Sensitivity Analysis In Practice

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Sensitivity Analysis in Practice

Author : Andrea Saltelli
Publisher : John Wiley & Sons
ISBN 13 : 047087094X
Total Pages : 232 pages
Book Rating : 4.4/5 (78 download)

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Book Synopsis Sensitivity Analysis in Practice by : Andrea Saltelli

Download or read book Sensitivity Analysis in Practice written by Andrea Saltelli and published by John Wiley & Sons. This book was released on 2004-07-16 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Sensitivity analysis should be considered a pre-requisite for statistical model building in any scientific discipline where modelling takes place. For a non-expert, choosing the method of analysis for their model is complex, and depends on a number of factors. This book guides the non-expert through their problem in order to enable them to choose and apply the most appropriate method. It offers a review of the state-of-the-art in sensitivity analysis, and is suitable for a wide range of practitioners. It is focussed on the use of SIMLAB – a widely distributed freely-available sensitivity analysis software package developed by the authors – for solving problems in sensitivity analysis of statistical models. Other key features: Provides an accessible overview of the current most widely used methods for sensitivity analysis. Opens with a detailed worked example to explain the motivation behind the book. Includes a range of examples to help illustrate the concepts discussed. Focuses on implementation of the methods in the software SIMLAB - a freely-available sensitivity analysis software package developed by the authors. Contains a large number of references to sources for further reading. Authored by the leading authorities on sensitivity analysis.

Global Sensitivity Analysis

Author : Andrea Saltelli
Publisher : John Wiley & Sons
ISBN 13 : 9780470725177
Total Pages : 304 pages
Book Rating : 4.7/5 (251 download)

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Book Synopsis Global Sensitivity Analysis by : Andrea Saltelli

Download or read book Global Sensitivity Analysis written by Andrea Saltelli and published by John Wiley & Sons. This book was released on 2008-02-28 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: Complex mathematical and computational models are used in all areas of society and technology and yet model based science is increasingly contested or refuted, especially when models are applied to controversial themes in domains such as health, the environment or the economy. More stringent standards of proofs are demanded from model-based numbers, especially when these numbers represent potential financial losses, threats to human health or the state of the environment. Quantitative sensitivity analysis is generally agreed to be one such standard. Mathematical models are good at mapping assumptions into inferences. A modeller makes assumptions about laws pertaining to the system, about its status and a plethora of other, often arcane, system variables and internal model settings. To what extent can we rely on the model-based inference when most of these assumptions are fraught with uncertainties? Global Sensitivity Analysis offers an accessible treatment of such problems via quantitative sensitivity analysis, beginning with the first principles and guiding the reader through the full range of recommended practices with a rich set of solved exercises. The text explains the motivation for sensitivity analysis, reviews the required statistical concepts, and provides a guide to potential applications. The book: Provides a self-contained treatment of the subject, allowing readers to learn and practice global sensitivity analysis without further materials. Presents ways to frame the analysis, interpret its results, and avoid potential pitfalls. Features numerous exercises and solved problems to help illustrate the applications. Is authored by leading sensitivity analysis practitioners, combining a range of disciplinary backgrounds. Postgraduate students and practitioners in a wide range of subjects, including statistics, mathematics, engineering, physics, chemistry, environmental sciences, biology, toxicology, actuarial sciences, and econometrics will find much of use here. This book will prove equally valuable to engineers working on risk analysis and to financial analysts concerned with pricing and hedging.

Sensitivity Analysis

Author : Andrea Saltelli
Publisher : Wiley
ISBN 13 : 9780470743829
Total Pages : 0 pages
Book Rating : 4.7/5 (438 download)

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Book Synopsis Sensitivity Analysis by : Andrea Saltelli

Download or read book Sensitivity Analysis written by Andrea Saltelli and published by Wiley. This book was released on 2009-03-16 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Wiley Paperback Series makes valuable content more accessible to a new generation of statisticians, mathematicians and scientists. Sensitivity analysis is used to ascertain how a given model output depends upon the input parameters. This is an important method for checking the quality of a given model, as well as a powerful tool for checking the robustness and reliability of its analysis. The topic is acknowledged as essential for good modelling practice and is an implicit part of any modelling field. Offers an accessible introduction to sensitivity analysis. Covers all the latest research. Illustrates concepts with numerous examples, applications and case studies. Includes contributions from the leading researchers active in developing strategies for sensitivity analysis. The principles of sensitivity analysis are carefully described and suitable methods for approaching many types of problems are given. The book introduces the modeller to the entire casual assessment chain, from data to predictions, whilst explaining the impact of source uncertainties and framing assumptions. A ‘hitch-hikers guide’ is included to allow the more experienced reader to readily access specific applications. Modellers from a wide range of disciplines, including biostatistics, economics, environmental impact assessment, chemistry and engineering will benefit greatly from the numerous examples and applications. "Presents many different sensitivity analysis methodologies and demonstrates their usefulness in scientific research." (Zentralblatt MATH)

The Prevention and Treatment of Missing Data in Clinical Trials

Author : National Research Council
Publisher : National Academies Press
ISBN 13 : 030918651X
Total Pages : 163 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis The Prevention and Treatment of Missing Data in Clinical Trials by : National Research Council

Download or read book The Prevention and Treatment of Missing Data in Clinical Trials written by National Research Council and published by National Academies Press. This book was released on 2010-12-21 with total page 163 pages. Available in PDF, EPUB and Kindle. Book excerpt: Randomized clinical trials are the primary tool for evaluating new medical interventions. Randomization provides for a fair comparison between treatment and control groups, balancing out, on average, distributions of known and unknown factors among the participants. Unfortunately, these studies often lack a substantial percentage of data. This missing data reduces the benefit provided by the randomization and introduces potential biases in the comparison of the treatment groups. Missing data can arise for a variety of reasons, including the inability or unwillingness of participants to meet appointments for evaluation. And in some studies, some or all of data collection ceases when participants discontinue study treatment. Existing guidelines for the design and conduct of clinical trials, and the analysis of the resulting data, provide only limited advice on how to handle missing data. Thus, approaches to the analysis of data with an appreciable amount of missing values tend to be ad hoc and variable. The Prevention and Treatment of Missing Data in Clinical Trials concludes that a more principled approach to design and analysis in the presence of missing data is both needed and possible. Such an approach needs to focus on two critical elements: (1) careful design and conduct to limit the amount and impact of missing data and (2) analysis that makes full use of information on all randomized participants and is based on careful attention to the assumptions about the nature of the missing data underlying estimates of treatment effects. In addition to the highest priority recommendations, the book offers more detailed recommendations on the conduct of clinical trials and techniques for analysis of trial data.

Basics and Trends in Sensitivity Analysis: Theory and Practice in R

Author : Sébastien Da Veiga
Publisher : SIAM
ISBN 13 : 1611976693
Total Pages : 307 pages
Book Rating : 4.6/5 (119 download)

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Book Synopsis Basics and Trends in Sensitivity Analysis: Theory and Practice in R by : Sébastien Da Veiga

Download or read book Basics and Trends in Sensitivity Analysis: Theory and Practice in R written by Sébastien Da Veiga and published by SIAM. This book was released on 2021-10-14 with total page 307 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides an overview of global sensitivity analysis methods and algorithms, including their theoretical basis and mathematical properties. The authors use a practical point of view and real case studies as well as numerous examples, and applications of the different approaches are illustrated throughout using R code to explain their usage and usefulness in practice. Basics and Trends in Sensitivity Analysis: Theory and Practice in R covers a lot of material, including theoretical aspects of Sobol’ indices as well as sampling-based formulas, spectral methods, and metamodel-based approaches for estimation purposes; screening techniques devoted to identifying influential and noninfluential inputs; variance-based measures when model inputs are statistically dependent (and several other approaches that go beyond variance-based sensitivity measures); and a case study in R related to a COVID-19 epidemic model where the full workflow of sensitivity analysis combining several techniques is presented. This book is intended for engineers, researchers, and undergraduate students who use complex numerical models and have an interest in sensitivity analysis techniques and is appropriate for anyone with a solid mathematical background in basic statistical and probability theories who develops and uses numerical models in all scientific and engineering domains.

Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide

Author : Agency for Health Care Research and Quality (U.S.)
Publisher : Government Printing Office
ISBN 13 : 1587634236
Total Pages : 204 pages
Book Rating : 4.5/5 (876 download)

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Book Synopsis Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide by : Agency for Health Care Research and Quality (U.S.)

Download or read book Developing a Protocol for Observational Comparative Effectiveness Research: A User's Guide written by Agency for Health Care Research and Quality (U.S.) and published by Government Printing Office. This book was released on 2013-02-21 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: This User’s Guide is a resource for investigators and stakeholders who develop and review observational comparative effectiveness research protocols. It explains how to (1) identify key considerations and best practices for research design; (2) build a protocol based on these standards and best practices; and (3) judge the adequacy and completeness of a protocol. Eleven chapters cover all aspects of research design, including: developing study objectives, defining and refining study questions, addressing the heterogeneity of treatment effect, characterizing exposure, selecting a comparator, defining and measuring outcomes, and identifying optimal data sources. Checklists of guidance and key considerations for protocols are provided at the end of each chapter. The User’s Guide was created by researchers affiliated with AHRQ’s Effective Health Care Program, particularly those who participated in AHRQ’s DEcIDE (Developing Evidence to Inform Decisions About Effectiveness) program. Chapters were subject to multiple internal and external independent reviews. More more information, please consult the Agency website: www.effectivehealthcare.ahrq.gov)

Estimands, Estimators and Sensitivity Analysis in Clinical Trials

Author : Craig Mallinckrodt
Publisher : CRC Press
ISBN 13 : 0429950063
Total Pages : 345 pages
Book Rating : 4.4/5 (299 download)

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Book Synopsis Estimands, Estimators and Sensitivity Analysis in Clinical Trials by : Craig Mallinckrodt

Download or read book Estimands, Estimators and Sensitivity Analysis in Clinical Trials written by Craig Mallinckrodt and published by CRC Press. This book was released on 2019-12-23 with total page 345 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concepts of estimands, analyses (estimators), and sensitivity are interrelated. Therefore, great need exists for an integrated approach to these topics. This book acts as a practical guide to developing and implementing statistical analysis plans by explaining fundamental concepts using accessible language, providing technical details, real-world examples, and SAS and R code to implement analyses. The updated ICH guideline raises new analytic and cross-functional challenges for statisticians. Gaps between different communities have come to surface, such as between causal inference and clinical trialists, as well as among clinicians, statisticians, and regulators when it comes to communicating decision-making objectives, assumptions, and interpretations of evidence. This book lays out a path toward bridging some of these gaps. It offers A common language and unifying framework along with the technical details and practical guidance to help statisticians meet the challenges A thorough treatment of intercurrent events (ICEs), i.e., postrandomization events that confound interpretation of outcomes and five strategies for ICEs in ICH E9 (R1) Details on how estimands, integrated into a principled study development process, lay a foundation for coherent specification of trial design, conduct, and analysis needed to overcome the issues caused by ICEs: A perspective on the role of the intention-to-treat principle Examples and case studies from various areas Example code in SAS and R A connection with causal inference Implications and methods for analysis of longitudinal trials with missing data Together, the authors have offered the readers their ample expertise in clinical trial design and analysis, from an industrial and academic perspective.

Sensitivity & Uncertainty Analysis, Volume 1

Author : Dan G. Cacuci
Publisher : CRC Press
ISBN 13 : 1135442983
Total Pages : 304 pages
Book Rating : 4.1/5 (354 download)

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Book Synopsis Sensitivity & Uncertainty Analysis, Volume 1 by : Dan G. Cacuci

Download or read book Sensitivity & Uncertainty Analysis, Volume 1 written by Dan G. Cacuci and published by CRC Press. This book was released on 2003-05-28 with total page 304 pages. Available in PDF, EPUB and Kindle. Book excerpt: As computer-assisted modeling and analysis of physical processes have continued to grow and diversify, sensitivity and uncertainty analyses have become indispensable investigative scientific tools in their own right. While most techniques used for these analyses are well documented, there has yet to appear a systematic treatment of the method based on adjoint operators, which is applicable to a much wider variety of problems than methods traditionally used in control theory. This book fills that gap, focusing on the mathematical underpinnings of the Adjoint Sensitivity Analysis Procedure (ASAP) and the use of deterministically obtained sensitivities for subsequent uncertainty analysis.

Secondary Analysis of Electronic Health Records

Author : MIT Critical Data
Publisher : Springer
ISBN 13 : 3319437429
Total Pages : 427 pages
Book Rating : 4.3/5 (194 download)

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Book Synopsis Secondary Analysis of Electronic Health Records by : MIT Critical Data

Download or read book Secondary Analysis of Electronic Health Records written by MIT Critical Data and published by Springer. This book was released on 2016-09-09 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book trains the next generation of scientists representing different disciplines to leverage the data generated during routine patient care. It formulates a more complete lexicon of evidence-based recommendations and support shared, ethical decision making by doctors with their patients. Diagnostic and therapeutic technologies continue to evolve rapidly, and both individual practitioners and clinical teams face increasingly complex ethical decisions. Unfortunately, the current state of medical knowledge does not provide the guidance to make the majority of clinical decisions on the basis of evidence. The present research infrastructure is inefficient and frequently produces unreliable results that cannot be replicated. Even randomized controlled trials (RCTs), the traditional gold standards of the research reliability hierarchy, are not without limitations. They can be costly, labor intensive, and slow, and can return results that are seldom generalizable to every patient population. Furthermore, many pertinent but unresolved clinical and medical systems issues do not seem to have attracted the interest of the research enterprise, which has come to focus instead on cellular and molecular investigations and single-agent (e.g., a drug or device) effects. For clinicians, the end result is a bit of a “data desert” when it comes to making decisions. The new research infrastructure proposed in this book will help the medical profession to make ethically sound and well informed decisions for their patients.

Missing Data in Longitudinal Studies

Author : Michael J. Daniels
Publisher : CRC Press
ISBN 13 : 9781420011180
Total Pages : 328 pages
Book Rating : 4.0/5 (111 download)

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Book Synopsis Missing Data in Longitudinal Studies by : Michael J. Daniels

Download or read book Missing Data in Longitudinal Studies written by Michael J. Daniels and published by CRC Press. This book was released on 2008-03-11 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: Drawing from the authors’ own work and from the most recent developments in the field, Missing Data in Longitudinal Studies: Strategies for Bayesian Modeling and Sensitivity Analysis describes a comprehensive Bayesian approach for drawing inference from incomplete data in longitudinal studies. To illustrate these methods, the authors employ several data sets throughout that cover a range of study designs, variable types, and missing data issues. The book first reviews modern approaches to formulate and interpret regression models for longitudinal data. It then discusses key ideas in Bayesian inference, including specifying prior distributions, computing posterior distribution, and assessing model fit. The book carefully describes the assumptions needed to make inferences about a full-data distribution from incompletely observed data. For settings with ignorable dropout, it emphasizes the importance of covariance models for inference about the mean while for nonignorable dropout, the book studies a variety of models in detail. It concludes with three case studies that highlight important features of the Bayesian approach for handling nonignorable missingness. With suggestions for further reading at the end of most chapters as well as many applications to the health sciences, this resource offers a unified Bayesian approach to handle missing data in longitudinal studies.

Sensitivity Analysis in Linear Systems

Author : Assem Deif
Publisher : Springer Science & Business Media
ISBN 13 : 364282739X
Total Pages : 235 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Sensitivity Analysis in Linear Systems by : Assem Deif

Download or read book Sensitivity Analysis in Linear Systems written by Assem Deif and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: A text surveying perturbation techniques and sensitivity analysis of linear systems is an ambitious undertaking, considering the lack of basic comprehensive texts on the subject. A wide-ranging and global coverage of the topic is as yet missing, despite the existence of numerous monographs dealing with specific topics but generally of use to only a narrow category of people. In fact, most works approach this subject from the numerical analysis point of view. Indeed, researchers in this field have been most concerned with this topic, although engineers and scholars in all fields may find it equally interesting. One can state, without great exaggeration, that a great deal of engineering work is devoted to testing systems' sensitivity to changes in design parameters. As a rule, high-sensitivity elements are those which should be designed with utmost care. On the other hand, as the mathematical modelling serving for the design process is usually idealized and often inaccurately formulated, some unforeseen alterations may cause the system to behave in a slightly different manner. Sensitivity analysis can help the engineer innovate ways to minimize such system discrepancy, since it starts from the assumption of such a discrepancy between the ideal and the actual system.

Multiple Imputation and its Application

Author : James Carpenter
Publisher : John Wiley & Sons
ISBN 13 : 1119942276
Total Pages : 368 pages
Book Rating : 4.1/5 (199 download)

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Book Synopsis Multiple Imputation and its Application by : James Carpenter

Download or read book Multiple Imputation and its Application written by James Carpenter and published by John Wiley & Sons. This book was released on 2012-12-21 with total page 368 pages. Available in PDF, EPUB and Kindle. Book excerpt: A practical guide to analysing partially observeddata. Collecting, analysing and drawing inferences from data iscentral to research in the medical and social sciences.Unfortunately, it is rarely possible to collect all the intendeddata. The literature on inference from the resultingincomplete data is now huge, and continues to grow both asmethods are developed for large and complex data structures, and asincreasing computer power and suitable software enable researchersto apply these methods. This book focuses on a particular statistical method foranalysing and drawing inferences from incomplete data, calledMultiple Imputation (MI). MI is attractive because it is bothpractical and widely applicable. The authors aim is to clarify theissues raised by missing data, describing the rationale for MI, therelationship between the various imputation models and associatedalgorithms and its application to increasingly complex datastructures. Multiple Imputation and its Application: Discusses the issues raised by the analysis of partiallyobserved data, and the assumptions on which analyses rest. Presents a practical guide to the issues to consider whenanalysing incomplete data from both observational studies andrandomized trials. Provides a detailed discussion of the practical use of MI withreal-world examples drawn from medical and social statistics. Explores handling non-linear relationships and interactionswith multiple imputation, survival analysis, multilevel multipleimputation, sensitivity analysis via multiple imputation, usingnon-response weights with multiple imputation and doubly robustmultiple imputation. Multiple Imputation and its Application is aimed atquantitative researchers and students in the medical and socialsciences with the aim of clarifying the issues raised by theanalysis of incomplete data data, outlining the rationale for MIand describing how to consider and address the issues that arise inits application.

Bayesian Data Analysis, Third Edition

Author : Andrew Gelman
Publisher : CRC Press
ISBN 13 : 1439840954
Total Pages : 677 pages
Book Rating : 4.4/5 (398 download)

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Book Synopsis Bayesian Data Analysis, Third Edition by : Andrew Gelman

Download or read book Bayesian Data Analysis, Third Edition written by Andrew Gelman and published by CRC Press. This book was released on 2013-11-01 with total page 677 pages. Available in PDF, EPUB and Kindle. Book excerpt: Now in its third edition, this classic book is widely considered the leading text on Bayesian methods, lauded for its accessible, practical approach to analyzing data and solving research problems. Bayesian Data Analysis, Third Edition continues to take an applied approach to analysis using up-to-date Bayesian methods. The authors—all leaders in the statistics community—introduce basic concepts from a data-analytic perspective before presenting advanced methods. Throughout the text, numerous worked examples drawn from real applications and research emphasize the use of Bayesian inference in practice. New to the Third Edition Four new chapters on nonparametric modeling Coverage of weakly informative priors and boundary-avoiding priors Updated discussion of cross-validation and predictive information criteria Improved convergence monitoring and effective sample size calculations for iterative simulation Presentations of Hamiltonian Monte Carlo, variational Bayes, and expectation propagation New and revised software code The book can be used in three different ways. For undergraduate students, it introduces Bayesian inference starting from first principles. For graduate students, the text presents effective current approaches to Bayesian modeling and computation in statistics and related fields. For researchers, it provides an assortment of Bayesian methods in applied statistics. Additional materials, including data sets used in the examples, solutions to selected exercises, and software instructions, are available on the book’s web page.

Handbook of Uncertainty Quantification

Author : Roger Ghanem
Publisher : Springer
ISBN 13 : 9783319123844
Total Pages : 0 pages
Book Rating : 4.1/5 (238 download)

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Book Synopsis Handbook of Uncertainty Quantification by : Roger Ghanem

Download or read book Handbook of Uncertainty Quantification written by Roger Ghanem and published by Springer. This book was released on 2016-05-08 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The topic of Uncertainty Quantification (UQ) has witnessed massive developments in response to the promise of achieving risk mitigation through scientific prediction. It has led to the integration of ideas from mathematics, statistics and engineering being used to lend credence to predictive assessments of risk but also to design actions (by engineers, scientists and investors) that are consistent with risk aversion. The objective of this Handbook is to facilitate the dissemination of the forefront of UQ ideas to their audiences. We recognize that these audiences are varied, with interests ranging from theory to application, and from research to development and even execution.

Uncertainty in Industrial Practice

Author : Etienne de Rocquigny
Publisher : John Wiley & Sons
ISBN 13 : 0470770740
Total Pages : 364 pages
Book Rating : 4.4/5 (77 download)

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Book Synopsis Uncertainty in Industrial Practice by : Etienne de Rocquigny

Download or read book Uncertainty in Industrial Practice written by Etienne de Rocquigny and published by John Wiley & Sons. This book was released on 2008-09-15 with total page 364 pages. Available in PDF, EPUB and Kindle. Book excerpt: Managing uncertainties in industrial systems is a daily challenge to ensure improved design, robust operation, accountable performance and responsive risk control. Authored by a leading European network of experts representing a cross section of industries, Uncertainty in Industrial Practice aims to provide a reference for the dissemination of uncertainty treatment in any type of industry. It is concerned with the quantification of uncertainties in the presence of data, model(s) and knowledge about the system, and offers a technical contribution to decision-making processes whilst acknowledging industrial constraints. The approach presented can be applied to a range of different business contexts, from research or early design through to certification or in-service processes. The authors aim to foster optimal trade-offs between literature-referenced methodologies and the simplified approaches often inevitable in practice, owing to data, time or budget limitations of technical decision-makers. Uncertainty in Industrial Practice: Features recent uncertainty case studies carried out in the nuclear, air & space, oil, mechanical and civil engineering industries set in a common methodological framework. Presents methods for organizing and treating uncertainties in a generic and prioritized perspective. Illustrates practical difficulties and solutions encountered according to the level of complexity, information available and regulatory and financial constraints. Discusses best practice in uncertainty modeling, propagation and sensitivity analysis through a variety of statistical and numerical methods. Reviews recent standards, references and available software, providing an essential resource for engineers and risk analysts in a wide variety of industries. This book provides a guide to dealing with quantitative uncertainty in engineering and modelling and is aimed at practitioners, including risk-industry regulators and academics wishing to develop industry-realistic methodologies.

Invitation to Linear Programming and Game Theory

Author : David C. Vella
Publisher : Cambridge University Press
ISBN 13 : 1108476252
Total Pages : 543 pages
Book Rating : 4.1/5 (84 download)

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Book Synopsis Invitation to Linear Programming and Game Theory by : David C. Vella

Download or read book Invitation to Linear Programming and Game Theory written by David C. Vella and published by Cambridge University Press. This book was released on 2021-03-11 with total page 543 pages. Available in PDF, EPUB and Kindle. Book excerpt: Discover interplay between matrices, linear programming, and game theory at an introductory level, requiring only high school algebra and curiosity.

Parametric Sensitivity in Chemical Systems

Author : Arvind Varma
Publisher : Cambridge University Press
ISBN 13 : 9780521019842
Total Pages : 360 pages
Book Rating : 4.0/5 (198 download)

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Book Synopsis Parametric Sensitivity in Chemical Systems by : Arvind Varma

Download or read book Parametric Sensitivity in Chemical Systems written by Arvind Varma and published by Cambridge University Press. This book was released on 2005-09-15 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: The behavior of a chemical system is affected by many physicochemical parameters. The sensitivity of the system's behavior to changes in parameters is known as parametric sensitivity. When a system operates in a parametrically sensitive region, its performance becomes unreliable and changes sharply with small variations in parameters. Thus, it is of great value to those who design and operate chemical systems to be able to analyze and predict their sensitivity behavior. This book is the first to provide a thorough treatment of the concept of parametric sensitivity and the mathematical tool it generated, sensitivity analysis. The emphasis is on applications to real situations. The book begins with definitions of various sensitivity indices and describes the numerical techniques most commonly used for their evaluation. Extensively illustrated chapters discuss sensitivity analysis in a variety of chemical reactors--batch, tubular, continuous-flow, fixed-bed--and in combustion systems, mechanistic studies, air pollution, and metabolic processes. Seniors and graduate students in various fields of science and engineering, researchers, and practicing engineers will welcome this valuable resource.