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Author : Inger Helene Madshus
Publisher :
ISBN 13 : 9783642536960
Total Pages : 204 pages
Book Rating : 4.5/5 (369 download)
Download or read book Signalling from Internalised Growth Factor Receptors written by Inger Helene Madshus and published by . This book was released on 2014-01-15 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Inger Helene Madshus
Publisher : Springer Science & Business Media
ISBN 13 : 3540694943
Total Pages : 190 pages
Book Rating : 4.5/5 (46 download)
Download or read book Signalling from Internalised Growth Factor Receptors written by Inger Helene Madshus and published by Springer Science & Business Media. This book was released on 2013-06-05 with total page 190 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.
Author : Christophe Lamaze
Publisher : Springer
ISBN 13 : 3319967045
Total Pages : 329 pages
Book Rating : 4.3/5 (199 download)
Download or read book Endocytosis and Signaling written by Christophe Lamaze and published by Springer. This book was released on 2018-08-10 with total page 329 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on the context dependency of cell signaling by showing how the endosomal system helps to structure and regulate signaling pathways. The location and concentration of signaling nodes regulate their activation cycles and engagement with distinct effector pathways. Whilst many cell signaling pathways are initiated from the cell surface, endocytosis provides an opportunity for modulating signaling networks’ output. In this book, first a series of reviews describe the endocytic and endosomal system and show how these subcellular platforms sort and regulate a wide range of signaling pathway components and phenotypic outputs. The book then reviews the latest scientific insights into how endocytic trafficking and subcellular location modulate a set of major pathways that are essential to normal cellular function and organisms’ development.
Author : G V Sherbet
Publisher : Elsevier
ISBN 13 : 0123878209
Total Pages : 368 pages
Book Rating : 4.1/5 (238 download)
Download or read book Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy written by G V Sherbet and published by Elsevier. This book was released on 2011-07-12 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: Recent years have seen a considerable emphasis on growth factors and the elucidation of their mode of function, which has led to the recognition that growth factors, their receptors as well as downstream elements of signalling associated with their function might be potential targets in therapeutic management of human diseases. Humanised monoclonal antibodies raised against growth factor receptors have proved to be valuable for targeted cancer treatment and in patient management. This book reviews the latest developments providing insights into the signalling processes involved in morphogenesis and pathogenesis with emphasis on using the elements of the signalling cascades as targets for therapeutic deployment. Provides a fundamental understanding of the basic functions of growth factors and their receptors, describing how they are linked in biological processes Aids the development of therapeutic treatments for cancer Focuses on the interrelationships and convergence of growth factors and their receptors in development and pathogenesis and encourages greater cooperation and integration in the areas of developmental, cancer and cancer therapeutic research
Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0080920918
Total Pages : 3048 pages
Book Rating : 4.0/5 (89 download)
Download or read book Handbook of Cell Signaling written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2009-11-03 with total page 3048 pages. Available in PDF, EPUB and Kindle. Book excerpt: Handbook of Cell Signaling, Three-Volume Set, 2e, is a comprehensive work covering all aspects of intracellular signal processing, including extra/intracellular membrane receptors, signal transduction, gene expression/translation, and cellular/organotypic signal responses. The second edition is an up-to-date, expanded reference with each section edited by a recognized expert in the field. Tabular and well illustrated, the Handbook will serve as an in-depth reference for this complex and evolving field. Handbook of Cell Signaling, 2/e will appeal to a broad, cross-disciplinary audience interested in the structure, biochemistry, molecular biology and pathology of cellular effectors. Contains over 350 chapters of comprehensive coverage on cell signaling Includes discussion on topics from ligand/receptor interactions to organ/organism responses Provides user-friendly, well-illustrated, reputable content by experts in the field
Author : Robert C. Bast, Jr.
Publisher : John Wiley & Sons
ISBN 13 : 111900084X
Total Pages : 2008 pages
Book Rating : 4.1/5 (19 download)
Download or read book Holland-Frei Cancer Medicine written by Robert C. Bast, Jr. and published by John Wiley & Sons. This book was released on 2017-03-10 with total page 2008 pages. Available in PDF, EPUB and Kindle. Book excerpt: Holland-Frei Cancer Medicine, Ninth Edition, offers a balanced view of the most current knowledge of cancer science and clinical oncology practice. This all-new edition is the consummate reference source for medical oncologists, radiation oncologists, internists, surgical oncologists, and others who treat cancer patients. A translational perspective throughout, integrating cancer biology with cancer management providing an in depth understanding of the disease An emphasis on multidisciplinary, research-driven patient care to improve outcomes and optimal use of all appropriate therapies Cutting-edge coverage of personalized cancer care, including molecular diagnostics and therapeutics Concise, readable, clinically relevant text with algorithms, guidelines and insight into the use of both conventional and novel drugs Includes free access to the Wiley Digital Edition providing search across the book, the full reference list with web links, illustrations and photographs, and post-publication updates
Author : Derek Leroith
Publisher : Springer Science & Business Media
ISBN 13 : 9780306478468
Total Pages : 524 pages
Book Rating : 4.4/5 (784 download)
Download or read book Insulin-like Growth Factor Receptor Signalling written by Derek Leroith and published by Springer Science & Business Media. This book was released on 2003-07-31 with total page 524 pages. Available in PDF, EPUB and Kindle. Book excerpt: Insulin-like growth factors are ubiquitously expressed and are crucial for growth and function of almost all cells. Together with their binding proteins and receptors, they form a widely studied biological system involving many proteins and characterized by complex interactions. In addition to its significance in growth and development, the insulin-like growth factor system also has important roles in a wide variety of pathological states. This has led to interest in the therapeutic potential of insulin-like growth factors and their binding proteins as candidate drug targets. This comprehensive book contains current information on both basic science and clinical aspects of IGFs and their regulatory proteins, with emphasis on their relevance to cancer.
Author :
Publisher : ScholarlyEditions
ISBN 13 : 1464996369
Total Pages : 270 pages
Book Rating : 4.4/5 (649 download)
Download or read book Peptide Receptors—Advances in Research and Application: 2012 Edition written by and published by ScholarlyEditions. This book was released on 2012-12-26 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: Peptide Receptors—Advances in Research and Application: 2012 Edition is a ScholarlyEditions™ eBook that delivers timely, authoritative, and comprehensive information about Peptide Receptors. The editors have built Peptide Receptors—Advances in Research and Application: 2012 Edition on the vast information databases of ScholarlyNews.™ You can expect the information about Peptide Receptors in this eBook to be deeper than what you can access anywhere else, as well as consistently reliable, authoritative, informed, and relevant. The content of Peptide Receptors—Advances in Research and Application: 2012 Edition has been produced by the world’s leading scientists, engineers, analysts, research institutions, and companies. All of the content is from peer-reviewed sources, and all of it is written, assembled, and edited by the editors at ScholarlyEditions™ and available exclusively from us. You now have a source you can cite with authority, confidence, and credibility. More information is available at http://www.ScholarlyEditions.com/.
Author :
Publisher :
ISBN 13 :
Total Pages : 1808 pages
Book Rating : 4.:/5 (31 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1999 with total page 1808 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : G. V. Sherbet
Publisher : Elsevier
ISBN 13 : 9780323165310
Total Pages : 368 pages
Book Rating : 4.1/5 (653 download)
Download or read book Growth Factors and Their Receptors in Cell Differentiation, Cancer and Cancer Therapy written by G. V. Sherbet and published by Elsevier. This book was released on 2011-07 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Bruce Alberts
Publisher :
ISBN 13 : 9780815332183
Total Pages : 0 pages
Book Rating : 4.3/5 (321 download)
Download or read book Molecular Biology of The Cell written by Bruce Alberts and published by . This book was released on 2002 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Y. Kitagawa
Publisher : Elsevier Science
ISBN 13 : 9781559383448
Total Pages : 236 pages
Book Rating : 4.3/5 (834 download)
Download or read book Signal Transduction through Growth Factor Receptors written by Y. Kitagawa and published by Elsevier Science. This book was released on 1994-06-15 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intense interest has been focused on the proliferation and differentiation of cells in multicellular organisms, because these events play a key role in embryogenesis, and coordinate the development and maintenance of the whole body by recruiting the mature cells with specific functions and regulating the formation of organs. Proteins, called growth factors, are mainly responsible for determining the fate of cells. The actions of growth factors are mediated by their interaction with specific receptors composed of an extracellular ligand-binding portion, a membrane spanning region, and a cytoplasmic region. The most important question is: How is the interaction of a ligand with its receptor transferred through the cytoplasmic membrane into the intracellular machinery that governs cell behavior? Tremendous efforts devoted to cloning growth factor receptors have made it possible to dissect receptor structures into functional domains: a ligand-binding site, a signal transducer region, and a regulatory domain. The first exciting finding was that receptors for epidermal growth factor (EGF), insulin, insulin-like growth factor (JGF), platelet-derived growth factor (PDGF), and several other growth factors were tyrosine kinases that were regulated by binding to individual specific ligands; the receptors are membrane-associated allosteric enzymes. In addition to the tyrosine kinase receptor family, a new receptor family has recently been found which has no tyrosine kinase domain, but has two characteristic conserved features (two pairs of cysteines and a Trp-Ser-X-Trp-Ser motif) in the extracellular region. Receptors of prolactin, growth hormone, and several hemopoietic growth factors including IL-2, IL-3, IL-5, IL-6, granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), and erythropoietin belong to this new family. Some chapters selected for this volume deal with two tyrosine kinase receptors (receptors for insulin and hepatocyte growth factor), six receptors (for IL-3, IL-5, IL-6, G-CSF, GM-CSF, and erythropoietin) in a new receptor family, and one unique receptor (IL-1 receptor) that does not belong to any known receptor family. Emphasis on a new receptor family is possible because of remarkable progress in the elucidation of receptor compnents that construct high-affinity ligand binding sites and signal transducers. Although we are still far from a full understanding of the molecular bases connecting ligand binding with cell behavior, the editors believe that one can appreciate through these authoritative reviews where the field is now and where it is proceeding in the years ahead.
Author : John D. Haley
Publisher : Springer Science & Business Media
ISBN 13 : 1597453560
Total Pages : 393 pages
Book Rating : 4.5/5 (974 download)
Download or read book EGFR Signaling Networks in Cancer Therapy written by John D. Haley and published by Springer Science & Business Media. This book was released on 2009-03-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.
Author : Satu Vainikka
Publisher :
ISBN 13 : 9789529079735
Total Pages : 56 pages
Book Rating : 4.0/5 (797 download)
Download or read book Signal Transduction and Expression of Fibroblast Growth Factor Receptor-4 written by Satu Vainikka and published by . This book was released on 1996 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : John Hancock
Publisher : Oxford University Press
ISBN 13 : 0198859589
Total Pages : 183 pages
Book Rating : 4.1/5 (988 download)
Download or read book Cell Signalling written by John Hancock and published by Oxford University Press. This book was released on 2021 with total page 183 pages. Available in PDF, EPUB and Kindle. Book excerpt: Written primarily for students embarking on an undergraduate bioscience degree, this primer provides a clear introduction to the main aspects of cell signalling in biological systems, demystifying the subject for those new to the field. The primer provides an overview of cell signalling and highlights its importance in all organisms, before going on to describe the main components of cell signalling and examples of signal transduction pathways. The discussion then progresses on to key physiological conditions in which cell signalling has an instrumental role: cancer, apoptosis and diabetes. After getting to grips with the fundamentals of the subject, Cell Signalling opens a discussion on the future of the discipline, including how manipulation of cell signalling pathways is seen as the biggest target for the pharmaceutical industry, and how crop diseases, plant survival during stress, and post-harvest storage are all influenced by cell signalling pathways. Cell Signalling is supported by online resources and is available for students and institutions to purchase in a variety of formats. The e-book offers a mobile experience and convenient access along with functionality tools, navigation features and links that offer extra learning support: www.oxfordtextbooks.co.uk/ebooks The online resources include: For students: - Self-test questions For registered adopters of the book: - Figures from the book, available to download
Author : Andreja Ambriovic-Ristov
Publisher : Frontiers Media SA
ISBN 13 : 2832517781
Total Pages : 252 pages
Book Rating : 4.8/5 (325 download)
Download or read book Integrin adhesion receptors in health and disease written by Andreja Ambriovic-Ristov and published by Frontiers Media SA. This book was released on 2023-03-17 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ralph A. Bradshaw
Publisher : Academic Press
ISBN 13 : 0123822122
Total Pages : 456 pages
Book Rating : 4.1/5 (238 download)
Download or read book Functioning of Transmembrane Receptors in Signaling Mechanisms written by Ralph A. Bradshaw and published by Academic Press. This book was released on 2011-04-05 with total page 456 pages. Available in PDF, EPUB and Kindle. Book excerpt: A primary component of cell signaling research, this title covers the principal membrane-bound receptor families, including their structural organization. Written and edited by experts in the field, this book provides up-to-date research on transmembrane signaling entities and their initiating responses following extracellular stimulation. Articles written and edited by experts in the field Thematic volume covering effectors, cytosolic events, nuclear, and cytoplasmic events Up-to-date research on signaling systems and mutations in transcription factors that provide new targets for treating disease
