Read Books Online and Download eBooks, EPub, PDF, Mobi, Kindle, Text Full Free.
Sigma Receptors
Download Sigma Receptors full books in PDF, epub, and Kindle. Read online Sigma Receptors ebook anywhere anytime directly on your device. Fast Download speed and no annoying ads. We cannot guarantee that every ebooks is available!
Book Synopsis Sigma Receptors: Their Role in Disease and as Therapeutic Targets by : Sylvia B. Smith
Download or read book Sigma Receptors: Their Role in Disease and as Therapeutic Targets written by Sylvia B. Smith and published by Springer. This book was released on 2017-03-16 with total page 311 pages. Available in PDF, EPUB and Kindle. Book excerpt: Originally confused with opioid receptors and then orphan receptors with no biological function, Sigma Receptors are now recognized as relevant to many degenerative diseases with remarkable potential as therapeutic targets. In this text, new information about the structure of sigma 1 receptor, its binding sites are provided as well as its expression in many cell types. It’s putative role in degenerative neuronal diseases including amyotrophic lateral sclerosis, Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, pain, drug addiction and locomotor activity. Their roles in possible treatments for blinding retinal diseases emphasize the tremendous far-reaching potential for ligands for these receptors. Exciting breakthroughs in this dynamic field in the last decade are reported herein, which will guide future investigators in determining the full potential of this unique, yet abundantly expressed protein.
Download or read book Sigma Proteins written by Felix J. Kim and published by . This book was released on 2017 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Sigma Proteins: Evolution of the Concept of Sigma Receptors by : Felix J. Kim
Download or read book Sigma Proteins: Evolution of the Concept of Sigma Receptors written by Felix J. Kim and published by Springer. This book was released on 2017-10-05 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Two sigma receptor subtypes have been proposed, sigma1 and 2. Much of our understanding of this system is based on biochemical and pharmacological characterization of the cloned sigma1 receptor subtype (Sigma1). It has become clear that sigma receptors are not canonical receptors. Sigma1 is highly conserved among mammalian species, however, it does not share significant homology with any other mammalian protein. Although a range of structurally diverse small molecules bind Sigma1 with high affinity, and it has been associated with a broad range of signaling systems, Sigma1 itself has no known signaling or enzymatic activity. The evolution of this field over nearly four decades has more recently led to a fundamental shift in the concept of “sigma receptors” to what may more accurately and generally be called sigma proteins. Largely based on traditional pharmacologic approaches, the Sigma1 protein has been associated with a broad range of signaling systems, including G-protein coupled receptors, NMDA receptors, and ion channels. Sigma proteins have been linked to a range of physiological processes, including intracellular calcium signaling, neuroprotection, learning, memory, and cognition. Emerging genetic, clinical, and mechanism focused molecular pharmacology data demonstrate the involvement of proteins in a range of pathophysiologies and disorders including neurodegenerative disease, pain, addiction, psychomotor stimulant abuse, and cancer. However, an understanding of the physiological role of sigma proteins has remained elusive. Emerging data associate Sigma1 with chaperone-like activities or molecular scaffold functions. This book aims to provide an updated perspective on this rapidly evolving field undergoing changes in fundamental concepts of key importance to the discipline of pharmacology. It focusses on the reported roles of sigma proteins in pathophysiology and on emergent therapeutic initiatives.
Book Synopsis Sigma Receptors by : Rae R. Matsumoto
Download or read book Sigma Receptors written by Rae R. Matsumoto and published by Springer Science & Business Media. This book was released on 2007-02-15 with total page 416 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an update on sigma receptors, and summarizes recent advances in the medicinal chemistry, molecular biology, and cell biology of sigma receptors. It describes the functional effects mediated by these receptors and the potential clinical implications of these actions. The information is put in a historical perspective. This provides a launching point from which future studies and research directions can easily be developed.
Download or read book Sigma Receptors written by Yossef Itzhak and published by Academic Press. This book was released on 1994-05-28 with total page 370 pages. Available in PDF, EPUB and Kindle. Book excerpt: The sigma receptor was originally thought to be a subset of the opioid receptor family, and it is less than 10 years since it was recognized that this receptor represents unique binding sites in mammalian brain and peripheral organs, distinct from any other known neurotransmitter receptor.
Book Synopsis Brain Lipids in Synaptic Function and Neurological Disease by : Jacques Fantini
Download or read book Brain Lipids in Synaptic Function and Neurological Disease written by Jacques Fantini and published by Academic Press. This book was released on 2015-05-12 with total page 398 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipids are the most abundant organic compounds found in the brain, accounting for up to 50% of its dry weight. The brain lipidome includes several thousands of distinct biochemical structures whose expression may greatly vary according to age, gender, brain region, cell type, as well as subcellular localization. In synaptic membranes, brain lipids specifically interact with neurotransmitter receptors and control their activity. Moreover, brain lipids play a key role in the generation and neurotoxicity of amyloidogenic proteins involved in the pathophysiology of neurological diseases. The aim of this book is to provide for the first time a comprehensive overview of brain lipid structures, and to explain the roles of these lipids in synaptic function, and in neurodegenerative diseases, including Alzheimer's, Creutzfeldt-Jakob's and Parkinson's. To conclude the book, the authors present new ideas that can drive innovative therapeutic strategies based on the knowledge of the role of lipids in brain disorders. - Written to provide a "hands-on" approach for readers - Biochemical structures explained with molecular models, and molecular mechanisms explained with simple drawings - Step-by-step guide to memorize and draw lipid structures - Each chapter features a content summary, up-to-date references for additional study, and a key experiment with an explanation of the technique
Book Synopsis Imaging of the Human Brain in Health and Disease by : Philip Seeman
Download or read book Imaging of the Human Brain in Health and Disease written by Philip Seeman and published by Elsevier. This book was released on 2013-11-15 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Brain imaging technology remains at the forefront of advances in both our understanding of the brain and our ability to diagnose and treat brain disease and disorders. Imaging of the Human Brain in Health and Disease examines the localization of neurotransmitter receptors in the nervous system of normal, healthy humans and compares that with humans who are suffering from various neurologic diseases. Opening chapters introduce the basic science of imaging neurotransmitters, including sigma, acetylcholine, opioid, and dopamine receptors. Imaging the healthy and diseased brain includes brain imaging of anger, pain, autism, the release of dopamine, the impact of cannabinoids, and Alzheimer's disease. This book is a valuable companion to a wide range of scholars, students, and researchers in neuroscience, clinical neurology, and psychiatry, and provides a detailed introduction to the application of advanced imaging to the treatment of brain disorders and disease. - A focused introduction to imaging healthy and diseased brains - Focuses on the primary neurotransmitter release - Includes sigma, acetylcholine, opioid, and dopamine receptors - Presents the imaging of healthy and diseased brains via anger, pain, autism, and Alzheimer's disease
Book Synopsis The Neuroscience of Cocaine by : Victor R Preedy
Download or read book The Neuroscience of Cocaine written by Victor R Preedy and published by Academic Press. This book was released on 2017-05-23 with total page 776 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Neuroscience of Cocaine: Mechanisms and Treatment explores the complex effects of this drug, addressing the neurobiology behind cocaine use and the psychosocial and behavioral factors that impact cocaine use and abuse. This book provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms. Cocaine is one of the most highly abused illicit drugs worldwide and is frequently associated with other forms of drug addiction and misuse, but researchers are still struggling to understand cocaine’s neuropharmacological profile and the mechanisms of its effects and manifestations at the cognitive level. Cessation of cocaine use can lead to numerous adverse withdrawal conditions, from the cellular and molecular level to the behavioral level of the individual user. Written by worldwide experts in cocaine addiction, this book assists neuroscientists and other addiction researchers in unraveling the many complex facets of cocaine use and abuse. Contains in each chapter an abstract, key facts, mini dictionary of terms, and summary points to aid in understanding Illustrated in full color Provides unique full coverage of all aspects of cocaine and its related pathology Provides researchers with an up-to-date understanding of the mechanisms behind cocaine use, and aids them in deriving new pharmacological compounds and therapeutic regimens to treat dependency and withdrawal symptoms
Book Synopsis Handbook of Veterinary Pain Management - E-Book by : James S. Gaynor
Download or read book Handbook of Veterinary Pain Management - E-Book written by James S. Gaynor and published by Elsevier Health Sciences. This book was released on 2008-01-29 with total page 672 pages. Available in PDF, EPUB and Kindle. Book excerpt: You can trust this user-friendly guide to help you meet the increasing need for effective pain management in the animals you treat. It provides instant access to clinically relevant information on pain assessment, pharmaceutical and non-pharmaceutical treatment options, guidelines for managing acute and chronic pain, and unique aspects of pain management in dogs, cats, horses, cattle, birds, reptiles, ferrets, and rabbits. User-friendly format helps you quickly and easily find essential pain management information. Helpful boxes and tables provide at-a-glance access to pharmacologic protocols and clinical applications, including dosages, indications, contraindications, and side effects. Complementary and alternative treatment strategies are included throughout to assist you in using the latest non-pharmacological pain interventions. Case studies clearly illustrate the practical applications of key concepts in the clinical setting and help you sharpen your pain assessment and management skills. New contributors — many of the most respected experts in the field — share their insights and experiences to bring you the most current thinking in this ever-changing discipline. Completely revised and updated content throughout ensures you are using the best and most current information available on analgesic drugs and pain management techniques. An expanded chapter on Pain Management in Horses and Cattle explores the latest advances in treating this group of animals. Eight new chapters offer cutting-edge coverage of hot topics in the field, including: Pain Management in the Cat Pain Management for the Pet Bird Clinical Approaches to Analgesia in Reptiles Clinical Approaches to Analgesia in Ferrets and Rabbits Physical Therapy and Rehabilitation in Dogs Rehabilitation Methods and Modalities for the Cat Quality of Life Issues Hospice and Palliative Care
Book Synopsis Ligands for the Sigma Receptor and the Mu-opioid Receptor by : Yu Lu
Download or read book Ligands for the Sigma Receptor and the Mu-opioid Receptor written by Yu Lu and published by . This book was released on 2007 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The sigma receptor is a unique receptor family with two subtypes: sigma-1 and sigma-2. In order to conduct structure-activity relationship studies (SAR), a series of specific 1-phenylpropyl-4-benzylpiperidine and 1-phenylpropyl-4- benzylpiperazine analogues were synthesized as sigma ligands. Sigma receptors binding assays were conducted for the piperidine analogues. The last chapter is concerned with the opioid receptors, which have three subtypes: mu, delta, and kappa. The [mu]-opioid receptor is believed to be the subtype with the most clinical importance. In order to obtain [mu]-opioid tetrapeptide ligand I-Dmt-D-Ala-Phe-Orn-NH2 with high affinity and proper lipophilicity, mono-iodination reaction was studied on the 2,6-dimethyl-L-tyrosine residue.
Book Synopsis Nonclinical Assessment of Abuse Potential for New Pharmaceuticals by : Carrie Markgraf
Download or read book Nonclinical Assessment of Abuse Potential for New Pharmaceuticals written by Carrie Markgraf and published by Academic Press. This book was released on 2015-07-14 with total page 321 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nonclinical Assessment of Abuse Potential for New Pharmaceuticals offers a complete reference on the current international regulatory guidelines and details best practice methodology for the three standard animal models used to evaluate abuse potential: physical dependence, self-administration and drug discrimination. This book also includes chapters on alternative models and examples of when you should use these alternatives. Case histories are provided at the end of the book to show how the data generated from the animal models play a pivitol role in the submission package for a new drug. By incorporating all of this information into one book, Nonclinical Assessment of Abuse Potential for New Pharmaceuticals is your single resource for everything you need to know to understand and implement the assessment of abuse liability. Provides a consolidated overview of the complex regulatory landscape Offers best practice methodology for conducting animal studies, including selection of doses and positive control agents that will help you improve your own abuse potential studies Includes real-life examples to illustrate how nonclinical data fit into the submission strategy
Download or read book Sigma, PCP, and NMDA Receptors written by and published by . This book was released on 1993 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Sigma Receptors by : Stephen T. Safrany
Download or read book Sigma Receptors written by Stephen T. Safrany and published by Frontiers Media SA. This book was released on 2020-10-27 with total page 215 pages. Available in PDF, EPUB and Kindle. Book excerpt: This eBook is a collection of articles from a Frontiers Research Topic. Frontiers Research Topics are very popular trademarks of the Frontiers Journals Series: they are collections of at least ten articles, all centered on a particular subject. With their unique mix of varied contributions from Original Research to Review Articles, Frontiers Research Topics unify the most influential researchers, the latest key findings and historical advances in a hot research area! Find out more on how to host your own Frontiers Research Topic or contribute to one as an author by contacting the Frontiers Editorial Office: frontiersin.org/about/contact.
Book Synopsis The Essence of Analgesia and Analgesics by : Raymond S. Sinatra
Download or read book The Essence of Analgesia and Analgesics written by Raymond S. Sinatra and published by Cambridge University Press. This book was released on 2010-10-14 with total page 551 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Essence of Analgesia and Analgesics is an invaluable practical resource for clinicians giving pain relief in any clinical setting, describing the pharmacologic principles and clinical use of all available pain medications. As well as detailed overviews of pain processing and analgesic theory, sections are dedicated to oral and panteral opioid analgesics, neuraxial opioids, NSAIDs, local anesthetics, anticonvulsant type analgesics, NMDA antagonists, alpha adrenergic analgesics, antidepressant analgesics, muscle relaxants, adjuvant medications, and new and emerging analgesics. The concise format of the chapters allows for quick and easy reading and assimilation of information. Enhanced by summary tables and figures, each chapter provides an overview of a particular drug, covering chemical structure, mode of activity, indications, contraindications, common doses and uses, advantages and disadvantages, and drug related adverse events. Key references are also provided. Edited by leading experts in pain management, this is essential reading for any clinician involved in pain management.
Book Synopsis Acetylcholine, Sigma Receptors, CCK and Eicosanoids, Neurotoxins by : T. W. Stone
Download or read book Acetylcholine, Sigma Receptors, CCK and Eicosanoids, Neurotoxins written by T. W. Stone and published by Taylor & Francis. This book was released on 1993 with total page 272 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis The Sigma-RBI Handbook of Receptor Classification and Signal Transduction by : Keith J. Watling
Download or read book The Sigma-RBI Handbook of Receptor Classification and Signal Transduction written by Keith J. Watling and published by . This book was released on 2006 with total page 376 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Antipsychotic Drugs and Their Side-Effects by : Thomas R.E. Barnes
Download or read book Antipsychotic Drugs and Their Side-Effects written by Thomas R.E. Barnes and published by Academic Press. This book was released on 2013-10-22 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: In line with other volumes in the Neuroscience Perspectives Series, this volume covers the background, pharmacology, molecular biology, and biochemistry of antipsychotic drugs, together with an overview assessment of the therapeutic considerations. Over the past 40 years, the effectiveness of conventional neuroleptic agents for psychotic illness has been offset by a wide range of adverse side-effects, including motor side-effects like parkinsonism. Studies show that lowering doses may still produce the antipsychotic effect while lessening the risk of side-effects. As all available antispychotic drugs are able to block dopamine, specifically D2 receptors, doses below the threshold level for producing acute motor disorder can still be therapeutically effective. With the identification and characterization of multiple dopamine receptors, the possibility of more selective drugs with better side-effect potential has arisen. Other novel antipsychotic agents include D1 receptor blockers, partial dopamine agonists and non-dopamine drugs such as 5-HT receptor blockers, sigma receptor antagonists and NMDA receptor agonists. This volume reviews both the basic science of the conventional and atypical neuroleptics and their present and potential therapeutic use.
