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Author : Ingrid Charlotte Northwood
Publisher :
ISBN 13 :
Total Pages : 376 pages
Book Rating : 4.:/5 (26 download)
Download or read book Signal Transduction by the Epidermal Growth Factor Receptor written by Ingrid Charlotte Northwood and published by . This book was released on 1991 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Inger Helene Madshus
Publisher : Springer Science & Business Media
ISBN 13 : 3540694943
Total Pages : 208 pages
Book Rating : 4.5/5 (46 download)
Download or read book Signalling from Internalised Growth Factor Receptors written by Inger Helene Madshus and published by Springer Science & Business Media. This book was released on 2013-06-05 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews knowledge on the interconnection of signal transduction and endocytosis/intracellular trafficking. The chapters cover knowledge obtained by using different model systems. The first chapter deals with Receptor Tyrosin Kinases (RTKs) with emphasis on the Epidermal Growth Factor Receptor (EGF receptor) and the Platelet Derived Growth Factor Receptor (PDGF receptor). The second chapter deals with the RTK c-Met and with how this RTK becomes carcinogenic. The third chapter reviews recent understanding on the mechanisms of action of the numerous fibroblast growth factors and their receptors. In the fourth chapter we learn about the trafficking of and signalling from the Growth Hormone Receptor and how this receptor is controlled by ubiquitination. The fifth chapter is devoted to the Interleukin II receptor, essential for activation of T cells. Links between ubiquitination, signalling, endocytosis, and sorting are reviewed. The last chapter discusses current views on how monoubiquitination controls both signalling and trafficking and thereby the final outcome of receptor activation.
Author : Marcel Spaargaren
Publisher :
ISBN 13 : 9789039300541
Total Pages : 131 pages
Book Rating : 4.3/5 (5 download)
Download or read book Signal transduction by the epidermal growth factor receptor written by Marcel Spaargaren and published by . This book was released on 1992 with total page 131 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Rakesh Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1402078226
Total Pages : 331 pages
Book Rating : 4.4/5 (2 download)
Download or read book Molecular Targeting and Signal Transduction written by Rakesh Kumar and published by Springer Science & Business Media. This book was released on 2004-04-30 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.
Author : Gijsbertus Franciscus Maria Verheijden
Publisher :
ISBN 13 :
Total Pages : 105 pages
Book Rating : 4.:/5 (661 download)
Download or read book Epidermal Growth Factor Receptor Dimerization and Signal Transduction written by Gijsbertus Franciscus Maria Verheijden and published by . This book was released on 1992 with total page 105 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Y. Kitagawa
Publisher : Elsevier Science
ISBN 13 : 9781559383448
Total Pages : 236 pages
Book Rating : 4.3/5 (834 download)
Download or read book Signal Transduction through Growth Factor Receptors written by Y. Kitagawa and published by Elsevier Science. This book was released on 1994-06-15 with total page 236 pages. Available in PDF, EPUB and Kindle. Book excerpt: Intense interest has been focused on the proliferation and differentiation of cells in multicellular organisms, because these events play a key role in embryogenesis, and coordinate the development and maintenance of the whole body by recruiting the mature cells with specific functions and regulating the formation of organs. Proteins, called growth factors, are mainly responsible for determining the fate of cells. The actions of growth factors are mediated by their interaction with specific receptors composed of an extracellular ligand-binding portion, a membrane spanning region, and a cytoplasmic region. The most important question is: How is the interaction of a ligand with its receptor transferred through the cytoplasmic membrane into the intracellular machinery that governs cell behavior? Tremendous efforts devoted to cloning growth factor receptors have made it possible to dissect receptor structures into functional domains: a ligand-binding site, a signal transducer region, and a regulatory domain. The first exciting finding was that receptors for epidermal growth factor (EGF), insulin, insulin-like growth factor (JGF), platelet-derived growth factor (PDGF), and several other growth factors were tyrosine kinases that were regulated by binding to individual specific ligands; the receptors are membrane-associated allosteric enzymes. In addition to the tyrosine kinase receptor family, a new receptor family has recently been found which has no tyrosine kinase domain, but has two characteristic conserved features (two pairs of cysteines and a Trp-Ser-X-Trp-Ser motif) in the extracellular region. Receptors of prolactin, growth hormone, and several hemopoietic growth factors including IL-2, IL-3, IL-5, IL-6, granulocyte colony-stimulating factor (G-CSF), granulocyte/macrophage colony-stimulating factor (GM-CSF), and erythropoietin belong to this new family. Some chapters selected for this volume deal with two tyrosine kinase receptors (receptors for insulin and hepatocyte growth factor), six receptors (for IL-3, IL-5, IL-6, G-CSF, GM-CSF, and erythropoietin) in a new receptor family, and one unique receptor (IL-1 receptor) that does not belong to any known receptor family. Emphasis on a new receptor family is possible because of remarkable progress in the elucidation of receptor compnents that construct high-affinity ligand binding sites and signal transducers. Although we are still far from a full understanding of the molecular bases connecting ligand binding with cell behavior, the editors believe that one can appreciate through these authoritative reviews where the field is now and where it is proceeding in the years ahead.
Author : Norma D. Flores
Publisher :
ISBN 13 :
Total Pages : 176 pages
Book Rating : 4.:/5 (862 download)
Download or read book Mechanism of Primary Signal Transduction in Epidermal Growth Factor Receptor written by Norma D. Flores and published by . This book was released on 1999 with total page 176 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : R.B. Lichtner
Publisher : Springer Science & Business Media
ISBN 13 : 3662033917
Total Pages : 303 pages
Book Rating : 4.6/5 (62 download)
Download or read book EGF Receptor in Tumor Growth and Progression written by R.B. Lichtner and published by Springer Science & Business Media. This book was released on 2013-04-17 with total page 303 pages. Available in PDF, EPUB and Kindle. Book excerpt: The last 15 years have brought an understanding of growth and differentiation at the molecular level, expanding our knowledge of the origin and progression of cancer. Early breakthroughs defining growth control pathways came via studies of oncogenes, mutated signaling molecules that have lost the capacity to tum off their proliferative signal. Oncogenes with diverse growth-promoting activities have been discovered, covering the gamut from cell surface to nuclear signaling. Sequencing of these oncogenes revealed that they were mutated forms of captured cellular genes and displayed tyrosine kinase activity. The epidermal growth factor (EGF) receptor was the first of 40-50 transmembrane tyrosine kinase receptors to be cloned and sequenced. Beyond cell proliferation, activation of EGF receptor by its specific ligands controls important physiological processes, such as cell differentiation, apoptosis, cell migration, and cell shape. Activation of autocrine growth loops, consisting in solid human tumors of upregulated expression of EGFR together with increased production of ligands suggested its crucial role in autonomous tumor growth.
Author : John D. Haley
Publisher : Springer Science & Business Media
ISBN 13 : 1597453560
Total Pages : 393 pages
Book Rating : 4.5/5 (974 download)
Download or read book EGFR Signaling Networks in Cancer Therapy written by John D. Haley and published by Springer Science & Business Media. This book was released on 2009-03-01 with total page 393 pages. Available in PDF, EPUB and Kindle. Book excerpt: The epidermal gro wth factor (EGF ) receptor and its downstream signal transduction networks have been implicated in the ontology and maintenance of tumor tissues, which has motivated the discovery and development of molecularly targeted anti-EGF receptor therapies. Over decades of study, the EGF receptor structure, its ligand binding domains, the physical biochemistry underlying its intrinsic tyrosine kinase catalytic function and the modular interactions with SH2, PTB, and SH3 domain containing signaling adaptor p- teins required for signal transduction, have been extensively dissected. Not only is the EGF receptor the nexus of many streams of information, but it also forms one part of a calcul- ing device by forming dimers and oligomers with the other three receptors in its family in response to at least eleven ligands (some of which are expressed in multiple forms with overlapping or quite distinct functions). This phenomenon, while recruiting to the inner surface of the cell membrane and activating multiple second messenger proteins, also allows the possibility of cross talk between these systems, permitting a further layer of information to be exchanged. Less well described are the cross re gulation of the EGF receptor and other anti-apoptotic, mitogenic and metabolic signaling systems. The study of these systems has yielded new surprises. One hurdle in these efforts has been that signal transduction pathways have frequently been defined in the generic absence of their tissue-specific or cell-interaction specific context.
Author : William S. Chen
Publisher :
ISBN 13 :
Total Pages : 304 pages
Book Rating : 4.:/5 (318 download)
Download or read book Functional Studies of the Epidermal Growth Factor Receptor written by William S. Chen and published by . This book was released on 1989 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : J. E. Kudlow
Publisher : Springer Science & Business Media
ISBN 13 : 1475719809
Total Pages : 237 pages
Book Rating : 4.4/5 (757 download)
Download or read book Biology of Growth Factors written by J. E. Kudlow and published by Springer Science & Business Media. This book was released on 2013-11-09 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: Growth factors are elaborated to control the growth of cells in such physiological processes as wound healing, tissue regeneration and the immune response. Abnormal production of these growth factors, their receptors or intracellular med!ators of their action may lead to disease states including oncogenesis. This volume will focus on exciting developments in defining the precise molecular lesions that permit the conversion of controlled proliferative signals to neoplasia, on the possible involvement of growth factors in the development of blood vessel diseases as seen in diabetes and atherosclerosis, on the altered immune surveillance that leads to autoimmunity and on the fundamental mechanisms by which growth factors signal their target cells. We expect that the contents of this volume will help promote understanding of the role of these fundamental biological processes and their alterations in a wide variety of disease states and stimulate new investi gations in this important area of biomedical research. The Editors v CONTENTS PERSPECTIVES ON THE CONTROL OF GROWTH AND DIFFERENTIATION Perspectives on the Biology of Growth Factors . . . •. . . . . . . . . . . . . . . • I. B. Fritz Platelet-Derived Growth Factor- Its Role in Health and Disease. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 9 R. Ross and E. W. Raines Molecular and Developmental Biology Aspects of Fibroblast Growth Factor. • . . . . . . . . . . . . . . • . . . . . . . . . • • . . . . . . . . . . . . . . . . . . • 23 D. Gospodarowicz Chemical and Biochemical Properties of Human Angiogenin. . . . . . . . . . 41 B. L. Vallee and J. F. Riordan GROWTH FACTOR - ONCOGENE RELATIONSHIPS Structure - Function Relationships in Cellular and Viral fps/fes Cytoplasmic Protein-Tyrosine Kinases. . . . . . . . . . . . . . . . . . . . . . . . 55 T. Pawson. P. Greer, M. Moran, K.
Author : Rakesh Kumar
Publisher : Springer Science & Business Media
ISBN 13 : 1402078471
Total Pages : 331 pages
Book Rating : 4.4/5 (2 download)
Download or read book Molecular Targeting and Signal Transduction written by Rakesh Kumar and published by Springer Science & Business Media. This book was released on 2006-04-18 with total page 331 pages. Available in PDF, EPUB and Kindle. Book excerpt: Our limited understanding of cellular regulatory signal-transduction-networks has been a barrier to progress in improving the overall cure-rate of human cancers. Delineation of the physiologic roles of the specific regulatory signaling components, with known association with metastatic phenotypes, is a highly promising area which will likely provide the next generation of targeted strategies in the future of molecular cancer medicine. These signaling components are likely to be used in diagnosis, prognosis, and as novel targets for therapeutic development. This book brings together up-to-date summaries by leading cancer researchers on the major principles of cancer cell biology: survival, apoptosis, adhesion, and cell cycle deregulation. It is directed at clinicians and scientists working in the areas of experimental and molecular therapeutics, molecular medicine, translational cancer research, and bio-medical sciences in general.
Author : Lai Kuan Goh
Publisher :
ISBN 13 :
Total Pages : 314 pages
Book Rating : 4.:/5 (811 download)
Download or read book Endocytosis of Epidermal Growth Factor Receptor written by Lai Kuan Goh and published by . This book was released on 2010 with total page 314 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Erik Wåhlén
Publisher :
ISBN 13 : 9789151321622
Total Pages : 0 pages
Book Rating : 4.3/5 (216 download)
Download or read book Regulation and Signal Transduction of the Platelet-derived Growth Factor Receptor and the Epidermal Growth Factor Receptor written by Erik Wåhlén and published by . This book was released on 2024 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Norbert Prenzel
Publisher :
ISBN 13 :
Total Pages : 20 pages
Book Rating : 4.:/5 (314 download)
Download or read book The Epidermal Growth Factor Receptor Family as a Central Element for Cellular Signal Transduction and Diversification written by Norbert Prenzel and published by . This book was released on 2001 with total page 20 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : A.E. Evangelopoulos
Publisher : Springer Science & Business Media
ISBN 13 : 3642742009
Total Pages : 398 pages
Book Rating : 4.6/5 (427 download)
Download or read book Receptors, Membrane Transport and Signal Transduction written by A.E. Evangelopoulos and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: A NATO Advanced study Institute on "Receptors, Membrane Trans port and Signal Transduction", was held on the Island of Spet sai, Greece, from August 16-27, 1988, in order to consider re cent developments in membrane receptor research, membrane trans port and signal transduction mechanisms. These topics were put in the larger context of current knowledge on the structure and function of membranes; connections between different fields of research were established by in-depth dis cussions of energy transduction and transport mechanisms. The general principles of regulation by signal transduction and protein phosphorylation/dephosphorylation were presented in the context of specific cellular processes. Discussions included al so the role of protein tyrosine kinases which are structurally related to oncogene products and, therefore, implicated in va rious aspects of cell development and transformation. This book presents the content of the major lectures and a se lection of the most relevant posters presented during the course of the Institute. The book is intended to make the proceedings of the Institute accessible to a larger audience and to offer a comprehensive account of those topics on receptors, membrane transport and signal transduction that were discussed extensive ly during the course of the Institute. February 1989 The Editors CONTENTS I. G-PROTEINS, ADENYLATE CYCLASE AND PROTEIN PHOSPHORYLATION Selective regulation of G proteins by Cell surface receptors ......... .
Author : Andrea Becchetti
Publisher : Springer
ISBN 13 : 9781461425830
Total Pages : 0 pages
Book Rating : 4.4/5 (258 download)
Download or read book Integrins and Ion Channels written by Andrea Becchetti and published by Springer. This book was released on 2012-05-27 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic. We believe the multifaceted regulatory interplay between integrin receptors and ion channels offers a rich and challenging field for researchers seeking broad biological perspectives. By mediating cell adhesion to the extracellular matrix, integrins regulate many developmental processes in the widest sense (from cell choice between differentiation and proliferation, to tissue remodeling and organogenesis). Rapidly growing evidence shows that frequent communication takes place between cell adhesion receptors and channel proteins. This may occur through formation of multiprotein membrane complexes that regulate ion fluxes as well as a variety of intracellular signaling pathways. In other cases, cross talk is more indirect and mediated by cellular messengers such as G proteins. These interactions are reciprocal, in that ion channel stimulation often controls integrin activation or expression. From a functional standpoint, studying the interplay between integrin receptors and ion channels clarifies how the extracellular matrix regulates processes as disparate as muscle excitability, synaptic plasticity and lymphocyte activation, just to mention a few. The derangement of these processes has many implications for pathogenesis processes, in particular for tumor invasiveness and some cardiovascular and neurologic diseases. This book provides a general introduction to the problems and methods of this blossoming field.
