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Seldi Tof Mass Spectrometry
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Book Synopsis Seldi-Tof Mass Spectrometry by : Charlotte H. Clarke
Download or read book Seldi-Tof Mass Spectrometry written by Charlotte H. Clarke and published by Humana Press. This book was released on 2016-05-01 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: Coupling features of chromatography and mass spectrometry, SELDI is a popular method of biomarker discovery. This volume reviews its current applications, emphasizing study and experimental design, data analysis and interpretation, and assay development.
Book Synopsis Medical Applications of Mass Spectrometry by : Karoly Vekey
Download or read book Medical Applications of Mass Spectrometry written by Karoly Vekey and published by Elsevier. This book was released on 2011-08-11 with total page 607 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass spectrometry is fast becoming an indispensable field for medical professionals. The mass spectrometric analysis of metabolites and proteins promises to revolutionize medical research and clinical diagnostics. As this technology rapidly enters the medical field, practicing professionals and students need to prepare to take full advantage of its capabilities. Medical Applications of Mass Spectrometry addresses the key issues in the medical applications of mass spectrometry at the level appropriate for the intended readership. It will go a long way to help the utilization of mass spectrometry in medicine.The book comprises five parts. A general overview is followed by a description of the basic sampling and separation methods in analytical chemistry. In the second part a solid foundation in mass spectrometry and modern techniques of data analysis is presented. The third part explains how mass spectrometry is used in exploring various classes of biomolecules, including proteins and lipids. In the fourth section mass spectrometry is introduced as a diagnostic tool in clinical treatment, infectious pathogen research, neonatal diagnostics, cancer, brain and allergy research, as well as in various fields of medicine: cardiology, pulmonology, neurology, psychiatric diseases, hemato-oncology, urologic diseases, gastrointestinal diseases, gynecology and pediatrics. The fifth part covers emerging applications in biomarker discovery and in mass spectrometric imaging. * Provides a broad look at how the medical field is benefiting from advances in mass spectrometry.* Guides the reader from basic principles and methods to cutting edge applications.* There is NO comparable book on the market to fill this fast growing field.
Book Synopsis MALDI-TOF and Tandem MS for Clinical Microbiology by : Haroun N. Shah
Download or read book MALDI-TOF and Tandem MS for Clinical Microbiology written by Haroun N. Shah and published by John Wiley & Sons. This book was released on 2017-03-31 with total page 850 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book highlights the triumph of MALDI-TOF mass spectrometry over the past decade and provides insight into new and expanding technologies through a comprehensive range of short chapters that enable the reader to gauge their current status and how they may progress over the next decade. This book serves as a platform to consolidate current strengths of the technology and highlight new frontiers in tandem MS/MS that are likely to eventually supersede MALDI-TOF MS. Chapters discuss: Challenges of Identifying Mycobacterium to the Species level Identification of Bacteroides and Other Clinically Relevant Anaerobes Identification of Species in Mixed Microbial Populations Detection of Resistance Mechanisms Proteomics as a biomarker discovery and validation platform Determination of Antimicrobial Resistance using Tandem Mass Spectrometry
Book Synopsis Analyzing Biomolecular Interactions by Mass Spectrometry by : Jeroen Kool
Download or read book Analyzing Biomolecular Interactions by Mass Spectrometry written by Jeroen Kool and published by John Wiley & Sons. This book was released on 2015-05-04 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph reviews all relevant technologies based on mass spectrometry that are used to study or screen biological interactions in general. Arranged in three parts, the text begins by reviewing techniques nowadays almost considered classical, such as affinity chromatography and ultrafiltration, as well as the latest techniques. The second part focusses on all MS-based methods for the study of interactions of proteins with all classes of biomolecules. Besides pull down-based approaches, this section also emphasizes the use of ion mobility MS, capture-compound approaches, chemical proteomics and interactomics. The third and final part discusses other important technologies frequently employed in interaction studies, such as biosensors and microarrays. For pharmaceutical, analytical, protein, environmental and biochemists, as well as those working in pharmaceutical and analytical laboratories.
Book Synopsis Analysis of SELDI Mass Spectra for Biomarker Discovery and Cancer Classification by :
Download or read book Analysis of SELDI Mass Spectra for Biomarker Discovery and Cancer Classification written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The thesis focused on data analysis of surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS) for biomarker discovery and cancer classification. It investigated quantitative measures of reproducibility and found that SELDI protein profiles are affected by sample storage and processing procedure. Two new peak alignment algorithms were proposed, one of which achieved the best performance when compared to the existing methods. The assumption of normality of SELDI protein profiles, on which the standard statistical methods are based, was examined. Normality tests and the multiple testing procedures revealed that SELDI protein profiles do not follow normal distributions, implying that it may be reliable to use non-parametric methods for detecting disease-associated proteins. A new normalisation algorithm was proposed, and was shown to give a better improvement of normality compared with the existing methods. An integrated algorithm to discover proteomic biomarkers for cancer diagnosis was proposed and applied to two published SELDI data sets. The results demonstrated that the receiver operating characteristic (ROC) curve method may be more reliable to determine the discriminatory powers of the identified biomarkers compared to Wilcoxon test. The methods for proteomic biomarker discovery presented here may be generalisable and applicable to other mass spectrometry and genomics approaches.
Book Synopsis Fundamentals of Data Mining in Genomics and Proteomics by : Werner Dubitzky
Download or read book Fundamentals of Data Mining in Genomics and Proteomics written by Werner Dubitzky and published by Springer Science & Business Media. This book was released on 2007-04-13 with total page 300 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents state-of-the-art analytical methods from statistics and data mining for the analysis of high-throughput data from genomics and proteomics. It adopts an approach focusing on concepts and applications and presents key analytical techniques for the analysis of genomics and proteomics data by detailing their underlying principles, merits and limitations.
Download or read book MALDI MS written by Franz Hillenkamp and published by John Wiley & Sons. This book was released on 2013-12-23 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book on MALDI MS, now finally available in its second edition and edited by one of its inventors, gives an in-depth description of the many different applications, along with a detailed discussion of the technology itself. Thoroughly updated and expanded, with contributions from key players in the field, this unique book provides a comprehensive overview of MALDI MS along with its possibilities and limitations. The initial chapters deal with the technology and the instrumental setup, followed by chapters on the use of MALDI MS in protein research (including proteomics), genomics, glycomics and lipidomics. The option of MALDI-MS for the analysis of polymers and small molecules are also covered in separate chapters, while new to this edition is a section devoted to the interplay of MALDI MS and bioinformatics. A much-needed practical and educational asset for individuals, academic institutions and companies in the field of bioanalytics.
Book Synopsis Analysis of SELDI Mass Spectra for Biomarker Discovery and Cancer Classification by : Yaping Cheng
Download or read book Analysis of SELDI Mass Spectra for Biomarker Discovery and Cancer Classification written by Yaping Cheng and published by . This book was released on 2009 with total page 244 pages. Available in PDF, EPUB and Kindle. Book excerpt: The thesis focused on data analysis of surface-enhanced laser desorption/ionisation time-of-flight mass spectrometry (SELDI-TOF MS) for biomarker discovery and cancer classification. It investigated quantitative measures of reproducibility and found that SELDI protein profiles are affected by sample storage and processing procedure. Two new peak alignment algorithms were proposed, one of which achieved the best performance when compared to the existing methods. The assumption of normality of SELDI protein profiles, on which the standard statistical methods are based, was examined. Normality tests and the multiple testing procedures revealed that SELDI protein profiles do not follow normal distributions, implying that it may be reliable to use non-parametric methods for detecting disease-associated proteins. A new normalisation algorithm was proposed, and was shown to give a better improvement of normality compared with the existing methods. An integrated algorithm to discover proteomic biomarkers for cancer diagnosis was proposed and applied to two published SELDI data sets. The results demonstrated that the receiver operating characteristic (ROC) curve method may be more reliable to determine the discriminatory powers of the identified biomarkers compared to Wilcoxon test. The methods for proteomic biomarker discovery presented here may be generalisable and applicable to other mass spectrometry and genomics approaches.
Book Synopsis Mass Spectrometry by : Marek Smoluch
Download or read book Mass Spectrometry written by Marek Smoluch and published by John Wiley & Sons. This book was released on 2019-07-11 with total page 450 pages. Available in PDF, EPUB and Kindle. Book excerpt: Provides a comprehensive description of mass spectrometry basics, applications, and perspectives Mass spectrometry is a modern analytical technique, allowing for fast and ultrasensitive detection and identification of chemical species. It can serve for analysis of narcotics, counterfeit medicines, components of explosives, but also in clinical chemistry, forensic research and anti-doping analysis, for identification of clinically relevant molecules as biomarkers of various diseases. This book describes everything readers need to know about mass spectrometry—from the instrumentation to the theory and applications. It looks at all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS (paying special attention to various methodologies and data interpretation). It also contains a list of key terms for easier and faster understanding of the material by newcomers to the subject and test questions to assist lecturers. Knowing how crucial it is for young researchers to fully understand both the power of mass spectrometry and the importance of other complementary methodologies, Mass Spectrometry: An Applied Approach teaches that it should be used in conjunction with other techniques such as NMR, pharmacological tests, structural identification, molecular biology, in order to reveal the true function(s) of the identified molecule. Provides a description of mass spectrometry basics, applications and perspectives of the technique Oriented to a broad audience with limited or basic knowledge in mass spectrometry instrumentation, theory, and its applications in order to enhance their competence in this field Covers all aspects of mass spectrometry, including inorganic, organic, forensic, and biological MS with special attention to application of various methodologies and data interpretation Includes a list of key terms, and test questions, for easier and faster understanding of the material Mass Spectrometry: An Applied Approach is highly recommended for advanced students, young scientists, and anyone involved in a field that utilizes the technique.
Book Synopsis The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology by : Fernando Cobo
Download or read book The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology written by Fernando Cobo and published by Academic Press. This book was released on 2018-08-03 with total page 299 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Use of Mass Spectrometry Technology (MALDI-TOF) in Clinical Microbiology presents the state-of the-art for MALDI-TOF mass spectrometry. It is a key reference defining how MALDI-TOF mass spectrometry is used in clinical settings as a diagnostic tool of microbial identification and characterization that is based on the detection of a mass of molecules. The book provides updated applications of MALDI-TOF techniques in clinical microbiology, presenting the latest information available on a technology that is now used for rapid microbial identification at relatively low cost, thus offering an alternative to conventional laboratory diagnosis and proteomic identification systems. Although the main use of the technology has, until now, been identification or typing of bacteria from a positive culture, applications in the field of virology, mycology, microbacteriology and resistances are opening up new opportunities. Presents updated applications of MALDI-TOF techniques in clinical microbiology Describes the use of mass spectrometry in the lab, the principles of the technology, preparation of samples, device calibration and maintenance, treatment of microorganisms, and quality control Presents key information for researchers, including possible uses of the technology, differences between devices, how to interpret results, and future applications Covers the topic in a systematic and comprehensive manner that is useful to both clinicians and researchers
Book Synopsis Mass Spectrometry in Medicinal Chemistry by : Klaus Wanner
Download or read book Mass Spectrometry in Medicinal Chemistry written by Klaus Wanner and published by John Wiley & Sons. This book was released on 2007-06-27 with total page 460 pages. Available in PDF, EPUB and Kindle. Book excerpt: This first overview of mass spectrometry-based pharmaceutical analysis is the key to improved high-throughput drug screening, rational drug design and analysis of multiple ligand-target interactions. The ready reference opens with a general introduction to the use of mass spectrometry in pharmaceutical screening, followed by a detailed description of recently developed analytical systems for use in the pharmaceutical laboratory. Applications range from simple binding assays to complex screens of biological activity and systems containing multiple targets or ligands -- all highly relevant techniques in the early stages in drug discovery, from target characterization to hit and lead finding.
Book Synopsis Screening Assay for Enzymes Involved in Pathophysiology Using SELDI-TOF Mass Spectrometry by : Khalid M. Elased
Download or read book Screening Assay for Enzymes Involved in Pathophysiology Using SELDI-TOF Mass Spectrometry written by Khalid M. Elased and published by . This book was released on 2002 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The invention provides methods for quantifying enzymatic activity of an enzyme with a known substrate. The methods employ SELDI-TOF mass spectrometry, and are suitable, in particular, for assaying aspects of the renin-angiotensin system. The methods may be utilized to assess and/or monitor biological conditions associated with the renin-angiotensin system prior to the manifestation of known physiological and biomarkers for such conditions. The methods are suitable for analysis of pharmacological effectors of the renin-angiotensin system, and are particularly suitable for automation and high-throughput screening assay design.
Book Synopsis Detection of Serum Lysophosphatidic Acids Using Affinity Binding and Surface Enhanced Laser Desorption/Ionization (SELDI) Time of Flight Mass Spectrometry by :
Download or read book Detection of Serum Lysophosphatidic Acids Using Affinity Binding and Surface Enhanced Laser Desorption/Ionization (SELDI) Time of Flight Mass Spectrometry written by and published by . This book was released on 2004 with total page 62 pages. Available in PDF, EPUB and Kindle. Book excerpt: We proposed to apply two novel technologies to the development of an approach suitable for screening for ovarian cancer in high and low risk women. The first of these is a novel approach to the development of antibodies which will recognize specific phospholipids and lysophospholipids present in ovarian cancer patients and the second of these is SELDI tof mass spectroscopy. These two technologies will be merged with powerful computing tools to develop approaches capable of detecting ovarian cancer at an early, curable stage. This approach will further benefit from the expertise of the Mills laboratory (LPA screening, SELDI tof) with that of the Prestwich laboratory (lipid synthesis and antibody development). Progress We have demonstrated that SELDI mass spectroscopy has the ability to detect model lysophospholipids present in plasma and serum. The sensitivity of the assay using standard capture chips is low and would require relatively large volumes of sera to detect the different lysophospholipid isoforms. This will require prepurification approaches to concentrate the lipids which we have now developed. We have obtained a pan sphingosine 1 phosphate antibody as a capture reagent. This antibody is able to bind all isoforms of S1P and when combined with SELDI should allow detection of isoforms of this lysophospholipid. We have shown that the antibodies can detect SIP levels in complex ascites mixtures. We are currently evaluating different CHIP forms for SELDI and developing LPA antibodies as well as obtaining LPA binding proteins to increase the ability to capture lysophospholipids through collaborative approaches.
Book Synopsis Mass Spectrometry by : Edmond de Hoffmann
Download or read book Mass Spectrometry written by Edmond de Hoffmann and published by Wiley. This book was released on 2001-10-10 with total page 420 pages. Available in PDF, EPUB and Kindle. Book excerpt: Offers a complete overview of the principles, theories and key applications of modern mass spectrometry in this introductory textbook. Following on from the highly successful first edition, this edition is extensively updated including new techniques and applications. All instrumental aspects of mass spectrometry are clearly and concisely described; sources, analysers and detectors. * Revised and updated * Numerous examples and illustrations are combined with a series of exercises to help encourage student understanding * Includes biological applications, which have been significantly expanded and updated * Also includes coverage of ESI and MALDI
Book Synopsis Time-of-flight Mass Spectrometry by : Robert J. Cotter
Download or read book Time-of-flight Mass Spectrometry written by Robert J. Cotter and published by . This book was released on 1997 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the basic principles of time-of-flight (TOF) mass spectrometry with a strong emphasis on applications in biological research. It describes many innovative techniques, including orthogonal extraction, post source decay, and delayed extraction, and surveys ionization techniques used on TOF mass spectrometers such as electron impact, plasma desorption, SIMS, FAB, laser desorption, MALDI, and electrospray. The book features chapters on applications to peptides/proteins, oligonucleotides, and other biological macromolecules, and examines how techniques might be used in sequencing the human genome.
Book Synopsis Mass Spectrometry and Biomarkers Development by : K.D. Rodland
Download or read book Mass Spectrometry and Biomarkers Development written by K.D. Rodland and published by IOS Press. This book was released on 2004 with total page 56 pages. Available in PDF, EPUB and Kindle. Book excerpt: One of the major goals of twenty-first century medicine is the identification of biomarkers for the earliest possible stages of disease involvement so that prompt clinical intervention can limit damage, reverse pathological change, and ideally effect a complete cure. New developments in the analytical field of mass spectrometry are providing clinicians and translational scientists with even more powerful tools for the discovery of novel biomarkers. A key requirement for the successful application of mass spectrometric approaches to biomarker discovery is a clear reference standard for the 'normal' human proteome, and a better understanding of the sources and extent of 'normal' variability in human plasma proteins. This special issue of Disease Markers includes examples of biomarker discovery efforts directed at breast and prostate cancers, diabetes mellitus, and heart disease.
Book Synopsis Mass Spectrometry by : Jürgen H Gross
Download or read book Mass Spectrometry written by Jürgen H Gross and published by Springer Science & Business Media. This book was released on 2006-04-05 with total page 534 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mass Spectrometry is an ideal textbook for students and professionals as well as newcomers to the field. Starting from the very first principles of gas-phase ion chemistry and isotopic properties, the textbook takes the reader through the design of mass analyzers and ionization methods all the way to mass spectral interpretation and coupling techniques. Step-by-step, the reader learns how mass spectrometry works and what it can do. The book comprises a balanced mixture of practice-oriented information and theoretical background. It features a clear layout and a wealth of high-quality figures. Exercises and solutions are located on the Springer Global Web.
