foundations of high-dimensional statistics, this new edition: Offers revised chapters from the previous edition, with the inclusion of many additional materials on some important topics, including compress sensing, estimation with convex constraints, the slope estimator, simultaneously low-rank and row-sparse linear regression, or aggregation of a continuous set of estimators. Introduces three new chapters on iterative algorithms, clustering, and minimax lower bounds. Provides enhanced appendices, minimax lower-bounds mainly with the addition of the Davis-Kahan perturbation bound and of two simple versions of the Hanson-Wright concentration inequality. Covers cutting-edge statistical methods including model selection, sparsity and the Lasso, iterative hard thresholding, aggregation, support vector machines, and learning theory. Provides detailed exercises at the end of every chapter with collaborative solutions on a wiki site. Illustrates concepts with simple but clear practical examples.

Sparse Modeling

Author : Irina Rish
Publisher : CRC Press
ISBN 13 : 1439828695
Total Pages : 255 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Sparse Modeling by : Irina Rish

Download or read book Sparse Modeling written by Irina Rish and published by CRC Press. This book was released on 2014-12-01 with total page 255 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sparse models are particularly useful in scientific applications, such as biomarker discovery in genetic or neuroimaging data, where the interpretability of a predictive model is essential. Sparsity can also dramatically improve the cost efficiency of signal processing. Sparse Modeling: Theory, Algorithms, and Applications provides an introduction to the growing field of sparse modeling, including application examples, problem formulations that yield sparse solutions, algorithms for finding such solutions, and recent theoretical results on sparse recovery. The book gets you up to speed on the latest sparsity-related developments and will motivate you to continue learning about the field. The authors first present motivating examples and a high-level survey of key recent developments in sparse modeling. The book then describes optimization problems involving commonly used sparsity-enforcing tools, presents essential theoretical results, and discusses several state-of-the-art algorithms for finding sparse solutions. The authors go on to address a variety of sparse recovery problems that extend the basic formulation to more sophisticated forms of structured sparsity and to different loss functions. They also examine a particular class of sparse graphical models and cover dictionary learning and sparse matrix factorizations.

Signal Processing and Machine Learning for Biomedical Big Data

Author : Ervin Sejdic
Publisher : CRC Press
ISBN 13 : 149877346X
Total Pages : 624 pages
Book Rating : 4.4/5 (987 download)

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Book Synopsis Signal Processing and Machine Learning for Biomedical Big Data by : Ervin Sejdic

Download or read book Signal Processing and Machine Learning for Biomedical Big Data written by Ervin Sejdic and published by CRC Press. This book was released on 2018-07-04 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Within the healthcare domain, big data is defined as any ``high volume, high diversity biological, clinical, environmental, and lifestyle information collected from single individuals to large cohorts, in relation to their health and wellness status, at one or several time points.'' Such data is crucial because within it lies vast amounts of invaluable information that could potentially change a patient's life, opening doors to alternate therapies, drugs, and diagnostic tools. Signal Processing and Machine Learning for Biomedical Big Data thus discusses modalities; the numerous ways in which this data is captured via sensors; and various sample rates and dimensionalities. Capturing, analyzing, storing, and visualizing such massive data has required new shifts in signal processing paradigms and new ways of combining signal processing with machine learning tools. This book covers several of these aspects in two ways: firstly, through theoretical signal processing chapters where tools aimed at big data (be it biomedical or otherwise) are described; and, secondly, through application-driven chapters focusing on existing applications of signal processing and machine learning for big biomedical data. This text aimed at the curious researcher working in the field, as well as undergraduate and graduate students eager to learn how signal processing can help with big data analysis. It is the hope of Drs. Sejdic and Falk that this book will bring together signal processing and machine learning researchers to unlock existing bottlenecks within the healthcare field, thereby improving patient quality-of-life. Provides an overview of recent state-of-the-art signal processing and machine learning algorithms for biomedical big data, including applications in the neuroimaging, cardiac, retinal, genomic, sleep, patient outcome prediction, critical care, and rehabilitation domains. Provides contributed chapters from world leaders in the fields of big data and signal processing, covering topics such as data quality, data compression, statistical and graph signal processing techniques, and deep learning and their applications within the biomedical sphere. This book’s material covers how expert domain knowledge can be used to advance signal processing and machine learning for biomedical big data applications.

Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics

Author : Elena Marchiori
Publisher : Springer Science & Business Media
ISBN 13 : 3540787569
Total Pages : 222 pages
Book Rating : 4.5/5 (47 download)

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Book Synopsis Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics by : Elena Marchiori

Download or read book Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics written by Elena Marchiori and published by Springer Science & Business Media. This book was released on 2008-03-14 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 6th European Conference on Evolutionary Computation, Machine Learning and Data Mining in Bioinformatics, EvoBIO 2008, held in Naples, Italy, in March 2008 colocated with the Evo* 2008 events. The 18 revised full papers were carefully reviewed and selected from 63 submissions. EvoBio is the premiere European event for experts in computer science meeting with experts in bioinformatics and the biological sciences, all interested in the interface between evolutionary computation, machine learning, data mining, bioinformatics, and computational biology. Topics addressed by the papers include biomarker discovery, cell simulation and modeling, ecological modeling, uxomics, gene networks, biotechnology, metabolomics, microarray analysis, phylogenetics, protein interactions, proteomics, sequence analysis and alignment, as well as systems biology.

Data Mining for Bioinformatics

Author : Sumeet Dua
Publisher : CRC Press
ISBN 13 : 0849328012
Total Pages : 351 pages
Book Rating : 4.8/5 (493 download)

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Book Synopsis Data Mining for Bioinformatics by : Sumeet Dua

Download or read book Data Mining for Bioinformatics written by Sumeet Dua and published by CRC Press. This book was released on 2012-11-06 with total page 351 pages. Available in PDF, EPUB and Kindle. Book excerpt: Covering theory, algorithms, and methodologies, as well as data mining technologies, Data Mining for Bioinformatics provides a comprehensive discussion of data-intensive computations used in data mining with applications in bioinformatics. It supplies a broad, yet in-depth, overview of the application domains of data mining for bioinformatics to help readers from both biology and computer science backgrounds gain an enhanced understanding of this cross-disciplinary field. The book offers authoritative coverage of data mining techniques, technologies, and frameworks used for storing, analyzing, and extracting knowledge from large databases in the bioinformatics domains, including genomics and proteomics. It begins by describing the evolution of bioinformatics and highlighting the challenges that can be addressed using data mining techniques. Introducing the various data mining techniques that can be employed in biological databases, the text is organized into four sections: Supplies a complete overview of the evolution of the field and its intersection with computational learning Describes the role of data mining in analyzing large biological databases—explaining the breath of the various feature selection and feature extraction techniques that data mining has to offer Focuses on concepts of unsupervised learning using clustering techniques and its application to large biological data Covers supervised learning using classification techniques most commonly used in bioinformatics—addressing the need for validation and benchmarking of inferences derived using either clustering or classification The book describes the various biological databases prominently referred to in bioinformatics and includes a detailed list of the applications of advanced clustering algorithms used in bioinformatics. Highlighting the challenges encountered during the application of classification on biological databases, it considers systems of both single and ensemble classifiers and shares effort-saving tips for model selection and performance estimation strategies.