Role Of Mitochondria In Neurological Disease

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Mitochondria and Brain Disorders

Author : Stavros Baloyannis
Publisher : BoD – Books on Demand
ISBN 13 : 1789855314
Total Pages : 125 pages
Book Rating : 4.7/5 (898 download)

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Book Synopsis Mitochondria and Brain Disorders by : Stavros Baloyannis

Download or read book Mitochondria and Brain Disorders written by Stavros Baloyannis and published by BoD – Books on Demand. This book was released on 2020-03-11 with total page 125 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mitochondrion is a unique and ubiquitous organelle that contains its own genome, encoding essential proteins that are major components of the respiratory chain and energy production system. Mitochondria play a dominant role in the life and function of eukaryotic cells including neurons and glia, as their survival and activity depend upon mitochondrial energy production and supply. Besides energy production, mitochondria also play a vital role in calcium homeostasis and may induce apoptosis by excitotoxicity. Mitochondrial dysfunction is related to common neurological diseases, such as Parkinson's disease, Alzheimer's disease, Friedreich's ataxia, Huntington's disease, and Multiple Sclerosis. An efficient treatment of mitochondrial dysfunction would open new horizons in the therapeutic perspectives of a substantial number of inflammatory and degenerative neurological disorders.

Mitochondrial Dysfunction in Neurodegenerative Disorders

Author : Amy Katherine Reeve
Publisher : Springer Science & Business Media
ISBN 13 : 0857297015
Total Pages : 252 pages
Book Rating : 4.8/5 (572 download)

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Book Synopsis Mitochondrial Dysfunction in Neurodegenerative Disorders by : Amy Katherine Reeve

Download or read book Mitochondrial Dysfunction in Neurodegenerative Disorders written by Amy Katherine Reeve and published by Springer Science & Business Media. This book was released on 2011-11-15 with total page 252 pages. Available in PDF, EPUB and Kindle. Book excerpt: As age related diseases increase in prevalence and impact more significantly on medical resources it is imperative to understand these diseases and the mechanisms behind their progression. New research has stimulated a growing interest in mitochondrial involvement in neurodegenerative disorders such as Parkinson’s disease, Alzheimer’s disease and multiple sclerosis and the mechanisms which lead from mitochondrial dysfunction to neurodegeneration. Mitochondrial Dysfunction in Neurodegenerative Disorders brings together contributions from leaders in the field internationally on the various ways in which mitochondrial dysfunction contributes to the pathogenesis of these diseases, guiding the reader through the basic functions of mitochondria and the mechanisms that lead to their dysfunction, to the consequences of this dysfunction on neuronal function before finishing with the modelling of these disorders and discussion of new potential therapeutic targets. Mitochondrial Dysfunction in Neurodegenerative Disorders provides an accessible, authoritative guide to this important area for neurologists; research and clinical neuroscientists; neuropathologists; and residents with an interest in clinical research.

Mitochondrial Dysfunction

Author : Lawrence H. Lash
Publisher : Elsevier
ISBN 13 : 1483218619
Total Pages : 527 pages
Book Rating : 4.4/5 (832 download)

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Book Synopsis Mitochondrial Dysfunction by : Lawrence H. Lash

Download or read book Mitochondrial Dysfunction written by Lawrence H. Lash and published by Elsevier. This book was released on 2013-10-22 with total page 527 pages. Available in PDF, EPUB and Kindle. Book excerpt: Methods in Toxicology, Volume 2: Mitochondrial Dysfunction provides a source of methods, techniques, and experimental approaches for studying the role of abnormal mitochondrial function in cell injury. The book discusses the methods for the preparation and basic functional assessment of mitochondria from liver, kidney, muscle, and brain; the methods for assessing mitochondrial dysfunction in vivo and in intact organs; and the structural aspects of mitochondrial dysfunction are addressed. The text also describes chemical detoxification and metabolism as well as specific metabolic reactions that are especially important targets or indicators of damage. The methods for measurement of alterations in fatty acid and phospholipid metabolism and for the analysis and manipulation of oxidative injury and antioxidant systems are also considered. The book further tackles additional methods on mitochondrial energetics and transport processes; approaches for assessing impaired function of mitochondria; and genetic and developmental aspects of mitochondrial disease and toxicology. The text also looks into mitochondrial DNA synthesis, covalent binding to mitochondrial DNA, DNA repair, and mitochondrial dysfunction in the context of developing individuals and cellular differentiation. Microbiologists, toxicologists, biochemists, and molecular pharmacologists will find the book invaluable.

Mitochondria in Neurological Disorders

Author : Rajat Sandhir
Publisher : Academic Press
ISBN 13 : 0128217324
Total Pages : 500 pages
Book Rating : 4.1/5 (282 download)

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Book Synopsis Mitochondria in Neurological Disorders by : Rajat Sandhir

Download or read book Mitochondria in Neurological Disorders written by Rajat Sandhir and published by Academic Press. This book was released on 2021-12-01 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria in Neurological Diseases highlights various therapeutic approaches targeting mitochondria in neurological conditions. Focused on diverse neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease, depression, and Amyotrophic lateral sclerosis, topics span basic mitochondrial physiology to mitochondrial dynamics and to the altered states of the nervous system. This book is appropriate for anyone interested in learning more about the physiological and pathophysiological functions of mitochondria in the nervous system. Provides up-to-date information on role of mitochondria in nervous system for graduate students and researchers Presents chapters on energy substrate utilization, calcium handling, mitochondria-organelle communication, and cell signaling Discusses recent techniques in understanding mitochondrial functions in the nervous system Emphasizes the role of altered mitochondrial functions in various neurological conditions and their potential treatment strategies for targeting mitochondria Includes chapter references (key articles, books, protocols) for additional detailed study

Role of Mitochondria in Neurological Disease

Author : Anthony S. Basile
Publisher :
ISBN 13 :
Total Pages : 118 pages
Book Rating : 4.:/5 (314 download)

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Book Synopsis Role of Mitochondria in Neurological Disease by : Anthony S. Basile

Download or read book Role of Mitochondria in Neurological Disease written by Anthony S. Basile and published by . This book was released on 2002 with total page 118 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondrial Dynamics and Neurodegeneration

Author : Bingwei Lu
Publisher : Springer Science & Business Media
ISBN 13 : 940071291X
Total Pages : 271 pages
Book Rating : 4.4/5 (7 download)

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Book Synopsis Mitochondrial Dynamics and Neurodegeneration by : Bingwei Lu

Download or read book Mitochondrial Dynamics and Neurodegeneration written by Bingwei Lu and published by Springer Science & Business Media. This book was released on 2011-05-16 with total page 271 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Mitochondrial Disorders in Neurology

Author : Anthony H.V. Schapira
Publisher : Butterworth-Heinemann
ISBN 13 : 1483193691
Total Pages : 265 pages
Book Rating : 4.4/5 (831 download)

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Book Synopsis Mitochondrial Disorders in Neurology by : Anthony H.V. Schapira

Download or read book Mitochondrial Disorders in Neurology written by Anthony H.V. Schapira and published by Butterworth-Heinemann. This book was released on 2013-10-22 with total page 265 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondrial Disorders in Neurology provides an overview of mitochondrial diseases. This book discusses the effects of mitochondrial dysfunction based on the relevant biochemistry and molecular genetics. The abnormal muscle and mitochondrial morphology in a variety of clinical presentations from isolated ophthalmoplegia to severe encephalopathy are also elaborated. This text likewise deliberates Leber's hereditary optic neuropathy, neurodegenerative disorders, and respiratory chain defects. Other topics covered include mitochondrial DNA and the genetics of mitochondrial disease; cytochrome oxidase deficiency; use of tissue culture in the diagnosis of mitochondrial disease; and advances in mitochondrial genetics. This publication is a good source for clinicians and students concerned with the defective mitochondrial function.

The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria

Author : J. Marie Hardwick
Publisher : John Wiley & Sons
ISBN 13 : 1118709233
Total Pages : 453 pages
Book Rating : 4.1/5 (187 download)

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Book Synopsis The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria by : J. Marie Hardwick

Download or read book The Functions, Disease-Related Dysfunctions, and Therapeutic Targeting of Neuronal Mitochondria written by J. Marie Hardwick and published by John Wiley & Sons. This book was released on 2015-10-19 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents advances in the field of neuronal mitochondria – functions, relation to therapeutics, and pharmacology. For scientists and researchers in both industry and academia, this book provides detailed discussion, examples, and approaches, to illustrate the potential of mitochondria as therapeutic targets for neuronal diseases. • Helps readers understand the regulation of mitochondrial cellular processes, such as substrate metabolism, energy production, and programmed versus sporadic cell death • Offers insights on the development of strategies for targeted therapeutic approaches and potential personalized treatments • Includes examples of mitochondrial drugs, development, and mitochondria-targeted approaches for more efficient treatment methods and further developments in the field • Covers the model systems and approaches needed for the development of new drugs for the central nervous system to provide potential modern therapeutics for neurodegenerative disorders

Mitochondrial Inhibitors and Neurodegenerative Disorders

Author : Paul R. Sanberg
Publisher : Springer Science & Business Media
ISBN 13 : 1592596924
Total Pages : 316 pages
Book Rating : 4.5/5 (925 download)

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Book Synopsis Mitochondrial Inhibitors and Neurodegenerative Disorders by : Paul R. Sanberg

Download or read book Mitochondrial Inhibitors and Neurodegenerative Disorders written by Paul R. Sanberg and published by Springer Science & Business Media. This book was released on 1999-10-01 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria have long been the Rodney Dangerfield of cellular organelles. Believed to be the remnants of bacterial infection of eukaryotic cells eons ago, the mitochondrion evolved a symbiotic relationship in which it dutifully served as the efficient source of A TP for cell function. The extraordinary dependence of cells on the energy provided by mito chondrial oxidative metabolism of glucose, especially through critical organs such as the heart and brain, is underlined by the fatal consequences of toxins that interfere with the mitochondrial electron transport system. Consistent with their ancestry, the mitochondria have their own DNA that encodes many but not all of their proteins. The mitochon dria and their genes come from the mother via the ovum since sperm do not possess mitochondria. This extranuclear form of inheritance derived exclusively from the female side has proven to be a powerful tool for tracing the evolution by the number of base substitutions in mtDNA. That mitochondrial gene mutations might be a source of human dis ease became evident a decade ago with the characterization of a group of multisystem disorders, typically involving the nervous system, which are transmitted from mother to child. Specific point mutations in mtDNA have been associated with the different syndromes.

Pharmacology of Mitochondria

Author : Harpreet Singh
Publisher : Springer
ISBN 13 : 3319573136
Total Pages : 491 pages
Book Rating : 4.3/5 (195 download)

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Book Synopsis Pharmacology of Mitochondria by : Harpreet Singh

Download or read book Pharmacology of Mitochondria written by Harpreet Singh and published by Springer. This book was released on 2017-08-11 with total page 491 pages. Available in PDF, EPUB and Kindle. Book excerpt: This special book is conceived to highlight mitochondrial structural and functional integrity and how they are associated with several human diseases such as cardiovascular, cancer, renal, neurological disorder, and genetic disorders. The chapters contributed by leading mitochondrial researchers in the handbook will take us through the novel pharmacological strategies via mitochondria to understand their physiological and pathological role as well as present them as therapeutic targets.

Mitochondrial Function and Dysfunction

Author : Anthony Schapira
Publisher : Elsevier
ISBN 13 : 0080489079
Total Pages : 581 pages
Book Rating : 4.0/5 (84 download)

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Book Synopsis Mitochondrial Function and Dysfunction by : Anthony Schapira

Download or read book Mitochondrial Function and Dysfunction written by Anthony Schapira and published by Elsevier. This book was released on 2003-01-10 with total page 581 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are critical to the survival of cells, therefore, it is not surprising that abnormalities in mitochondrial function may lead to human disease. This book concentrates on the biology and pathology of mitochondria, covering some ot the important basic science features of the biology of mitochondria. It then moves on to discuss the breadth of human diseases related to mitochondrial dysfunction, including Parkinson's disease, Amyotrophic Lateral Sclerosis (ALS), and Alzheimer's disease.* Provides comprehensive coverage of basic science and clinical features of mitochondrial dysfunction* Presents detailed analysis of "hot" topics in mitochondrial function and neurodegenerative diseases* Includes outstanding list of contributing authors

Mitochondria in Health and Diseases

Author : Sabzali Javadov
Publisher :
ISBN 13 : 9783039363841
Total Pages : 434 pages
Book Rating : 4.3/5 (638 download)

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Book Synopsis Mitochondria in Health and Diseases by : Sabzali Javadov

Download or read book Mitochondria in Health and Diseases written by Sabzali Javadov and published by . This book was released on 2020-09-04 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are subcellular organelles evolved by the endosymbiosis of bacteria with eukaryotic cells. They are the main source of ATP in the cell and engaged in other aspects of cell metabolism and cell function, including the regulation of ion homeostasis, cell growth, redox status, and cell signaling. Due to their central role in cell life and death, mitochondria are also involved in the pathogenesis and progression of human diseases/conditions, including neurodegenerative and cardiovascular disorders, cancer, diabetes, inflammation, and aging. However, despite the increasing number of studies, precise mechanisms whereby mitochondria are involved in the regulation of basic physiological functions, as well as their role in the cell under pathophysiological conditions, remain unknown. A lack of in-depth knowledge of the regulatory mechanisms of mitochondrial metabolism and function, as well as interplay between the factors that transform the organelle from its role in pro-survival to pro-death, have hindered the development of new mitochondria-targeted pharmacological and conditional approaches for the treatment of human diseases. This book highlights the latest achievements in elucidating the role of mitochondria under physiological conditions, in various cell/animal models of human diseases, and in patients.

Mitochondrial Dynamics and Neurodegeneration

Author : Bingwei Lu
Publisher : Springer
ISBN 13 : 9789400712928
Total Pages : 260 pages
Book Rating : 4.7/5 (129 download)

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Book Synopsis Mitochondrial Dynamics and Neurodegeneration by : Bingwei Lu

Download or read book Mitochondrial Dynamics and Neurodegeneration written by Bingwei Lu and published by Springer. This book was released on 2013-01-02 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are essential organelles in eukaryotic cells that control such diverse processes as energy metabolism, calcium buffering, and cell death. Recent studies have revealed that changes in mitochondrial morphology by fission and fusion, a process known as mitochondrial dynamics, is particularly important for neuronal function and survival. Defects in this process are commonly found in neurodegenerative diseases, offering a new paradigm for investigating mechanisms of neurodegeneration. To provide researchers working on neurodegenerative diseases and mitochondria with updated information on this rapidly progressing field, we have invited experts in the field to critically review recent progresses and identify future research directions. The topics include genetics of mitochondrial dynamics, mitochondrial dynamics and bioenergetics, autophagy, apoptosis, and axonal transport, and its role in neurological diseases, including Alzheimer’s, Parkinson’s, and Huntington’s diseases.

Mitochondrial Function

Author : William S. Allison
Publisher :
ISBN 13 :
Total Pages : pages
Book Rating : 4.:/5 (639 download)

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Book Synopsis Mitochondrial Function by : William S. Allison

Download or read book Mitochondrial Function written by William S. Allison and published by . This book was released on 2009 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Mitochondria and Free Radicals in Neurodegenerative Diseases

Author : M. Flint Beal
Publisher : Wiley-Liss
ISBN 13 : 9780471141426
Total Pages : 0 pages
Book Rating : 4.1/5 (414 download)

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Book Synopsis Mitochondria and Free Radicals in Neurodegenerative Diseases by : M. Flint Beal

Download or read book Mitochondria and Free Radicals in Neurodegenerative Diseases written by M. Flint Beal and published by Wiley-Liss. This book was released on 1997-08-12 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: The discovery that several major human neurodegenerative diseases are associated with mitochondrial dysfunction has provided new opportunities for a better understanding of these diseases. In this book, major figures in the field offer state-of-the-art reviews of the role of mitochondrial dysfunction and oxidative damage in the pathogenesis of neurodegenerative diseases. Because many of the topics presented overlap with one another, the result is the most comprehensive review of the subject to date. Mitochondria and Free Radicals in Neurodegenerative Diseases begins with a historical overview of the field presented by one of its distinguished founders. The book goes on to supply detailed information on energy metabolism in normal brain function and to explore the role of oxidative damage—which may be a consequence of mitochondrial dysfunction—in the nervous system. Other early chapters focus on energy dysfunction leading to excitotoxic cell damage, the role of mitochondrial toxins in the pathogenesis of animal models of neurodegenerative diseases, and the role of mitochondria in aging. Additional topics include: Neurologic and neuropathologic consequences of mitochondrial disorders The role of mitochondria and oxidative damage in amyotrophic lateral sclerosis, Parkinson's disease, Huntington's disease, Alzheimer's disease, and cerebellar degenerations Using MRI spectroscopy to assess energy defects in patients with neurodegenerative diseases Potential therapies for neurodegenerative diseases The role of glutamate receptor antagonists for therapy Known approaches to improving energy function in mitochondrial disorders Free radical scavengers and other innovative therapeutic approaches Cover image: Three-dimensional reconstruction of an isolated, condensed rat-liver mitochondrion, obtained by electron tomography, courtesy of Dr. Carmen A. Mannella and Wadsworth Center. Reproduced with permission from TiBS (1997) vol. 22, issue 2, pp. 37-38.

Neuro-Mitochondrial Nexus

Author : Mayur Kale
Publisher :
ISBN 13 : 9789999315821
Total Pages : 0 pages
Book Rating : 4.3/5 (158 download)

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Book Synopsis Neuro-Mitochondrial Nexus by : Mayur Kale

Download or read book Neuro-Mitochondrial Nexus written by Mayur Kale and published by . This book was released on 2024-02-24 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Mitochondria are central to neuronal health, serving as the primary energy producers within cells. This vital role makes them a focal point in understanding various neurological disorders. Across conditions such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis (ALS), multiple sclerosis, neuroinflammatory disorders, neurodevelopmental disorders, stroke, and traumatic brain injury (TBI), mitochondrial dysfunction emerges as a common thread. In Alzheimer's disease, for instance, dysfunctional mitochondria contribute to the accumulation of amyloid-beta plaques and tau protein tangles, accelerating neurodegeneration. Similarly, in Parkinson's disease, mitochondrial impairment disrupts cellular energy production, exacerbating the loss of dopaminergic neurons and leading to motor dysfunction. ALS, characterized by the progressive degeneration of motor neurons, also exhibits mitochondrial dysfunction, further contributing to the disease pathology. Additionally, in conditions like multiple sclerosis and neuroinflammatory disorders, dysfunctional mitochondria exacerbate inflammation and neuronal damage. The role of mitochondria extends beyond neurodegenerative diseases; in neurodevelopmental disorders such as autism and intellectual disabilities, disturbances in mitochondrial dynamics impact neuronal connectivity and synaptic function. Furthermore, mitochondrial impairment plays a significant role in acute neurological insults like stroke and TBI, exacerbating neuronal injury and complicating recovery processes. Despite the challenges posed by mitochondrial dysfunction in neurological disorders, there is growing interest in mitochondrial therapeutics as a promising avenue for neuroprotection and disease modification. Investigating the neuroprotective potential of mitochondrial-targeted interventions opens new avenues for therapeutic development and offers hope for mitigating the impact of mitochondrial dysfunction across a spectrum of neurological conditions.

Mitochondrial Disorders in Neurology 2

Author : Anthony Henry Vernon Schapira
Publisher : Butterworth-Heinemann
ISBN 13 :
Total Pages : 332 pages
Book Rating : 4.3/5 (91 download)

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Book Synopsis Mitochondrial Disorders in Neurology 2 by : Anthony Henry Vernon Schapira

Download or read book Mitochondrial Disorders in Neurology 2 written by Anthony Henry Vernon Schapira and published by Butterworth-Heinemann. This book was released on 2002 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt: Gain practical explanations of the science underlying mitochondrial disorders in neurology. Written by leading experts, this new Blue Book helps you recognize and manage the diseases. Includes: Sections on the role of mitochondria in neurodegenerative disease The development of animal models for mitochondrial diseases The design of treatments for patients with mitochondrial defects