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Screen To Identify The Novel Pancreatic Gene Synaptotagmin 13 Syt13
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Book Synopsis Screen to identify the novel pancreatic gene Synaptotagmin 13 (Syt13) by : Stefanie Willmann
Download or read book Screen to identify the novel pancreatic gene Synaptotagmin 13 (Syt13) written by Stefanie Willmann and published by GRIN Verlag. This book was released on 2016-09-12 with total page 242 pages. Available in PDF, EPUB and Kindle. Book excerpt: Doctoral Thesis / Dissertation from the year 2016 in the subject Biology - Developmental Biology, grade: bestanden, Technical University of Munich (IDR), language: English, abstract: The pancreas is a compound gland which regulates nutrition homeostasis in mammals. Impairment in the Insulin-producing β-cells of the pancreas will lead to either type 1 or 2 diabetes. We focused on pancreas development, as the different lineages of the pancreas segregate. In the mRNA screening approach during the so-called secondary transition of the pancreas, we identified known and novel pancreatic genes. Thus, faciliating the understanding of pancreatic signaling and lineage determing factors. Furthermore, the novel pancreatic-related candidate gene Syt13 was analyzed for localization and function in the pancreatic gland, highlighting endocrine lineage commitment and ß-cell development. Der Pankreas ist ein komplexes Organ dass für das Ernährungsgleichgewicht im Körper wichtig ist. Beeinträchtigungen in den Insulin produzierenden β-Zellen des Pankreas führt entweder zu Typ1 oder Typ2 Diabetes. In der Entwicklung des Pankreas entstehen die unterschiedlichen Verzweigungen des Pankreas wie azinare, duktale und endokrine Zellen. In einem mRNA Screening Ansatz haben wir in der sekundären Transition, in der sich die unterschiedlichen Linien des Pankreas aufteilen, bekannte und unbekannte Gene identifiziert. Dabei haben wir das Gen Syt13 weiter analysiert in Bezug auf Lokalisation und Funktion im Pankreas. Die bisherigen Experimente zeigten einen Zusammenhang zwischen Syt13 in der Aufspaltung in endokrine Zellen und in der Reifung zu ß-Zellen [...]
Book Synopsis Regulation of microRNAs by : Helge Großhans
Download or read book Regulation of microRNAs written by Helge Großhans and published by Springer Science & Business Media. This book was released on 2010-12-10 with total page 160 pages. Available in PDF, EPUB and Kindle. Book excerpt: Given this pervasiveness and importance of miRNA-mediated gene regulation, it should come as little surprise that miRNAs themselves are also highly regulated. However, the recent explosion of knowledge on this topic has been remarkable, providing a primary motivation for publication of this book. As miRNAs are transcribed by RNA polymerase II, the enzyme that also generates mRNAs, it was perhaps not unexpected that miRNA transcription would be subject to regulation, and we have willfully mitted this aspect from this monograph. However, what has been unexpected is the extent of post-transcriptional regulation of miRNAs that is illustrated in this book.
Book Synopsis Industrial Policy and Prospects, 2001 A.D. by : P. D. Malgavkar
Download or read book Industrial Policy and Prospects, 2001 A.D. written by P. D. Malgavkar and published by . This book was released on 1988 with total page 110 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Book Synopsis Summer at the French Café by : Sue Moorcroft
Download or read book Summer at the French Café written by Sue Moorcroft and published by HarperCollins UK. This book was released on 2022-05-12 with total page 346 pages. Available in PDF, EPUB and Kindle. Book excerpt: ‘Unputdownable... A perfect summer holiday read’ ⭐⭐⭐⭐⭐ Reader Review Sparkling sun, strolls in the gorgeous French countryside, that first sip of cool, crisp wine – Summer is Kat’s favourite season. And this year should be no exception...
Book Synopsis Stem Cells in Development and Disease by :
Download or read book Stem Cells in Development and Disease written by and published by Academic Press. This book was released on 2004-05-31 with total page 270 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume of Current Topics in Developmental Biology showcases the research and therapeutic value of stem cells, and is proof of the increasing maturation of the fields of regenerative and molecular medicine. Reviews include: * Therapeutic cloning and tissue engineering to produce functional replacement tissues. * The role of the protein a-synuclein in a host of neurodegenerative diseases, which may be the first to benefit from stem cell therapy. * The curious array of functions in eukaryotic DNA methyltransferase, crucial for normal development and at the core of epigenetics regulation. * Influencing stem cell differentiation with mechanical stress, another example of genes versus the environment. * The process of mammalian hematopoeisis, and inducing it in model organisms with embryonic stem cells. * The regulation of differential parental germline genetic imprinting, central for epigenetics. * The molecular function and regulation of the cystic fibrosis gene, critical for understanding the complete molecular mechanism of this devastating disorder, which might soon be treatable with stem cells. This volume comprehensively describes some of the most current issues in stem cell biology, and is an exciting preview of therapies that may soon be applied in the clinic. It is essential reading for researchers, clinicians, and trainees alike. * Therapeutic Cloning and Tissue Engineering * Structure and function of eukaryotic DNA methyltransferases * Mechanical Signals as Regulators of Stem Cell Fate * Molecular basis for the Chloride Channel Activity of CFTR and the Consequences of Disease Causing Mutations
Book Synopsis Mammalian Artificial Chromosomes by : Vittorio Sgaramella
Download or read book Mammalian Artificial Chromosomes written by Vittorio Sgaramella and published by Springer Science & Business Media. This book was released on 2008-02-02 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: In 1996, we organized a workshop, inter alia, at the National Research Co- cil in Milan under the generous sponsorship of the European Science Foun- tion. On that occasion, a small group of investigators convened from many countries and presented early evidence of the possibility of assembling basic units of mammalian chromosomes into artificial constructs (or, indeed, red- ing the relevant components to more manageable dimensions and defined c- stitution). Progress in the following years has been slow but steady. Many scientists who took part in the workshop have since been engaged in active and prod- tive research. It goes to the credit of Humana Press to have realized the need for a book on artificial chromosomes that aims to provide better tools to all scientists committed to this field who are confronted with very difficult tech- cal problems. We have strived to cover in Mammalian Artificial Chromosomes: Methods and Protocols all relevant areas of artificial chromosome research, from basic genetics to daring attempts to build new tools for genetic therapy. We are of course grateful to the authors who have accepted the task of describing the technical steps and pitfalls that can be encountered in their research. Rarely has a very delicate methodology been presented with such meticulous care. We have been helped in this enterprise by the excellent librarian of the LITA Institute in Segrate, Italy, Ms. Claudia Piergigli, whom we thank warmly. Ms.
