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Author : Anna Dürig
Publisher :
ISBN 13 :
Total Pages : 334 pages
Book Rating : 4.:/5 (428 download)
Download or read book Second Messenger Mediated Spatiotemporal Control of Cell Cycle and Development written by Anna Dürig and published by . This book was released on 2008 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Emanuele Biondi
Publisher : Springer Nature
ISBN 13 : 3030906213
Total Pages : 305 pages
Book Rating : 4.0/5 (39 download)
Download or read book Cell Cycle Regulation and Development in Alphaproteobacteria written by Emanuele Biondi and published by Springer Nature. This book was released on 2022-03-14 with total page 305 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book provides a comprehensive overview of the cell cycle regulation and development in Alphaproteobacteria. Cell cycle and cellular differentiation are fascinating biological phenomena that are highly regulated in all organisms. In the last decades, many laboratories around the world have been investigating these processes in Alphaproteobacteria. This bacterial class comprises important bacterial species, studied by fundamental and applied research. The complexity of cell cycle regulation and many examples of cellular differentiations in this bacterial group represent the main motives of this book. The book starts with discussing the regulation of cell cycle in alphaproteobacterial species from a system biology perspective. The following chapters specifically focus on the model species Caulobacter crescentus multiple layers of regulation, from transcriptional cascades to proteolysis and dynamic subcellular regulation of cell cycle regulators. In addition, the cell division process, chromosome segregation and growth of the cell envelope is described in detail. The last part of the book covers examples of non-Caulobacter alphaproteobacterial models, such as Agrobacterium tumefaciens, Brucella species and Sinorhizobium meliloti and also discusses possible applications. This book will be of interest to researchers in microbiology and cell biology labs working on cell cycle regulation and development.
Author : Alan J. Wolfe
Publisher : American Society for Microbiology Press
ISBN 13 : 1555814999
Total Pages : 714 pages
Book Rating : 4.5/5 (558 download)
Download or read book The Second Messenger Cyclic Di-GMP written by Alan J. Wolfe and published by American Society for Microbiology Press. This book was released on 2010-01-05 with total page 714 pages. Available in PDF, EPUB and Kindle. Book excerpt: A comprehensive reference on the state of the science for both experienced researchers and for those who are interested in discovering its many promising applications. • Examines c-di-GMP signaling from a variety of angles, beginning with an introductory chapter that compares c-di-GMP to the better-known second messenger cAMP. • Recounts the discovery of c-di-GMP, explains the important role of bioinformatics in the development and continued evolution of the field, and describes the fundamental structure, function, regulation, and integration of c-di-GMP pathways. • Explores the role of c-di-GMP in such diverse processes as flagellar biogenesis and motility, extracellular polysaccharide biosynthesis, biofilm development, virulence, and innate host immunity.
Author : Gregory R. Bock
Publisher : John Wiley and Sons
ISBN 13 : 9780471496625
Total Pages : 274 pages
Book Rating : 4.4/5 (966 download)
Download or read book The Cell Cycle and Development written by Gregory R. Bock and published by John Wiley and Sons. This book was released on 2001-06-29 with total page 274 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book brings together scientists working at the interface between the cell cycle, cell growth and development in a variety of model systems and research paradigms. The focus is on understanding how such diverse developmental inputs can modulate cell cycle regulation and, reciprocally, how a common way of regulating cell cycle progression can participate in different developmental strategies.
Author : Shan-Ho Chou
Publisher : Springer Nature
ISBN 13 : 3030333086
Total Pages : 640 pages
Book Rating : 4.0/5 (33 download)
Download or read book Microbial Cyclic Di-Nucleotide Signaling written by Shan-Ho Chou and published by Springer Nature. This book was released on 2020-03-05 with total page 640 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book explores the broad and diverse biological and physiological impacts of established and newly discovered cyclic di-nucleotide second messenger signaling systems, while also providing descriptions of the intriguing biochemical characteristics of multiple turnover enzymes and receptors. The respective chapters discuss the commonalities and diversity of cyclic di-GMP, cyclic di-AMP and recently discovered cyclic GMP-AMP signaling systems in manifold Gram-negative and Gram-positive bacteria. The global human pathogens Mycobacterium tuberculosis, Vibrio cholerae, Salmonella typhimurium, Escherichia coli and Streptococcus pneumoniae, the facultative human pathogen Pseudomonas aeruginosa, global plant pathogens as exemplified by Xanthomonas campestris and Burkholderia spp., and the omnipresent probiotic Lactobacilli, as well as environmentally important photoautotrophic cyanobacteria, the multicellular Myxococcus xanthus, and chemolithotrophic Acidithiobacillus are among the representatives of the microbial kingdom that are described. In turn, the various aspects of bacterial physiology affected by these signaling systems– e.g. biofilm formation and dispersal, the cell cycle, motility, virulence, production of antimicrobials, fundamental metabolism and osmohomeostasis – are discussed in detail in the context of different microorganisms. Dedicated chapters focus on the population diversity of cyclic dinucleotide signaling systems, their tendency to be horizontally transferred, the cyclic di-GMP signaling system in the social amoeba Dictyostelium, honorary cyclic (di)nucleotides, and the development of strategies for interfering with cyclic dinucleotide signaling in order to manipulate microbial behavior. Taken together, the chapters provide an authoritative source of information for a broad readership: beginners and advanced researchers from various disciplines; individuals seeking a broad overview of cyclic di-nucleotide signaling; and those who want to learn more about specific aspects. Also featuring reviews with a forward-looking perspective, the book offers a valuable source of inspiration for future research directions.
Author : Reinhard Krämer
Publisher : John Wiley & Sons
ISBN 13 : 3527629246
Total Pages : 513 pages
Book Rating : 4.5/5 (276 download)
Download or read book Bacterial Signaling written by Reinhard Krämer and published by John Wiley & Sons. This book was released on 2009-12-09 with total page 513 pages. Available in PDF, EPUB and Kindle. Book excerpt: Providing a comprehensive insight into cellular signaling processes in bacteria with a special focus on biotechnological implications, this is the first book to cover intercellular as well as intracellular signaling and its relevance for biofilm formation, host pathogen interactions, symbiotic relationships, and photo- and chemotaxis. In addition, it deals in detail with principal bacterial signaling mechanisms -- making this a valuable resource for all advanced students in microbiology. Dr. Krämer is a world-renowned expert in intracellular signaling and its implications for biotechnology processes, while Dr. Jung is an expert on intercellular signaling and its relevance for biomedicine and agriculture.
Author : Gamini Seneviratne
Publisher : Springer Nature
ISBN 13 : 9811599122
Total Pages : 387 pages
Book Rating : 4.8/5 (115 download)
Download or read book Role of Microbial Communities for Sustainability written by Gamini Seneviratne and published by Springer Nature. This book was released on 2021-01-27 with total page 387 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is about the role played by microbes in their community mode in sustaining ecosystems. The descriptions given in its chapters indicate clearly that microbial communities are more effective in delivering multifaceted benefits to the soil-plant system than those offered by microbial monocultures in planktonic modes. The role these communities play in a multitude of microbe-microbe and plant-microbe interactions have not yet been fully exploited to gain benefits in this field as well as to achieve sustainability in agriculture practices. Amply discussed are the beneficial characteristics and metabolic capacities of specific microbial groups and the use of microbial traits for the benefit of plant growth. The book suggests the need to develop new microbial technologies to utilize plant-associated microbes for increased crop productivity and agroecosystem balance in order to ensure sustainability. This also provides an effective guidance to scientists, academics, researchers, students and policy makers of the sphere to achieve the above outcomes.
Author : Klaus Okkenhaug
Publisher : Frontiers Media SA
ISBN 13 : 2889194191
Total Pages : 140 pages
Book Rating : 4.8/5 (891 download)
Download or read book PI3K signalling written by Klaus Okkenhaug and published by Frontiers Media SA. This book was released on 2015-03-05 with total page 140 pages. Available in PDF, EPUB and Kindle. Book excerpt: The PI3Ks control many key functions in immune cells. PI3Ks phosphorylate PtdIns(4,5)P2 to yield PtdIns(3,4,5)P3. Initially, PI3K inhibitors such as Wortmannin, LY294002 and Rapamycin were used to establish a central role for Pi3K pathway in immune cells. Considerable progress in understanding the role of this pathway in cells of the immune system has been made in recent years, starting with analysis of various PI3K and Pten knockout mice and subsequently mTOR and Foxo knockout mice. Together, these experiments have revealed how PI3Ks control B cell and T cell development, T helper cell differentiation, regulatory T cell development and function, B cell and T cell trafficking, immunoglobulin class switching and much, much more. The PI3Kd inhibitor idelalisib has recently been approved for the treatment of B cell lymphoma. Clinical trials of other PI3K inhibitors in autoimmune and inflammatory diseases are also in progress. This is an opportune time to consider a Research Topic considering when what we have learned about the PI3K signalling module in lymphocyte biology and how this is making an impact on clinical immunology and haematology.
Author :
Publisher :
ISBN 13 :
Total Pages : 1732 pages
Book Rating : 4.3/5 (243 download)
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1995 with total page 1732 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Author : Ronald P. Rubin
Publisher : CRC Press
ISBN 13 : 1000153592
Total Pages : 168 pages
Book Rating : 4.0/5 (1 download)
Download or read book Lipid Second Messengers written by Ronald P. Rubin and published by CRC Press. This book was released on 2020-10-14 with total page 168 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lipid Second Messengers provides detailed methodology for analysis of various lipid signaling pathways. Authoritative contributors explain the factors that regulate lipid second messenger production by agonist-activated enzymes and examine their products. Topics discussed include procedures used to measure lipid-derived mediators such as lysophospholipids, arachidonic acid, eicosanoids, anandamide, and ceramides, and the enzymes responsible for generating these messengers, such as phospholipases, prostaglandin endoperoxide synthases, and sphingomyelinase.
Author : Tanja Petnicki-Ocwieja
Publisher : Frontiers Media SA
ISBN 13 : 2889195570
Total Pages : 116 pages
Book Rating : 4.8/5 (891 download)
Download or read book Lyme Disease: Recent Advances and Perspectives written by Tanja Petnicki-Ocwieja and published by Frontiers Media SA. This book was released on 2015-08-08 with total page 116 pages. Available in PDF, EPUB and Kindle. Book excerpt: The interplay between host and pathogen is a complex co-evolutionary battle of surveillance and evasion. The pathogen continuously develops mechanisms to subvert the immune response in order to establish infection while the immune system responds with novel mechanisms of detection. Because the majority of Lyme disease pathology is due to an over-exuberant immune response, much research in Borrelia burgdorferi pathogenesis has been devoted to understanding the mammalian host response to the bacterium. Immunological studies continue to be an active area of research employing emerging techniques, such as intra-vital imaging. These studies have furthered our understanding of inflammatory processes during long-term infection and provided some surprising insights, such as the continued presence of bacterial products after clearance. The field of Lyme disease has long debated the etiology of long-term inflammation and recent studies in the murine host have shed light on relevant cell types and inflammatory mediators that participate in the pathology of Lyme arthritis. Live imaging and bioluminescent studies have allowed for a novel view of the bacterial life cycle, including the tick mid-gut, tick-to-mammal transmission and dissemination throughout a mouse. A number of tick and bacterial proteins have been shown to participate in the completion of the enzootic cycle. Novel mechanisms of gene regulation are continuously being identified. However, B. burgdorferi lacks many traditional virulence factors, such as toxins or specialized secretion systems. Many genes in the B. burgdorferi genome have no known homolog in other bacteria. Therefore, studies focusing on host-pathogen interactions have therefore been limited by an incomplete understanding of the repertoire of bacterial virulence factors. Questions such as how the pathogen causes disease, colonizes the tick and evades host immune-surveillance have been difficult to address. Genetic studies involving single gene deletions have identified a number of important bacterial proteins, but a large-scale genomics approach to identify virulence factors has not been attempted until recently. The generation of a site-directed mutagenesis library is an important step towards a detailed analysis of the B. burgdorferi genome and pathogenome. Using this library, high-throughput genomic studies, utilizing techniques such as massively parallel sequencing have been promising and could be used to identify novel virulence determinants of disease in the mammalian host or persistence in the tick vector. Continued research on this unique pathogen and its specific interaction with host and vector may have far reaching consequences and provide insights for diverse disciplines including ecology, infectious disease, and immunology. Here, several reviews will discuss the most recent advances and future studies to be undertaken in the field of B. burgdorferi biology.
Author : Ayse Basak Engin
Publisher : Springer Nature
ISBN 13 : 3030498441
Total Pages : 415 pages
Book Rating : 4.0/5 (34 download)
Download or read book Protein Kinase-mediated Decisions Between Life and Death written by Ayse Basak Engin and published by Springer Nature. This book was released on 2021-02-04 with total page 415 pages. Available in PDF, EPUB and Kindle. Book excerpt: Protein phosphorylation via protein kinases is an inevitable process that alters physiological and pathological functions of the cells. Thus, protein kinases play key roles in the regulation of cell life or death decisions. Protein kinases are frequently a driving factor in a variety of human diseases including aging and cellular senescence, immune system and endothelial dysfunctions, cancers, insulin resistance, cholestasis and neurodegenerative diseases, as well as bacterial resistance in persistent infections. Recent developments in quantitative proteomics provide important opinions on kinase inhibitor selectivity and their modes of action in the biological context. Protein Kinase-mediated Decisions Between Life and Death aims to have the reader catch insights about up-to-date opinions on “Protein Kinases” related pathways that threaten human health and life. As “Protein Kinases” are related to many health problems, clinicians, basic science researchers and students need this information. Chapter “Signal Transduction in Immune Cells and Protein Kinases” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com.
Author : J. Reinert
Publisher : Springer Science & Business Media
ISBN 13 : 354037390X
Total Pages : 336 pages
Book Rating : 4.5/5 (43 download)
Download or read book Cell Cycle and Cell Differentiation written by J. Reinert and published by Springer Science & Business Media. This book was released on 2013-06-29 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt: It is instructive to compare the response of biologists to the two themes that comprise the title of this volume. The concept of the cell cycle-in contra distinction to cell division-is a relatively recent one. Nevertheless biologists of all persuasions appreciate and readily agree on the central problems in this area. Issues ranging from mechanisms that initiate and integrate the synthesis of chro mosomal proteins and DNA during S-phase of mitosis to the manner in which assembly of microtubules and their interactions lead to the segregation of metaphase chromosomes are readily followed by botanists and zoologists, as well as by cell and molecular biologists. These problems are crisp and well-defined. The current state of "cell differentiation" stands in sharp contrast. This, one of the oldest problems in experimental biology, almost defies definition today. The difficulties arise not only from a lack of pertinent information on the regulatory mechanisms, but also from conflicting basic concepts in this field. One of the ways in which this situation might be improved would be to find a broader experimental basis, including a better understanding of the relationship between the cell cycle and cell differentiation.
Author : Hisao Masai
Publisher : Springer
ISBN 13 : 9811069557
Total Pages : 581 pages
Book Rating : 4.8/5 (11 download)
Download or read book DNA Replication written by Hisao Masai and published by Springer. This book was released on 2018-01-22 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book reviews the latest trends and future directions of DNA replication research. The contents reflect upon the principles that have been established through the genetic and enzymatic studies of bacterial, viral, and cellular replication during the past decades. The book begins with a historical overview of the studies on eukaryotic DNA replication by Professor Thomas Kelly, a pioneer of the field. The following chapters include genome-wide studies of replication origins and initiation factor binding, as well as the timing of DNA replications, mechanisms of initiation, DNA chain elongation and termination of DNA replication, the structural basis of functions of protein complexes responsible for execution of DNA replication, cell cycle-dependent regulation of DNA replication, the nature of replication stress and cells’ strategy to deal with the stress, and finally how all these phenomena are interconnected to genome instability and development of various diseases. By reviewing the existing concepts ranging from the old principles to the newest ideas, the book gives readers an opportunity to learn how the classical replication principles are now being modified and new concepts are being generated to explain how genome DNA replication is achieved with such high adaptability and plasticity. With the development of new methods including cryoelectron microscopy analyses of huge protein complexes, single molecular analyses of initiation and elongation of DNA replication, and total reconstitution of eukaryotic DNA replication with purified factors, the field is enjoying one of its most exciting moments, and this highly timely book conveys that excitement to all interested readers.
Author : Alan R. Saltiel
Publisher : Springer Science & Business Media
ISBN 13 : 0387722041
Total Pages : 223 pages
Book Rating : 4.3/5 (877 download)
Download or read book Mechanisms of Insulin Action written by Alan R. Saltiel and published by Springer Science & Business Media. This book was released on 2007-10-05 with total page 223 pages. Available in PDF, EPUB and Kindle. Book excerpt: More than 18 million people in the United States have diabetes mellitus, and about 90% of these have the type 2 form of the disease. This book attempts to dissect the complexity of the molecular mechanisms of insulin action with a special emphasis on those features of the system that are subject to alteration in type 2 diabetes and other insulin resistant states. It explores insulin action at the most basic levels, through complex systems.
Author : Jose C. Jimenez-Lopez
Publisher : BoD – Books on Demand
ISBN 13 : 9535131699
Total Pages : 344 pages
Book Rating : 4.5/5 (351 download)
Download or read book Cytoskeleton written by Jose C. Jimenez-Lopez and published by BoD – Books on Demand. This book was released on 2017-05-17 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: The cytoskeleton is a highly dynamic intracellular platform constituted by a three-dimensional network of proteins responsible for key cellular roles as structure and shape, cell growth and development, and offering to the cell with "motility" that being the ability of the entire cell to move and for material to be moved within the cell in a regulated fashion (vesicle trafficking). The present edition of Cytoskeleton provides new insights into the structure-functional features, dynamics, and cytoskeleton's relationship to diseases. The authors' contribution in this book will be of substantial importance to a wide audience such as clinicians, researches, educators, and students interested in getting updated knowledge about molecular basis of cytoskeleton, such as regulation of cell vital processes by actin-binding proteins as cell morphogenesis, motility, their implications in cell signaling, as well as strategies for clinical trial and alternative therapies based in multitargeting molecules to tackle diseases, that is, cancer.
Author : Nicholas Sperelakis
Publisher : Elsevier
ISBN 13 : 0080574556
Total Pages : 1262 pages
Book Rating : 4.0/5 (85 download)
Download or read book Cell Physiology Source Book written by Nicholas Sperelakis and published by Elsevier. This book was released on 2012-12-02 with total page 1262 pages. Available in PDF, EPUB and Kindle. Book excerpt: This authoritative book gathers together a broad range of ideas and topics that define the field. It provides clear, concise, and comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics. The Third Edition contains substantial new material. Most chapters have been thoroughly reworked. The book includes chapters on important topics such as sensory transduction, the physiology of protozoa and bacteria, the regulation of cell division, and programmed cell death. Completely revised and updated - includes 8 new chapters on such topics as membrane structure, intracellular chloride regulation, transport, sensory receptors, pressure, and olfactory/taste receptors Includes broad coverage of both animal and plant cells Appendixes review basics of the propagation of action potentials, electricity, and cable properties Authored by leading experts in the field Clear, concise, comprehensive coverage of all aspects of cellular physiology from fundamental concepts to more advanced topics
