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Simulating Particle Deposition In A Human Replica Lung Model
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Book Synopsis Simulating Particle Deposition in a Human Replica Lung Model by : Pravir Kumar Rai
Download or read book Simulating Particle Deposition in a Human Replica Lung Model written by Pravir Kumar Rai and published by . This book was released on 2004 with total page 188 pages. Available in PDF, EPUB and Kindle. Book excerpt: Presents the numerical simulation results on the 3 generation Weibel lung model and a 3-dimensional morphologically accurate human replica lung model made from MRI scans of a hollow cast taken from autopsy. Velocity profiles, secondary flows, wall shear rate as well as particle deposition were studied. Specific carcinogen particles examined were NNK and BaP, present in cigarette smoke.
Book Synopsis Particle Deposition in Replica Healthy and Emphysematous Alveolar Models Using Computational Fluid Dynamics by : Edward M. Harding
Download or read book Particle Deposition in Replica Healthy and Emphysematous Alveolar Models Using Computational Fluid Dynamics written by Edward M. Harding and published by . This book was released on 2010 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Particle deposition in the pulmonary region of the lung has gained increasing interest in the past years. Of particular interest are nano-sized particles, because they have the potential of crossing the blood-gas barrier and into the capillaries. Many factors contribute to how and where particles deposit, such as lung morphology, breathing conditions, fluid flow characteristics, and alveolar wall movement. These many factors make simulating particle deposition in the alveoli difficult. The experimental in vivo studies have commonly used micron sized particles and there is a lack of data for smaller sized particles. Due to these many factors, deposition in the pulmonary region is not well understood. Furthermore, little attention has been paid to the emphysematous lungs, which have characteristics quite different than the healthy lung. In this work, healthy and emphysematous replica acinus models were created from human lung casts using a 3D reconstruction software package. The models were used for simulating the particle deposition due to diffusion using Fine Particle Model (FPM). The FPM program was validated against an analytical solution using a straight tube, before moving on to predict the deposition in the alveolar models. Two particle sizes, 1 and 3 nm, were used to understand and compare pure diffusion in the lung using concentration contours. Results showed the particle deposition rate (particles/s) to be higher in the emphysemic. However, deposition rate per area (particles/m2s) was found to be higher in the healthy model. The deposition efficiency (% of particles that deposit) of the healthy model was greater than the emphysemic model, consistent with literature. Results were found to be lower than experimental in vivo measurements and whole lung model of local alveolar deposition (particles deposited in alveoli/particles entering alveoli) in comparison to our results in the pulmonary region, showing the importance of including axial diffusion effects. More work must be done experimentally and numerically before an understanding of deposition of particles of this size can be determined."--Abstract.
Book Synopsis Numerical Simulation of Particle Deposition in the Human Lungs by : Thomas Gengenbach
Download or read book Numerical Simulation of Particle Deposition in the Human Lungs written by Thomas Gengenbach and published by . This book was released on 2012 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Computational Fluid and Particle Dynamics in the Human Respiratory System by : Jiyuan Tu
Download or read book Computational Fluid and Particle Dynamics in the Human Respiratory System written by Jiyuan Tu and published by Springer Science & Business Media. This book was released on 2012-09-18 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional research methodologies in the human respiratory system have always been challenging due to their invasive nature. Recent advances in medical imaging and computational fluid dynamics (CFD) have accelerated this research. This book compiles and details recent advances in the modelling of the respiratory system for researchers, engineers, scientists, and health practitioners. It breaks down the complexities of this field and provides both students and scientists with an introduction and starting point to the physiology of the respiratory system, fluid dynamics and advanced CFD modeling tools. In addition to a brief introduction to the physics of the respiratory system and an overview of computational methods, the book contains best-practice guidelines for establishing high-quality computational models and simulations. Inspiration for new simulations can be gained through innovative case studies as well as hands-on practice using pre-made computational code. Last but not least, students and researchers are presented the latest biomedical research activities, and the computational visualizations will enhance their understanding of physiological functions of the respiratory system.
Book Synopsis Particle Deposition Studies in a Human Lung Bifurcation Model by : Jeffrey Hsu
Download or read book Particle Deposition Studies in a Human Lung Bifurcation Model written by Jeffrey Hsu and published by . This book was released on 1994 with total page 210 pages. Available in PDF, EPUB and Kindle. Book excerpt: A human lung bifurcation model was designed and developed specifically to measure particle deposition.
Book Synopsis Voltaire en son temps by : René Pomeau
Download or read book Voltaire en son temps written by René Pomeau and published by . This book was released on 1995 with total page 876 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Construction of in Vitro Human Breathing Lung Model for Observation of Particle Deposition by : Yuan-Yuan Hsiao
Download or read book Construction of in Vitro Human Breathing Lung Model for Observation of Particle Deposition written by Yuan-Yuan Hsiao and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Simulation of Turbulent Airflow and Particle Deposition in Human and Animal Airways by : Taylor Steven Geisler
Download or read book Simulation of Turbulent Airflow and Particle Deposition in Human and Animal Airways written by Taylor Steven Geisler and published by . This book was released on 2019 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Prolonged exposure to inhaled micron-sized airborne particles is a known public health concern. These particles impact the health of staggering numbers of residents of polluted urban areas, as well as significant portions of the third world where it is still common to burn wood or charcoal indoors for cooking or heating. An understanding of the fate of inhaled particles in the lungs is useful for assessing their associated health risks, as well as improving the effectiveness of respiratory drug delivery techniques. The transport of microparticles is inseparable from behavior of the suspending airflow and this is studied using computational fluid dynamics techniques. The anatomy of the airways seems to have evolved to encourage turbulent airflow for functions such as mixing of flow to promote the warming and humidification of inhaled air, as well as for filtration. Large eddy simulation models are employed to capture turbulent flow in extremely complex patient-specific airway geometries. These collectively comprise the oral and nasal cavities, larynx, trachea, and the bronchial tree. The flow in anatomically-accurate rhesus macaque airways is also studied. Simulations are carried out for inspiratory flow rates corresponding to nominal Reynolds numbers in the hundreds to low-thousands yet somewhat surprisingly yield unsteady flows due to local geometric factors. A computed mean flow field is compared extensively with magnetic resonance velocimetry measurements carried out in the same computed-tomography--based lung geometry, showing good agreement. Microparticle deposition predictions are also verified. Focus is placed on the dynamics of the flow in the nasal airway, trachea, and bronchial tree. After becoming unsteady at constrictions in the upper airways, the flow is found to be chaotic, exhibiting fluctuations with broad-band spectra even at the most distal simulated airways in which the Reynolds numbers are as low as 300. The unsteadiness is attributed to the convection of turbulent structures produced in the upper airways as well as to local kinetic energy production throughout the bronchial tree.
Book Synopsis Particle Deposition Driven by Vortex Pairs in the Human Lung by : Franka Schröder
Download or read book Particle Deposition Driven by Vortex Pairs in the Human Lung written by Franka Schröder and published by . This book was released on 2015 with total page 144 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Numerical Simulation of Airflow, Particle Deposition and Drug Delivery in a Representative Human Nasal Airway Model by : Huawei Shi
Download or read book Numerical Simulation of Airflow, Particle Deposition and Drug Delivery in a Representative Human Nasal Airway Model written by Huawei Shi and published by . This book was released on 2006 with total page 187 pages. Available in PDF, EPUB and Kindle. Book excerpt: Keywords: CFD, drug delivery, airflow, particle deposition, nasal airway.
Book Synopsis Computer Simulation of Inspiratory Flow and Particle Deposition in Human Oral Airway by : Xiaobo Zhu
Download or read book Computer Simulation of Inspiratory Flow and Particle Deposition in Human Oral Airway written by Xiaobo Zhu and published by . This book was released on 2001 with total page 104 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Particle-Lung Interactions by : Peter Gehr
Download or read book Particle-Lung Interactions written by Peter Gehr and published by CRC Press. This book was released on 2009-09-25 with total page 324 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written by an expanded team of leading international scientists, the second edition thoroughly investigates research and therapies for managing adverse physiological effects of air-borne particles on the respiratory tract. The book examines the lung as the gateway for particle damage to organs outside the respiratory system and provide the informat
Book Synopsis Computational Fluid and Particle Dynamics in the Human Respiratory System by : Jiyuan Tu
Download or read book Computational Fluid and Particle Dynamics in the Human Respiratory System written by Jiyuan Tu and published by Springer Science & Business Media. This book was released on 2012-09-17 with total page 383 pages. Available in PDF, EPUB and Kindle. Book excerpt: Traditional research methodologies in the human respiratory system have always been challenging due to their invasive nature. Recent advances in medical imaging and computational fluid dynamics (CFD) have accelerated this research. This book compiles and details recent advances in the modelling of the respiratory system for researchers, engineers, scientists, and health practitioners. It breaks down the complexities of this field and provides both students and scientists with an introduction and starting point to the physiology of the respiratory system, fluid dynamics and advanced CFD modeling tools. In addition to a brief introduction to the physics of the respiratory system and an overview of computational methods, the book contains best-practice guidelines for establishing high-quality computational models and simulations. Inspiration for new simulations can be gained through innovative case studies as well as hands-on practice using pre-made computational code. Last but not least, students and researchers are presented the latest biomedical research activities, and the computational visualizations will enhance their understanding of physiological functions of the respiratory system.
Book Synopsis Morphometry of the Human Lung by : Ewald R. Weibel
Download or read book Morphometry of the Human Lung written by Ewald R. Weibel and published by Academic Press. This book was released on 2013-10-22 with total page 164 pages. Available in PDF, EPUB and Kindle. Book excerpt: Morphometry of the Human Lung considers the developments in understanding the quantitative anatomy of the lung, and in the correlation of anatomy with physiology. This book is composed of 11 chapters, and begins with an overview of a systematic approach to a quantitative morphologic analysis of the architecture of the human lung, followed by a presentation of general problems of methodology and the derivation of reliable dimensional models of this organ. The subsequent chapters describe the methods of preparation of tissues, methods of random sampling, and adaptation of methodologies from other fields of science. These topics are followed by discussions the mathematical formulations for the translation of the data into the desired geometric forms and a technique of counting. The final chapters look into the mode of distribution and geometric forms that should eventually facilitate mathematical and physical considerations regarding the function of the lungs. These chapters also consider the application of these quantitative methods to the study of pathologic specimens, providing a most timely renovation of morphologic pathology. This book will be of value to pulmonologists, physiologists, and researchers who are interested in lung morphometry.
Author :United States. Public Health Service. Office of the Surgeon General Publisher : ISBN 13 : Total Pages :728 pages Book Rating :4.:/5 (318 download)
Book Synopsis How Tobacco Smoke Causes Disease by : United States. Public Health Service. Office of the Surgeon General
Download or read book How Tobacco Smoke Causes Disease written by United States. Public Health Service. Office of the Surgeon General and published by . This book was released on 2010 with total page 728 pages. Available in PDF, EPUB and Kindle. Book excerpt: This report considers the biological and behavioral mechanisms that may underlie the pathogenicity of tobacco smoke. Many Surgeon General's reports have considered research findings on mechanisms in assessing the biological plausibility of associations observed in epidemiologic studies. Mechanisms of disease are important because they may provide plausibility, which is one of the guideline criteria for assessing evidence on causation. This report specifically reviews the evidence on the potential mechanisms by which smoking causes diseases and considers whether a mechanism is likely to be operative in the production of human disease by tobacco smoke. This evidence is relevant to understanding how smoking causes disease, to identifying those who may be particularly susceptible, and to assessing the potential risks of tobacco products.
Book Synopsis Colloids in Drug Delivery by : Monzer Fanun
Download or read book Colloids in Drug Delivery written by Monzer Fanun and published by CRC Press. This book was released on 2016-04-19 with total page 652 pages. Available in PDF, EPUB and Kindle. Book excerpt: Colloidal drug delivery systems present a range of therapeutic benefits in the treatment of a number of challenging conditions, allowing researchers to cross barriers that have previously prevented efficient treatment while offering improved and more targeted absorption. Summarizing recent research in the field, Colloids in Drug Delivery assembles
Author :Sponsored by The Health Effects Institute Publisher :National Academies Press ISBN 13 :0309037263 Total Pages :703 pages Book Rating :4.3/5 (9 download)
Book Synopsis Air Pollution, the Automobile, and Public Health by : Sponsored by The Health Effects Institute
Download or read book Air Pollution, the Automobile, and Public Health written by Sponsored by The Health Effects Institute and published by National Academies Press. This book was released on 1988-01-01 with total page 703 pages. Available in PDF, EPUB and Kindle. Book excerpt: "The combination of scientific and institutional integrity represented by this book is unusual. It should be a model for future endeavors to help quantify environmental risk as a basis for good decisionmaking." â€"William D. Ruckelshaus, from the foreword. This volume, prepared under the auspices of the Health Effects Institute, an independent research organization created and funded jointly by the Environmental Protection Agency and the automobile industry, brings together experts on atmospheric exposure and on the biological effects of toxic substances to examine what is knownâ€"and not knownâ€"about the human health risks of automotive emissions.
