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Skin Pharmacology And Toxicology
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Book Synopsis Skin Pharmacology and Toxicology by : Corrado L. Galli
Download or read book Skin Pharmacology and Toxicology written by Corrado L. Galli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 310 pages. Available in PDF, EPUB and Kindle. Book excerpt: Major skin diseases, including acne, psoriasis and eczcma, affect the majority of the population at some time in their lives. In general, these diseases are physically and psychologically disfiguring for the sufferers; furthermore, by their very chronic nature skin diseases, unlike most other disease processes, present both acute and chronic therapy problems. In addition, the chronic nature of these diseases can present certain economic problems. Firstly, chronic therapy is becoming increasingly expensive and secondly, patients adhering to a strict treatment regimen will frequently be absent from their gainful employment for either medical consultation or treatment. Given that in all NATO countries the average age of the population is continually increasing, these chronic skin diseases will increase in importance in the coming years. Furthermore, as the average population age increases, additional disease processes such as skin photodamage and carcinogenicity risk becoming major areas of therapeutic concern. This book reviews in detail the major scientific areas of interest for research and clinical scientists working in skin pharmacology and toxicology. The basic principles relating to an understanding of how drugs and chemicals may influence either the skin or the body as a whole are discussed in detail by recognized international scientific experts.
Book Synopsis Principles and Practice of Skin Toxicology by : Robert Chilcott
Download or read book Principles and Practice of Skin Toxicology written by Robert Chilcott and published by John Wiley & Sons. This book was released on 2008-07-31 with total page 392 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by authorities in the field, this book provides a “bottom up” approach to studying skin toxicology. Principles and Practice of Skin Toxicology clearly outlines basic concepts, cites historical and modern references and contains a dictionary for easy reference. The inclusion of global legislation and regulatory aspects on the topic makes this a comprehensive review for every practitioner, clinical researcher in industry and academia, and MSc and PhD student of toxicology. Different sections cover skin structure and function, principles and measurement of skin absorption, clinical aspects of dermal toxicity and in vitro alternatives. A section on regulatory and legislative aspects includes case studies from the UK that fulfill European Union and US FDA requirements. A glossary provides definitions of technical terms, and the chapters contain an introduction, learning boxes and summary section for ease of use. Includes a chapter on drug delivery through the skin. Addresses risk assessment: a key area for the interpretation of skin absorption data that is rarely covered.
Download or read book Pharmacology of the Skin II written by and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 602 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin as in animal models, where they may be more relevant to human physiology and disease. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of aetiology and mechanism. For example, whilst the argument continued un resolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis retinoic acid, was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on aetiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as for the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Book Synopsis Toxicology of the Skin by : Nancy A. Monteiro-Riviere
Download or read book Toxicology of the Skin written by Nancy A. Monteiro-Riviere and published by CRC Press. This book was released on 2010-02-17 with total page 452 pages. Available in PDF, EPUB and Kindle. Book excerpt: This key volume of the Target Organ Toxicology Series provides a fresh and modern approach to the subject of skin toxicology from the perspective of how the skin forms a barrier that protects the body from the external environment and how chemicals and drugs interact with the barrier properties of the skin. Any defects or perturbations to this barr
Book Synopsis Pharmacology of the Skin by : Hasan Mukhtar
Download or read book Pharmacology of the Skin written by Hasan Mukhtar and published by Springer. This book was released on 1991-12-07 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a balanced, state-of-the-art summary of pharmacology as it relates to the skin. Topics discussed include structure of the skin and its barrier function; model systems for research in skin pharmacology; the drug metabolizing capability of the skin, skin pharmacology in health and disease; the role of oxidants and antioxidants in the skin; immunopharmacology of the skin; signal transduction, protein kinase C and the role of the eicosanoid receptors in skin; and cutaneous chemical- and photo-carcinogenesis. Pharmacology of the Skin provides essential information for investigators working in cutaneous biology, investigative and clinical dermatologists, pharmacologists, pharmacists, biochemists, and workers in the pharmaceutical industry engaged in drug development.
Book Synopsis Dermatotoxicology by : Klaus Peter Wilhelm
Download or read book Dermatotoxicology written by Klaus Peter Wilhelm and published by CRC Press. This book was released on 2012-09-27 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: The foundational reference in dermal toxicology, this classic text has been completely revised to bring it up to date in the new Eighth Edition, with almost a third of its chapters being newly added. The structure of the text has also been reorganized to enable easier location of a topic of interest. With contributions from leading international ex
Book Synopsis Exogenous Dermatology by : Christian Surber
Download or read book Exogenous Dermatology written by Christian Surber and published by S Karger Ag. This book was released on 1995 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This concise collection of contributions brings together researchers from many areas of dermatology, including allergology, bioengineering and pharmacology, in commemoration of the 65th birthday of Howard I. Maibach. It reflects only a small number of the fields where Professor Maibach has made a lasting impression. Highlights of this volume include a study on an allergen bank and the ideas behind it, a comprehensive presentation of textile dye contact allergens, and the clinical standardization of the TRUE Test formaldehyde patch. Contributions in bioengineering and occupational dermatology deal with quantification of biophysical properties of the skin, irritancy exposure assessment in metal workers, and the effects of surfactants on skin hydration. A large section on skin pharmacology provides the reader with solid research data and incisive commentaries from researchers and leading authorities on issues of in vitro and in vivo percutaneous absorption, skin metabolism, topical bioavailability and bioequivalency. Dermatologists, pharmacologists and toxicologists will have much to gain from having a copy of this volume close at hand.
Book Synopsis Toxicology of Skin by : Howard I. Maibach
Download or read book Toxicology of Skin written by Howard I. Maibach and published by CRC Press. This book was released on 2001-03-15 with total page 573 pages. Available in PDF, EPUB and Kindle. Book excerpt: Toxic injury to the skin in the general population, and particularly in western populations, is on the increase. This is partly due to the expanding number of natural and man-made chemicals present in our everyday environment. The need for a thorough understanding of the skin, and the mechanisms of toxicity therein, has never been more pressing. Th
Download or read book Pharmacology of the Skin I written by and published by Springer. This book was released on 2011-12-21 with total page 510 pages. Available in PDF, EPUB and Kindle. Book excerpt: The recent interest in the pharmacology of the skin and the treatment of its diseases has come about for two reasons. The first is a realisation that many aspects of pharmacology can be studied as easily in human skin, where they may be more relevant to human physiology and diseases, as in animal models. Examples of this are the action of various vasoactive agents and the isolation of mediators of inflammation after UV irradiation and antigen-induced dermatitis. The second reason is the fortuitous realisation that a pharmacological approach to the treatment of skin disease need not always await the full elucidation of etiology and mechanism. For example, whilst the argument continued unresolved as to whether the pilo-sebaceous infection which constitutes acne was due to a blocked duct or to a simple increase in sebum production, 13-cis-retinoic acid was found quite by chance totally to ablate the disease; again, whilst cyclosporin, fresh from its triumphs in organ transplantation, has been found able to suppress the rash of psoriasis, it has resuscitated the debate on etiology. We are therefore entering a new era in which the pharmacology and clinical pharmacology of skin are being studied as a fascinating new way of exploring questions of human physiology and pharmacology as well as an important step in the development and study of new drugs, use of which will improve disease control and at the same time help to define pathological mechanisms.
Book Synopsis Dermatology, Clinical Pharmacology, Toxicology, Environmental Medicine, Psychiatry by : William J. Harrington
Download or read book Dermatology, Clinical Pharmacology, Toxicology, Environmental Medicine, Psychiatry written by William J. Harrington and published by . This book was released on 1976 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Skin Reactions to Drugs by : Kirsti Kauppinen
Download or read book Skin Reactions to Drugs written by Kirsti Kauppinen and published by CRC-Press. This book was released on 1998-06-01 with total page 178 pages. Available in PDF, EPUB and Kindle. Book excerpt: Emphasising the mechanisms and clinical and laboratory proof of a cause-and-effect relationship between drugs and adverse reactions, this book discusses the technique of drug challenge, which has been extensively developed in Finland, but not commonly practiced in the rest of the world. 12 of the most common drug eruptions are described both clinically and histologically. It features a chapter on systemic contact dermatitis and also addresses cutaneous adverse drug reactions that appear in HIV-infected patients. 40 full-color photographs provide vivid examples of the reactions being discussed. A highly practical resource for practicing physicians and other health care workers.
Download or read book Dermatotoxicology written by Hongbo Zhai and published by CRC Press. This book was released on 2004-02-25 with total page 1232 pages. Available in PDF, EPUB and Kindle. Book excerpt: For twenty-five years, Dermatotoxicology has stood as the definitive reference book in the field. A generation of toxicologists and dermatologists has consulted this volume throughout their careers, finding within it a wealth of theoretical and practical guidance. Updated and expanded to reflect the latest developments in skin toxicology, De
Book Synopsis Metals and the Skin by : Richard H. Guy
Download or read book Metals and the Skin written by Richard H. Guy and published by CRC Press. This book was released on 1999-04-05 with total page 440 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Addresses the increase of toxic heavy metals in the environment. Sets the standard for future research in interactions between the skin and metals and metal compounds-covering the general toxicology of 35 metals and metalloids, their occurrence in the environment, significance in nutrition, skin diffusivity, occupational exposure risks, and immunotoxicity."
Book Synopsis DERMATOTOXICOLOGY 4ED by : Francis Nicholas Marzulli
Download or read book DERMATOTOXICOLOGY 4ED written by Francis Nicholas Marzulli and published by CRC Press. This book was released on 1991-06 with total page 1116 pages. Available in PDF, EPUB and Kindle. Book excerpt: A guide to the field of dermatotoxicology. This edition includes fundamental information on the mechanisms of action of toxic substances on skin as well as practical information on the varied responses of skin to specific toxic substances and approaches to evaluating dermal toxicity. Other topics discussed include: hostile natural elements, such as ultraviolet radiation, poisonous plants, man-made detergents and chemicals; problems associated with chronic occupational skin exposure to toxic chemicals; animal alternative research programmes; carcinogenic and Photo Carcinogenic Potential Of Xenobiotic Chemicals; Oculotoxicity; Risk assessment and management; and cosmetic safety. Anatomical factors affecting barrier functions/ lipids of the permeability barrier/the skin immune system.
Book Synopsis Skin Sensitization in Chemical Risk Assessment by : World Health Organization
Download or read book Skin Sensitization in Chemical Risk Assessment written by World Health Organization and published by World Health Organization. This book was released on 2008 with total page 91 pages. Available in PDF, EPUB and Kindle. Book excerpt: This Harmonization Project Document presents the conclusions of an IPCS Workshop on Skin Sensitization in Chemical Risk Assessment. The workshop focused on the question of methods for dose-response assessment, to evaluate the relative ability of a chemical to induce sensitization in the skin, and hence inform risk assessment for humans. In addition this publication includes a series of short articles on this topic by leading experts in the field. The conclusions of the workshop cover such aspects as the nature and utility for risk assessment of the data produced by non-animal test methods (such as quantitative structure-activity relationships), in vitro testing approaches, animal test methods, and epidemiological studies. While traditional animal test methods used for identification and regulation of skin sensitizers have focused on determining whether or not a substance is a sensitizer, this report describes the use of tests for deriving more informative potency information. This book will be useful to toxicologists, researchers, regulatory authorities and industry.
Book Synopsis Dermal Absorption and Toxicity Assessment, Second Edition by : Michael S. Roberts
Download or read book Dermal Absorption and Toxicity Assessment, Second Edition written by Michael S. Roberts and published by CRC Press. This book was released on 2008 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: The source Dermal Absorption and Toxicity Assessment supplies a state-of-the-art overview of the dermal absorption process, and is divided into six well organized sections. Written by internationally recognized experts in the field, this Second Edition is a complete revised and updated text, covering the wide range of methods used to assess skin absorption and the various governmental and industrial programs concerned with skin permeation and toxicity. These include alternative in silico, in vitro, and in vivo strategies to conduct studies for regulatory requirements. To make room for this new expanded content, the editors are publishing a concurrent text entitled: Dermatological and Cosmetic Development with a concentration on subjects concerned with dermatological and cosmetic therapies
Download or read book Skin Permeability written by H. Schaefer and published by Springer. This book was released on 2011-12-06 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt:
