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Author : Ingolf E Blasig
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (819 download)
Download or read book Signal Transduction in the Blood-brain Barrier written by Ingolf E Blasig and published by . This book was released on 2001 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Amrit Rattan K. Baidwan-macfarland
Publisher : Authorhouse UK
ISBN 13 : 9781728386867
Total Pages : 302 pages
Book Rating : 4.3/5 (868 download)
Download or read book Signal and Response - Signal Transduction written by Amrit Rattan K. Baidwan-macfarland and published by Authorhouse UK. This book was released on 2019-03-30 with total page 302 pages. Available in PDF, EPUB and Kindle. Book excerpt: The ground-breaking scientific study of Amrit Rattan K Baidwan Macfarland (Amrit K Macfarland) asks why and how malignant cancers can be cured. This scientific status is visualised through novel ALL cells lines in vitro, in vivo, and in developing natural human foetal tissues. The resistance status of malignancy to treatment is determined by an inextricable connection between P-gp expression in malignant cell membranes exposed to drugs, blood-brain barrier developmental cells in human foetal cells, and ALL blood cells undergoing chemotherapy. A new type of concept is introduced here as a human P-gp resistance amalgamation (P-gp-MDR) is conceived. Multidrug resistance is created due to cellular and barrier programs through the expression of a membrane drug efflux pump with an ability to create downstream signal transduction systems and which regulates its function and activity. This includes cellular and barrier capacities to generate unforeseen, innovative signalling pathways on multiple levels that can jeopardise treatment pathways at key stages in a fatal way. At present, these systems were unrecognised as potential elements for targeting the killing of deadly malignancies, both in primary and secondary forms. The fact that the blood-brain barrier is such a robust, intelligent entity, interfaced between blood and brain, indicates that it is the essential guardian for the survival of the brain, and thus all human biological systems depend on it. Its expression is seen in developing foetal brain tissues. However, it is also a stumbling block to the eradication of malignant cells. These findings of inducible P-gp expression in cancer cells and those that will constitute the blood-brain barrier creates intense tension both in the malignant systems as well as in the natural systems surrounding them, raising questions as to how to intervene to preserve the normal and retain its autonomy whilst destroying destructive actions, like hijackings by the malignant cells; the source of these abnormal responses remains to be answered. This book dynamically argues that P-gp MDR 1 and MDR 3 and the expressive Pg-p brain-blood functions are necessary to address for new chemotherapeutic challenges. It is important to study in general and specific, intelligent malignant, and natural systems that create multidrug resistance to treatment. The creativity and actions of P-gp and its polymorphisms are distinct in natural cells and malignant cells, and P-gp and its polymorphisms are involved in the creation of acute multidrug resistance, and they act as deadly programmed protectors of the biological environments of malignant cells and the cells exposed to drug treatments. As such the structure and function of P-gp together constitutes fatal ends for the host and its systems - based on studies of human cell lines, in vitro systems, in vivo foetal systems, in vivo blood cell systems - and exhibits non-cooperation of cells to multidrug treatments. In short, ALL is a multifaceted disease and displays abnormal activation of signalling pathways, which in turn activate drug-resistance pumps. The ability to target elements that activate the drug transporter P-gp will then be key to success to overcome cancers in this cutting edge field of nano-micro-molecular genetics. AUTHORHOUSE - ACADEMIC PRESS
Author : Pierre-Olivier Couraud
Publisher : Springer Science & Business Media
ISBN 13 : 1475794894
Total Pages : 366 pages
Book Rating : 4.4/5 (757 download)
Download or read book Biology and Physiology of the Blood-Brain Barrier written by Pierre-Olivier Couraud and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 366 pages. Available in PDF, EPUB and Kindle. Book excerpt: The endothelial cells of the cerebral vasculature constitute, together with perivascular elements (astrocytes, pcricytes, basement membrane), the blood-brain barrier (BBB), which strictly limits and specifically controls the exchanges between the blood and the cerebral extracellular spacc.The existence of such a physical, enzymatic, and active barrier isolating the central nervous system has broad physiological, biological, pharmacological, and patho logical consequences, most of which are not yet fully elucidated. The Cerebral Vascular Biology conference (CVB '95) was organized and held at the "Carre des Sciences" in Paris on July I 0-12, 1995. Like the CVB '92 conference held in Duluth, Minnesota, three years ago, the objectives were to provide a forum for presentation of the most recent progresses and to stimulate discussions in the ticld of the biology, physiology. and pathology of the blood-brain barrier. The Paris conference gathered more than !50 participants. including investigators in basic neuroscience, physicians. and stu dents, who actively contributed to the scientific program by their oral or poster presentations. This volume contains a collection of short articles that summarize most of the new data that were presented at the conference. Six thematic parts focus on physiological transports. drug delivery, multidrug resistance P-glycoprotein, signal transduction at the BBB. interactions between the immune system and the cerebral endothelial cells, and the blood-brain barrier-related pathologies in the central nervous system. In addition, two introductory articles present new insights in the rapidly evolving topics of cerebral angiogenesis and gene transfer to the brain.
Author : William M. Pardridge
Publisher : Lippincott Williams & Wilkins
ISBN 13 :
Total Pages : 504 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Blood-brain Barrier written by William M. Pardridge and published by Lippincott Williams & Wilkins. This book was released on 1993 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The characterization of the blood-brain barrier (BBB) is undergoing a paradigm shift as the century-old concept of a passive, impermeable barrier that segregates blood and brain interstitial fluid is giving way to the idea that the BBB is a dynamic conduit for the transport between blood and brain of those nutrients, peptides, proteins, or immune cells that have access to certain transport systems localized within the BBB membranes. This volume contains 20 contributed chapters organized in four parts: cell-cell interactions, subcellular organelle function, signal transduction mechanisms, and gene expression. There is also a foreword by the late W.H. Oldendorf (1925-1992) on the teleology of the blood-brain barrier and the survival advantage conferred upon the organism by its presence in the vertebrate brain. Annotation copyright by Book News, Inc., Portland, OR
Author : Oliver von Bohlen und Halbach
Publisher : John Wiley & Sons
ISBN 13 : 3527609075
Total Pages : 402 pages
Book Rating : 4.5/5 (276 download)
Download or read book Neurotransmitters and Neuromodulators written by Oliver von Bohlen und Halbach and published by John Wiley & Sons. This book was released on 2006-12-13 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: A complete update of the highly acclaimed handbook with data on all neurotransmitters and the majority of neuromodulators. The coverage is now even more comprehensive, with 15% more entries on neuropeptides, "classic" neurotransmitters and related substances in a clear, alphabetical format. The methodological section has been expanded by 50% and now includes color figures, plus new chapters on genomics, proteomics, databases, microarrays, MALDI-TOF, neutrophins, FGF, endocannabinoids and neuroimaging. The text provides clearly structured information on the biosynthesis and degradation, localization, receptors, signal transduction pathways, and biological effects in the central nervous system, with all substances uniformly treated for an easy comparison of data. Furthermore, introductory chapters on receptors, transporters, and the blood-brain barrier make this an indispensable tool for researchers, teachers, and advanced students, as well as a must-have for every neuroscientist.
Author : Chase Wood
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (126 download)
Download or read book Structure and Mechanism of the Blood-brain Barrier Lipid Transporter MFSD2A written by Chase Wood and published by . This book was released on 2021 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ion channels and transporters carry out a variety of critical physiological processes, being pivotal in signal transduction, metabolism, and cellular homeostasis. The Major Facilitator Superfamily (MFS) represents the largest group of secondary active transporters identified to date, responsible for translocating numerous diverse substrates. Due to their diverse array of substrates, the MFS proteins represent attractive targets for drug discovery and mechanistic studies. Major facilitator superfamily containing domain 2a (Mfsd2a) is a novel lysolipid transporter within MFS, transporting docosahexanoic acid (DHA) conjugated to lysophosphatidylcholine (LPC), which is crucial for proper brain development. Mfsd2a's lipid transport function has also been found to be key for inhibiting transcytosis at the blood-brain barrier (BBB), ultimately regulating BBB permeability. An exciting possibility raised by this physiological function is modulating Mfsd2a to manipulate BBB permeability for therapeutic treatments. However, a lack of structural information impedes a mechanistic understanding of this key transporter. Herein, I detail the work to determine the cryo-EM structure of Mfsd2a. Based on the Mfsd2a structure, key residues important for activity have also been mapped out in order to improve our understanding of Mfsd2a transport mechanism. The insights into Mfsd2a lipid transport can be leveraged as a foundation to guide future therapeutic development.
Author : Wei Zheng
Publisher : CRC Press
ISBN 13 : 9781420023404
Total Pages : 668 pages
Book Rating : 4.0/5 (234 download)
Download or read book The Blood-Cerebrospinal Fluid Barrier written by Wei Zheng and published by CRC Press. This book was released on 2005-03-30 with total page 668 pages. Available in PDF, EPUB and Kindle. Book excerpt: Despite the existence of two barrier systems in the brain, research over the last century has mostly focused on the blood-brain barrier rather than on the blood-CSF barrier. Today, there is a greater understanding of the function of the blood-CSF barrier and of the choroid plexus, a tissue that is the primary site of this barrier. With the growing number of studies that focus on the role of the blood-CSF barrier in CNS homeostasis and neurological disorders, a modern overview of the blood-CSF barrier is long overdue. The Blood-Cerebrospinal Fluid Barrier is exclusively devoted to the blood-CSF barrier. Internationally renowned experts discuss the most recent progress in the field of choroid plexus physiology and update our knowledge of the function of the blood-CSF barrier. The book begins with an overview of the development and morphology of the choroid plexus, and then covers various aspects of its function, such as the regulation of choroidal blood flow, ion transport, and the production and transport of polypeptides. Following an extensive section on the role of the choroid plexus in CNS disorders, the final section discusses in vitro, in vivo, and in situ models of the blood-CSF barrier. This unique book analyzes a wealth of new research on the proven and potential roles of the choroid plexus/blood-CSF barrier in the brain. It is a valuable resource that will foster future studies in neuroscience, pharmacology, and toxicology.
Author : Derek J. Chadwick
Publisher : John Wiley & Sons
ISBN 13 : 0470319429
Total Pages : 260 pages
Book Rating : 4.4/5 (73 download)
Download or read book Vascular Development written by Derek J. Chadwick and published by John Wiley & Sons. This book was released on 2007-08-20 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: The formation of blood vessels is an essential aspect of embryogenesis in vertebrates. It is a central feature of numerous post-embryonic processes, including tissue and organ growth and regeneration. It is also part of the pathology of tumour formation and certain inflammatory conditions. In recent years, comprehension of the molecular genetics of blood vessel formation has progressed enormously and studies in vertebrate model systems, especially the mouse and the zebrafish, have identified a common set of molecules and processes that are conserved throughout vertebrate embryogenesis while, in addition, highlighting aspects that may differ between different animal groups. The discovery in the past decade of the crucial role of new blood vessel formation for the development of cancers has generated great interest in angiogenesis (the formation of new blood vessels from pre-existing ones), with its major implications for potential cancer-control strategies. In addition, there are numerous situations where therapeutic treatments either require or would be assisted by vasculogenesis (the de novo formation of blood vessels). In particular, post-stroke therapies could include treatments that stimulate neovascularization of the affected tissues. The development of such treatments, however, requires thoroughly understanding the developmental properties of endothelial cells and the basic biology of blood vessel formation. While there are many books on angiogenesis, this unique book focuses on exactly this basic biology and explores blood vessel formation in connection with tissue development in a range of animal models. It includes detailed discussions of relevant cell biology, genetics and embryogenesis of blood vessel formation and presents insights into the cross-talk between developing blood vessels and other tissues. With contributions from vascular biologists, cell biologists and developmental biologists, a comprehensive and highly interdisciplinary volume is the outcome.
Author : William M. Pardridge
Publisher : Cambridge University Press
ISBN 13 : 9780521581240
Total Pages : 504 pages
Book Rating : 4.5/5 (812 download)
Download or read book Introduction to the Blood-Brain Barrier written by William M. Pardridge and published by Cambridge University Press. This book was released on 1998-08-28 with total page 504 pages. Available in PDF, EPUB and Kindle. Book excerpt: The blood-brain barrier serves to protect the brain from toxic substances whilst simultaneously allowing access to essential nutrients and chemical signals. At the interface between brain and body, knowledge of the blood-brain barrier forms an essential component in the complete understanding of a large proportion of medical disciplines. Nevertheless, it seems that ignorance of both the biology of this important membrane and the methodology suitable for its investigation still remains an impediment to progress in many fields, including, for example, the development of new and efficacious neuropharmaceuticals, cerebrovascular disease, Alzheimer's disease, cerebral AIDS and brain tumours. This introduction for both researchers and clinicians across the medical sciences is intended to aid both those beginning work directly in this area and those wishing simply to be better informed when interpreting information where the blood-brain barrier may be involved. Advances in both methodology and biology are detailed in 50 chapters from international authorities.
Author : D.J. Begley
Publisher : Springer Science & Business Media
ISBN 13 : 1489910549
Total Pages : 323 pages
Book Rating : 4.4/5 (899 download)
Download or read book New Concepts of a Blood—Brain Barrier written by D.J. Begley and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 323 pages. Available in PDF, EPUB and Kindle. Book excerpt: The scientific contribution of Mike Bradbury to the study of the blood-brain barrier is considerable and wide-ranging, starting with his M.D. thesis in 1962 and still continuing today. The varied spectrum of topics relating to the blood-brain barrier presented in this volume and the many geographical locations from which both speakers and participants gathered to attend the symposium are a fitting testament both to Mike's wide-spread influence in the field and to the esteem in which he is held. When we first had the idea of afestschrift to mark Mike's retirement as Professor of Physiology at King's College London and the beginning of a new vie libre as scientist and yachtsman the plan was initially for a gathering of all of the many colleagues, collaborators and students who had worked with him over the years. However what we had not taken into account was the closeness of the international community of workers in the field, the widespread influence that Mike had wielded and the speed with which word would spread. We should have anticipated all three. The final outcome was an excellent symposium with the majority of the world's key workers either contributing or attending. We hope that this volume presents an adequate record of the meeting.
Author : Gert Fricker
Publisher : Springer
ISBN 13 : 3662437872
Total Pages : 169 pages
Book Rating : 4.6/5 (624 download)
Download or read book The Blood Brain Barrier (BBB) written by Gert Fricker and published by Springer. This book was released on 2014-10-24 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Medicinal chemistry is both science and art. The science of medicinal chemistry offers mankind one of its best hopes for improving the quality of life. The art of medicinal chemistry continues to challenge its practitioners with the need for both intuition and experience to discover new drugs. Hence sharing the experience of drug research is uniquely beneficial to the field of medicinal chemistry. Drug research requires interdisciplinary team-work at the interface between chemistry, biology and medicine. Therefore, the topic-related series Topics in Medicinal Chemistry covers all relevant aspects of drug research, e.g. pathobiochemistry of diseases, identification and validation of (emerging) drug targets, structural biology, drugability of targets, drug design approaches, chemogenomics, synthetic chemistry including combinatorial methods, bioorganic chemistry, natural compounds, high-throughput screening, pharmacological in vitro and in vivo investigations, drug-receptor interactions on the molecular level, structure-activity relationships, drug absorption, distribution, metabolism, elimination, toxicology and pharmacogenomics. In general, special volumes are edited by well known guest editors.
Author : Katerina Dorovini-Zis
Publisher : CRC Press
ISBN 13 : 1498727093
Total Pages : 390 pages
Book Rating : 4.4/5 (987 download)
Download or read book The Blood-Brain Barrier in Health and Disease, Volume Two written by Katerina Dorovini-Zis and published by CRC Press. This book was released on 2015-10-21 with total page 390 pages. Available in PDF, EPUB and Kindle. Book excerpt: Located at the interface between blood and the brain, the blood-brain barrier is a dynamic permeability barrier formed by a continuous layer of specialized endothelial cells endowed with important permeability, transport, and regulatory functions that both protect the internal milieu of the brain and allow essential nutrients to be transported into
Author : David Kobiler
Publisher : Springer Science & Business Media
ISBN 13 : 1461505798
Total Pages : 450 pages
Book Rating : 4.4/5 (615 download)
Download or read book Blood-Brain Barrier written by David Kobiler and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vasculature of the central nervous system (eNS) is characterized by the existence of the blood-brain barrier (BBB), which can be regarded as both an anatomical and physiological phenomenon. The BBB is formed by a complex cellular system of endothelial cells, astroglia, pericytes, perivascular macrophages and a basal membrane, although the anatomic substrate of the BBB is the interendothelial tight junctions that form a continuous sealing. The BBB serves as an exquisitely controlled, functional gate to the eNS. It not only protects the brain from agents in the blood that could impair neurological function, but also controls the influx and efflux of numerous substances to maintain proper homeostasis and provide the brain with necessary nutrients. The structural and functional integrity of the BBB was shown to be dramatically altered during various diseases of the eNS, including neoplasia, ischemia, trauma, hypertension, inflammation and epilepsy. Recent years research has partially elucidated the mechanisms underlying the development of some of these brain disorders as well as the pathways used by different pathogens, like bacteria and viruses, to initiate eNS infections. The development of in vitro models of the BBB had instrumental role in the understanding of the involvement of the BBB in the pathogenesis of several eNS diseases. The intimate, functional association between the function of the brain and the activity of the BBB makes the later a target for pharmacological modulation that will expand the therapeutic possibilities for a range of neurological diseases.
Author : Sarah Y. Yuan
Publisher : Biota Publishing
ISBN 13 : 1615041214
Total Pages : 160 pages
Book Rating : 4.6/5 (15 download)
Download or read book Regulation of Endothelial Barrier Function written by Sarah Y. Yuan and published by Biota Publishing. This book was released on 2011-02-01 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: The vascular endothelium lining the inner surface of blood vessels serves as the first interface for circulating blood components to interact with cells of the vascular wall and surrounding extravascular tissues. In addition to regulating blood delivery and perfusion, a major function of vascular endothelia, especially those in exchange microvessels (capillaries and postcapillary venules), is to provide a semipermeable barrier that controls blood–tissue exchange of fluids, nutrients, and metabolic wastes while preventing pathogens or harmful materials in the circulation from entering into tissues. During host defense against infection or tissue injury, endothelial barrier dysfunction occurs as a consequence as well as cause of inflammatory responses. Plasma leakage disturbs fluid homeostasis and impairs tissue oxygenation, a pathophysiological process contributing to multiple organ dysfunction associated with trauma, infection, metabolic disorder, and other forms of disease. In this book, we provide an updated overview of microvascular endothelial barrier structure and function in health and disease. The discussion is initiated with the basic physiological principles of fluid and solute transport across microvascular endothelium, followed by detailed information on endothelial cell–cell and cell–matrix interactions and the experimental techniques that are employed to measure endothelial permeability. Further discussion focuses on the signaling and molecular mechanisms of endothelial barrier responses to various stimulations or drugs, as well as their relevance to several common clinical conditions. Taken together, this book provides a comprehensive analysis of microvascular endothelial cell and molecular pathophysiology. Such information will assist scientists and clinicians in advanced basic and clinical research for improved health care.
Author :
Publisher : Elsevier
ISBN 13 : 044319405X
Total Pages : 304 pages
Book Rating : 4.4/5 (431 download)
Download or read book Blood-Brain Barrier written by and published by Elsevier. This book was released on 2024-07-20 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters. Each chapter is written by an international board of authors. Provides the latest information on blood-brain barrier research Offers outstanding and original reviews on a range ofblood-brain barrier research topics Serves as an indispensable reference for researchers and students alike
Author : Anthony J. Suckling
Publisher : Ellis Horwood
ISBN 13 :
Total Pages : 216 pages
Book Rating : 4.3/5 (91 download)
Download or read book The Blood-brain Barrier in Health and Disease written by Anthony J. Suckling and published by Ellis Horwood. This book was released on 1986 with total page 216 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Sukriti Nag
Publisher : Springer Science & Business Media
ISBN 13 : 1592594190
Total Pages : 543 pages
Book Rating : 4.5/5 (925 download)
Download or read book Blood'Brain Barrier written by Sukriti Nag and published by Springer Science & Business Media. This book was released on 2008-02-01 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Blood–brain barrier (BBB) breakdown leading to cerebral edema occurs in many brain diseases—such as trauma, stroke, inflammation, infection, and tumors—and is an important factor in the mortality arising from these con- tions. Despite the importance of the BBB in the pathogenesis of these diseases, the molecular mechanisms occurring at the BBB are not completely und- stood. In the last decade a number of molecules have been identified not only in endothelial cells, but also in astrocytes, pericytes, and the perivascular cells that interact with endothelium to maintain cerebral homeostasis. However, the precise cellular interactions at a molecular level in steady states and d- eases have still to be determined. The introduction of new research techniques during the last decade or so provide an opportunity to study the molecular mec- nisms occurring at the BBB in diseases. The Blood–Brain Barrier: Biology and Research Protocols provides the reader with details of selected morphologic, permeability, transport, in vitro, and molecular techniques for BBB studies, all written by experts in the field. Each part is preceded by a review that emphasizes the advantages and pitfalls of particular techniques, as well as offering much relevant current information. The techniques provided will be helpful to both beginners in BBB research and those more experienced investigators who wish to add a specific technique to those already available in their laboratories.
