Selective Heat Sensitivity Of Cancer Cells

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Selective Heat Sensitivity of Cancer Cells

Author : A. Rossi-Fanelli
Publisher : Springer Science & Business Media
ISBN 13 : 3642810802
Total Pages : 334 pages
Book Rating : 4.6/5 (428 download)

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Book Synopsis Selective Heat Sensitivity of Cancer Cells by : A. Rossi-Fanelli

Download or read book Selective Heat Sensitivity of Cancer Cells written by A. Rossi-Fanelli and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.

Hyperthermia In Cancer Treatment: A Primer

Author : Gian F. Baronzio
Publisher : Springer Science & Business Media
ISBN 13 : 0387334416
Total Pages : 382 pages
Book Rating : 4.3/5 (873 download)

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Book Synopsis Hyperthermia In Cancer Treatment: A Primer by : Gian F. Baronzio

Download or read book Hyperthermia In Cancer Treatment: A Primer written by Gian F. Baronzio and published by Springer Science & Business Media. This book was released on 2008-05-08 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: Following an introductory overview, Hyperthermia In Cancer Treatment: A Primer comprehensively describes the biological reasons for associating hyperthermia with radiation and chemotherapy and the biological and clinical effects of hyperthermia on cancerous and normal tissues. The volume’s 20 chapters are arranged in three principal parts: physical and methodological studies, biologic principles, and clinical studies.

Heat Shock Proteins in Cancer

Author : Stuart K. Calderwood
Publisher : Springer Science & Business Media
ISBN 13 : 1402064012
Total Pages : 399 pages
Book Rating : 4.4/5 (2 download)

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Book Synopsis Heat Shock Proteins in Cancer by : Stuart K. Calderwood

Download or read book Heat Shock Proteins in Cancer written by Stuart K. Calderwood and published by Springer Science & Business Media. This book was released on 2007-09-09 with total page 399 pages. Available in PDF, EPUB and Kindle. Book excerpt: Heat shock proteins are emerging as important molecules in the development of cancer and as key targets in cancer therapy. These proteins enhance the growth of cancer cells and protect tumors from treatments such as drugs or surgery. However, new drugs have recently been developed particularly those targeting heat shock protein 90. As heat shock protein 90 functions to stabilize many of the oncogenes and growth promoting proteins in cancer cells, such drugs have broad specificity in many types of cancer cell and offer the possibility of evading the development of resistance through point mutation or use of compensatory pathways. Heat shock proteins have a further property that makes them tempting targets in cancer immunotherapy. These proteins have the ability to induce an inflammatory response when released in tumors and to carry tumor antigens to antigen presenting cells. They have thus become important components of anticancer vaccines. Overall, heat shock proteins are important new targets in molecular cancer therapy and can be approached in a number of contrasting approaches to therapy.

Selective Heat Sensitivity of Cancer Cells

Author : A. Rossi-Fanelli
Publisher : Springer
ISBN 13 : 9783642810817
Total Pages : 192 pages
Book Rating : 4.8/5 (18 download)

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Book Synopsis Selective Heat Sensitivity of Cancer Cells by : A. Rossi-Fanelli

Download or read book Selective Heat Sensitivity of Cancer Cells written by A. Rossi-Fanelli and published by Springer. This book was released on 2011-12-30 with total page 192 pages. Available in PDF, EPUB and Kindle. Book excerpt: Since the first observations of Busch in 1866, the possible use of heat as a therapeutic agent in the cure of cancer has been repeatedly subject to bursts of interest, almost invariably followed by periods of neglect and skepticism. In 1963-1964, this problem was again attacked by us both from the biochemical and from the clinical points of view. The first results of this joint effort were positive beyond expectation, and generated a new revial of studies aimed at the identification of the nature of the bio chemical lesion as well as at the optimization of technique and of the therapeutic schedules connected with clinical use. Although the number of mammalian tumors which have been proved to be heat-sensitive is now relatively large, and although in some cases a correlation has been demonstrated between tumorigenicity and heat-sensitivity of in vitro cultured cell lines, the question of a direct and constant relationship between neoplastic character and higher sensitivity to hyperthermic exposure is still open to continuing investigation and reappraisal. Several studies deal in fact with the determination of the conditions under which, in vitro and or in vivo, different tumors are efficiently damaged by elevated temperatures.

HSF1 and Molecular Chaperones in Biology and Cancer

Author : Marc Laurence Mendillo
Publisher : Springer Nature
ISBN 13 : 3030402045
Total Pages : 185 pages
Book Rating : 4.0/5 (34 download)

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Book Synopsis HSF1 and Molecular Chaperones in Biology and Cancer by : Marc Laurence Mendillo

Download or read book HSF1 and Molecular Chaperones in Biology and Cancer written by Marc Laurence Mendillo and published by Springer Nature. This book was released on 2020-04-15 with total page 185 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.

Oncothermia: Principles and Practices

Author : Andras Szasz
Publisher : Springer Science & Business Media
ISBN 13 : 9048194989
Total Pages : 575 pages
Book Rating : 4.0/5 (481 download)

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Book Synopsis Oncothermia: Principles and Practices by : Andras Szasz

Download or read book Oncothermia: Principles and Practices written by Andras Szasz and published by Springer Science & Business Media. This book was released on 2010-11-23 with total page 575 pages. Available in PDF, EPUB and Kindle. Book excerpt: Oncothermia is the next generation medical innovation that delivers selective, controlled and deep energy for cancer treatment. The basic principles for oncothermia stem from oncological hyperthermia, the oldest approach to treating cancer. Nevertheless, hyperthermia has been wrought with significant controversy, mostly stemming from shortcomings of controlled energy delivery. Oncothermia has been able to overcome these insufficiencies and prove to be a controlled, safe and efficacious treatment option. This book is the first attempt to elucidate the theory and practice of oncothermia, based on rigorous mathematical and biophysical analysis, not centered on the temperature increase. It is supported by numerous in-vitro and in-vivo findings and twenty years of clinical experience. This book will help scientists, researchers and medical practitioners in understanding the scientific and conceptual underpinnings of oncothermia and will add another valuable tool in the fight against cancer. Professor Andras Szasz is the inventor of oncothermia and the Head of St Istvan University's Biotechnics Department in Hungary. He has published over 300 papers and lectured at various universities around the world. Dr. Oliver Szasz is the managing director of Oncotherm, the global manufacturer and distributor of medical devices for cancer treatment used in Europe & Asia since the late 1980s. Dr. Nora Szasz is currently a management consultant in healthcare for McKinsey & Co.

Thermoradiotherapy and Thermochemotherapy

Author : M.Heinrich Seegenschmiedt
Publisher : Springer Science & Business Media
ISBN 13 : 3642578586
Total Pages : 479 pages
Book Rating : 4.6/5 (425 download)

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Book Synopsis Thermoradiotherapy and Thermochemotherapy by : M.Heinrich Seegenschmiedt

Download or read book Thermoradiotherapy and Thermochemotherapy written by M.Heinrich Seegenschmiedt and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 479 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyperthermia has been found to be of great benefit in combination with radiation therapy or chemotherapy in the management of patients with difficult and com plicated tumor problems. It has been demonstrated to increase the efficacy, of ionising radiation when used locally but also has been of help in combination with systemic chemotherapy where hyperthermia is carried out to the total body. Problems remain with regard to maximizing the effects of hyperthermia as in fluenced by blood flow, heat loss, etc. The present volume defines the current knowledge relative to hyperthermia with radiation therapy and/or chemotherapy, giving a comprehensive overview of its use in cancer management. Philadelphia/Hamburg, June 1995 L.W. BRADY H.-P. HEILMANN Preface In an attempt to overcome tumor resistance, hypoxia, or unfavorable tumor condi tions, oncological research has come to focus on gene therapy, immunotherapy, new cytotoxic agents, and increasingly sophisticated radiotherapy. Radiation research has been directed towards heavy particle therapy and modification of the radiation response by either protecting or sensitizing agents. Improved dose localization using rotational or conformal strategies has also been implemented. Recently, changes in radiation fractionation schedules have shown promise of better results. Hyperthermia in cancer therapy can be viewed similarly as another means to increase the sensitivity of tumors to radio- and chemotherapy.

Comparative Oncology

Author : Alecsandru Ioan Baba
Publisher :
ISBN 13 : 9789732714577
Total Pages : 787 pages
Book Rating : 4.7/5 (145 download)

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Book Synopsis Comparative Oncology by : Alecsandru Ioan Baba

Download or read book Comparative Oncology written by Alecsandru Ioan Baba and published by . This book was released on 2007 with total page 787 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Cold Plasma Cancer Therapy

Author : Michael Keidar
Publisher : Morgan & Claypool Publishers
ISBN 13 : 1643274341
Total Pages : 98 pages
Book Rating : 4.6/5 (432 download)

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Book Synopsis Cold Plasma Cancer Therapy by : Michael Keidar

Download or read book Cold Plasma Cancer Therapy written by Michael Keidar and published by Morgan & Claypool Publishers. This book was released on 2019-04-01 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cold atmospheric plasma (CAP) emerges as a possible new modality for cancer treatment. This book provides a comprehensive introduction into fundamentals of the CAP and plasma devices used in plasma medicine. An analysis of the mechanisms of plasma interaction with cancer and normal cells including description of possible mechanisms of plasma selectivity is included. Recent advances in the field, the primary challenges and future directions are presented.

Nanooncology

Author : Gil Gonçalves
Publisher : Springer
ISBN 13 : 9783319898773
Total Pages : 0 pages
Book Rating : 4.8/5 (987 download)

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Book Synopsis Nanooncology by : Gil Gonçalves

Download or read book Nanooncology written by Gil Gonçalves and published by Springer. This book was released on 2018-06-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents a systematic overview of the most relevant nanomaterials and their respective intrinsic properties that have been highly explored by the scientific community and pharmaceutical companies in several different modalities for cancer therapy and bioimaging. The chapters explore the synergistic effects provided by the different nanostructured materials and highlight the main in vitro and in vivo therapeutic achievements on cancer. This work also provides relevant discussion about the recent progresses and future challenges that nanotechnology faces on the conception of more efficient nanoformulations against primary tumors, circulating cancer cells and metastases.

Innovative Medicine

Author : Kazuwa Nakao
Publisher : Springer
ISBN 13 : 4431556516
Total Pages : 330 pages
Book Rating : 4.4/5 (315 download)

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Book Synopsis Innovative Medicine by : Kazuwa Nakao

Download or read book Innovative Medicine written by Kazuwa Nakao and published by Springer. This book was released on 2015-10-13 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is devoted to innovative medicine, comprising the proceedings of the Uehara Memorial Foundation Symposium 2014. It remains extremely rare for the findings of basic research to be developed into clinical applications, and it takes a long time for the process to be achieved. The task of advancing the development of basic research into clinical reality lies with translational science, yet the field seems to struggle to find a way to move forward. To create innovative medical technology, many steps need to be taken: development and analysis of optimal animal models of human diseases, elucidation of genomic and epidemiological data, and establishment of “proof of concept”. There is also considerable demand for progress in drug research, new surgical procedures, and new clinical devices and equipment. While the original research target may be rare diseases, it is also important to apply those findings more broadly to common diseases. The book covers a wide range of topics and is organized into three complementary parts. The first part is basic research for innovative medicine, the second is translational research for innovative medicine, and the third is new technology for innovative medicine. This book helps to understand innovative medicine and to make progress in its realization.

Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression

Author : Robert Fried
Publisher : Elsevier
ISBN 13 : 012824013X
Total Pages : 246 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression by : Robert Fried

Download or read book Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression written by Robert Fried and published by Elsevier. This book was released on 2021-03-05 with total page 246 pages. Available in PDF, EPUB and Kindle. Book excerpt: Starving Cancer Cells: Evidence-Based Strategies to Slow Cancer Progression - A Selection of Readings for Health Services Providers presents an edited and annotated collection of recent medical journal publications and abstracts illustrating new approaches to treatment derived from the metabolic theory of cancer. It intends to shed an early light on a relatively new approach to our understanding of the cancer cell idiosyncratic metabolic dysfunction, and on evidence-based new treatment strategies derived from that understanding. The book discusses topics such as tumor starvation by L-arginine deprivation; L-canavanine depriving tumors of L-arginine in pancreatic, multiple myeloma and breast cancer; glucose deprivation and intermittent fasting; glutamine uptake in cancer; the relation of oxygen-starved cancer cells with aspartate; and reducing tolerance of tumor cells to nutrition starvation. The content is presented in a contextualized and practical way in order to facilitate the transition from bench to bedside. This is a valuable resource for practitioners, oncologists and other members of healthcare chain who are interested in learning more about the most recent tumor cell starvation strategies and how they can improve overall treatment outcome. Provides extensive comments on scientific publications detailing recent findings about tumor cell auxotrophy applied to tumor cell starvation strategies Helps the reader to find relevant and practical information on cancer cell starvation, otherwise spread through niched specialized journals, in one single place Comments on the recent findings putting them in context of clinical practice in order to provide the reader with means of translating high level research to the clinics

Consensus on Hyperthermia for the 1990s

Author : Haim I. Bicher
Publisher : Springer Science & Business Media
ISBN 13 : 1468457667
Total Pages : 545 pages
Book Rating : 4.4/5 (684 download)

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Book Synopsis Consensus on Hyperthermia for the 1990s by : Haim I. Bicher

Download or read book Consensus on Hyperthermia for the 1990s written by Haim I. Bicher and published by Springer Science & Business Media. This book was released on 2013-03-08 with total page 545 pages. Available in PDF, EPUB and Kindle. Book excerpt: Hyperthermia as a safe and effective cancer treatment modality is rapidly evolving propelled by widespread research and clinical efforts worldwide. Presentations on Hyperthermia experience are now commonplace at Oncology meetings, as are congresses dedicated entirely to the intertwined interactions between basic sciences and patient treatment that together are forming the structure of a new medical specialty. Such was the XII International Symposium on Clinical Hyperthermia held in Rome, Italy, April 27 - 29, 1989. Papers presented therein constitute the backbone of this book. Biology research has provided data describing mechanisms of action for the cancer cell killing and physiological effects of Hyperthermia. Physics research has led to the development of equipment enabling treatment of many areas of the human body, as well as explained the limitations that still constrain our ability to treat, especially in the areas of deep seated tumor heating and non-invasive thermometry. The main question that will decide the future of this modality is that of its clinical use. To put it succinctly, what do we do with this potentially useful tool in an everyday clinical oncological practice . •• ? This is the main question addressed in this book as "Consensus on Hyperthermia for the 1990s. " The book in cludes 28 presented papers and 25 invited chapters from some of the leading experts in the field. Their basic mechanisms of action were physics principles, treatment quality assurance and especially, clinical indications.

Focus on Leukemia Research

Author : Rafael M. Romero
Publisher : Nova Publishers
ISBN 13 : 9781594540936
Total Pages : 206 pages
Book Rating : 4.5/5 (49 download)

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Book Synopsis Focus on Leukemia Research by : Rafael M. Romero

Download or read book Focus on Leukemia Research written by Rafael M. Romero and published by Nova Publishers. This book was released on 2004 with total page 206 pages. Available in PDF, EPUB and Kindle. Book excerpt: This new book brings together leading research from around the globe. Leukaemia is cancer that begins in blood cells. In people with leukaemia, the bone marrow produces abnormal white blood cells. The abnormal cells are leukaemia cells. At first, leukaemia cells function almost normally. In time, they may crowd out normal white blood cells, red blood cells, and platelets. The scope of the book includes the four common types of leukaemia: chronic lymphocytic leukaemia (chronic lymphoblastic leukaemia, CLL) - most often affecting people over age 55; chronic myeloid leukaemia (chronic myelogenous leukaemia, CML) - affects mainly adults; acute lymphocytic leukaemia (acute lymphoblastic leukaemia, ALL) - the most common type of leukaemia in young children; and acute myeloid leukaemia (acute myelogenous leukaemia, AML) - which occurs in both adults and children. New advances in diagnosis, pathogenesis and therapy are also presented.

Immunodiagnosis and Immunotherapy of Malignant Tumors

Author : H.-D. Flad
Publisher : Springer Science & Business Media
ISBN 13 : 3642671667
Total Pages : 333 pages
Book Rating : 4.6/5 (426 download)

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Book Synopsis Immunodiagnosis and Immunotherapy of Malignant Tumors by : H.-D. Flad

Download or read book Immunodiagnosis and Immunotherapy of Malignant Tumors written by H.-D. Flad and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 333 pages. Available in PDF, EPUB and Kindle. Book excerpt: The concept of immunologic responses against tumors is currently under intense scrutiny throughout the world. The evidence for the existence of tumor-specific transplantation antigens (TSTA) and specific immune reactions to them in experimental animals is overwhelming. The available data concerning human tumors are controversial. The reason for this is partially that antigens detectable on human tumors by in vitro assays have not been biologically characterized. In other words, we do not know if the antigens on human tumors are acting as the targets for immunologically mediated rejection processes in vivo. It was the purpose of this workshop to bring experimental tumor immunologists and clinical oncologists together in order to disclose facts and limits in tumor immunology. Clinicians were to learn how shaky the ground becomes once the experimentalist looks beyond the edge of the mouse cage. Tumor biologists heard the clinicians' urgent cry for controlled randomized trials of immunotherapy which thus reflects clearly that immunotherapy in its present form without knowledge of dose-effect-relationship does not work. Nobody would deny that the problem of human cancer smells of immunology, but since we are just about to taste it the essential ingredient might be different. In other words one might look at present rather at immunological epiphenomena than at mechanisms of tumor immul1lty operating in vivo. This problem was among others a central issue of this workshop.

Thermal Effects on Cells and Tissues

Author : M. Urano
Publisher : CRC Press
ISBN 13 : 146656377X
Total Pages : 221 pages
Book Rating : 4.4/5 (665 download)

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Book Synopsis Thermal Effects on Cells and Tissues by : M. Urano

Download or read book Thermal Effects on Cells and Tissues written by M. Urano and published by CRC Press. This book was released on 2023-01-06 with total page 221 pages. Available in PDF, EPUB and Kindle. Book excerpt: Volume 1 of Thermal Effects on Cells and Tissues covers Hyperthermia and Oncology. This is a collection of eight essays.

Theory and Applications of Heat Transfer in Humans, 2 Volume Set

Author : Devashish Shrivastava
Publisher : John Wiley & Sons
ISBN 13 : 1119127300
Total Pages : 897 pages
Book Rating : 4.1/5 (191 download)

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Book Synopsis Theory and Applications of Heat Transfer in Humans, 2 Volume Set by : Devashish Shrivastava

Download or read book Theory and Applications of Heat Transfer in Humans, 2 Volume Set written by Devashish Shrivastava and published by John Wiley & Sons. This book was released on 2018-07-02 with total page 897 pages. Available in PDF, EPUB and Kindle. Book excerpt: An authoritative guide to theory and applications of heat transfer in humans Theory and Applications of Heat Transfer in Humans 2V Set offers a reference to the field of heating and cooling of tissue, and associated damage. The author—a noted expert in the field—presents, in this book, the fundamental physics and physiology related to the field, along with some of the recent applications, all in one place, in such a way as to enable and enrich both beginner and advanced readers. The book provides a basic framework that can be used to obtain ‘decent’ estimates of tissue temperatures for various applications involving tissue heating and/or cooling, and also presents ways to further develop more complex methods, if needed, to obtain more accurate results. The book is arranged in three sections: The first section, named ‘Physics’, presents fundamental mathematical frameworks that can be used as is or combined together forming more complex tools to determine tissue temperatures; the second section, named ‘Physiology’, presents ideas and data that provide the basis for the physiological assumptions needed to develop successful mathematical tools; and finally, the third section, named ‘Applications’, presents examples of how the marriage of the first two sections are used to solve problems of today and tomorrow. This important text is the vital resource that: Offers a reference book in the field of heating and cooling of tissue, and associated damage. Provides a comprehensive theoretical and experimental basis with biomedical applications Shows how to develop and implement both, simple and complex mathematical models to predict tissue temperatures Includes simple examples and results so readers can use those results directly or adapt them for their applications Designed for students, engineers, and other professionals, a comprehensive text to the field of heating and cooling of tissue that includes proven theories with applications. The author reveals how to develop simple and complex mathematical models, to predict tissue heating and/or cooling, and associated damage.